Neutrophils at work

STIM1 calcium sensor is required for activation of the phagocyte oxidase during inflammation and host defense

(2014) H. Zhang et al.   BLOOD

Advances in stem cell mobilization

(2014) Rusudan K. Hopman et al.   BLOOD REVIEWS

Crosstalk between Sentinel and Helper Macrophages Permits Neutrophil Migration into Infected Uroepithelium

(2014) Marzena Schiwon et al.   CELL

Transmigrating Neutrophils Shape the Mucosal Microenvironment through Localized Oxygen Depletion to Influence Resolution of Inflammation

(2014) Eric L. Campbell et al.   IMMUNITY

Central Role of Conventional Dendritic Cells in Regulation of Bone Marrow Release and Survival of Neutrophils

(2014) J. Jiao et al.   JOURNAL OF IMMUNOLOGY

Phagocytosis of Staphylococcus aureus by Human Neutrophils Prevents Macrophage Efferocytosis and Induces Programmed Necrosis

(2014) M. C. Greenlee-Wacker et al.   JOURNAL OF IMMUNOLOGY

Kupffer cells and activation of endothelial TLR4 coordinate neutrophil adhesion within liver sinusoids during endotoxemia

(2013) Braedon McDonald et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Neutrophil Intercellular Communication in Acute Lung Injury. Emerging Roles of Microparticles and Gap Junctions

(2013) Viola Dengler et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Suppression of Hyaluronan Synthesis Alleviates Inflammatory Responses in Murine Arthritis and in Human Rheumatoid Synovial Fibroblasts

(2013) Yutaka Yoshioka et al.   ARTHRITIS AND RHEUMATISM

Neutrophil differentiation into a unique hybrid population exhibiting dual phenotype and functionality of neutrophils and dendritic cells

(2013) H. Matsushima et al.   BLOOD

Emergence, origin, and function of neutrophil-dendritic cell hybrids in experimentally induced inflammatory lesions in mice

(2013) S. Geng et al.   BLOOD

Phosphoinositide 3-kinase inhibition restores neutrophil accuracy in the elderly: toward targeted treatments for immunosenescence

(2013) E. Sapey et al.   BLOOD

Mast cell and macrophage chemokines CXCL1/CXCL2 control the early stage of neutrophil recruitment during tissue inflammation

(2013) K. De Filippo et al.   BLOOD

Neutrophil myeloperoxidase regulates T-cell-driven tissue inflammation in mice by inhibiting dendritic cell function

(2013) D. Odobasic et al.   BLOOD

Synchronized integrin engagement and chemokine activation is crucial in neutrophil extracellular trap-mediated sterile inflammation

(2013) J. Rossaint et al.   BLOOD

NETosis: how vital is it?

(2013) B. G. Yipp et al.   BLOOD

Rhythmic Modulation of the Hematopoietic Niche through Neutrophil Clearance

(2013) María Casanova-Acebes et al.   CELL

Neutrophils Recruited to Sites of Infection Protect from Virus Challenge by Releasing Neutrophil Extracellular Traps

(2013) Craig N. Jenne et al.   Cell Host & Microbe

Neutrophil microparticles modulate cytokine production by natural killer cells

(2013) Boris K. Pliyev et al.   CYTOKINE

Microparticle alpha-2-macroglobulin enhances pro-resolving responses and promotes survival in sepsis

(2013) Jesmond Dalli et al.   EMBO Molecular Medicine

Functional and genetic characterization of two extremely rare cases of Williams–Beuren Syndrome associated with chronic granulomatous disease

(2013) Marie J Stasia et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Diacylglycerol Kinases Terminate Diacylglycerol Signaling during the Respiratory Burst Leading to Heterogeneous Phagosomal NADPH Oxidase Activation

(2013) Daniel Schlam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neutrophils control the magnitude and spread of the immune response in a thromboxane A2-mediated process

(2013) Chiao-Wen Yang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neutrophil mobilization via plerixafor-mediated CXCR4 inhibition arises from lung demargination and blockade of neutrophil homing to the bone marrow

(2013) Sapna Devi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulation of Circulating Neutrophil Numbers under Homeostasis and in Disease

(2013) Natasha Strydom et al.   Journal of Innate Immunity

Heterogeneity in Neutrophil Microparticles Reveals Distinct Proteome and Functional Properties

(2013) Jesmond Dalli et al.   MOLECULAR & CELLULAR PROTEOMICS

Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches

(2013) Lei Ding et al.   NATURE

Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo

(2013) Tim Lämmermann et al.   NATURE

Voltage-Gated Proton Channels: Molecular Biology, Physiology, and Pathophysiology of the HV Family

(2013) Thomas E. DeCoursey   PHYSIOLOGICAL REVIEWS

Cyclic AMP Responsive Element Binding Proteins Are Involved in ‘Emergency’ Granulopoiesis through the Upregulation of CCAAT/Enhancer Binding Protein β

(2013) Hideyo Hirai et al.   PLoS One

Role of neutrophils in systemic autoimmune diseases

(2013) Mariana J Kaplan   ARTHRITIS RESEARCH & THERAPY

Current insights into neutrophil homeostasis

(2012) Stefanie Bugl et al.   Annals of the New York Academy of Sciences

Leukocyte adhesion deficiencies

(2012) Suhair Hanna et al.   Annals of the New York Academy of Sciences

ICAM-1-activated Src and eNOS signaling increase endothelial cell surface PECAM-1 adhesivity and neutrophil transmigration

(2012) G. Liu et al.   BLOOD

Steady-state neutrophil homeostasis is dependent on TLR4/TRIF signaling

(2012) S. Bugl et al.   BLOOD

Antibacterial effect of microvesicles released from human neutrophilic granulocytes

(2012) C. I. Timar et al.   BLOOD

Neutrophil extracellular traps mediate transfer of cytoplasmic neutrophil antigens to myeloid dendritic cells toward ANCA induction and associated autoimmunity

(2012) S. Sangaletti et al.   BLOOD

Neutrophil Extracellular Traps Mediate a Host Defense Response to Human Immunodeficiency Virus-1

(2012) Tatsuya Saitoh et al.   Cell Host & Microbe

Intravascular Neutrophil Extracellular Traps Capture Bacteria from the Bloodstream during Sepsis

(2012) Braedon McDonald et al.   Cell Host & Microbe

Leukocyte-Derived Microparticles in Vascular Homeostasis

(2012) Anne Angelillo-Scherrer   CIRCULATION RESEARCH

STIM1 Juxtaposes ER to Phagosomes, Generating Ca2+ Hotspots that Boost Phagocytosis

(2012) Paula Nunes et al.   CURRENT BIOLOGY

Chloride transport in functionally active phagosomes isolated from Human neutrophils

(2012) Martha L. Aiken et al.   FREE RADICAL BIOLOGY AND MEDICINE

Chronic Granulomatous Disease

(2012) Steven M. Holland   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Leukocyte Adhesion Deficiencies

(2012) Edith van de Vijver et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Adrenergic Nerves Govern Circadian Leukocyte Recruitment to Tissues

(2012) Christoph Scheiermann et al.   IMMUNITY

Neutrophils Transport Antigen from the Dermis to the Bone Marrow, Initiating a Source of Memory CD8+ T Cells

(2012) Darragh Duffy et al.   IMMUNITY

Ectosomes of polymorphonuclear neutrophils activate multiple signaling pathways in macrophages

(2012) Ceylan Eken et al.   IMMUNOBIOLOGY

Direct in vivo observations of P-selectin glycoprotein ligand-1-mediated leukocyte–endothelial cell interactions in the pulmonary microvasculature in abdominal sepsis in mice

(2012) J. Roller et al.   INFLAMMATION RESEARCH

Uropod elongation is a common final step in leukocyte extravasation through inflamed vessels

(2012) Young-Min Hyun et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neutrophil depletion impairs natural killer cell maturation, function, and homeostasis

(2012) Baptiste N. Jaeger et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pericytes support neutrophil subendothelial cell crawling and breaching of venular walls in vivo

(2012) Doris Proebstl et al.   JOURNAL OF EXPERIMENTAL MEDICINE

p40phox Expression Regulates Neutrophil Recruitment and Function during the Resolution Phase of Intestinal Inflammation

(2012) K. L. Conway et al.   JOURNAL OF IMMUNOLOGY

Tissue-Specific Neutrophil Recruitment into the Lung, Liver, and Kidney

(2012) Jan Rossaint et al.   Journal of Innate Immunity

Myeloperoxidase: a front-line defender against phagocytosed microorganisms

(2012) S. J. Klebanoff et al.   JOURNAL OF LEUKOCYTE BIOLOGY

K+-Cl−cotransport mediates the bactericidal activity of neutrophils by regulating NADPH oxidase activation

(2012) Yuan-Ting Sun et al.   JOURNAL OF PHYSIOLOGY-LONDON

‘Slings’ enable neutrophil rolling at high shear

(2012) Prithu Sundd et al.   NATURE

Endothelial and perivascular cells maintain haematopoietic stem cells

(2012) Lei Ding et al.   NATURE

Capillary and arteriolar pericytes attract innate leukocytes exiting through venules and 'instruct' them with pattern-recognition and motility programs

(2012) Konstantin Stark et al.   NATURE IMMUNOLOGY

Infection-induced NETosis is a dynamic process involving neutrophil multitasking in vivo

(2012) Bryan G Yipp et al.   NATURE MEDICINE

Functionally relevant neutrophilia in CD11c diphtheria toxin receptor transgenic mice

(2012) André P Tittel et al.   NATURE METHODS

Neutrophil Extracellular Traps Directly Induce Epithelial and Endothelial Cell Death: A Predominant Role of Histones

(2012) Mona Saffarzadeh et al.   PLoS One

Depletion of Dendritic Cells Enhances Innate Anti-Bacterial Host Defense through Modulation of Phagocyte Homeostasis

(2012) Stella E. Autenrieth et al.   PLoS Pathogens

The Cystic Fibrosis Neutrophil: A Specialized Yet Potentially Defective Cell

(2011) Elaine Hayes et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Neutrophil survival and c-kit+-progenitor proliferation in Staphylococcus aureus-infected skin wounds promote resolution

(2011) M.-H. Kim et al.   BLOOD

Killing by neutrophil extracellular traps: fact or folklore?

(2011) R. Menegazzi et al.   BLOOD

Orais and STIMs: physiological mechanisms and disease

(2011) A. Berna-Erro et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

A subset of neutrophils in human systemic inflammation inhibits T cell responses through Mac-1

(2011) Janesh Pillay et al.   JOURNAL OF CLINICAL INVESTIGATION

Dissociation of VE-PTP from VE-cadherin is required for leukocyte extravasation and for VEGF-induced vascular permeability in vivo

(2011) Andre Broermann et al.   JOURNAL OF EXPERIMENTAL MEDICINE

An Essential Role of STIM1, Orai1, and S100A8-A9 Proteins for Ca2+ Signaling and Fc R-Mediated Phagosomal Oxidative Activity

(2011) N. Steinckwich et al.   JOURNAL OF IMMUNOLOGY

Lung Neutrophils Facilitate Activation of Naive Antigen-Specific CD4+ T Cells during Mycobacterium tuberculosis Infection

(2011) R. Blomgran et al.   JOURNAL OF IMMUNOLOGY

In vivo-transmigrated human neutrophils are resistant to antiapoptotic stimulation

(2011) Karin Christenson et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Myeloperoxidase associated with neutrophil extracellular traps is active and mediates bacterial killing in the presence of hydrogen peroxide

(2011) Heather Parker et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The junctional adhesion molecule JAM-C regulates polarized transendothelial migration of neutrophils in vivo

(2011) Abigail Woodfin et al.   NATURE IMMUNOLOGY

B cell–helper neutrophils stimulate the diversification and production of immunoglobulin in the marginal zone of the spleen

(2011) Irene Puga et al.   NATURE IMMUNOLOGY

Myeloperoxidase is required for neutrophil extracellular trap formation: implications for innate immunity

(2010) K. D. Metzler et al.   BLOOD

CCR7 is involved in the migration of neutrophils to lymph nodes

(2010) C. Beauvillain et al.   BLOOD

Ectosomes as modulators of inflammation and immunity

(2010) S. Sadallah et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Neutrophils, from Marrow to Microbes

(2010) Niels Borregaard   IMMUNITY

Ectosomes Released by Polymorphonuclear Neutrophils Induce a MerTK-dependent Anti-inflammatory Pathway in Macrophages

(2010) Ceylan Eken et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps

(2010) Venizelos Papayannopoulos et al.   JOURNAL OF CELL BIOLOGY

PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps

(2010) Pingxin Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neutrophils Influence the Level of Antigen Presentation during the Immune Response to Protein Antigens in Adjuvants

(2010) C.-W. Yang et al.   JOURNAL OF IMMUNOLOGY

In Cystic Fibrosis Homozygotes and Heterozygotes, Neutrophil Apoptosis Is Delayed and Modulated by Diamide or Roscovitine: Evidence for an Innate Neutrophil Disturbance

(2010) Sandra Moriceau et al.   Journal of Innate Immunity

CFTR-mediated halide transport in phagosomes of human neutrophils

(2010) Richard G. Painter et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Activation of the Raf-MEK-ERK pathway is required for neutrophil extracellular trap formation

(2010) Abdul Hakkim et al.   Nature Chemical Biology

Breaching multiple barriers: leukocyte motility through venular walls and the interstitium

(2010) Sussan Nourshargh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Molecular and Functional Characterization of Hv1 Proton Channel in Human Granulocytes

(2010) Gábor L. Petheő et al.   PLoS One

In vivo two-photon imaging reveals monocyte-dependent neutrophil extravasation during pulmonary inflammation

(2010) D. Kreisel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Voltage-gated proton channel is expressed on phagosomes

(2009) Yoshifumi Okochi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Restoration of NET formation by gene therapy in CGD controls aspergillosis

(2009) M. Bianchi et al.   BLOOD

A new genetic subgroup of chronic granulomatous disease with autosomal recessive mutations in p40phox and selective defects in neutrophil NADPH oxidase activity

(2009) J. D. Matute et al.   BLOOD

Recent developments and complexities in neutrophil transmigration

(2009) Abigail Woodfin et al.   CURRENT OPINION IN HEMATOLOGY

Apoptotic Cells Promote Their Own Clearance and Immune Tolerance through Activation of the Nuclear Receptor LXR

(2009) Noelia A-Gonzalez et al.   IMMUNITY

Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation

(2009) Yanming Wang et al.   JOURNAL OF CELL BIOLOGY

VSOP/Hv1 proton channels sustain calcium entry, neutrophil migration, and superoxide production by limiting cell depolarization and acidification

(2009) Antoun El Chemaly et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-17A Controls IL-17F Production and Maintains Blood Neutrophil Counts in Mice

(2009) S. von Vietinghoff et al.   JOURNAL OF IMMUNOLOGY

Neutrophil Bleaching of GFP-Expressing Staphylococci: Probing the Intraphagosomal Fate of Individual Bacteria

(2009) J. Schwartz et al.   JOURNAL OF IMMUNOLOGY

Modulation of CXC Chemokine Receptor Expression and Function in Human Neutrophils during Aging In Vitro Suggests a Role in Their Clearance from Circulation

(2009) Katja C. Weisel et al.   MEDIATORS OF INFLAMMATION

Hv1 proton channels are required for high-level NADPH oxidase-dependent superoxide production during the phagocyte respiratory burst

(2009) I. S. Ramsey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polymorphonuclear neutrophils and T lymphocytes: strange bedfellows or brothers in arms?

(2009) Ingrid Müller et al.   TRENDS IN IMMUNOLOGY

Inflammatory Bowel Disease in CGD Reproduces the Clinicopathological Features of Crohn's Disease

(2008) Daniel J B Marks et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Annexin 1 mediates the rapid anti-inflammatory effects of neutrophil-derived microparticles

(2008) J. Dalli et al.   BLOOD

Expression, activation, and function of integrin  M 2 (Mac-1) on neutrophil-derived microparticles

(2008) E. Pluskota et al.   BLOOD

Biological Roles for the NOX Family NADPH Oxidases

(2008) William M. Nauseef   JOURNAL OF BIOLOGICAL CHEMISTRY