Omecamtiv mercabil and blebbistatin modulate cardiac contractility by perturbing the regulatory state of the myosin filament

Omecamtiv Mecarbil Enhances the Duty Ratio of Human β-Cardiac Myosin Resulting in Increased Calcium Sensitivity and Slowed Force Development in Cardiac Muscle

(2017) Anja M. Swenson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutations

(2017) Suman Nag et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Heart failure drug changes the mechanoenzymology of the cardiac myosin powerstroke

(2017) John A. Rohde et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myosin filament activation in the heart is tuned to the mechanical task

(2017) Massimo Reconditi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutations

(2017) Suman Nag et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Effects of myosin variants on interacting-heads motif explain distinct hypertrophic and dilated cardiomyopathy phenotypes

(2017) Lorenzo Alamo et al.   eLife

Acute Treatment With Omecamtiv Mecarbil to Increase Contractility in Acute Heart Failure

(2016) John R. Teerlink et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Piperine’s mitigation of obesity and diabetes can be explained by its up-regulation of the metabolic rate of resting muscle

(2016) Leonardo Nogara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myosin light chain phosphorylation enhances contraction of heart muscle via structural changes in both thick and thin filaments

(2016) Thomas Kampourakis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Titin strain contributes to the Frank–Starling law of the heart by structural rearrangements of both thin- and thick-filament proteins

(2016) Younss Ait-Mou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice

(2016) E. M. Green et al.   SCIENCE

Thick filament mechano-sensing is a calcium-independent regulatory mechanism in skeletal muscle

(2016) L. Fusi et al.   Nature Communications

Spectroscopic Studies of the Super Relaxed State of Skeletal Muscle

(2016) Leonardo Nogara et al.   PLoS One

Omecamtiv Mecarbil Modulates the Kinetic and Motile Properties of Porcine β-Cardiac Myosin

(2015) Yingying Liu et al.   BIOCHEMISTRY

Orientation of the N- and C-Terminal Lobes of the Myosin Regulatory Light Chain in Cardiac Muscle

(2015) Thomas Kampourakis et al.   BIOPHYSICAL JOURNAL

The novel cardiac myosin activator omecamtiv mecarbil increases the calcium sensitivity of force production in isolated cardiomyocytes and skeletal muscle fibres of the rat

(2015) L Nagy et al.   BRITISH JOURNAL OF PHARMACOLOGY

Omecamtiv Mecarbil, a Cardiac Myosin Activator, Increases Ca2+ Sensitivity in Myofilaments With a Dilated Cardiomyopathy Mutant Tropomyosin E54K

(2015) Megan S. Utter et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Phosphorylation of myosin regulatory light chain controls myosin head conformation in cardiac muscle

(2015) Thomas Kampourakis et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Molecular effects of the myosin activator omecamtiv mecarbil on contractile properties of skinned myocardium lacking cardiac myosin binding protein-C

(2015) Ranganath Mamidi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Force generation by skeletal muscle is controlled by mechanosensing in myosin filaments

(2015) Marco Linari et al.   NATURE

Targeting the sarcomere to correct muscle function

(2015) Peter M. Hwang et al.   NATURE REVIEWS DRUG DISCOVERY

Structural basis for drug-induced allosteric changes to human β-cardiac myosin motor activity

(2015) Donald A. Winkelmann et al.   Nature Communications

Safety and Tolerability of Omecamtiv Mecarbil During Exercise in Patients With Ischemic Cardiomyopathy and Angina

(2015) Barry H. Greenberg et al.   JACC-Heart Failure

Hypertrophic and Dilated Cardiomyopathy: Four Decades of Basic Research on Muscle Lead to Potential Therapeutic Approaches to These Devastating Genetic Diseases

(2014) James A. Spudich   BIOPHYSICAL JOURNAL

The Myosin Inhibitor Blebbistatin Stabilizes the Super-Relaxed State in Skeletal Muscle

(2014) Clyde Wilson et al.   BIOPHYSICAL JOURNAL

Regulatory domain of troponin moves dynamically during activation of cardiac muscle

(2014) Ivanka Sevrieva et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Myosin binding protein-C activates thin filaments and inhibits thick filaments in heart muscle cells

(2014) Thomas Kampourakis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myosin-binding protein C displaces tropomyosin to activate cardiac thin filaments and governs their speed by an independent mechanism

(2014) Ji Young Mun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small molecule-mediated refolding and activation of myosin motor function

(2014) Michael B Radke et al.   eLife

Genetic mutations and mechanisms in dilated cardiomyopathy

(2013) Elizabeth M. McNally et al.   JOURNAL OF CLINICAL INVESTIGATION

Structural basis of the relaxed state of a Ca2+-regulated myosin filament and its evolutionary implications

(2013) J. L. Woodhead et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myosin binding protein-C phosphorylation is the principal mediator of protein kinase A effects on thick filament structure in myocardium

(2012) Brett A. Colson et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Structure, interactions and function of the N-terminus of cardiac myosin binding protein C (MyBP-C): who does what, with what, and to whom?

(2012) Mark Pfuhl et al.   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

The myosin interacting-heads motif is present in the relaxed thick filament of the striated muscle of scorpion

(2012) Antonio Pinto et al.   JOURNAL OF STRUCTURAL BIOLOGY

Atomic model of the human cardiac muscle myosin filament

(2012) H. A. AL-Khayat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A New State of Cardiac Myosin with Very Slow ATP Turnover: A Potential Cardioprotective Mechanism in the Heart

(2011) Pleuni Hooijman et al.   BIOPHYSICAL JOURNAL

A Molecular Model of Phosphorylation-Based Activation and Potentiation of Tarantula Muscle Thick Filaments

(2011) Reicy Brito et al.   JOURNAL OF MOLECULAR BIOLOGY

The effects of the cardiac myosin activator, omecamtiv mecarbil, on cardiac function in systolic heart failure: a double-blind, placebo-controlled, crossover, dose-ranging phase 2 trial

(2011) John GF Cleland et al.   LANCET

Dose-dependent augmentation of cardiac systolic function with the selective cardiac myosin activator, omecamtiv mecarbil: a first-in-man study

(2011) John R Teerlink et al.   LANCET

Cardiac Myosin Activation: A Potential Therapeutic Approach for Systolic Heart Failure

(2011) F. I. Malik et al.   SCIENCE

Sarcomere Gene Mutations in Hypertrophy and Heart Failure

(2010) Hiroyuki Morita et al.   Journal of Cardiovascular Translational Research

Myosin ATP turnover rate is a mechanism involved in thermogenesis in resting skeletal muscle fibers

(2009) M. A. Stewart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Blebbistatin Stabilizes the Helical Order of Myosin Filaments by Promoting the Switch 2 Closed State

(2008) Fa-Qing Zhao et al.   BIOPHYSICAL JOURNAL

Three-Dimensional Reconstruction of Tarantula Myosin Filaments Suggests How Phosphorylation May Regulate Myosin Activity

(2008) Lorenzo Alamo et al.   JOURNAL OF MOLECULAR BIOLOGY

Calcium- and myosin-dependent changes in troponin structure during activation of heart muscle

(2008) Yin-Biao Sun et al.   JOURNAL OF PHYSIOLOGY-LONDON

Three-dimensional structure of vertebrate cardiac muscle myosin filaments

(2008) M. E. Zoghbi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA