Regulation of neutrophil functions through inhibitory receptors: an emerging paradigm in health and disease

Signal Inhibitory Receptor on Leukocytes-1 Limits the Formation of Neutrophil Extracellular Traps, but Preserves Intracellular Bacterial Killing

(2016) Kristof Van Avondt et al.   JOURNAL OF IMMUNOLOGY

Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease

(2016) Christian Lood et al.   NATURE MEDICINE

Immunoreceptors on neutrophils

(2016) Dieke J. van Rees et al.   SEMINARS IN IMMUNOLOGY

Pseudomonas aeruginosa Evolutionary Adaptation and Diversification in Cystic Fibrosis Chronic Lung Infections

(2016) Craig Winstanley et al.   TRENDS IN MICROBIOLOGY

Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential

(2015) Padmanee Sharma et al.   CELL

How methicillin-resistant Staphylococcus aureus evade neutrophil killing

(2015) Mallary Greenlee-Wacker et al.   CURRENT OPINION IN HEMATOLOGY

Immunomodulatory activity of extracellular Hsp70 mediated via paired receptors Siglec-5 and Siglec-14

(2015) J. J. Fong et al.   EMBO JOURNAL

The killer-cell immunoglobulin-like receptors of macaques

(2015) Benjamin N. Bimber et al.   IMMUNOLOGICAL REVIEWS

Co-evolution of the MHC class I and KIR gene families in rhesus macaques: ancestry and plasticity

(2015) Natasja G. de Groot et al.   IMMUNOLOGICAL REVIEWS

Of ITIMs, ITAMs, and ITAMis: revisiting immunoglobulin Fc receptor signaling

(2015) Andrew Getahun et al.   IMMUNOLOGICAL REVIEWS

Surveillance of cell and tissue perturbation by receptors in the LRC

(2015) John Trowsdale et al.   IMMUNOLOGICAL REVIEWS

Mouse and human FcR effector functions

(2015) Pierre Bruhns et al.   IMMUNOLOGICAL REVIEWS

The Biology and Disease Relevance of CD300a, an Inhibitory Receptor for Phosphatidylserine and Phosphatidylethanolamine

(2015) Olatz Zenarruzabeitia et al.   JOURNAL OF IMMUNOLOGY

Neutrophils in viral infections: Current concepts and caveats

(2015) I. E. Galani et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Host and pathogen hyaluronan signal through human siglec-9 to suppress neutrophil activation

(2015) Ismael Secundino et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

A global reference for human genetic variation

(2015) Richard A. Gibbs et al.   NATURE

Staphylococcal manipulation of host immune responses

(2015) Vilasack Thammavongsa et al.   NATURE REVIEWS MICROBIOLOGY

The future of immune checkpoint therapy

(2015) P. Sharma et al.   SCIENCE

Suppression of a Natural Killer Cell Response by Simian Immunodeficiency Virus Peptides

(2015) Jamie L. Schafer et al.   PLoS Pathogens

Bacterial Immune Evasion through Manipulation of Host Inhibitory Immune Signaling

(2015) Kristof Van Avondt et al.   PLoS Pathogens

Neutrophils: Between Host Defence, Immune Modulation, and Tissue Injury

(2015) Philipp Kruger et al.   PLoS Pathogens

Subterfuge and Sabotage: Evasion of Host Innate Defenses by Invasive Gram-Positive Bacterial Pathogens

(2014) Cheryl Y.M. Okumura et al.   Annual Review of Microbiology

Clec12a Is an Inhibitory Receptor for Uric Acid Crystals that Regulates Inflammation in Response to Cell Death

(2014) Konstantin Neumann et al.   IMMUNITY

In vivoevidence that secretion of HLA-G by immunogenic tumor cells allows their evasion from immunosurveillance

(2014) Laure Loumagne et al.   INTERNATIONAL JOURNAL OF CANCER

Siglec-5 and Siglec-14 are polymorphic paired receptors that modulate neutrophil and amnion signaling responses to group BStreptococcus

(2014) Syed Raza Ali et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Comparison of Proteins Expressed on Secretory Vesicle Membranes and Plasma Membranes of Human Neutrophils

(2014) S. M. Uriarte et al.   JOURNAL OF IMMUNOLOGY

Inhibitory Immunoglobulin-Like Receptors LILRB and PIR-B Negatively Regulate Osteoclast Development

(2014) Y. Mori et al.   JOURNAL OF IMMUNOLOGY

PIR-B-Deficient Mice Are Susceptible to Salmonella Infection

(2014) I. Torii et al.   JOURNAL OF IMMUNOLOGY

Macrophage- and Neutrophil-Derived TNF-α Instructs Skin Langerhans Cells To Prime Antiviral Immune Responses

(2014) Olivier Epaulard et al.   JOURNAL OF IMMUNOLOGY

Signal Regulatory Protein Alpha Is Present in Several Neutrophil Granule Populations and Is Rapidly Mobilized to the Cell Surface to Negatively Fine-Tune Neutrophil Accumulation in Inflammation

(2014) Åsa Stenberg et al.   Journal of Innate Immunity

High plasma levels of HLA-G are associated with low birth weight and with an increased risk of malaria in infancy

(2014) Ibrahim Sadissou et al.   MALARIA JOURNAL

Neutrophils at work

(2014) William M Nauseef et al.   NATURE IMMUNOLOGY

Engagement of myelomonocytic Siglecs by tumor-associated ligands modulates the innate immune response to cancer

(2014) Heinz Läubli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a human neonatal immune-metabolic network associated with bacterial infection

(2014) Claire L. Smith et al.   Nature Communications

LILRB2 Interaction with HLA Class I Correlates with Control of HIV-1 Infection

(2014) Arman A. Bashirova et al.   PLoS Genetics

Group B Streptococcus Engages an Inhibitory Siglec through Sialic Acid Mimicry to Blunt Innate Immune and Inflammatory Responses In Vivo

(2014) Yung-Chi Chang et al.   PLoS Pathogens

Controlling Natural Killer Cell Responses: Integration of Signals for Activation and Inhibition

(2013) Eric O. Long et al.   Annual Review of Immunology

Neutrophils Versus Staphylococcus aureus: A Biological Tug of War

(2013) András N. Spaan et al.   Annual Review of Microbiology

Siglec-E is a negative regulator of acute pulmonary neutrophil inflammation and suppresses CD11b  2-integrin-dependent signaling

(2013) S. J. McMillan et al.   BLOOD

Neutrophils mediate antibody-induced antitumor effects in mice

(2013) M. Albanesi et al.   BLOOD

Rapid evolution of binding specificities and expression patterns of inhibitory CD33-related Siglecs in primates

(2013) Vered Padler-Karavani et al.   FASEB JOURNAL

Distinct Roles for Neutrophils and Dendritic Cells in Inflammation and Autoimmunity in motheaten Mice

(2013) Clare L. Abram et al.   IMMUNITY

Diversity of the human LILRB3/A6 locus encoding a myeloid inhibitory and activating receptor pair

(2013) Arman A. Bashirova et al.   IMMUNOGENETICS

Neutrophil cell surface receptors and their intracellular signal transduction pathways

(2013) Krisztina Futosi et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Diverse novel functions of neutrophils in immunity, inflammation, and beyond

(2013) Attila Mócsai   JOURNAL OF EXPERIMENTAL MEDICINE

Proteome profiling of human neutrophil granule subsets, secretory vesicles, and cell membrane: correlation with transcriptome profiling of neutrophil precursors

(2013) Sara Rørvig et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Ligation of Signal Inhibitory Receptor on Leukocytes-1 Suppresses the Release of Neutrophil Extracellular Traps in Systemic Lupus Erythematosus

(2013) Kristof Van Avondt et al.   PLoS One

Exocytosis acts as a modulator of the ILT4-mediated inhibition of neutrophil functions

(2013) J. Baudhuin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human LilrB2 Is a  -Amyloid Receptor and Its Murine Homolog PirB Regulates Synaptic Plasticity in an Alzheimer's Model

(2013) T. Kim et al.   SCIENCE

Molecular mechanisms regulating NETosis in infection and disease

(2013) Nora Branzk et al.   Seminars in Immunopathology

Neutrophil extracellular chromatin traps connect innate immune response to autoimmunity

(2013) Marko Radic et al.   Seminars in Immunopathology

Inflammation-induced proteolytic processing of the SIRPα cytoplasmic ITIM in neutrophils propagates a proinflammatory state

(2013) Ke Zen et al.   Nature Communications

Neutrophil Function: From Mechanisms to Disease

(2012) Borko Amulic et al.   Annual Review of Immunology

Siglecs and Immune Regulation

(2012) Shiv Pillai et al.   Annual Review of Immunology

Neutrophil Extracellular Traps Mediate a Host Defense Response to Human Immunodeficiency Virus-1

(2012) Tatsuya Saitoh et al.   Cell Host & Microbe

HLA-G1 and HLA-G5 active dimers are present in malignant cells and effusions: The influence of the tumor microenvironment

(2012) Sonia Zilberman et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Neutrophils Transport Antigen from the Dermis to the Bone Marrow, Initiating a Source of Memory CD8+ T Cells

(2012) Darragh Duffy et al.   IMMUNITY

Neutrophil extracellular traps: Is immunity the second function of chromatin?

(2012) Volker Brinkmann et al.   JOURNAL OF CELL BIOLOGY

HLA-B27 Homodimers and Free H Chains Are Stronger Ligands for Leukocyte Ig-like Receptor B2 than Classical HLA Class I

(2012) J. Giles et al.   JOURNAL OF IMMUNOLOGY

Inhibitory Receptor Paired Ig-like Receptor B Is Exploited by Staphylococcus aureus for Virulence

(2012) M. Nakayama et al.   JOURNAL OF IMMUNOLOGY

Sialoglycoproteins adsorbed by Pseudomonas aeruginosa facilitate their survival by impeding neutrophil extracellular trap through siglec-9

(2012) B. Khatua et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Inhibitory receptors bind ANGPTLs and support blood stem cells and leukaemia development

(2012) Junke Zheng et al.   NATURE

Systemic inhibition of myeloid dendritic cells by circulating HLA class I molecules in HIV-1 infection

(2012) Jinghe Huang et al.   Retrovirology

The Cell Biology of Phagocytosis

(2011) Ronald S. Flannagan et al.   Annual Review of Pathology-Mechanisms of Disease

Inhibition of human Vγ9Vδ2 T-cell antitumoral activity through HLA-G: implications for immunotherapy of cancer

(2011) Emilie Lesport et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Immune inhibitory receptors: Essential regulators of phagocyte function

(2011) Tessa A. M. Steevels et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

HLA-G inhibition of NK-cell cytolytic function is uncoupled from tumor cell lipid raft reorganization

(2011) Jeremy Baudhuin et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Paired Immunoglobin-like Receptor-B Regulates the Suppressive Function and Fate of Myeloid-Derived Suppressor Cells

(2011) Ge Ma et al.   IMMUNITY

Differential but Competitive Binding of Nogo Protein and Class I Major Histocompatibility Complex (MHCI) to the PIR-B Ectodomain Provides an Inhibition of Cells

(2011) Haruka Matsushita et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HLA Class I Allelic Sequence and Conformation Regulate Leukocyte Ig-Like Receptor Binding

(2011) D. C. Jones et al.   JOURNAL OF IMMUNOLOGY

CD47-signal regulatory protein-  (SIRP ) interactions form a barrier for antibody-mediated tumor cell destruction

(2011) X. W. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of HLA-G in immunity and hematopoiesis

(2010) Edgardo D. Carosella et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Neutrophils, from Marrow to Microbes

(2010) Niels Borregaard   IMMUNITY

Signaling and ligand interaction of ILT7: receptor-mediated regulatory mechanisms for plasmacytoid dendritic cells

(2010) Wei Cao et al.   IMMUNOLOGICAL REVIEWS

Relative Over-Reactivity of Human versus Chimpanzee Lymphocytes: Implications for the Human Diseases Associated with Immune Activation

(2010) P. C. Soto et al.   JOURNAL OF IMMUNOLOGY

Signal Inhibitory Receptor on Leukocytes-1 Is a Novel Functional Inhibitory Immune Receptor Expressed on Human Phagocytes

(2010) T. A. M. Steevels et al.   JOURNAL OF IMMUNOLOGY

Soluble HLA-G Inhibits Myeloid Dendritic Cell Function in HIV-1 Infection by Interacting with Leukocyte Immunoglobulin-Like Receptor B2

(2010) Jinghe Huang et al.   JOURNAL OF VIROLOGY

Mutational Escape in HIV-1 CTL Epitopes Leads to Increased Binding to Inhibitory Myelomonocytic MHC Class I Receptors

(2010) Yue Yang et al.   PLoS One

Molecular mimicry of host sialylated glycans allows a bacterial pathogen to engage neutrophil Siglec-9 and dampen the innate immune response

(2009) A. F. Carlin et al.   BLOOD

ILT2/HLA-G interaction impairs NK-cell functions through the inhibition of the late but not the early events of the NK-cell activating synapse

(2009) Benoit Favier et al.   FASEB JOURNAL

Human melanoma cell secreting human leukocyte antigen–G5 inhibit natural killer cell cytotoxicity by impairing lytic granules polarization toward target cell

(2009) Emilie Lesport et al.   HUMAN IMMUNOLOGY

HLA-B*35-Px–mediated acceleration of HIV-1 infection by increased inhibitory immunoregulatory impulses

(2009) Jinghe Huang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Group BStreptococcussuppression of phagocyte functions by protein-mediated engagement of human Siglec-5

(2009) Aaron F. Carlin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Siglec-9 and SHP-1 Are Differentially Expressed in Neonatal and Adult Neutrophils

(2009) Ramachandran Rashmi et al.   PEDIATRIC RESEARCH

The Counterbalance Theory for Evolution and Function of Paired Receptors

(2008) A. Neil Barclay et al.   IMMUNITY

Negative signaling by inhibitory receptors: the NK cell paradigm

(2008) Eric O. Long   IMMUNOLOGICAL REVIEWS

Immunoreceptor tyrosine-based inhibition motifs: a quest in the past and future

(2008) Marc Daëron et al.   IMMUNOLOGICAL REVIEWS

Enhancing SIV-specific immunity in vivo by PD-1 blockade

(2008) Vijayakumar Velu et al.   NATURE

PirB is a Functional Receptor for Myelin Inhibitors of Axonal Regeneration

(2008) J. K. Atwal et al.   SCIENCE

The CD300a (IRp60) inhibitory receptor is rapidly up-regulated on human neutrophils in response to inflammatory stimuli and modulates CD32a (FcγRIIa) mediated signaling

(2007) Yelina Alvarez et al.   MOLECULAR IMMUNOLOGY