Intriguing Roles for Endothelial ADAM10/Notch Signaling in the Development of Organ-Specific Vascular Beds

Glomerular endothelial cell maturation depends on ADAM10, a key regulator of Notch signaling

(2018) Gregory Farber et al.   ANGIOGENESIS

Clonal Expansion of Endothelial Cells Contributes to Ischemia-Induced NeovascularizationNovelty and Significance

(2018) Yosif Manavski et al.   CIRCULATION RESEARCH

Microvascular Mural Cell Organotypic Heterogeneity and Functional Plasticity

(2018) Annegret Holm et al.   TRENDS IN CELL BIOLOGY

Activating NOTCH1 Mutations Define a Distinct Subgroup of Patients With Adenoid Cystic Carcinoma Who Have Poor Prognosis, Propensity to Bone and Liver Metastasis, and Potential Responsiveness to Notch1 Inhibitors

(2017) Renata Ferrarotto et al.   JOURNAL OF CLINICAL ONCOLOGY

Cell–matrix signals specify bone endothelial cells during developmental osteogenesis

(2017) Urs H. Langen et al.   NATURE CELL BIOLOGY

Organotypic vasculature: From descriptive heterogeneity to functional pathophysiology

(2017) Hellmut G. Augustin et al.   SCIENCE

Notch-Jagged complex structure implicates a catch bond in tuning ligand sensitivity

(2017) Vincent C. Luca et al.   SCIENCE

Morphogenesis and maturation of the embryonic and postnatal intestine

(2017) Alana M. Chin et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Uncontrolled angiogenic precursor expansion causes coronary artery anomalies in mice lacking Pofut1

(2017) Yidong Wang et al.   Nature Communications

O-GlcNAc on NOTCH1 EGF repeats regulates ligand-induced Notch signaling and vascular development in mammals

(2017) Shogo Sawaguchi et al.   eLife

In vitro modeling of endothelial interaction with macrophages and pericytes demonstrates Notch signaling function in the vascular microenvironment

(2016) Ian W. Tattersall et al.   ANGIOGENESIS

Bone marrow-derived cells in ocular neovascularization: contribution and mechanisms

(2016) Fan Gao et al.   ANGIOGENESIS

Diabetes-Induced Jagged1 Overexpression in Endothelial Cells Causes Retinal Capillary Regression in a Murine Model of Diabetes MellitusClinical Perspective

(2016) Chang-Hwan Yoon et al.   CIRCULATION

ADAM10-Dependent Signaling Through Notch1 and Notch4 Controls Development of Organ-Specific Vascular BedsNovelty and Significance

(2016) Rolake O. Alabi et al.   CIRCULATION RESEARCH

Blood vessel formation and function in bone

(2016) Kishor K. Sivaraj et al.   DEVELOPMENT

Notch signalling in ventricular chamber development and cardiomyopathy

(2016) Gaetano D'Amato et al.   FEBS Journal

Endothelial notch signaling is essential to prevent hepatic vascular malformations in mice

(2016) Henar Cuervo et al.   HEPATOLOGY

Genetic lineage tracing identifies endocardial origin of liver vasculature

(2016) Hui Zhang et al.   NATURE GENETICS

Notch signalling in context

(2016) Sarah J. Bray   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Stability and function of adult vasculature is sustained by Akt/Jagged1 signalling axis in endothelium

(2016) Bethany A. Kerr et al.   Nature Communications

Blood flow controls bone vascular function and osteogenesis

(2016) Saravana K. Ramasamy et al.   Nature Communications

Endothelial Jagged1 Antagonizes Dll4 Regulation of Endothelial Branching and Promotes Vascular Maturation Downstream of Dll4/Notch1

(2015) A.-R. Pedrosa et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Endothelial Metabolism Driving Angiogenesis

(2015) Anna Rita Cantelmo et al.   CANCER JOURNAL

State-of-the-Art Methods for Evaluation of Angiogenesis and Tissue Vascularization: A Scientific Statement From the American Heart Association

(2015) M. Simons et al.   CIRCULATION RESEARCH

Cellular Origin and Developmental Program of Coronary Angiogenesis

(2015) X. Tian et al.   CIRCULATION RESEARCH

Targeting Notch Signaling with a Notch2/Notch3 Antagonist (Tarextumab) Inhibits Tumor Growth and Decreases Tumor-Initiating Cell Frequency

(2015) W.-C. Yen et al.   CLINICAL CANCER RESEARCH

Venous-derived angioblasts generate organ-specific vessels during zebrafish embryonic development

(2015) G. Hen et al.   DEVELOPMENT

Notch3-Jagged signaling controls the pool of undifferentiated airway progenitors

(2015) M. Mori et al.   DEVELOPMENT

Mechanical Allostery: Evidence for a Force Requirement in the Proteolytic Activation of Notch

(2015) Wendy R. Gordon et al.   DEVELOPMENTAL CELL

The molecular regulation of arteriovenous specification and maintenance

(2015) Jason E. Fish et al.   DEVELOPMENTAL DYNAMICS

VEGF‐C is required for intestinal lymphatic vessel maintenance and lipid absorption

(2015) Harri Nurmi et al.   EMBO Molecular Medicine

Stem cell and progenitor fate in the mammalian intestine: Notch and lateral inhibition in homeostasis and disease

(2015) R. Sancho et al.   EMBO REPORTS

The cell biology of renal filtration

(2015) Rizaldy P. Scott et al.   JOURNAL OF CELL BIOLOGY

DLL4 promotes continuous adult intestinal lacteal regeneration and dietary fat transport

(2015) Jeremiah Bernier-Latmani et al.   JOURNAL OF CLINICAL INVESTIGATION

23814, an Inhibitory Antibody of Ligand-Mediated Notch1 Activation, Modulates Angiogenesis and Inhibits Tumor Growth without Gastrointestinal Toxicity

(2015) T. Proia et al.   MOLECULAR CANCER THERAPEUTICS

Therapeutic antibodies reveal Notch control of transdifferentiation in the adult lung

(2015) Daniel Lafkas et al.   NATURE

Wiring the Vascular Network with Neural Cues: A CNS Perspective

(2015) Thomas Wälchli et al.   NEURON

Jagged mediates differences in normal and tumor angiogenesis by affecting tip-stalk fate decision

(2015) Marcelo Boareto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

VEGFR3 does not sustain retinal angiogenesis without VEGFR2

(2015) Georgia Zarkada et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of tissue morphogenesis by endothelial cell-derived signals

(2015) Saravana K. Ramasamy et al.   TRENDS IN CELL BIOLOGY

Blockade of Specific NOTCH Ligands: A New Promising Approach in Cancer Therapy

(2015) Anaïs Briot et al.   Cancer Discovery

Pericytes are progenitors for coronary artery smooth muscle

(2015) Katharina S Volz et al.   eLife

Notching on Cancer’s Door: Notch Signaling in Brain Tumors

(2015) Marcin Teodorczyk et al.   Frontiers in Oncology

Signaling Pathways in the Specification of Arteries and Veins

(2014) Monica Corada et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Notch functions in developmental and tumour angiogenesis by diverse mechanisms1

(2014) Thaned Kangsamaksin et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Notch4 reveals a novel mechanism regulating Notch signal transduction

(2014) A.C. James et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The sinus venosus contributes to coronary vasculature through VEGFC-stimulated angiogenesis

(2014) H. I. Chen et al.   DEVELOPMENT

Molecular identification of venous progenitors in the dorsal aorta reveals an aortic origin for the cardinal vein in mammals

(2014) H. Lindskog et al.   DEVELOPMENT

Excessive vascular sprouting underlies cerebral hemorrhage in mice lacking  V 8-TGF  signaling in the brain

(2014) T. D. Arnold et al.   DEVELOPMENT

Deletion of Rbpj from postnatal endothelium leads to abnormal arteriovenous shunting in mice

(2014) C. M. Nielsen et al.   DEVELOPMENT

Spatiotemporal mapping of vascularization and innervation in the fetal murine intestine

(2014) John Hatch et al.   DEVELOPMENTAL DYNAMICS

TACE/ADAM17 Is Essential for Oligodendrocyte Development and CNS Myelination

(2014) J. Palazuelos et al.   JOURNAL OF NEUROSCIENCE

Regulated Proteolysis of NOTCH2 and NOTCH3 Receptors by ADAM10 and Presenilins

(2014) A. J. Groot et al.   MOLECULAR AND CELLULAR BIOLOGY

Intestinal crypt homeostasis revealed at single-stem-cell level by in vivo live imaging

(2014) Laila Ritsma et al.   NATURE

Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone

(2014) Anjali P. Kusumbe et al.   NATURE

Endothelial Notch activity promotes angiogenesis and osteogenesis in bone

(2014) Saravana K. Ramasamy et al.   NATURE

Patterning the renal vascular bed

(2014) Doris Herzlinger et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

NOTCH Decoys That Selectively Block DLL/NOTCH or JAG/NOTCH Disrupt Angiogenesis by Unique Mechanisms to Inhibit Tumor Growth

(2014) Thaned Kangsamaksin et al.   Cancer Discovery

The Notch ligand Jagged1 as a target for anti-tumor therapy

(2014) Demin Li   Frontiers in Oncology

Role of Endothelial Cell Metabolism in Vessel Sprouting

(2013) Katrien De Bock et al.   Cell Metabolism

Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries

(2013) Xueying Tian et al.   CELL RESEARCH

Neurovascular development and links to disease

(2013) Christiana Ruhrberg et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Notch signaling is required for the formation of mesangial cells from a stromal mesenchyme precursor during kidney development

(2013) S. C. Boyle et al.   DEVELOPMENT

Notch controls retinal blood vessel maturation and quiescence

(2013) M. Ehling et al.   DEVELOPMENT

BRG1 promotes COUP-TFII expression and venous specification during embryonic vascular development

(2013) R. B. Davis et al.   DEVELOPMENT

Epidermal ADAM17 Is Dispensable for Notch Activation

(2013) Arjan J. Groot et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Lack of ADAM10 in endothelial cells affects osteoclasts at the chondro-osseus junction

(2013) Ren Zhao et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

ADAM17 Controls Endochondral Ossification by Regulating Terminal Differentiation of Chondrocytes

(2013) Katherine C. Hall et al.   MOLECULAR AND CELLULAR BIOLOGY

Control of vessel sprouting by genetic and metabolic determinants

(2013) Guy Eelen et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Sox17 is indispensable for acquisition and maintenance of arterial identity

(2013) Monica Corada et al.   Nature Communications

Endocardial Cells Form the Coronary Arteries by Angiogenesis through Myocardial-Endocardial VEGF Signaling

(2012) Bingruo Wu et al.   CELL

Endothelial deletion of murine Jag1 leads to valve calcification and congenital heart defects associated with Alagille syndrome

(2012) J. J. Hofmann et al.   DEVELOPMENT

Coordinating Tissue Interactions: Notch Signaling in Cardiac Development and Disease

(2012) José Luis de la Pompa et al.   DEVELOPMENTAL CELL

Notch Activation by the Metalloproteinase ADAM17 Regulates Myeloproliferation and Atopic Barrier Immunity by Suppressing Epithelial Cytokine Synthesis

(2012) Aditya Murthy et al.   IMMUNITY

Biology of the apelin-APJ axis in vascular formation

(2012) H. Kidoya et al.   JOURNAL OF BIOCHEMISTRY

The molecular basis of T cell acute lymphoblastic leukemia

(2012) Pieter Van Vlierberghe et al.   JOURNAL OF CLINICAL INVESTIGATION

Epidermal ADAM17 maintains the skin barrier by regulating EGFR ligand–dependent terminal keratinocyte differentiation

(2012) Claus-Werner Franzke et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF–VEGFR2 signalling

(2012) Rui Benedito et al.   NATURE

Lineage Tracing Reveals Lgr5+ Stem Cell Activity in Mouse Intestinal Adenomas

(2012) A. G. Schepers et al.   SCIENCE

Notch4 Normalization Reduces Blood Vessel Size in Arteriovenous Malformations

(2012) P. A. Murphy et al.   Science Translational Medicine

The double-edged sword of Notch signaling in cancer

(2012) Andrew P. South et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The Dll4/Notch pathway controls postangiogenic blood vessel remodeling and regression by modulating vasoconstriction and blood flow

(2011) I. B. Lobov et al.   BLOOD

Deletion of Adam10 in endothelial cells leads to defects in organ-specific vascular structures

(2011) K. Glomski et al.   BLOOD

Notch signaling regulates remodeling and vessel diameter in the extraembryonic yolk sac

(2011) Jessica N Copeland et al.   BMC DEVELOPMENTAL BIOLOGY

Basic and Therapeutic Aspects of Angiogenesis

(2011) Michael Potente et al.   CELL

Differential Notch Signaling in the Epicardium Is Required for Cardiac Inflow Development and Coronary Vessel Morphogenesis

(2011) Gonzalo del Monte et al.   CIRCULATION RESEARCH

The disintegrin/metalloproteinase Adam10 is essential for epidermal integrity and Notch-mediated signaling

(2011) S. Weber et al.   DEVELOPMENT

Embryonic origin of the adult hematopoietic system: advances and questions

(2011) A. Medvinsky et al.   DEVELOPMENT

Stepwise arteriovenous fate acquisition during mammalian vasculogenesis

(2011) Diana C. Chong et al.   DEVELOPMENTAL DYNAMICS

Notch regulation of tumor angiogenesis

(2011) Esther Bridges et al.   Future Oncology

Isolation and function of mouse tissue resident vascular precursors marked by myelin protein zero

(2011) Yoshiaki Kubota et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Identification of a coronary stem cell in the human heart

(2011) Annarosa Leri et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Redundancy and specificity of the metalloprotease system mediating oncogenic NOTCH1 activation in T-ALL

(2011) M L Sulis et al.   LEUKEMIA

Chromatin modification of Notch targets in olfactory receptor neuron diversification

(2011) Keita Endo et al.   NATURE NEUROSCIENCE

Molecular control of endothelial cell behaviour during blood vessel morphogenesis

(2011) Shane P. Herbert et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Evidence for Increased Exposure of the Notch1 Metalloprotease Cleavage Site upon Conversion to an Activated Conformation

(2011) Kittichoat Tiyanont et al.   STRUCTURE

Combination of Dll4/Notch and Ephrin-B2/EphB4 targeted therapy is highly effective in disrupting tumor angiogenesis

(2010) Dusan Djokovic et al.   BMC CANCER

Pathological Neovascularization Is Reduced by Inactivation of ADAM17 in Endothelial Cells but Not in Pericytes

(2010) Gisela Weskamp et al.   CIRCULATION RESEARCH

Adam10 is essential for early embryonic cardiovascular development

(2010) Chi Zhang et al.   DEVELOPMENTAL DYNAMICS

ADAM10 is essential for Notch2-dependent marginal zone B cell development and CD23 cleavage in vivo

(2010) David R. Gibb et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice

(2010) Athena Chalaris et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Disintegrin/Metalloproteinase ADAM10 Is Essential for the Establishment of the Brain Cortex

(2010) E. Jorissen et al.   JOURNAL OF NEUROSCIENCE

Therapeutic antibody targeting of individual Notch receptors

(2010) Yan Wu et al.   NATURE

Coronary arteries form by developmental reprogramming of venous cells

(2010) Kristy Red-Horse et al.   NATURE

Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting

(2010) Lars Jakobsson et al.   NATURE CELL BIOLOGY

Characterization of Notch1 Antibodies That Inhibit Signaling of Both Normal and Mutated Notch1 Receptors

(2010) Miguel Aste-Amézaga et al.   PLoS One

Molecular differentiation and specialization of vascular beds

(2009) Susana F. Rocha et al.   ANGIOGENESIS

Computer-aided quantification of retinal neovascularization

(2009) A. Stahl et al.   ANGIOGENESIS

VEGFRs and Notch: a dynamic collaboration in vascular patterning: Figure 1

(2009) Lars Jakobsson et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The Notch Ligands Dll4 and Jagged1 Have Opposing Effects on Angiogenesis

(2009) Rui Benedito et al.   CELL

Jagged Gives Endothelial Tip Cells an Edge

(2009) Steven Suchting et al.   CELL

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

Arterial–Venous Specification During Development

(2009) Matthew R. Swift et al.   CIRCULATION RESEARCH

Notch signaling controls the balance of ciliated and secretory cell fates in developing airways

(2009) P.-N. Tsao et al.   DEVELOPMENT

Notch signaling promotes airway mucous metaplasia and inhibits alveolar development

(2009) J. S. Guseh et al.   DEVELOPMENT

Nrarp Coordinates Endothelial Notch and Wnt Signaling to Control Vessel Density in Angiogenesis

(2009) Li-Kun Phng et al.   DEVELOPMENTAL CELL

Angiogenesis: A Team Effort Coordinated by Notch

(2009) L.-K. Phng et al.   DEVELOPMENTAL CELL

Crosstalk of VEGF and Notch pathways in tumour angiogenesis: therapeutic implications

(2009) Ji-Liang Li   Frontiers in Bioscience-Landmark

Metalloprotease ADAM10 Is Required for Notch1 Site 2 Cleavage

(2009) Geert van Tetering et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The CXCL12 (SDF-1)/CXCR4 Axis Is Essential for the Development of Renal Vasculature

(2009) Y. Takabatake et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Selective Use of ADAM10 and ADAM17 in Activation of Notch1 Signaling

(2009) E. C. Bozkulak et al.   MOLECULAR AND CELLULAR BIOLOGY

Quantification of oxygen-induced retinopathy in the mouse: a model of vessel loss, vessel regrowth and pathological angiogenesis

(2009) Kip M Connor et al.   Nature Protocols

Control of vascular morphogenesis and homeostasis through the angiopoietin–Tie system

(2009) Hellmut G. Augustin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Overexpression of delta-like 4 induces arterialization and attenuates vessel formation in developing mouse embryos

(2008) A. Trindade et al.   BLOOD

Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL

(2008) W. R. Gordon et al.   BLOOD

Brothers and Sisters

(2008) Julius Aitsebaomo et al.   CIRCULATION RESEARCH

Development of the renal glomerulus: good neighbors and good fences

(2008) S. E. Quaggin et al.   DEVELOPMENT

Artery and vein size is balanced by Notch and ephrin B2/EphB4 during angiogenesis

(2008) Y. H. Kim et al.   DEVELOPMENT

Expression of active Notch1 in avian coronary development

(2008) Ke Yang et al.   DEVELOPMENTAL DYNAMICS

Spatial and temporal role of the apelin/APJ system in the caliber size regulation of blood vessels during angiogenesis

(2008) Hiroyasu Kidoya et al.   EMBO JOURNAL

ADAM10 is essential for proteolytic activation of Notch during thymocyte development

(2008) L. Tian et al.   INTERNATIONAL IMMUNOLOGY

The molecular logic of Notch signaling - a structural and biochemical perspective

(2008) W. R. Gordon et al.   JOURNAL OF CELL SCIENCE

Glomerular Endothelial Cells Form Diaphragms during Development and Pathologic Conditions

(2008) K. Ichimura et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

How Do Mesangial and Endothelial Cells Form the Glomerular Tuft?

(2008) M. R. Vaughan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Germ line activation of the Tie2 and SMMHC promoters causes noncell-specific deletion of floxed alleles

(2008) Willem J. de Lange et al.   PHYSIOLOGICAL GENOMICS

Clipping, shedding and RIPping keep immunity on cue

(2008) Gillian Murphy et al.   TRENDS IN IMMUNOLOGY