Pulmonary surfactant as a versatile biomaterial to fight COVID-19

Surfactant for Treatment of ARDS in COVID-19 Patient

(2021) Moshe Heching et al.   CHEST

6-month consequences of COVID-19 in patients discharged from hospital: a cohort study

(2021) Chaolin Huang et al.   LANCET

Alarming COVID variants show vital role of genomic surveillance

(2021) David Cyranoski   NATURE

Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape

(2021) Paul-Albert Koenig et al.   SCIENCE

Mechanism of SARS-CoV-2 polymerase stalling by remdesivir

(2021) Goran Kokic et al.   Nature Communications

SP-A and SP-D: Dual Functioning Immune Molecules With Antiviral and Immunomodulatory Properties

(2021) Alastair Watson et al.   Frontiers in Immunology

The Inhibitory Effect of Curosurf® and Alveofact® on the Formation of Neutrophil Extracellular Traps

(2021) Annabell Schulz et al.   Frontiers in Immunology

Pulmonary Surfactant and Drug Delivery: An Interface-Assisted Carrier to Deliver Surfactant Protein SP-D Into the Airways

(2021) Cristina García-Mouton et al.   Frontiers in Bioengineering and Biotechnology

siRNA Therapeutics against Respiratory Viral Infections—What Have We Learned for Potential COVID‐19 Therapies?

(2021) Aditi Mehta et al.   Advanced Healthcare Materials

Lack of Effectiveness of Repurposed Drugs for COVID-19 Treatment

(2021) Miguel Angel Martinez   Frontiers in Immunology

Surfactant Protein B Promotes Cytosolic SiRNA Delivery by Adopting a Virus-like Mechanism of Action

(2021) Roberta Guagliardo et al.   ACS Nano

A Recombinant Fragment of Human Surfactant Protein D Binds Spike Protein and Inhibits Infectivity and Replication of SARS-CoV-2 in Clinical Samples

(2021) Taruna Madan et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

(2021) Obbina Abani et al.   LANCET

Inhaled budesonide in the treatment of early COVID-19 (STOIC): a phase 2, open-label, randomised controlled trial

(2021) Sanjay Ramakrishnan et al.   Lancet Respiratory Medicine

Human Surfactant Protein D Binds Spike Protein and Acts as an Entry Inhibitor of SARS-CoV-2 Pseudotyped Viral Particles

(2021) Miao-Hsi Hsieh et al.   Frontiers in Immunology

Serum surfactant protein D in COVID-19 is elevated and correlated with disease severity

(2021) Ming Tong et al.   BMC INFECTIOUS DISEASES

Clinical trials with antiviral drugs against COVID ‐19: some progress and many shattered hopes

(2021) Harald Brüssow   ENVIRONMENTAL MICROBIOLOGY

Use of exogenous pulmonary surfactant in acute respiratory distress syndrome (ARDS): Role in SARS-CoV-2-related lung injury

(2021) Francesco Cattel et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

COVID antiviral pills: what scientists still want to know

(2021) Heidi Ledford   NATURE

Functional and Structural Characterization of a Lyophilized Pulmonary Surfactant Directly Applied onto the Air-Liquid Interface

(2020) Mercedes Echaide et al.   BIOPHYSICAL JOURNAL

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

Ambroxol for the treatment of children with acute and chronic respiratory diseases: an overview of efficacy and safety

(2020) Ahmad Kantar et al.   MULTIDISCIPLINARY RESPIRATORY MEDICINE

Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies

(2020) Daniel Wrapp et al.   CELL

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

(2020) Alexandra C. Walls et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Plasma IP-10 and MCP-3 levels are highly associated with disease severity and predict the progression of COVID-19

(2020) Yang Yang et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Targeting potential drivers of COVID-19: Neutrophil extracellular traps

(2020) Betsy J. Barnes et al.   JOURNAL OF EXPERIMENTAL MEDICINE

COVID-19: consider cytokine storm syndromes and immunosuppression

(2020) Puja Mehta et al.   LANCET

COVID-19 with spontaneous pneumomediastinum

(2020) Changyu Zhou et al.   LANCET INFECTIOUS DISEASES

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

(2020) David E. Gordon et al.   NATURE

Cell entry mechanisms of SARS-CoV-2

(2020) Jian Shang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

On the Alert for Cytokine Storm: Immunopathology in COVID ‐19

(2020) Lauren A. Henderson et al.   Arthritis & Rheumatology

A Physiologically Informed Strategy to Effectively Open, Stabilize, and Protect the Acutely Injured Lung

(2020) Gary F. Nieman et al.   Frontiers in Physiology

Expression of the SARS-CoV-2 cell receptor gene ACE2 in a wide variety of human tissues

(2020) Meng-Yuan Li et al.   Infectious Diseases of Poverty

Research and Development on Therapeutic Agents and Vaccines for COVID-19 and Related Human Coronavirus Diseases

(2020) Cynthia Liu et al.   ACS Central Science

Master Regulator Analysis of the SARS-CoV-2/Human Interactome

(2020) Pietro H. Guzzi et al.   Journal of Clinical Medicine

Persistent Symptoms in Patients After Acute COVID-19

(2020) Angelo Carfì et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Dexamethasone nanomedicines for COVID-19

(2020) Twan Lammers et al.   Nature Nanotechnology

Dexamethasone in Hospitalized Patients with Covid-19 — Preliminary Report

(2020)   NEW ENGLAND JOURNAL OF MEDICINE

The chemistry, biology and pharmacology of the cyclopentenone prostaglandins

(2020) Sumner H. Burstein   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Immunosuppression during the COVID-19 pandemic in neuromyelitis optica spectrum disorders patients: A new challenge

(2020) Edgar Carnero Contentti et al.   Multiple Sclerosis and Related Disorders

Symptom Duration and Risk Factors for Delayed Return to Usual Health Among Outpatients with COVID-19 in a Multistate Health Care Systems Network — United States, March–June 2020

(2020) Mark W. Tenforde et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Prospects for RNAi Therapy of COVID-19

(2020) Hasan Uludağ et al.   Frontiers in Bioengineering and Biotechnology

Lung Surfactant for Pulmonary Barrier Restoration in Patients With COVID-19 Pneumonia

(2020) Ursula Mirastschijski et al.   Frontiers in Medicine

Lyophilization and nebulization of pulmonary surfactant-coated nanogels for siRNA inhalation therapy

(2020) Pieterjan Merckx et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

The inhaled steroid ciclesonide blocks SARS-CoV-2 RNA replication by targeting the viral replication-transcription complex in cultured cells

(2020) Shutoku Matsuyama et al.   JOURNAL OF VIROLOGY

Lopinavir–ritonavir in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

(2020) Peter W Horby et al.   LANCET

Are Serum Interleukin 6 and Surfactant Protein D Levels Associated with the Clinical Course of COVID-19?

(2020) Buğra Kerget et al.   LUNG

COVID-19-associated acute kidney injury: consensus report of the 25th Acute Disease Quality Initiative (ADQI) Workgroup

(2020) Mitra K. Nadim et al.   Nature Reviews Nephrology

Effect of Hydroxychloroquine in Hospitalized Patients with Covid-19

(2020)   NEW ENGLAND JOURNAL OF MEDICINE

Co-aerosolized Pulmonary Surfactant and Ambroxol for COVID-19 ARDS Intervention: What Are We Waiting for?

(2020) Pradeep Kumar   Frontiers in Bioengineering and Biotechnology

Optimizing Supportive Care in COVID-19 Patients: A Multidisciplinary Approach

(2020) Mohamed Abu Haleeqa et al.   Journal of Multidisciplinary Healthcare

Implications of renal ACE2 expression in the age of COVID-19

(2020) Husam M Salah et al.   EUROPEAN HEART JOURNAL

Neutrophils and COVID-19: The road so far

(2020) Luiz Henrique Agra Cavalcante-Silva et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Pulmonary surfactant and drug delivery: Vehiculization, release and targeting of surfactant/tacrolimus formulations

(2020) Alberto Hidalgo et al.   JOURNAL OF CONTROLLED RELEASE

Repurposed Antiviral Drugs for Covid-19 — Interim WHO Solidarity Trial Results

(2020)   NEW ENGLAND JOURNAL OF MEDICINE

The COVID-19 pandemic: a target for surfactant therapy?

(2020) Ruud A.W. Veldhuizen et al.   Expert Review of Respiratory Medicine

Towards the Molecular Mechanism of Pulmonary Surfactant Protein SP-B: At the Crossroad of Membrane Permeability and Interfacial Lipid Transfer

(2020) Marta Martínez-Calle et al.   JOURNAL OF MOLECULAR BIOLOGY

Acute respiratory distress syndrome

(2019) Michael A. Matthay et al.   Nature Reviews Disease Primers

Advances in synthetic lung surfactant protein technology

(2019) Frans J. Walther et al.   Expert Review of Respiratory Medicine

ROS‐Responsive Polymeric siRNA Nanomedicine Stabilized by Triple Interactions for the Robust Glioblastoma Combinational RNAi Therapy

(2019) Meng Zheng et al.   ADVANCED MATERIALS

Deposition of Aerosolized Lucinactant in Nonhuman Primates

(2019) Timothy J. Gregory et al.   Journal of Aerosol Medicine and Pulmonary Drug Delivery

Nanocarrier Lipid Composition Modulates the Impact of Pulmonary Surfactant Protein B (SP-B) on Cellular Delivery of siRNA

(2019) Roberta Guagliardo et al.   Pharmaceutics

Effective mRNA pulmonary delivery by dry powder formulation of PEGylated synthetic KL4 peptide

(2019) Yingshan Qiu et al.   JOURNAL OF CONTROLLED RELEASE

Combinational siRNA delivery using hyaluronic acid modified amphiphilic polyplexes against cell cycle and phosphatase proteins to inhibit growth and migration of triple-negative breast cancer cells

(2018) Manoj B. Parmar et al.   Acta Biomaterialia

Inhalation Techniques Used in Patients with Respiratory Failure Treated with Noninvasive Mechanical Ventilation

(2018) Patrycja Rzepka-Wrona et al.   Canadian Respiratory Journal

Surfactant protein B (SP-B) enhances the cellular siRNA delivery of proteolipid coated nanogels for inhalation therapy

(2018) Pieterjan Merckx et al.   Acta Biomaterialia

Pulmonary surfactant and drug delivery: Focusing on the role of surfactant proteins

(2018) Roberta Guagliardo et al.   JOURNAL OF CONTROLLED RELEASE

Synthetic surfactants with SP-B and SP-C analogues to enable worldwide treatment of neonatal respiratory distress syndrome and other lung diseases

(2018) J. Johansson et al.   JOURNAL OF INTERNAL MEDICINE

Drug repurposing: progress, challenges and recommendations

(2018) Sudeep Pushpakom et al.   NATURE REVIEWS DRUG DISCOVERY

Efficient Interfacially Driven Vehiculization of Corticosteroids by Pulmonary Surfactant

(2017) Alberto Hidalgo et al.   LANGMUIR

From Pulmonary Surfactant, Synthetic KL4 Peptide as Effective siRNA Delivery Vector for Pulmonary Delivery

(2017) Yingshan Qiu et al.   MOLECULAR PHARMACEUTICS

Combinatorial treatment of idiopathic pulmonary fibrosis using nanoparticles with prostaglandin E and siRNA(s)

(2017) Olga. B. Garbuzenko et al.   Nanomedicine-Nanotechnology Biology and Medicine

How Should Aerosols Be Delivered During Invasive Mechanical Ventilation?

(2017) Rajiv Dhand   Respiratory Care

Antiviral activity of recombinant porcine surfactant protein A against porcine reproductive and respiratory syndrome virus in vitro

(2016) Lan Li et al.   ARCHIVES OF VIROLOGY

Therapeutic nucleic acids: current clinical status

(2016) Kannan Sridharan et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Peptide-based synthetic pulmonary surfactant for the treatment of respiratory distress disorders

(2016) Otonye Braide-Moncoeur et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Anti-inflammatory effects of the new generation synthetic surfactant CHF5633 on Ureaplasma-induced cytokine responses in human monocytes

(2016) Kirsten Glaser et al.   Expert Review of Anti-Infective Therapy

Surfactant Protein A Prevents IFN-γ/IFN-γ Receptor Interaction and Attenuates Classical Activation of Human Alveolar Macrophages

(2016) Carlos M. Minutti et al.   JOURNAL OF IMMUNOLOGY

Structural analogs of pulmonary surfactant phosphatidylglycerol inhibit toll-like receptor 2 and 4 signaling

(2016) Pitchaimani Kandasamy et al.   JOURNAL OF LIPID RESEARCH

Single and Combinational siRNA Therapy of Cancer Cells: Probing Changes in Targeted and Nontargeted Mediators after siRNA Treatment

(2016) Hamidreza Montazeri Aliabadi et al.   MOLECULAR PHARMACEUTICS

Influence of agglomeration and specific lung lining lipid/protein interaction on short-term inhalation toxicity

(2016) Wendel Wohlleben et al.   Nanotoxicology

Effect of pulmonary surfactant on the dissolution, stability and uptake of zinc oxide nanowires by human respiratory epithelial cells

(2016) Ioannis G. Theodorou et al.   Nanotoxicology

Phospholipid Composition in Synthetic Surfactants Is Important for Tidal Volumes and Alveolar Stability in Surfactant-Treated Preterm Newborn Rabbits

(2016) Andrea Calkovska et al.   Neonatology

Activity and biophysical inhibition resistance of a novel synthetic lung surfactant containing Super-Mini-B DATK peptide

(2016) Robert H. Notter et al.   PeerJ

Effects of the New Generation Synthetic Reconstituted Surfactant CHF5633 on Pro- and Anti-Inflammatory Cytokine Expression in Native and LPS-Stimulated Adult CD14+ Monocytes

(2016) Kirsten Glaser et al.   PLoS One

Impact of the New Generation Reconstituted Surfactant CHF5633 on Human CD4+ Lymphocytes

(2016) Markus Fehrholz et al.   PLoS One

Proteomic and Lipidomic Analysis of Nanoparticle Corona upon Contact with Lung Surfactant Reveals Differences in Protein, but Not Lipid Composition

(2015) Simon Sebastian Raesch et al.   ACS Nano

Diseases of Pulmonary Surfactant Homeostasis

(2015) Jeffrey A. Whitsett et al.   Annual Review of Pathology-Mechanisms of Disease

Antimicrobial and Biophysical Properties of Surfactant Supplemented with an Antimicrobial Peptide for Treatment of Bacterial Pneumonia

(2015) Brandon J. H. Banaschewski et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Pulmonary Delivery of siRNA via Polymeric Vectors as Therapies of Asthma

(2015) Yuran Xie et al.   ARCHIV DER PHARMAZIE

Palmitoylation as a key factor to modulate SP-C–lipid interactions in lung surfactant membrane multilayers

(2015) Nuria Roldan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Composition, structure and mechanical properties define performance of pulmonary surfactant membranes and films

(2015) Elisa Parra et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Barrier or carrier? Pulmonary surfactant and drug delivery

(2015) Alberto Hidalgo et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

A model for the structure and mechanism of action of pulmonary surfactant protein B

(2015) Bárbara Olmeda et al.   FASEB JOURNAL

Hybrid pulmonary surfactant-coated nanogels mediate efficient in vivo delivery of siRNA to murine alveolar macrophages

(2015) Lynn De Backer et al.   JOURNAL OF CONTROLLED RELEASE

Bio-inspired materials in drug delivery: Exploring the role of pulmonary surfactant in siRNA inhalation therapy

(2015) Lynn De Backer et al.   JOURNAL OF CONTROLLED RELEASE

Bio-inspired pulmonary surfactant-modified nanogels: A promising siRNA delivery system

(2015) Lynn De Backer et al.   JOURNAL OF CONTROLLED RELEASE

OSCAR Is a Receptor for Surfactant Protein D That Activates TNF-α Release from Human CCR2+Inflammatory Monocytes

(2015) Alexander D. Barrow et al.   JOURNAL OF IMMUNOLOGY

Phosphatidylinositol inhibits respiratory syncytial virus infection

(2015) Mari Numata et al.   JOURNAL OF LIPID RESEARCH

A Unique Story in Neonatal Research: The Development of a Porcine Surfactant

(2015) Tore Curstedt et al.   Neonatology

Effect of exogenous pulmonary surfactants on mortality rate in neonatal respiratory distress syndrome: A network meta-analysis of randomized controlled trials

(2015) Liang Zhang et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Aerosolized Surfactants, Anti-Inflammatory Drugs, and Analgesics

(2015) D. F. Willson   Respiratory Care

Overcoming inactivation of the lung surfactant by serum proteins: a potential role for fluorocarbons?

(2015) Marie Pierre Krafft   Soft Matter

siRNA Delivery to the lung: What's new?

(2014) Olivia M. Merkel et al.   ADVANCED DRUG DELIVERY REVIEWS

Structure-function relationships in pulmonary surfactant membranes: From biophysics to therapy

(2014) Elena Lopez-Rodriguez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Investigating the Effect of Particle Size on Pulmonary Surfactant Phase Behavior

(2014) Akihisa T. Kodama et al.   BIOPHYSICAL JOURNAL

Leukocyte-associated Ig-like receptor-1 is a novel inhibitory receptor for surfactant protein D

(2014) Marloes J. M. Olde Nordkamp et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Nanoparticles modulate surfactant protein A and D mediated protection against influenza A infection in vitro

(2014) Z. McKenzie et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Endosome maturation, transport and functions

(2014) Cameron C. Scott et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Recombinant porcine surfactant protein D inhibits influenza A virus replication ex vivo

(2014) Marine L.B. Hillaire et al.   VIRUS RESEARCH

Endogenous lung surfactant inspired pH responsive nanovesicle aerosols: Pulmonary compatible and site-specific drug delivery in lung metastases

(2014) Nitin Joshi et al.   Scientific Reports

Physicochemical Properties of Nanoparticles Regulate Translocation across Pulmonary Surfactant Monolayer and Formation of Lipoprotein Corona

(2013) Guoqing Hu et al.   ACS Nano

Molecular Mechanisms of RNA Interference

(2013) Ross C. Wilson et al.   Annual Review of Biophysics

Biophysical inhibition of synthetic vs. naturally-derived pulmonary surfactant preparations by polymeric nanoparticles

(2013) Moritz Beck-Broichsitter et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Combined delivery of HMGB-1 box A peptide and S1PLyase siRNA in animal models of acute lung injury

(2013) Binna Oh et al.   JOURNAL OF CONTROLLED RELEASE

The influence of natural pulmonary surfactant on the efficacy of siRNA-loaded dextran nanogels

(2013) Lynn De Backer et al.   Nanomedicine

Image-based analysis of lipid nanoparticle–mediated siRNA delivery, intracellular trafficking and endosomal escape

(2013) Jerome Gilleron et al.   NATURE BIOTECHNOLOGY

Role of the N-Terminal Seven Residues of Surfactant Protein B (SP-B)

(2013) Mahzad Sharifahmadian et al.   PLoS One

Budesonide and formoterol effects on rhinovirus replication and epithelial cell cytokine responses

(2013) Yury A Bochkov et al.   RESPIRATORY RESEARCH

Protective Effect of Surfactant Protein D in Pulmonary Vaccinia Virus Infection: Implication of A27 Viral Protein

(2013) Julien Perino et al.   Viruses-Basel

Structure–function correlations of pulmonary surfactant protein SP-B and the saposin-like family of proteins

(2012) Bárbara Olmeda et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Diverse Functions of Pulmonary Collectins in Host Defense of the Lung

(2012) Shigeru Ariki et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

The acute respiratory distress syndrome

(2012) Michael A. Matthay et al.   JOURNAL OF CLINICAL INVESTIGATION

Therapeutic effects of inhaling aerosolized surfactant alone or with dexamethasone generated by a novel noninvasive apparatus on acute lung injury in rats

(2012) Ya-Min Yan et al.   Journal of Trauma and Acute Care Surgery

Comparison of poractant alfa and lyophilized lucinactant in a preterm lamb model of acute respiratory distress

(2012) Jan Mazela et al.   PEDIATRIC RESEARCH

SP-B and SP-C Containing New Synthetic Surfactant for Treatment of Extremely Immature Lamb Lung

(2012) Atsuyasu Sato et al.   PLoS One

New Surfactant with SP-B and C Analogs Gives Survival Benefit after Inactivation in Preterm Lambs

(2012) Matthias Seehase et al.   PLoS One

Adverse Biophysical Effects of Hydroxyapatite Nanoparticles on Natural Pulmonary Surfactant

(2011) Qihui Fan et al.   ACS Nano

Phosphatidylglycerol Suppresses Influenza A Virus Infection

(2011) Mari Numata et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Alterations of the C-terminal end do not affect in vitro or in vivo activity of surfactant protein C analogs

(2011) Andreas Almlén et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Pulmonary Gene Delivery Using Polymeric Nonviral Vectors

(2011) Olivia M. Merkel et al.   BIOCONJUGATE CHEMISTRY

Ambroxol: a multifaceted molecule with additional therapeutic potentials in respiratory disorders of childhood

(2011) Davide Paleari et al.   Expert Opinion on Drug Discovery

Infection of human alveolar macrophages by human coronavirus strain 229E

(2011) C. J. Funk et al.   JOURNAL OF GENERAL VIROLOGY

Uptake of nanoparticles by alveolar macrophages is triggered by surfactant protein A

(2011) Christian A. Ruge et al.   Nanomedicine-Nanotechnology Biology and Medicine

Comparison of Polymeric siRNA Nanocarriers in a Murine LPS-Activated Macrophage Cell Line: Gene Silencing, Toxicity and Off-Target Gene Expression

(2011) Linda B. Jensen et al.   PHARMACEUTICAL RESEARCH

Pathogenesis of indirect (secondary) acute lung injury

(2011) Mario Perl et al.   Expert Review of Respiratory Medicine

Update on Macrophage Clearance of Inhaled Micro- and Nanoparticles

(2010) Marianne Geiser   Journal of Aerosol Medicine and Pulmonary Drug Delivery

Biophysical investigation of pulmonary surfactant surface properties upon contact with polymeric nanoparticles in vitro

(2010) Moritz Beck-Broichsitter et al.   Nanomedicine-Nanotechnology Biology and Medicine

Critical Structural and Functional Roles for the N-Terminal Insertion Sequence in Surfactant Protein B Analogs

(2010) Frans J. Walther et al.   PLoS One

Biodegradable Dextran Nanogels for RNA Interference: Focusing on Endosomal Escape and Intracellular siRNA Delivery

(2009) Koen Raemdonck et al.   ADVANCED FUNCTIONAL MATERIALS

Cholesterol modulates the exposure and orientation of pulmonary surfactant protein SP-C in model surfactant membranes

(2009) L. Gómez-Gil et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

P63 (CKAP4) as an SP-A Receptor: Implications for Surfactant Turnover

(2009) Sandra Bates   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Synthetic peptides representing the N-terminal segment of surfactant protein C modulate LPS-stimulated TNF-α production by macrophages

(2009) Ignacio Garcia-Verdugo et al.   Innate Immunity

Anionic Pulmonary Surfactant Phospholipids Inhibit Inflammatory Responses from Alveolar Macrophages and U937 Cells by Binding the Lipopolysaccharide-interacting Proteins CD14 and MD-2

(2009) Koji Kuronuma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Surfactant Protein A Modulates Cell Surface Expression of CR3 on Alveolar Macrophages and Enhances CR3-mediated Phagocytosis

(2009) Malgorzata Gil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Surfactant Protein B Propeptide Contains a Saposin-Like Protein Domain with Antimicrobial Activity at Low pH

(2009) L. Yang et al.   JOURNAL OF IMMUNOLOGY

Animal-derived surfactants: where are we? The evidence from randomized, controlled clinical trials

(2009) R Ramanathan   Journal of Perinatology

Recombination, Reservoirs, and the Modular Spike: Mechanisms of Coronavirus Cross-Species Transmission

(2009) R. L. Graham et al.   JOURNAL OF VIROLOGY

Pulmonary surfactant phosphatidylglycerol inhibits respiratory syncytial virus-induced inflammation and infection

(2009) M. Numata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of pulmonary surfactant membranes and films: The role of proteins and lipid–protein interactions

(2008) Jesús Pérez-Gil   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

RNAi mechanisms and applications

(2008) Daniel H. Kim et al.   BIOTECHNIQUES

Maintaining the silence: reflections on long-term RNAi

(2008) Koen Raemdonck et al.   DRUG DISCOVERY TODAY

Ambroxol in the 21st century: pharmacological and clinical update

(2008) Mario Malerba et al.   Expert Opinion on Drug Metabolism & Toxicology

Surfactants: past, present and future

(2008) H L Halliday   Journal of Perinatology

Surfactant protein-A plays an important role in lung surfactant clearance: evidence using the surfactant protein-A gene-targeted mouse

(2007) Sandra R. Bates et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Metal Nanoparticle Pollutants Interfere with Pulmonary Surfactant Function In Vitro

(2007) Mandeep Singh Bakshi et al.   BIOPHYSICAL JOURNAL