More than complementing Tolls: complement-Toll-like receptor synergy and crosstalk in innate immunity and inflammation

Inhibition of pre-existing natural periodontitis in non-human primates by a locally administered peptide inhibitor of complement C3

(2016) Tomoki Maekawa et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Differential capacity for complement receptor-mediated immune evasion byPorphyromonas gingivalisdepending on the type of innate leukocyte

(2016) G. Hajishengallis et al.   Molecular Oral Microbiology

The complement system and toll-like receptors as integrated players in the pathophysiology of atherosclerosis

(2015) Anders Hovland et al.   ATHEROSCLEROSIS

The Novel Receptor C5aR2 Is Required for C5a-Mediated Human Mast Cell Adhesion, Migration, and Proinflammatory Mediator Production

(2015) Priyanka Pundir et al.   JOURNAL OF IMMUNOLOGY

Complement therapeutics in inflammatory diseases: promising drug candidates for C3-targeted intervention

(2015) D.C. Mastellos et al.   Molecular Oral Microbiology

Atheroprotective role of C5ar2 deficiency in apolipoprotein E-deficient mice

(2015) Jaco Selle et al.   THROMBOSIS AND HAEMOSTASIS

Polymicrobial synergy and dysbiosis in inflammatory disease

(2015) Richard J. Lamont et al.   TRENDS IN MOLECULAR MEDICINE

Complement System Part II: Role in Immunity

(2015) Nicolas S. Merle et al.   Frontiers in Immunology

CD14 and Complement Crosstalk and Largely Mediate the Transcriptional Response to Escherichia coli in Human Whole Blood as Revealed by DNA Microarray

(2015) Corinna Lau et al.   PLoS One

Porphyromonas gingivalis Manipulates Complement and TLR Signaling to Uncouple Bacterial Clearance from Inflammation and Promote Dysbiosis

(2014) Tomoki Maekawa et al.   Cell Host & Microbe

C5a2 can modulate ERK1/2 signaling in macrophages via heteromer formation with C5a1 and β-arrestin recruitment

(2014) Daniel E Croker et al.   IMMUNOLOGY AND CELL BIOLOGY

Complement Opsonization of HIV-1 Results in Decreased Antiviral and Inflammatory Responses in Immature Dendritic Cells via CR3

(2014) Rada Ellegård et al.   JOURNAL OF IMMUNOLOGY

The inflammophilic character of the periodontitis-associated microbiota

(2014) G. Hajishengallis   Molecular Oral Microbiology

Complement Receptor 3 Influences Toll-like Receptor 7/8-Dependent Inflammation

(2013) Joanne H. Reed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inflammatory Responses Induced by Lipopolysaccharide Are Amplified in Primary Human Monocytes but Suppressed in Macrophages by Complement Protein C5a

(2013) V. Seow et al.   JOURNAL OF IMMUNOLOGY

Complement Factor B Is the Downstream Effector of TLRs and Plays an Important Role in a Mouse Model of Severe Sepsis

(2013) L. Zou et al.   JOURNAL OF IMMUNOLOGY

Novel roles for complement receptors in T cell regulation and beyond

(2013) Claudia Kemper et al.   MOLECULAR IMMUNOLOGY

Fine Tuning Inflammation at the Front Door: Macrophage Complement Receptor 3-mediates Phagocytosis and Immune Suppression for Francisella tularensis

(2013) Shipan Dai et al.   PLoS Pathogens

C5L2: a controversial receptor of complement anaphylatoxin, C5a

(2012) Rui Li et al.   FASEB JOURNAL

Crosstalk between Toll like receptors and C5a receptor in human monocyte derived DCs suppress inflammatory cytokine production

(2012) Anouk Zaal et al.   IMMUNOBIOLOGY

Complement Activation Product C5a Is a Selective Suppressor of TLR4-Induced, but Not TLR3-Induced, Production of IL-27(p28) from Macrophages

(2012) M. Bosmann et al.   JOURNAL OF IMMUNOLOGY

Local Complement-Targeted Intervention in Periodontitis: Proof-of-Concept Using a C5a Receptor (CD88) Antagonist

(2012) T. Abe et al.   JOURNAL OF IMMUNOLOGY

Complement activation and toll-like receptor-2 signaling contribute to cytokine production after renal ischemia/reperfusion

(2012) Claudia R. Amura et al.   MOLECULAR IMMUNOLOGY

The keystone-pathogen hypothesis

(2012) George Hajishengallis et al.   NATURE REVIEWS MICROBIOLOGY

Low-Abundance Biofilm Species Orchestrates Inflammatory Periodontal Disease through the Commensal Microbiota and Complement

(2011) George Hajishengallis et al.   Cell Host & Microbe

MyD88-dependent production of IL-17F is modulated by the anaphylatoxin C5a via the Akt signaling pathway

(2011) Markus Bosmann et al.   FASEB JOURNAL

Evidence for anti-inflammatory effects of C5a on the innate IL-17A/IL-23 axis

(2011) Markus Bosmann et al.   FASEB JOURNAL

Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity

(2011) Taro Kawai et al.   IMMUNITY

A Systemic Lupus Erythematosus-associated R77H Substitution in the CD11b Chain of the Mac-1 Integrin Compromises Leukocyte Adhesion and Phagocytosis

(2011) Matthew MacPherson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modified Low Density Lipoprotein Stimulates Complement C3 Expression and Secretion via Liver X Receptor and Toll-like Receptor 4 Activation in Human Macrophages

(2011) Denis A. Mogilenko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crosstalk between Complement and Toll-Like Receptors

(2011) Wen-Chao Song   TOXICOLOGIC PATHOLOGY

Complement and periodontitis

(2010) George Hajishengallis   BIOCHEMICAL PHARMACOLOGY

The C5a Receptor (C5aR) C5L2 Is a Modulator of C5aR-mediated Signal Transduction

(2010) Claire E. Bamberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TLR-signaling Networks

(2010) J. Brown et al.   JOURNAL OF DENTAL RESEARCH

The C5a Receptor Impairs IL-12-Dependent Clearance of Porphyromonas gingivalis and Is Required for Induction of Periodontal Bone Loss

(2010) S. Liang et al.   JOURNAL OF IMMUNOLOGY

Pivotal Advance: The pattern recognition receptor ligands lipopolysaccharide and polyinosine-polycytidylic acid stimulate factor B synthesis by the macrophage through distinct but overlapping mechanisms

(2010) David J. Kaczorowski et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Complement regulates TLR4-mediated inflammatory responses during intestinal ischemia reperfusion

(2010) Michael R. Pope et al.   MOLECULAR IMMUNOLOGY

Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-b

(2010) Chaofeng Han et al.   NATURE IMMUNOLOGY

Complement: a key system for immune surveillance and homeostasis

(2010) Daniel Ricklin et al.   NATURE IMMUNOLOGY

Microbial Hijacking of Complement-Toll-Like Receptor Crosstalk

(2010) M. Wang et al.   Science Signaling

Crosstalk pathways between Toll-like receptors and the complement system

(2010) George Hajishengallis et al.   TRENDS IN IMMUNOLOGY

An Integrated View of Humoral Innate Immunity: Pentraxins as a Paradigm

(2009) Barbara Bottazzi et al.   Annual Review of Immunology

C1q enhances IFN-  production by antigen-specific T cells via the CD40 costimulatory pathway on dendritic cells

(2009) P. Baruah et al.   BLOOD

Complement promotes the development of inflammatory T-helper 17 cells through synergistic interaction with Toll-like receptor signaling and interleukin-6 production

(2009) C. Fang et al.   BLOOD

The Oral Microbial Consortium's Interaction with the Periodontal Innate Defense System

(2009) Richard P. Darveau   DNA AND CELL BIOLOGY

C5a receptor-deficient dendritic cells promote induction of Treg and Th17 cells

(2009) Donald J. Weaver et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Dendritic Cell Function in Allostimulation Is Modulated by C5aR Signaling

(2009) Q. Peng et al.   JOURNAL OF IMMUNOLOGY

Induction of Distinct TLR2-Mediated Proinflammatory and Proadhesive Signaling Pathways in Response to Porphyromonas gingivalis Fimbriae

(2009) G. Hajishengallis et al.   JOURNAL OF IMMUNOLOGY

Complement Activation by CpG in a Human Whole Blood Loop System: Mechanisms and Immunomodulatory Effects

(2009) S. M. Mangsbo et al.   JOURNAL OF IMMUNOLOGY

TLR2-Dependent Inflammatory Response to Porphyromonas gingivalis Is MyD88 Independent, whereas MyD88 Is Required To Clear Infection

(2009) E. Burns et al.   JOURNAL OF IMMUNOLOGY

When two is better than one: macrophages and neutrophils work in concert in innate immunity as complementary and cooperative partners of a myeloid phagocyte system

(2009) Manuel T. Silva   JOURNAL OF LEUKOCYTE BIOLOGY

Human genetic deficiencies reveal the roles of complement in the inflammatory network: Lessons from nature

(2009) K. T. Lappegard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD14-Mac-1 interactions in Bacillus anthracis spore internalization by macrophages

(2009) C. Oliva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TLRs and innate immunity

(2008) B. A. Beutler   BLOOD

Cyclic AMP plays a critical role in C3a-receptor-mediated regulation of dendritic cells in antigen uptake and T-cell stimulation

(2008) K. Li et al.   BLOOD

Signalling mechanisms for Toll-like receptor-activated neutrophil exocytosis: key roles for interleukin-1-receptor-associated kinase-4 and phosphatidylinositol 3-kinase but not Toll/IL-1 receptor (TIR) domain-containing adaptor inducing IFN-β (TRIF)

(2008) Agnieszka A. Brzezinska et al.   IMMUNOLOGY

Combined inhibition of complement and CD14 abolish E. coli-induced cytokine-, chemokine- and growth factor-synthesis in human whole blood

(2008) Ole-Lars Brekke et al.   MOLECULAR IMMUNOLOGY

Functional roles for C5a receptors in sepsis

(2008) Daniel Rittirsch et al.   NATURE MEDICINE