Article
Cardiac & Cardiovascular Systems
Thomas S. Metkus, Lori J. Sokoll, Andreas S. Barth, Matthew J. Czarny, Allison G. Hays, Charles J. Lowenstein, Erin D. Michos, Eric P. Nolley, Wendy S. Post, Jon R. Resar, David R. Thiemann, Jeffrey C. Trost, Rani K. Hasan
Summary: The study found that over 50% of intubated patients with severe COVID-19 had myocardial injury, which was associated with a higher mortality rate. Myocardial injury in COVID-19 was closely related to baseline comorbidities, age, and multisystem organ dysfunction. Compared with ARDS patients without COVID-19, COVID-19 patients were older and had poorer cardiac function, but had a lower incidence of myocardial injury.
Article
Medicine, General & Internal
Demetrios J. Kutsogiannis, Abdulrahman Alharthy, Abdullah Balhamar, Fahad Faqihi, John Papanikolaou, Saleh A. Alqahtani, Ziad A. Memish, Peter G. Brindley, Laurent Brochard, Dimitrios Karakitsos
Summary: This study compared the respiratory mechanics, inflammatory markers, and incidence of pulmonary embolism in COVID-19 associated ARDS patients and non-COVID-19 ARDS patients. The results showed that COVID-19 patients were slightly less recruitable and had a higher incidence of pulmonary embolism.
FRONTIERS IN MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Sergey N. Avdeev, Natalia Trushenko, Svetlana Yu Chikina, Natalia A. Tsareva, Zamira M. Merzhoeva, Andrey Yaroshetskiy, Violetta Sopova, Margarita Sopova, Oleg A. Rosenberg, Ralph Theo Schermuly, Djuro Kosanovic
Summary: Inhaled surfactant therapy in patients with COVID-19-associated ARDS significantly improved oxygenation parameters, reduced the need for intensive care and invasive mechanical ventilation, and shortened the duration of non-invasive ventilation and hospital stay.
RESPIRATORY MEDICINE
(2021)
Article
Critical Care Medicine
Francois Beloncle, Antoine Studer, Valerie Seegers, Jean-Christophe Richard, Christophe Desprez, Nicolas Fage, Hamid Merdji, Bertrand Pavlovsky, Julie Helms, Sibylle Cunat, Satar Mortaza, Julien Demiselle, Laurent Brochard, Alain Mercat, Ferhat Meziani
Summary: Differences in physiology were found between COVID-19 and non-COVID-19 patients with ARDS, with higher C-RS in COVID-19 patients initially. The relationship between C-RS and oxygenation was only seen in non-COVID-19 patients on day 1. Both COVID-19 and non-COVID-19 patients showed similar C-RS and VR at day 7.
Article
Critical Care Medicine
Michael Waters, James A. McKinnell, Andre C. Kalil, Greg S. Martin, Timothy G. Buchman, Wiebke Theess, Xiaoying Yang, Annemarie N. Lekkerkerker, Tracy Staton, Carrie M. Rosenberger, Rajita Pappu, Yehong Wang, Wenhui Zhang, Logan Brooks, Dorothy Cheung, Joshua Galanter, Hubert Chen, Divya Mohan, Melicent C. Peck
Summary: The study aimed to evaluate the safety and efficacy of astegolimab and efmarodocokin alfa for the treatment of severe COVID-19 pneumonia. The results showed that neither of the drugs improved the time to recovery and no new safety signals were observed.
CRITICAL CARE MEDICINE
(2023)
Article
Nutrition & Dietetics
Quirin Notz, Johannes Herrmann, Tobias Schlesinger, Peter Kranke, Magdalena Sitter, Philipp Helmer, Jan Stumpner, Daniel Roeder, Karin Amrein, Christian Stoppe, Christopher Lotz, Patrick Meybohm
Summary: Vitamin D deficiency is common in COVID-19 ARDS patients. While 25-hydroxyvitamin D status is not related to clinical course changes, low levels of 1,25-dihydroxyvitamin D are associated with prolonged mechanical ventilation and a worse APACHE II score.
CLINICAL NUTRITION
(2022)
Article
Medicine, General & Internal
Antonin Trimaille, Jecko Thachil, Benjamin Marchandot, Anais Curtiaud, Ian Leonard-Lorant, Adrien Carmona, Kensuke Matsushita, Chisato Sato, Laurent Sattler, Lelia Grunebaum, Yves Hansmann, Samira Fafi-Kremer, Laurence Jesel, Mickael Ohana, Olivier Morel
Summary: Elevated D-Dimers levels in COVID-19 patients may be associated with critical lung injuries and poor prognosis. Even in the absence of thrombotic events, D-Dimers quantification serves as a relevant marker for critical patient outcomes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Jianguo Zhang, Xing Huang, Daoyin Ding, Jinhui Zhang, Liusheng Xu, Zhenkui Hu, Wenrong Xu, Zhimin Tao
Summary: Comparing the characteristics of ALI between COVID-19 and non-COVID-19 patients in the ICU setting provided insights into the pathogenesis of ALI induced by different risk factors, suggesting distinct treatment plans.
FRONTIERS IN MEDICINE
(2021)
Article
Respiratory System
Cecilia Lopez-Martinez, Paula Martin-Vicente, Juan Gomez de Ona, Ines Lopez-Alonso, Helena Gil-Pena, Elias Cuesta-Llavona, Margarita Fernandez-Rodriguez, Irene Crespo, Estefania Salgado del Riego, Raquel Rodriguez-Garcia, Diego Parra, Javier Fernandez, Javier Rodriguez-Carrio, Francisco Jose Jimeno-Demuth, Alberto Davalos, Luis A. Chapado, Eliecer Coto, Guillermo M. Albaiceta, Laura Amado-Rodriguez
Summary: In this study, researchers identified two transcriptomic clusters in critically ill COVID-19 patients based on peripheral blood transcriptomes. One cluster was characterized by interferon-related expression and the other promoted B-cell activation. These clusters had different ICU outcomes, suggesting different pathogenetic mechanisms. The findings demonstrate the potential of transcriptomics in identifying patient endotypes for personalized therapies in severe COVID-19.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Respiratory System
Simone Piva, Robert M. DiBlasi, April E. Slee, Alan H. Jobe, Aldo M. Roccaro, Matteo Filippini, Nicola Latronico, Michele Bertoni, John C. Marshall, Michael A. Portman
Summary: The study demonstrates that surfactant delivery through bronchoscopy at a dose of 720 mg in 150 ml normal saline is feasible and safe for COVID-19 ARDS patients. Surfactant administration did not cause acute decompensation, may reduce mortality and mechanical ventilation duration in COVID-19 ARDS patients. This supports the need for future randomized clinical trials to evaluate the efficacy of meticulous sub-bronchial lavage with surfactant for COVID-19 ARDS patients.
RESPIRATORY RESEARCH
(2021)
Article
Multidisciplinary Sciences
Luis F. Reyes, Alirio Bastidas, Paula O. Narvaez, Daniela Parra-Tanoux, Yuli Fuentes, Cristian C. Serrano-Mayorga, Valentina Ortiz, Eder L. Caceres, Gustavo Ospina-Tascon, Ana M. Diaz, Manuel Jibaja, Magdalena Vera, Edwin Silva, Luis Antonio Gorordo-Delsol, Francesca Maraschin, Fabio Varon-Vega, Ricardo Buitrago, Marcela Poveda, Lina M. Saucedo, Elisa Estenssoro, Guillermo Ortiz, Nicolas Nin, Luis E. Calderon, Gina S. Montano, Aldair J. Chaar, Fernanda Garcia, Vanessa Ramirez, Fabricio Picoita, Cristian Pelaez, Luis Unigarro, Gilberto Friedman, Laura Cucunubo, Alejandro Bruhn, Glenn Hernandez, Ignacio Martin-Loeches
Summary: This study aims to investigate the clinical characteristics, in-hospital outcomes, and factors associated with ICU admission due to COVID-19 in Latin American countries. The results show a lower mortality rate for COVID-19 patients in Latin America compared to previous reports, but a higher mortality rate for ICU patients. Additionally, patients discharged from the ICU had worse self-care ability.
Article
Nutrition & Dietetics
Gema Villa Lopez, Maria Angeles Valero Zanuy, Ivan Gonzalez Barrios, Maria Maiz Jimenez, Pilar Gomis Munoz, Miguel Leon Sanz
Summary: The incidence of hypertriglyceridemia in critically ill patients with ARDS-COVID-19 receiving PN was 37 cases per 100 patient-days. Risk factors for this complication included obesity and the use of lopinavir/ritonavir or Propofol. Patients with hypertriglyceridemia required longer duration of PN support, but it did not affect mortality rates.
Editorial Material
Cardiac & Cardiovascular Systems
David J. Hall, Jefree J. Schulte, Erik E. Lewis, Swaroop R. Bommareddi, Charles T. Rohrer, Samir Sultan, James D. Maloney, Malcolm M. DeCamp, Daniel P. McCarthy
Summary: This article reports a case of lung transplantation for post-COVID-19 pulmonary fibrosis. The patient recovered rapidly after the surgery and has done well in follow-up.
ANNALS OF THORACIC SURGERY
(2022)
Article
Critical Care Medicine
Ellen A. Gorman, Jennifer Rynne, Hannah J. Gardiner, Anthony J. Rostron, Jonathan Bannard-Smith, Andrew M. Bentley, David Brealey, Christina Campbell, Gerard Curley, Mike Clarke, Ahilanadan Dushianthan, Phillip Hopkins, Colette Jackson, Kallirroi Kefela, Anna Krasnodembskaya, John G. Laffey, Cliona McDowell, Margaret McFarland, Jamie McFerran, Peter McGuigan, Gavin D. Perkins, Jonathan Silversides, Jon Smythe, Jacqui Thompson, William S. Tunnicliffe, Ingeborg D. M. Welters, Laura Amado-Rodriguez, Guillermo Albaiceta, Barry Williams, Manu Shankar-Hari, Daniel F. McAuley, Cecilia M. O'Kane
Summary: This study investigated the safety and efficacy of ORBCEL-C (CD362-enriched, umbilical cord-derived MSCs) in COVID-19-related ARDS. The results showed that ORBCEL-C did not improve surrogate outcomes of pulmonary organ dysfunction. Evaluation: 7/10.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Khaled Khudadah, Alaa Ramadan, Ahmed Othman, Neveen Refaey, Amr Elrosasy, Ayoub Rezkallah, Toka Heseba, Mostafa Hossam El Din Moawad, Ammar Mektebi, Sewar A. Elejla, Mohamed Abouzid, Basel Abdelazeem
Summary: Patients with COVID-19 have similar symptoms to neonatal respiratory distress syndrome. The spike protein of SARS-CoV-2 targets alveolar type 2 lung cells, leading to acute respiratory distress syndrome. Surfactant therapy improves respiratory parameters in COVID-19 patients, but further clinical trials are needed to determine its effect on mortality. Surfactants could also be used as a carrier for drug delivery, requiring more research efforts.
BIOSCIENCE REPORTS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Fatma Tortum, Erdal Tekin, Ali Gur, Bugra Kerget, Kamber Kasali
Summary: This study aimed to examine the correlation between the PaO2/FiO2 ratio and PACTOIR in patients with acute pulmonary embolism. The results showed a negative correlation between the PaO2/FiO2 ratio and PACTOIR, indicating that the degree of pulmonary artery obstruction and clinical severity can be predicted by calculating the PaO2/FiO2 ratio.
ACADEMIC RADIOLOGY
(2023)
Article
Medicine, Research & Experimental
Sevgi Karabulut Uzuncakmak, Alperen Aksakal, Ferhan Kerget, Pelin Aydin, Zekai Halici
Summary: The aim of this study was to investigate the expression of insulin-like growth factor binding protein 5 (IGFBP5) in COVID-19 patients and its relationship with COVID-19 laboratory findings and plasma osteopontin (OPN) levels. The results showed that COVID-19 patients had higher plasma OPN levels and lower IGFBP5 expression levels, with critically ill patients having even higher OPN levels and lower IGFBP5 levels than non-critically ill patients. Diagnositic analysis indicated that IGFBP5 expression and OPN levels could be used to distinguish between critically ill and non-critically ill patients. This study demonstrated that increased OPN and decreased IGFBP5 may be signs of poor prognosis in COVID-19 patients, and the tissue-specific expression of IGFBP5 in the lungs could play a role in understanding its function in COVID-19 cases.
ADVANCES IN MEDICAL SCIENCES
(2023)
Article
Medicine, Research & Experimental
Bugra Kerget, Hatice B. Ozkan, Fatih Alper, Metin Akgun
Summary: This study compared exhaled carbon monoxide (CO) levels in patients hospitalized for bacterial and COVID-19-related viral community-acquired pneumonia. The results showed that patients with COVID-19 pneumonia had significantly higher levels of exhaled CO compared to patients with bacterial pneumonia and healthy control subjects. This suggests that measuring exhaled CO levels could be used to differentiate between viral and bacterial lung infections.
BIOMARKERS IN MEDICINE
(2023)
Article
Medicine, General & Internal
Bugra Kerget, Gizem Cil, Omer Araz, Fatih Alper, Metin Akgun
Summary: This study compared the effects of nintedanib and pirfenidone in treating COVID-19-related fibrosis. Both drugs were effective in improving radiological score and pulmonary function, but nintedanib was more effective in increasing exercise capacity and saturation values, although it also caused more adverse drug effects.
Article
Critical Care Medicine
Zuhal Karakurt, Ozge Yilmaz, Huseyin Arikan, Pinar Ay, Canan Demir, Canan Gunduz Gurkan, Metin Akgun, Sonia Buist
Summary: The American Thoracic Society (ATS) MECOR Program aims to build research capacity in low and middle-income countries. This study reports the number and impact of published articles generated from research questions developed by students in the ATS MECOR Program in Turkiye between 2008 and 2018.
Article
Medicine, General & Internal
Alperen Aksakal, Bugra Kerget, Gizem Cil, Dursun Erol Afsin, Metin Akgun, Elif Yilmazel Ucar, Leyla Saglam
Summary: This study analyzed the effect of atmospheric pressure (AP) level and change on the development of pulmonary embolism (PE). It found that lower AP values were significantly associated with the incidence of PE. In particular, a drop in APmin compared to the previous day seemed to be most associated with PE development.
ANNALS OF SAUDI MEDICINE
(2023)
Article
Medical Laboratory Technology
Ferhan Kerget, Bugra Kerget, Esra Laloglu
Summary: This study aimed to determine the relationship between early serum Decoy receptor-3 (DcR3) level and clinical severity in patients with Crimean-Congo hemorrhagic fever (CCHF). The results showed that symptoms such as fever, hemorrhage, nausea, headache, diarrhea, and hypoxia were significantly more common in severe CCHF patients. Serum DcR3 levels were higher in severe CCHF patients compared to mild/moderate patients and healthy individuals. Serum DcR3 may serve as a potential indicator for early immunomodulatory therapy in CCHF.
CLINICAL BIOCHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
A. Aksakal, A. F. Kilic, D. E. Afsin, N. K. Baygutalp, B. Kerget
Summary: This study measured serum thrombin-activated fibrinolysis inhibitor (TAFI) levels in COVID-19 patients and determined its relationship with prognosis. The results showed significant differences in TAFI levels between severe and mild cases, and TAFI levels were able to predict mortality and intubation rates. Further research is needed to confirm TAFI levels as a prognostic biomarker in COVID-19 patients.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Letter
Medicine, General & Internal
Sevilay Ozmen, Funda Demirag, Fatih Alper, Onur Ceylan, Betul Gundogdu, Ömer Araz, Cigdem Kahraman, Adem Maman, Metin Akgun
EURASIAN JOURNAL OF MEDICINE
(2023)
Article
Pharmacology & Pharmacy
D. E. Afsin, A. Aksakal, A. F. Kilic, N. K. Baygutalp, B. Kerget
Summary: This study aimed to determine the serum levels of mannose-binding lectin (MBL) and its relationship with intensive care hospitalization. The results showed significant differences in MBL levels between different severity groups of COVID-19 patients. MBL may serve as a prognostic biomarker in COVID-19 patients.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Respiratory System
Elif Yilmazel Ucar, Omer Araz, Eda Celik, Bugra Kerget, Metin Akgun, Leyla Saglam
Summary: The aim of this study was to determine the optimal dose of thrombolytic therapy for patients with acute pulmonary thromboembolism (PTE) using clinical parameters. The study found that changes in pulse and saturation within the first 60 minutes of treatment are important indicators of treatment effectiveness.
EURASIAN JOURNAL OF PULMONOLOGY
(2022)
Article
Medical Laboratory Technology
Dursun E. Afsin, Bugra Kerget
Summary: Analysis of exhaled CO levels and CT scores of COVID-19 patients revealed higher levels in severe cases on admission, with a positive correlation between exhaled CO levels and CT scores. However, no significant differences were observed between groups upon discharge.
CLINICAL LABORATORY
(2022)
