Myosin Head Configurations in Resting and Contracting Murine Skeletal Muscle

Blebbistatin Effects Expose Hidden Secrets in the Force-Generating Cycle of Actin and Myosin

(2018) Mohammad A. Rahman et al.   BIOPHYSICAL JOURNAL

A small-molecule modulator of cardiac myosin acts on multiple stages of the myosin chemomechanical cycle

(2017) Raja F. Kawas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Omecamtiv mercabil and blebbistatin modulate cardiac contractility by perturbing the regulatory state of the myosin filament

(2017) Thomas Kampourakis et al.   JOURNAL OF PHYSIOLOGY-LONDON

Phosphorylation of cardiac myosin binding protein C releases myosin heads from the surface of cardiac thick filaments

(2017) Robert W. Kensler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myosin filament activation in the heart is tuned to the mechanical task

(2017) Massimo Reconditi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of myosin variants on interacting-heads motif explain distinct hypertrophic and dilated cardiomyopathy phenotypes

(2017) Lorenzo Alamo et al.   eLife

Biophysical properties of human β-cardiac myosin with converter mutations that cause hypertrophic cardiomyopathy

(2017) Masataka Kawana et al.   Science Advances

MYBPC3 mutations are associated with a reduced super-relaxed state in patients with hypertrophic cardiomyopathy

(2017) James W. McNamara et al.   PLoS One

Ablation of cardiac myosin binding protein-C disrupts the super-relaxed state of myosin in murine cardiomyocytes

(2016) James W. McNamara et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Titin strain contributes to the Frank–Starling law of the heart by structural rearrangements of both thin- and thick-filament proteins

(2016) Younss Ait-Mou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice

(2016) E. M. Green et al.   SCIENCE

Thick filament mechano-sensing is a calcium-independent regulatory mechanism in skeletal muscle

(2016) L. Fusi et al.   Nature Communications

FIT2D: a multi-purpose data reduction, analysis and visualization program

(2016) A. P. Hammersley   JOURNAL OF APPLIED CRYSTALLOGRAPHY

Spectroscopic Studies of the Super Relaxed State of Skeletal Muscle

(2016) Leonardo Nogara et al.   PLoS One

The myosin mesa and a possible unifying hypothesis for the molecular basis of human hypertrophic cardiomyopathy

(2015) James A. Spudich   BIOCHEMICAL SOCIETY TRANSACTIONS

Nebulin deficiency in adult muscle causes sarcomere defects and muscle-type-dependent changes in trophicity: novel insights in nemaline myopathy

(2015) Frank Li et al.   HUMAN MOLECULAR GENETICS

The Myosin Inhibitor Blebbistatin Stabilizes the Super-Relaxed State in Skeletal Muscle

(2014) Clyde Wilson et al.   BIOPHYSICAL JOURNAL

The fraction of strongly bound cross-bridges is increased in mice that carry the myopathy-linked myosin heavy chain mutation MYH4L342Q

(2013) J. Lindqvist et al.   Disease Models & Mechanisms

Pointed-end capping by tropomodulin modulates actomyosin crossbridge formation in skeletal muscle fibers

(2013) Julien Ochala et al.   FASEB JOURNAL

Evaluation of Muscle Function of the Extensor Digitorum Longus Muscle Ex vivo and Tibialis Anterior Muscle In situ in Mice

(2013) Chady H. Hakim et al.   Jove-Journal of Visualized Experiments

Myosin binding protein-C phosphorylation is the principal mediator of protein kinase A effects on thick filament structure in myocardium

(2012) Brett A. Colson et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Actin Structure and Function

(2011) Roberto Dominguez et al.   Annual Review of Biophysics

Thick-Filament Strain and Interfilament Spacing in Passive Muscle: Effect of Titin-Based Passive Tension

(2011) Thomas Irving et al.   BIOPHYSICAL JOURNAL

The Fraction of Myosin Motors That Participate in Isometric Contraction of Rabbit Muscle Fibers at Near-Physiological Temperature

(2011) Andrey K. Tsaturyan et al.   BIOPHYSICAL JOURNAL

A New State of Cardiac Myosin with Very Slow ATP Turnover: A Potential Cardioprotective Mechanism in the Heart

(2011) Pleuni Hooijman et al.   BIOPHYSICAL JOURNAL

In the Thick of It

(2011) Samantha P. Harris et al.   CIRCULATION RESEARCH

Myosin Heads Contribute to the Maintenance of Filament Order in Relaxed Rabbit Muscle

(2010) Sergey Y. Bershitsky et al.   BIOPHYSICAL JOURNAL

Fast X-Ray Recordings Reveal Dynamic Action of Contractile and Regulatory Proteins in Stretch-Activated Insect Flight Muscle

(2010) Hiroyuki Iwamoto et al.   BIOPHYSICAL JOURNAL

Myofilament length dependent activation

(2010) Pieter P. de Tombe et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

X-ray diffraction evidence for myosin-troponin connections and tropomyosin movement during stretch activation of insect flight muscle

(2010) R. J. Perz-Edwards et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A myopathy-linked tropomyosin mutation severely alters thin filament conformational changes during activation

(2010) J. Ochala et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamics of Thin-Filament Activation in Rabbit Skeletal Muscle Fibers Examined by Time-Resolved X-Ray Diffraction

(2009) Takumi Tamura et al.   BIOPHYSICAL JOURNAL

Stabilization of Helical Order in the Thick Filaments by Blebbistatin: Further Evidence of Coexisting Multiple Conformations of Myosin

(2009) Sengen Xu et al.   BIOPHYSICAL JOURNAL

Myosin regulatory light chain phosphorylation inhibits shortening velocities of skeletal muscle fibers in the presence of the myosin inhibitor blebbistatin

(2009) Melanie Stewart et al.   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

Blebbistatin Stabilizes the Helical Order of Myosin Filaments by Promoting the Switch 2 Closed State

(2008) Fa-Qing Zhao et al.   BIOPHYSICAL JOURNAL

Direct Modeling of X-Ray Diffraction Pattern from Contracting Skeletal Muscle

(2008) Natalia A. Koubassova et al.   BIOPHYSICAL JOURNAL

Reverse actin sliding triggers strong myosin binding that moves tropomyosin

(2008) T. I. Bekyarova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Three-dimensional structure of vertebrate cardiac muscle myosin filaments

(2008) M. E. Zoghbi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA