Organ-on-a-chip systems for vascular biology

Human Induced Pluripotent Stem Cell-Derived Brain Endothelial Cells: Current Controversies

(2021) Tyler M. Lu et al.   Frontiers in Physiology

Single-Cell Transcriptome Atlas of Murine Endothelial Cells

(2020) Joanna Kalucka et al.   CELL

Endothelial heterogeneity across distinct vascular beds during homeostasis and inflammation

(2020) Ankit Jambusaria et al.   eLife

Biophysical and biomolecular interactions of malaria-infected erythrocytes in engineered human capillaries

(2020) Christopher Arakawa et al.   Science Advances

Robotic fluidic coupling and interrogation of multiple vascularized organ chips

(2020) Richard Novak et al.   Nature Biomedical Engineering

Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2

(2020) Vanessa Monteil et al.   CELL

From Arteries to Capillaries: Approaches to Engineering Human Vasculature

(2020) Sharon Fleischer et al.   ADVANCED FUNCTIONAL MATERIALS

Reconstruction of the human blood–brain barrier in vitro reveals a pathogenic mechanism of APOE4 in pericytes

(2020) Joel W. Blanchard et al.   NATURE MEDICINE

Human organoids: model systems for human biology and medicine

(2020) Jihoon Kim et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Differentiation of Human Intestinal Organoids with Endogenous Vascular Endothelial Cells

(2020) Emily M. Holloway et al.   DEVELOPMENTAL CELL

Adaptable haemodynamic endothelial cells for organogenesis and tumorigenesis

(2020) Brisa Palikuqi et al.   NATURE

3D curvature-instructed endothelial flow response and tissue vascularization

(2020) Christian Mandrycky et al.   Science Advances

Advances in microphysiological blood-brain barrier (BBB) models towards drug delivery

(2020) Caleb S Lee et al.   CURRENT OPINION IN BIOTECHNOLOGY

Human in vitro vascularized micro-organ and micro-tumor models are reproducible organ-on-a-chip platforms for studies of anticancer drugs

(2020) Yizhong Liu et al.   TOXICOLOGY

Induced Pluripotent Stem Cell–Derived Endothelial Cells

(2019) Sae Jang et al.   AMERICAN JOURNAL OF PATHOLOGY

Translocating transcription factors in fluid shear stress-mediated vascular remodeling and disease

(2019) Elizabeth Min et al.   EXPERIMENTAL CELL RESEARCH

Bioprinted liver provides early insight into the role of Kupffer cells in TGF-β1 and methotrexate-induced fibrogenesis

(2019) Leah M. Norona et al.   PLoS One

Patterned human microvascular grafts enable rapid vascularization and increase perfusion in infarcted rat hearts

(2019) Meredith A. Redd et al.   Nature Communications

Renal reabsorption in 3D vascularized proximal tubule models

(2019) Neil Y. C. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Flow-enhanced vascularization and maturation of kidney organoids in vitro

(2019) Kimberly A. Homan et al.   NATURE METHODS

Organ-on-a-chip technology: turningt its potential for clinical benefit into reality

(2019) Malcolm Haddrick et al.   DRUG DISCOVERY TODAY

Binding Heterogeneity of Plasmodium falciparum to Engineered 3D Brain Microvessels Is Mediated by EPCR and ICAM-1

(2019) Maria Bernabeu et al.   mBio

A complex human gut microbiome cultured in an anaerobic intestine-on-a-chip

(2019) Sasan Jalili-Firoozinezhad et al.   Nature Biomedical Engineering

Generation of Human PSC-Derived Kidney Organoids with Patterned Nephron Segments and a De Novo Vascular Network

(2019) Jian Hui Low et al.   Cell Stem Cell

3D bioprinting of collagen to rebuild components of the human heart

(2019) A. Lee et al.   SCIENCE

Endothelial Cell Development and Its Application to Regenerative Medicine

(2019) Jingyao Qiu et al.   CIRCULATION RESEARCH

A biomimetic pancreatic cancer on-chip reveals endothelial ablation via ALK7 signaling

(2019) Duc-Huy T. Nguyen et al.   Science Advances

Engineering of human brain organoids with a functional vascular-like system

(2019) Bilal Cakir et al.   NATURE METHODS

Generation of blood vessel organoids from human pluripotent stem cells

(2019) Reiner A. Wimmer et al.   Nature Protocols

The in vivo endothelial cell translatome is highly heterogeneous across vascular beds

(2019) Audrey C. A. Cleuren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A glomerulus-on-a-chip to recapitulate the human glomerular filtration barrier

(2019) Astgik Petrosyan et al.   Nature Communications

Transforming Endothelium with Platelet‐Rich Plasma in Engineered Microvessels

(2019) Ryan J. Nagao et al.   Advanced Science

Vascularized Microfluidics and the Blood–Endothelium Interface

(2019) Christopher A. Hesh et al.   Micromachines

Advanced in vitro models of vascular biology: Human induced pluripotent stem cells and organ-on-chip technology

(2018) Amy Cochrane et al.   ADVANCED DRUG DELIVERY REVIEWS

3D self-organized microvascular model of the human blood-brain barrier with endothelial cells, pericytes and astrocytes

(2018) Marco Campisi et al.   BIOMATERIALS

Vascular Tissue Engineering: Progress, Challenges, and Clinical Promise

(2018) H.-H. Greco Song et al.   Cell Stem Cell

Engineering a multicellular vascular niche to model hematopoietic cell trafficking

(2018) Surya S. Kotha et al.   Stem Cell Research & Therapy

Microvasculature-on-a-chip for the long-term study of endothelial barrier dysfunction and microvascular obstruction in disease

(2018) Yongzhi Qiu et al.   Nature Biomedical Engineering

Harnessing cell pluripotency for cardiovascular regenerative medicine

(2018) Haodong Chen et al.   Nature Biomedical Engineering

A molecular atlas of cell types and zonation in the brain vasculature

(2018) Michael Vanlandewijck et al.   NATURE

Intriguing Roles for Endothelial ADAM10/Notch Signaling in the Development of Organ-Specific Vascular Beds

(2018) Rolake O. Alabi et al.   PHYSIOLOGICAL REVIEWS

Advances in organ-on-a-chip engineering

(2018) Boyang Zhang et al.   Nature Reviews Materials

Modeling organ-specific vasculature with organ-on-a-chip devices

(2018) Dawn S Y Lin et al.   NANOTECHNOLOGY

Wound Healing: A Cellular Perspective

(2018) Melanie Rodrigues et al.   PHYSIOLOGICAL REVIEWS

Reconstructing the Human Renal Vascular-Tubular Unit In Vitro

(2018) Samuel G. Rayner et al.   Advanced Healthcare Materials

Tissue engineering strategies for the induction of angiogenesis using biomaterials

(2018) Shirin Saberianpour et al.   Journal of Biological Engineering

Blood–brain barrier-on-a-chip: Microphysiological systems that capture the complexity of the blood–central nervous system interface

(2017) Duc TT Phan et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Liver sinusoidal endothelial cells: Physiology and role in liver diseases

(2017) Johanne Poisson et al.   JOURNAL OF HEPATOLOGY

A vascularized and perfused organ-on-a-chip platform for large-scale drug screening applications

(2017) Duc T. T. Phan et al.   LAB ON A CHIP

A non-canonical Notch complex regulates adherens junctions and vascular barrier function

(2017) William J. Polacheck et al.   NATURE

NOTCH1 is a mechanosensor in adult arteries

(2017) Julia J. Mack et al.   Nature Communications

Shear-induced Notch-Cx37-p27 axis arrests endothelial cell cycle to enable arterial specification

(2017) Jennifer S. Fang et al.   Nature Communications

Mechanobiology in Vascular Remodeling

(2017) Yue Han et al.   National Science Review

Directed differentiation of human pluripotent stem cells to blood-brain barrier endothelial cells

(2017) Tongcheng Qian et al.   Science Advances

Mature induced-pluripotent-stem-cell-derived human podocytes reconstitute kidney glomerular-capillary-wall function on a chip

(2017) Samira Musah et al.   Nature Biomedical Engineering

Cell behaviors and dynamics during angiogenesis

(2016) Charles Betz et al.   DEVELOPMENT

Engineered Microvessels for the Study of Human Disease

(2016) Samuel G. Rayner et al.   JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME

Endothelial fluid shear stress sensing in vascular health and disease

(2016) Nicolas Baeyens et al.   JOURNAL OF CLINICAL INVESTIGATION

Interstitial flow regulates the angiogenic response and phenotype of endothelial cells in a 3D culture model

(2016) Sudong Kim et al.   LAB ON A CHIP

Biomechanics of vascular mechanosensation and remodeling

(2016) Nicolas Baeyens et al.   MOLECULAR BIOLOGY OF THE CELL

Angiocrine functions of organ-specific endothelial cells

(2016) Shahin Rafii et al.   NATURE

Biodegradable scaffold with built-in vasculature for organ-on-a-chip engineering and direct surgical anastomosis

(2016) Boyang Zhang et al.   NATURE MATERIALS

Generating high-purity cardiac and endothelial derivatives from patterned mesoderm using human pluripotent stem cells

(2016) Nathan J Palpant et al.   Nature Protocols

Decellularized Human Kidney Cortex Hydrogels Enhance Kidney Microvascular Endothelial Cell Maturation and Quiescence

(2016) Ryan J. Nagao et al.   TISSUE ENGINEERING PART A

Stromal Cells in Dense Collagen Promote Cardiomyocyte and Microvascular Patterning in Engineered Human Heart Tissue

(2016) Meredith A. Roberts et al.   TISSUE ENGINEERING PART A

Editor’s Highlight: Modeling Compound-Induced FibrogenesisIn VitroUsing Three-Dimensional Bioprinted Human Liver Tissues

(2016) Leah M. Norona et al.   TOXICOLOGICAL SCIENCES

Kidney-on-a-Chip Technology for Drug-Induced Nephrotoxicity Screening

(2016) Martijn J. Wilmer et al.   TRENDS IN BIOTECHNOLOGY

Vascularization and Angiogenesis in Tissue Engineering: Beyond Creating Static Networks

(2016) Jeroen Rouwkema et al.   TRENDS IN BIOTECHNOLOGY

Fabrication of 3D Biomimetic Microfluidic Networks in Hydrogels

(2016) Keely A. Heintz et al.   Advanced Healthcare Materials

Endothelial cell control of thrombosis

(2015) Jonathan W. Yau et al.   BMC Cardiovascular Disorders

Intramembrane binding of VE-cadherin to VEGFR2 and VEGFR3 assembles the endothelial mechanosensory complex

(2015) Brian G. Coon et al.   JOURNAL OF CELL BIOLOGY

A Novel Three-Dimensional Human Peritubular Microvascular System

(2015) G. Ligresti et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A perisinusoidal niche for extramedullary haematopoiesis in the spleen

(2015) Christopher N. Inra et al.   NATURE

Generation of vascular endothelial and smooth muscle cells from human pluripotent stem cells

(2015) Christoph Patsch et al.   NATURE CELL BIOLOGY

Flow-driven assembly of VWF fibres and webs in in vitro microvessels

(2015) Ying Zheng et al.   Nature Communications

Human 3D vascularized organotypic microfluidic assays to study breast cancer cell extravasation

(2014) Jessie S. Jeon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High WSS or Low WSS? Complex Interactions of Hemodynamics with Intracranial Aneurysm Initiation, Growth, and Rupture: Toward a Unifying Hypothesis

(2013) H. Meng et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Endothelial Cell Sensing of Flow Direction

(2013) Chong Wang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Fluid Shear Stress on Endothelial Cells Modulates Mechanical Tension across VE-Cadherin and PECAM-1

(2013) Daniel E. Conway et al.   CURRENT BIOLOGY

The future of the patient-specific Body-on-a-chip

(2013) Adam Williamson et al.   LAB ON A CHIP

Tortuosity and other vessel attributes for arterioles and venules of the human cerebral cortex

(2013) Sylvie Lorthois et al.   MICROVASCULAR RESEARCH

Microfabrication of human organs-on-chips

(2013) Dongeun Huh et al.   Nature Protocols

Biomimetic model to reconstitute angiogenic sprouting morphogenesis in vitro

(2013) D.-H. T. Nguyen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Control of Perfusable Microvascular Network Morphology Using a Multiculture Microfluidic System

(2013) Jordan A. Whisler et al.   TISSUE ENGINEERING PART C-METHODS

Endothelial Cell Heterogeneity

(2013) W. C. Aird   Cold Spring Harbor Perspectives in Medicine

Microfluidic approaches for engineering vasculature

(2013) Joe Tien   Current Opinion in Chemical Engineering

Cardiovascular Development and Angiogenesis in the Early Vertebrate Embryo

(2013) Warren W. Burggren   Cardiovascular Engineering and Technology

Microfluidic Models of Vascular Functions

(2012) Keith H.K. Wong et al.   Annual Review of Biomedical Engineering

“Sprouting angiogenesis”, a reappraisal

(2012) Domenico Ribatti et al.   DEVELOPMENTAL BIOLOGY

Full range physiological mass transport control in 3D tissue cultures

(2012) Yu-Hsiang Hsu et al.   LAB ON A CHIP

Rapid casting of patterned vascular networks for perfusable engineered three-dimensional tissues

(2012) Jordan S. Miller et al.   NATURE MATERIALS

In vitro microvessels for the study of angiogenesis and thrombosis

(2012) Y. Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

VEGF and FGF prime vascular tube morphogenesis and sprouting directed by hematopoietic stem cell cytokines

(2011) A. N. Stratman et al.   BLOOD

Signal transduction in vasculogenesis and developmental angiogenesis

(2011) Sunita Patel-Hett et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Molecular mechanisms and clinical applications of angiogenesis

(2011) Peter Carmeliet et al.   NATURE

Effects of Disturbed Flow on Vascular Endothelium: Pathophysiological Basis and Clinical Perspectives

(2011) Jeng-Jiann Chiu et al.   PHYSIOLOGICAL REVIEWS

Fluid forces control endothelial sprouting

(2011) J. W. Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tubulogenesis during blood vessel formation

(2011) Ke Xu et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Microfluidic Platforms for Studies of Angiogenesis, Cell Migration, and Cell–Cell Interactions

(2010) Seok Chung et al.   ANNALS OF BIOMEDICAL ENGINEERING

Endothelial lumen signaling complexes control 3D matrix-specific tubulogenesis through interdependent Cdc42- and MT1-MMP-mediated events

(2010) A. Sacharidou et al.   BLOOD

Shear stress and the endothelial transport barrier

(2010) John M. Tarbell   CARDIOVASCULAR RESEARCH

The Effects of Hemodynamic Force on Embryonic Development

(2010) JAMES C. CULVER et al.   MICROCIRCULATION

Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels

(2010) B. Coste et al.   SCIENCE

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

VEGF and endothelial guidance in angiogenic sprouting

(2010) Holger Gerhardt   Organogenesis

PECAM-1 Is Necessary for Flow-Induced Vascular Remodeling

(2009) Zhongming Chen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Pericyte recruitment during vasculogenic tube assembly stimulates endothelial basement membrane matrix formation

(2009) A. N. Stratman et al.   BLOOD

Microenvironmental regulation of the sinusoidal endothelial cell phenotype in vitro

(2009) Sandra March et al.   HEPATOLOGY

Mechanotransduction in vascular physiology and atherogenesis

(2008) Cornelia Hahn et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY