Copper (Cu) induced changes of lipid metabolism through oxidative stress-mediated autophagy and Nrf2/PPARγ pathways

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Oxidative damage under As3+ and/or Cu2+ stress leads to apoptosis and autophagy and may be cross-talking with mitochondrial disorders in bursa of Fabricius

(2020) Menghao Guo et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Waterborne Cu exposure increased lipid deposition and lipogenesis by affecting Wnt/β-catenin pathway and the β-catenin acetylation levels of grass carp Ctenopharyngodon idella

(2020) Yi-Chuang Xu et al.   ENVIRONMENTAL POLLUTION

Nrf2: a dark horse in Alzheimer's disease treatment

(2020) Alsiddig Osama et al.   AGEING RESEARCH REVIEWS

Nuclear factor erythroid 2-related factor 2 (Nrf2) as a potential therapeutic target for vitiligo

(2020) Xiran Lin et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Waterborne copper exposure up-regulated lipid deposition through the methylation of GRP78 and PGC1α of grass carp Ctenopharyngodon idella

(2020) Yi-Huan Xu et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases

(2019) Antonio Cuadrado et al.   NATURE REVIEWS DRUG DISCOVERY

Pinitol consumption improves liver health status by reducing oxidative stress and fatty acid accumulation in subjects with non-alcoholic fatty liver disease: A randomized, double-blind, placebo-controlled trial

(2019) Eunok Lee et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Lipidomic biomarkers and mechanisms of lipotoxicity in non-alcoholic fatty liver disease

(2019) Gianluca Svegliati-Baroni et al.   FREE RADICAL BIOLOGY AND MEDICINE

Endoplasmic Reticulum Stress–Mediated Autophagy and Apoptosis Alleviate Dietary Fat–Induced Triglyceride Accumulation in the Intestine and in Isolated Intestinal Epithelial Cells of Yellow Catfish

(2019) Shi-Cheng Ling et al.   JOURNAL OF NUTRITION

Lipophagy mediated carbohydrate-induced changes of lipid metabolism via oxidative stress, endoplasmic reticulum (ER) stress and ChREBP/PPARγ pathways

(2019) Tao Zhao et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Nuclear Factor E2-Related Factor 2 Mediates Oxidative Stress-Induced Lipid Accumulation in Adipocytes by Increasing Adipogenesis and Decreasing Lipolysis

(2019) Xudong Sun et al.   ANTIOXIDANTS & REDOX SIGNALING

Oxidation of multiple MiT/TFE transcription factors links oxidative stress to transcriptional control of autophagy and lysosome biogenesis

(2019) Hongfeng Wang et al.   Autophagy

Lithium chloride promotes lipid accumulation through increased reactive oxygen species generation

(2019) Yunkyoung Lee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Oxidative stress and mitochondrial dysfunction mediated Cd-induced hepatic lipid accumulation in zebrafish Danio rerio

(2018) Ya-Xiong Pan et al.   AQUATIC TOXICOLOGY

Nrf2-Keap1 signaling in oxidative and reductive stress

(2018) Ilaria Bellezza et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Copper (II) and/or arsenite-induced oxidative stress cascades apoptosis and autophagy in the skeletal muscles of chicken

(2018) Yu Wang et al.   CHEMOSPHERE

Zinc reduces hepatic lipid deposition and activates lipophagy via Zn2+/MTF-1/PPARα and Ca2+/CaMKKβ/AMPK pathways

(2018) Chuan-Chuan Wei et al.   FASEB JOURNAL

SREBP1, PPARG and AMPK pathways mediated the Cu-induced change in intestinal lipogenesis and lipid transport of yellow catfish Pelteobagrus fulvidraco

(2018) Guang-Hui Chen et al.   FOOD CHEMISTRY

High fat diet-induced oxidative stress blocks hepatocyte nuclear factor 4α and leads to hepatic steatosis in mice

(2018) Dongsheng Yu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Nrf2-p62 autophagy pathway and its response to oxidative stress in hepatocellular carcinoma

(2018) Desirée Bartolini et al.   Translational Research

Zn Stimulates the Phospholipids Biosynthesis via the Pathways of Oxidative and Endoplasmic Reticulum Stress in the Intestine of Freshwater Teleost Yellow Catfish

(2018) Kun Wu et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Structure and Functional Analysis of Promoters from Two Liver Isoforms of CPT I in Grass Carp Ctenopharyngodon idella

(2017) Yi-Huan Xu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Regulation of NRF2 by Nutrient-Responsive Signaling and Its Role in Anabolic Cancer Metabolism

(2017) Sae Bom Lee et al.   ANTIOXIDANTS & REDOX SIGNALING

Transcriptional Regulation by Nrf2

(2017) Claudia Tonelli et al.   ANTIOXIDANTS & REDOX SIGNALING

Nonalcoholic Fatty Liver Disease: Pathogenesis and Disease Spectrum

(2016) Timothy Hardy et al.   Annual Review of Pathology-Mechanisms of Disease

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Autophagy, lipophagy and lysosomal lipid storage disorders

(2016) Carl Ward et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Autophagy and Lipid Droplets in the Liver

(2015) Nuria Martinez-Lopez et al.   Annual Review of Nutrition

Differential effects of dietary copper deficiency and excess on lipid metabolism in yellow catfish Pelteobagrus fulvidraco

(2015) Qi-Liang Chen et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY

Peroxisome proliferator-activated receptor gamma (PPARγ) in yellow catfish Pelteobagrus fulvidraco: Molecular characterization, mRNA expression and transcriptional regulation by insulin in vivo and in vitro

(2015) Jia-Lang Zheng et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis

(2015) Susmita Kaushik et al.   NATURE CELL BIOLOGY

The Dual Role of Nrf2 in Nonalcoholic Fatty Liver Disease: Regulation of Antioxidant Defenses and Hepatic Lipid Metabolism

(2015) Sílvia S. Chambel et al.   Biomed Research International

Autophagy inhibition uncovers the neurotoxic action of the antipsychotic drug olanzapine

(2015) Ljubica Vucicevic et al.   Autophagy

Cardiac Mitochondria and Reactive Oxygen Species Generation

(2014) Yeong-Renn Chen et al.   CIRCULATION RESEARCH

An Overview of Autophagy: Morphology, Mechanism, and Regulation

(2013) Katherine R. Parzych et al.   ANTIOXIDANTS & REDOX SIGNALING

Emerging Role of Nrf2 in Adipocytes and Adipose Biology

(2013) Kevin S. Schneider et al.   Advances in Nutrition

Effects of Waterborne Chronic Copper Exposure on Hepatic Lipid Metabolism and Metal-Element Composition in Synechogobius hasta

(2012) Qi-Liang Chen et al.   ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY

Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution

(2011) Keiko Taguchi et al.   GENES TO CELLS

A Role for Low Hepatic Copper Concentrations in Nonalcoholic Fatty Liver Disease

(2010) Elmar Aigner et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Transcription factor Nrf2 regulates SHP and lipogenic gene expression in hepatic lipid metabolism

(2010) Jiansheng Huang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Nrf2-regulated PPARγ Expression Is Critical to Protection against Acute Lung Injury in Mice

(2010) Hye-Youn Cho et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Nonalcoholic Fatty Liver Disease: Pathology and Pathogenesis

(2010) Dina G. Tiniakos et al.   Annual Review of Pathology-Mechanisms of Disease

Under the ROS: Thiol network is the principal suspect for autophagy commitment

(2010) Giuseppe Filomeni et al.   Autophagy

Effect of waterborne copper exposure on growth, hepatic enzymatic activities and histology in Synechogobius hasta

(2010) X.J. Liu et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Prevalence of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis Among a Largely Middle-Aged Population Utilizing Ultrasound and Liver Biopsy: A Prospective Study

(2010) Christopher D. Williams et al.   GASTROENTEROLOGY

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

(2010) Masaaki Komatsu et al.   NATURE CELL BIOLOGY

Dietary copper requirement of juvenile yellow catfish Pelteobagrus fulvidraco

(2009) X.-Y. TAN et al.   AQUACULTURE NUTRITION

New aspects of adipogenesis: Radicals and oxidative stress

(2009) Caroline Gummersbach et al.   DIFFERENTIATION

The Nrf2-Antioxidant Response Element Signaling Pathway and Its Activation by Oxidative Stress

(2009) Truyen Nguyen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

Oxidative stress induced lipid accumulation via SREBP1c activation in HepG2 cells

(2008) Mika Sekiya et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS