High fat diet-induced oxidative stress blocks hepatocyte nuclear factor 4α and leads to hepatic steatosis in mice

Daphnetin-mediated Nrf2 antioxidant signaling pathways ameliorate tert-butyl hydroperoxide ( t -BHP)-induced mitochondrial dysfunction and cell death

(2017) Hongming Lv et al.   FREE RADICAL BIOLOGY AND MEDICINE

Supplementation with antioxidant-rich extra virgin olive oil prevents hepatic oxidative stress and reduction of desaturation capacity in mice fed a high-fat diet: Effects on fatty acid composition in liver and extrahepatic tissues

(2016) Miguel Angel Rincón-Cervera et al.   NUTRITION

A metabolic stress-inducible miR-34a-HNF4α pathway regulates lipid and lipoprotein metabolism

(2015) Yang Xu et al.   Nature Communications

Hepatic mitochondrial and ER stress induced by defective PPARα signaling in the pathogenesis of hepatic steatosis

(2014) Qiaozhu Su et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

High fat diet aggravates arsenic induced oxidative stress in rat heart and liver

(2014) Mousumi Dutta et al.   FOOD AND CHEMICAL TOXICOLOGY

Hippo Signaling Influences HNF4A and FOXA2 Enhancer Switching during Hepatocyte Differentiation

(2014) Olivia Alder et al.   Cell Reports

Involvement of free radicals and oxidative stress in NAFLD/NASH

(2013) Y. Sumida et al.   FREE RADICAL RESEARCH

Nonalcoholic fatty liver disease, hepatic insulin resistance, and type 2 Diabetes

(2013) Andreas L. Birkenfeld et al.   HEPATOLOGY

Multiple Hits, Including Oxidative Stress, as Pathogenesis and Treatment Target in Non-Alcoholic Steatohepatitis (NASH)

(2013) Akinobu Takaki et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The global NAFLD epidemic

(2013) Rohit Loomba et al.   Nature Reviews Gastroenterology & Hepatology

NAFLD, NASH and liver cancer

(2013) Gregory A. Michelotti et al.   Nature Reviews Gastroenterology & Hepatology

Non-Alcoholic Fatty Liver Disease (NAFLD) and Its Connection with Insulin Resistance, Dyslipidemia, Atherosclerosis and Coronary Heart Disease

(2013) Melania Gaggini et al.   Nutrients

Hepatocyte-specific deletion of hepatocyte nuclear factor-4α in adult mice results in increased hepatocyte proliferation

(2012) Chad Walesky et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Suppression of Hepatocyte Proliferation by Hepatocyte Nuclear Factor 4α in Adult Mice

(2012) Jessica A. Bonzo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nrf2 inhibits hepatic iron accumulation and counteracts oxidative stress-induced liver injury in nutritional steatohepatitis

(2012) Kosuke Okada et al.   JOURNAL OF GASTROENTEROLOGY

NF-κB–inducing kinase (NIK) promotes hyperglycemia and glucose intolerance in obesity by augmenting glucagon action

(2012) Liang Sheng et al.   NATURE MEDICINE

Measuring reactive oxygen and nitrogen species with fluorescent probes: challenges and limitations

(2011) Balaraman Kalyanaraman et al.   FREE RADICAL BIOLOGY AND MEDICINE

Human Fatty Liver Disease: Old Questions and New Insights

(2011) J. C. Cohen et al.   SCIENCE

Hepatic Hepatocyte Nuclear Factor 4α Is Essential for Maintaining Triglyceride and Cholesterol Homeostasis

(2010) Liya Yin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Modification in Oxidative Stress, Inflammation, and Lipoprotein Assembly in Response to Hepatocyte Nuclear Factor 4α Knockdown in Intestinal Epithelial Cells

(2010) Valérie Marcil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PKCδ Is Activated in a Dietary Model of Steatohepatitis and Regulates Endoplasmic Reticulum Stress and Cell Death

(2010) Michael W. Greene et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Arachidonic acid release by H2O2mediated proliferation of mouse embryonic stem cells: Involvement of Ca2+/PKC and MAPKs-induced EGFR transactivation

(2009) Sang Hun Lee et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Hepatocyte Nuclear Factor 4  Coordinates a Transcription Factor Network Regulating Hepatic Fatty Acid Metabolism

(2009) C. P. Martinez-Jimenez et al.   MOLECULAR AND CELLULAR BIOLOGY

Increased Expression and Activity of the Transcription Factor FOXO1 in Nonalcoholic Steatohepatitis

(2008) L. Valenti et al.   DIABETES