The life cycle of phagosomes: formation, maturation, and resolution

Temporal neutrophil polarization following myocardial infarction

(2016) Yonggang Ma et al.   CARDIOVASCULAR RESEARCH

Are We Really Vastly Outnumbered? Revisiting the Ratio of Bacterial to Host Cells in Humans

(2016) Ron Sender et al.   CELL

Integrins Form an Expanding Diffusional Barrier that Coordinates Phagocytosis

(2016) Spencer A. Freeman et al.   CELL

The ESCRT machinery: new roles at new holes

(2016) Y Olmos et al.   CURRENT OPINION IN CELL BIOLOGY

A naturally occurring transcript variant of MARCO reveals the SRCR domain is critical for function

(2016) Kyle E Novakowski et al.   IMMUNOLOGY AND CELL BIOLOGY

The position of lysosomes within the cell determines their luminal pH

(2016) Danielle E. Johnson et al.   JOURNAL OF CELL BIOLOGY

mTOR controls lysosome tubulation and antigen presentation in macrophages and dendritic cells

(2016) Amra Saric et al.   MOLECULAR BIOLOGY OF THE CELL

Confined diffusion of transmembrane proteins and lipids induced by the same actin meshwork lining the plasma membrane

(2016) Takahiro K. Fujiwara et al.   MOLECULAR BIOLOGY OF THE CELL

A phosphoinositide conversion mechanism for exit from endosomes

(2016) Katharina Ketel et al.   NATURE

Dynamin-Actin Cross Talk Contributes to Phagosome Formation and Closure

(2016) Florence Marie-Anaïs et al.   TRAFFIC

Calcium-sensing receptors signal constitutive macropinocytosis and facilitate the uptake of NOD2 ligands in macrophages

(2016) Johnathan Canton et al.   Nature Communications

Chemokine Signaling Enhances CD36 Responsiveness toward Oxidized Low-Density Lipoproteins and Accelerates Foam Cell Formation

(2016) Harikesh S. Wong et al.   Cell Reports

GABARAP-mediated targeting of PI4K2A/PI4KIIα to autophagosomes regulates PtdIns4P-dependent autophagosome-lysosome fusion

(2015) Joseph Albanesi et al.   Autophagy

Phosphoinositides in phagocytosis and macropinocytosis

(2015) Roni Levin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Immune Interactions with Pathogenic and Commensal Fungi: A Two-Way Street

(2015) David M. Underhill et al.   IMMUNITY

Toll-like Receptor 4 Engagement on Dendritic Cells Restrains Phago-Lysosome Fusion and Promotes Cross-Presentation of Antigens

(2015) Andrés Alloatti et al.   IMMUNITY

Of ITIMs, ITAMs, and ITAMis: revisiting immunoglobulin Fc receptor signaling

(2015) Andrew Getahun et al.   IMMUNOLOGICAL REVIEWS

Barriers to the free diffusion of proteins and lipids in the plasma membrane

(2015) William S. Trimble et al.   JOURNAL OF CELL BIOLOGY

Growth factor signaling to mTORC1 by amino acid–laden macropinosomes

(2015) Sei Yoshida et al.   JOURNAL OF CELL BIOLOGY

Initiation of lamellipodia and ruffles involves cooperation between mDia1 and the Arp2/3 complex

(2015) T. Isogai et al.   JOURNAL OF CELL SCIENCE

Cherubism allele heterozygosity amplifies microbe-induced inflammatory responses in murine macrophages

(2015) Virginie Prod’Homme et al.   JOURNAL OF CLINICAL INVESTIGATION

ABCF1 extrinsically regulates retinal pigment epithelial cell phagocytosis

(2015) Feiye Guo et al.   MOLECULAR BIOLOGY OF THE CELL

SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1

(2015) Manuele Rebsamen et al.   NATURE

Innate control of actin nucleation determines two distinct migration behaviours in dendritic cells

(2015) Pablo Vargas et al.   NATURE CELL BIOLOGY

Isoform diversity in the Arp2/3 complex determines actin filament dynamics

(2015) Jasmine V. G. Abella et al.   NATURE CELL BIOLOGY

Tyrosine phosphatase SHP-2 mediates C-type lectin receptor–induced activation of the kinase Syk and anti-fungal TH17 responses

(2015) Zihou Deng et al.   NATURE IMMUNOLOGY

Phagocytosis of apoptotic cells in homeostasis

(2015) Sanja Arandjelovic et al.   NATURE IMMUNOLOGY

Phosphatidylinositol 4-phosphate and phosphatidylinositol 3-phosphate regulate phagolysosome biogenesis

(2015) Andreas Jeschke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Making sense of amino acid sensing

(2015) R. T. Abraham   SCIENCE

Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1

(2015) S. Wang et al.   SCIENCE

Sestrin2 is a leucine sensor for the mTORC1 pathway

(2015) R. L. Wolfson et al.   SCIENCE

Toll-like receptor ligands sensitize B-cell receptor signalling by reducing actin-dependent spatial confinement of the receptor

(2015) Spencer A. Freeman et al.   Nature Communications

Phosphoinositide 3-kinase enables phagocytosis of large particles by terminating actin assembly through Rac/Cdc42 GTPase-activating proteins

(2015) Daniel Schlam et al.   Nature Communications

LynA regulates an inflammation-sensitive signaling checkpoint in macrophages

(2015) Tanya S Freedman et al.   eLife

Neurofibromin controls macropinocytosis and phagocytosis in Dictyostelium

(2015) Gareth Bloomfield et al.   eLife

TLR Signals Induce Phagosomal MHC-I Delivery from the Endosomal Recycling Compartment to Allow Cross-Presentation

(2014) Priyanka Nair-Gupta et al.   CELL

BAR Domain Scaffolds in Dynamin-Mediated Membrane Fission

(2014) Oliver Daumke et al.   CELL

Actin Cytoskeleton Reorganization by Syk Regulates Fcγ Receptor Responsiveness by Increasing Its Lateral Mobility and Clustering

(2014) Valentin Jaumouillé et al.   DEVELOPMENTAL CELL

Lysosomal phospholipase A2: A novel player in host immunity toMycobacterium tuberculosis

(2014) Bianca E. Schneider et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Phagocytosis: receptors, signal integration, and the cytoskeleton

(2014) Spencer A. Freeman et al.   IMMUNOLOGICAL REVIEWS

The inverse BAR domain protein IBARa drives membrane remodeling to control osmoregulation, phagocytosis and cytokinesis

(2014) J. Linkner et al.   JOURNAL OF CELL SCIENCE

Expression of Wiskott-Aldrich Syndrome Protein in Dendritic Cells Regulates Synapse Formation and Activation of Naive CD8+ T Cells

(2014) J. Pulecio et al.   JOURNAL OF IMMUNOLOGY

Phagosome maturation in polarized macrophages

(2014) Johnathan Canton   JOURNAL OF LEUKOCYTE BIOLOGY

Contrasting phagosome pH regulation and maturation in human M1 and M2 macrophages

(2014) Johnathan Canton et al.   MOLECULAR BIOLOGY OF THE CELL

The phosphatidylserine receptor TIM4 utilizes integrins as coreceptors to effect phagocytosis

(2014) Ronald S. Flannagan et al.   MOLECULAR BIOLOGY OF THE CELL

Tracking single molecules at work in living cells

(2014) Akihiro Kusumi et al.   Nature Chemical Biology

Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages

(2014) Stanley Ching-Cheng Huang et al.   NATURE IMMUNOLOGY

Flagellin Treatment Prevents Increased Susceptibility to Systemic Bacterial Infection after Injury by Inhibiting Anti-Inflammatory IL-10+ IL-12- Neutrophil Polarization

(2014) Crystal J. Neely et al.   PLoS One

Priming by Chemokines Restricts Lateral Mobility of the Adhesion Receptor LFA-1 and Restores Adhesion to ICAM-1 Nano-Aggregates on Human Mature Dendritic Cells

(2014) Kyra J. E. Borgman et al.   PLoS One

TLR-dependent phagosome tubulation in dendritic cells promotes phagosome cross-talk to optimize MHC-II antigen presentation

(2014) A. R. Mantegazza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Haemophilus ducreyi LspA1 Protein Inhibits Phagocytosis By Using a New Mechanism Involving Activation of C-Terminal Src Kinase

(2014) D. A. Dodd et al.   mBio

Differential TAM receptor–ligand–phospholipid interactions delimit differential TAM bioactivities

(2014) Erin D Lew et al.   eLife

Molecular mechanism for Rabex-5 GEF activation by Rabaptin-5

(2014) Zhe Zhang et al.   eLife

An estimation of the number of cells in the human body

(2013) Eva Bianconi et al.   ANNALS OF HUMAN BIOLOGY

The large ectodomains of CD45 and CD148 regulate their segregation from and inhibition of ligated T-cell receptor

(2013) S.-P. Cordoba et al.   BLOOD

The Actin and Tetraspanin Networks Organize Receptor Nanoclusters to Regulate B Cell Receptor-Mediated Signaling

(2013) Pieta K. Mattila et al.   IMMUNITY

Phosphatidic Acid-dependent Recruitment and Function of the Rac Activator DOCK1 during Dorsal Ruffle Formation

(2013) Fumiyuki Sanematsu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Late endosomal transport and tethering are coupled processes controlled by RILP and the cholesterol sensor ORP1L

(2013) R. van der Kant et al.   JOURNAL OF CELL SCIENCE

Cdc42 and the Rho GEF intersectin-1 collaborate with Nck to promote N-WASP-dependent actin polymerisation

(2013) A. C. Humphries et al.   JOURNAL OF CELL SCIENCE

Macrophage Clearance of Neutrophil Extracellular Traps Is a Silent Process

(2013) C. Farrera et al.   JOURNAL OF IMMUNOLOGY

Cholesterol-binding molecules MLN64 and ORP1L mark distinct late endosomes with transporters ABCA3 and NPC1

(2013) Rik van der Kant et al.   JOURNAL OF LIPID RESEARCH

mTOR regulates phagosome and entotic vacuole fission

(2013) Matej Krajcovic et al.   MOLECULAR BIOLOGY OF THE CELL

Signal integration by mTORC1 coordinates nutrient input with biosynthetic output

(2013) Christian C. Dibble et al.   NATURE CELL BIOLOGY

The N-Terminal Domains of Vps3 and Vps8 Are Critical for Localization and Function of the CORVET Tethering Complex on Endosomes

(2013) Nadine Epp et al.   PLoS One

N2 Neutrophils, Novel Players in Brain Inflammation After Stroke

(2013) María Isabel Cuartero et al.   STROKE

Roles for Actin Assembly in Endocytosis

(2012) Olivia L. Mooren et al.   Annual Review of Biochemistry

Myosin II-dependent exclusion of CD45 from the site of Fcγ receptor activation during phagocytosis

(2012) Shota Yamauchi et al.   FEBS LETTERS

Physiologically aged red blood cells undergo erythrophagocytosis in vivo but not in vitro

(2012) Y. Gottlieb et al.   HAEMATOLOGICA

12/15-Lipoxygenase Orchestrates the Clearance of Apoptotic Cells and Maintains Immunologic Tolerance

(2012) Stefan Uderhardt et al.   IMMUNITY

Eps8 Protein Facilitates Phagocytosis by Increasing TLR4-MyD88 Protein Interaction in Lipopolysaccharide-stimulated Macrophages

(2012) Yen-Jen Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nck and Cdc42 co-operate to recruit N-WASP to promote FcγR-mediated phagocytosis

(2012) Anna E. Dart et al.   JOURNAL OF CELL SCIENCE

Efficient Clearance of Early Apoptotic Cells by Human Macrophages Requires M2c Polarization and MerTK Induction

(2012) G. Zizzo et al.   JOURNAL OF IMMUNOLOGY

Sec1/Munc18 protein Vps33 binds to SNARE domains and the quaternary SNARE complex

(2012) Braden T. Lobingier et al.   MOLECULAR BIOLOGY OF THE CELL

High-Resolution Transcriptome of Human Macrophages

(2012) Marc Beyer et al.   PLoS One

Bin2 Is a Membrane Sculpting N-BAR Protein That Influences Leucocyte Podosomes, Motility and Phagocytosis

(2012) María José Sánchez-Barrena et al.   PLoS One

Molecular architecture of the multisubunit homotypic fusion and vacuole protein sorting (HOPS) tethering complex

(2012) C. Brocker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Presentation of Phagocytosed Antigens by MHC Class I and II

(2012) Adriana R. Mantegazza et al.   TRAFFIC

The Cell Biology of Phagocytosis

(2011) Ronald S. Flannagan et al.   Annual Review of Pathology-Mechanisms of Disease

Cytoskeletal Control of CD36 Diffusion Promotes Its Receptor and Signaling Function

(2011) Khuloud Jaqaman et al.   CELL

Arl8 and SKIP Act Together to Link Lysosomes to Kinesin-1

(2011) Cláudia Rosa-Ferreira et al.   DEVELOPMENTAL CELL

Target-specific mechanics of phagocytosis: protrusive neutrophil response to zymosan differs from the uptake of antibody-tagged pathogens

(2011) C.-Y. Lee et al.   JOURNAL OF CELL SCIENCE

Phagosome dynamics during phagocytosis by neutrophils

(2011) Pontus Nordenfelt et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Subunit organization and Rab interactions of Vps-C protein complexes that control endolysosomal membrane traffic

(2011) Rachael L. Plemel et al.   MOLECULAR BIOLOGY OF THE CELL

Recruitment of OCRL and Inpp5B to phagosomes by Rab5 and APPL1 depletes phosphoinositides and attenuates Akt signaling

(2011) Michal Bohdanowicz et al.   MOLECULAR BIOLOGY OF THE CELL

Activation of the innate immune receptor Dectin-1 upon formation of a ‘phagocytic synapse’

(2011) Helen S. Goodridge et al.   NATURE

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

(2011) R. Zoncu et al.   SCIENCE

Equilibrative Nucleoside Transporter 3 Deficiency Perturbs Lysosome Function and Macrophage Homeostasis

(2011) C.-L. Hsu et al.   SCIENCE

Identification of the Switch in Early-to-Late Endosome Transition

(2010) Dmitry Poteryaev et al.   CELL

The Mon1-Ccz1 Complex Is the GEF of the Late Endosomal Rab7 Homolog Ypt7

(2010) Mirjana Nordmann et al.   CURRENT BIOLOGY

The Membrane Skeleton Controls Diffusion Dynamics and Signaling through the B Cell Receptor

(2010) Bebhinn Treanor et al.   IMMUNITY

Dynamic macrophage “probing” is required for the efficient capture of phagocytic targets

(2010) Ronald S. Flannagan et al.   JOURNAL OF CELL BIOLOGY

Amiloride inhibits macropinocytosis by lowering submembranous pH and preventing Rac1 and Cdc42 signaling

(2010) Mirkka Koivusalo et al.   JOURNAL OF CELL BIOLOGY

Golgi-to-phagosome transport of acid sphingomyelinase and prosaposin is mediated by sortilin

(2010) A. Wahe et al.   JOURNAL OF CELL SCIENCE

The role of calcium signaling in phagocytosis

(2010) Paula Nunes et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Termination of autophagy and reformation of lysosomes regulated by mTOR

(2010) Li Yu et al.   NATURE

Identification of two evolutionarily conserved genes regulating processing of engulfed apoptotic cells

(2010) Jason M. Kinchen et al.   NATURE

Nanoscale architecture of integrin-based cell adhesions

(2010) Pakorn Kanchanawong et al.   NATURE

Molecular mechanism of multivesicular body biogenesis by ESCRT complexes

(2010) Thomas Wollert et al.   NATURE

A nucleator arms race: cellular control of actin assembly

(2010) Kenneth G. Campellone et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN

(2009) Zvi G. Fridlender et al.   CANCER CELL

Modulation of immune cell signalling by the leukocyte common tyrosine phosphatase, CD45

(2009) A.E. Saunders et al.   CELLULAR SIGNALLING

Lysosomal degradation of membrane lipids

(2009) Thomas Kolter et al.   FEBS LETTERS

The Phagosomal Proteome in Interferon-γ-Activated Macrophages

(2009) Matthias Trost et al.   IMMUNITY

CD45, CD148, and Lyp/Pep: critical phosphatases regulating Src family kinase signaling networks in immune cells

(2009) Michelle L. Hermiston et al.   IMMUNOLOGICAL REVIEWS

FBP17 Mediates a Common Molecular Step in the Formation of Podosomes and Phagocytic Cups in Macrophages

(2009) Shigeru Tsuboi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cholesterol sensor ORP1L contacts the ER protein VAP to control Rab7–RILP–p150Gluedand late endosome positioning

(2009) Nuno Rocha et al.   JOURNAL OF CELL BIOLOGY

An electrostatic switch displaces phosphatidylinositol phosphate kinases from the membrane during phagocytosis

(2009) Gregory D. Fairn et al.   JOURNAL OF CELL BIOLOGY

Formyl Peptide Receptor-Like 2 Is Expressed and Functional in Plasmacytoid Dendritic Cells, Tissue-Specific Macrophage Subpopulations, and Eosinophils

(2009) T. Devosse et al.   JOURNAL OF IMMUNOLOGY

Nucleotide- and Activator-Dependent Structural and Dynamic Changes of Arp2/3 Complex Monitored by Hydrogen/Deuterium Exchange and Mass Spectrometry

(2009) Wendy D. Zencheck et al.   JOURNAL OF MOLECULAR BIOLOGY

Rabex-5 Is a Rab22 Effector and Mediates a Rab22-Rab5 Signaling Cascade in Endocytosis

(2009) Huaiping Zhu et al.   MOLECULAR BIOLOGY OF THE CELL

Cdc42 Regulates Fcγ Receptor-mediated Phagocytosis through the Activation and Phosphorylation of Wiskott-Aldrich Syndrome Protein (WASP) and Neural-WASP

(2009) Haein Park et al.   MOLECULAR BIOLOGY OF THE CELL

Antimicrobial mechanisms of phagocytes and bacterial evasion strategies

(2009) Ronald S. Flannagan et al.   NATURE REVIEWS MICROBIOLOGY

Hv1 proton channels are required for high-level NADPH oxidase-dependent superoxide production during the phagocyte respiratory burst

(2009) I. S. Ramsey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Voltage-gated proton channels maintain pH in human neutrophils during phagocytosis

(2009) D. Morgan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rab10 Regulates Phagosome Maturation and Its Overexpression RescuesMycobacterium-Containing Phagosomes Maturation

(2009) Carla M. P. Cardoso et al.   TRAFFIC

Dynamin 2 is required for actin assembly in phagocytosis in Sertoli cells

(2008) Atsushi Otsuka et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

NADPH oxidase controls phagosomal pH and antigen cross-presentation in human dendritic cells

(2008) A. R. Mantegazza et al.   BLOOD

CD18-dependent activation of the neutrophil NADPH oxidase during phagocytosis of Escherichia coli or Staphylococcus aureus is regulated by class III but not class I or II PI3Ks

(2008) K. E. Anderson et al.   BLOOD

CX3CL1/fractalkine is released from apoptotic lymphocytes to stimulate macrophage chemotaxis

(2008) L. A. Truman et al.   BLOOD

MyD88-independent activation of a novel actin-Cdc42/Rac pathway is required for Toll-like receptor-stimulated phagocytosis

(2008) Ling Kong et al.   CELL RESEARCH

Retromer

(2008) Juan S Bonifacino et al.   CURRENT OPINION IN CELL BIOLOGY

EFC/F-BAR proteins and the N-WASP–WIP complex induce membrane curvature-dependent actin polymerization

(2008) Kazunari Takano et al.   EMBO JOURNAL

Structurally Distinct Phosphatases CD45 and CD148 Both Regulate B Cell and Macrophage Immunoreceptor Signaling

(2008) Jing W. Zhu et al.   IMMUNITY

Cholesterol Accumulation by Macrophages Impairs Phagosome Maturation

(2008) Kassidy K. Huynh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of retromer recruitment to endosomes by sequential action of Rab5 and Rab7

(2008) Raul Rojas et al.   JOURNAL OF CELL BIOLOGY

PI3K accelerates, but is not required for, neutrophil chemotaxis to fMLP

(2008) B. Heit et al.   JOURNAL OF CELL SCIENCE

Membrane targeting of WAVE2 is not sufficient for WAVE2-dependent actin polymerization: a role for IRSp53 in mediating the interaction between Rac and WAVE2

(2008) W. Abou-Kheir et al.   JOURNAL OF CELL SCIENCE

Membrane Ruffles Capture C3bi-opsonized Particles in Activated Macrophages

(2008) Prerna C. Patel et al.   MOLECULAR BIOLOGY OF THE CELL

Role for Spi-C in the development of red pulp macrophages and splenic iron homeostasis

(2008) Masako Kohyama et al.   NATURE

Imaging of Rab5 activity identifies essential regulators for phagosome maturation

(2008) Masahiro Kitano et al.   NATURE

A pathway for phagosome maturation during engulfment of apoptotic cells

(2008) Jason M. Kinchen et al.   NATURE CELL BIOLOGY

Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium

(2008) Emyr Lloyd-Evans et al.   NATURE MEDICINE

Phagosome maturation: going through the acid test

(2008) Jason M. Kinchen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes

(2008) R. E. Infante et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

(2008) K. Trajkovic et al.   SCIENCE