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Title
Mechanism of SARS-CoV-2 polymerase stalling by remdesivir
Authors
Keywords
-
Journal
Nature Communications
Volume 12, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2021-01-13
DOI
10.1038/s41467-020-20542-0
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- (2020) John H. Beigel et al. NEW ENGLAND JOURNAL OF MEDICINE
- Compassionate Use of Remdesivir for Patients with Severe Covid-19
- (2020) Jonathan Grein et al. NEW ENGLAND JOURNAL OF MEDICINE
- Structure of the RNA-dependent RNA polymerase from COVID-19 virus
- (2020) Yan Gao et al. SCIENCE
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- (2020) Wanchao Yin et al. SCIENCE
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- (2020) Andrea J. Pruijssers et al. Cell Reports
- Directly Acting Antivirals for COVID-19: Where Do We Stand?
- (2020) Siew L. Teoh et al. Frontiers in Microbiology
- RNA-dependent RNA polymerase: Structure, mechanism, and drug discovery for COVID-19
- (2020) Yi Jiang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Template-dependent inhibition of coronavirus RNA-dependent RNA polymerase by remdesivir reveals a second mechanism of action
- (2020) Egor P Tchesnokov et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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- (2019) Egor Tchesnokov et al. Viruses-Basel
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- (2019) Robert N. Kirchdoerfer et al. Nature Communications
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- (2018) Maria L. Agostini et al. mBio
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- (2018) Pavel V. Afonine et al. Acta Crystallographica Section D-Structural Biology
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- MolProbity: More and better reference data for improved all-atom structure validation
- (2017) Christopher J. Williams et al. PROTEIN SCIENCE
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- (2017) Timothy P. Sheahan et al. Science Translational Medicine
- Nidovirus RNA polymerases: Complex enzymes handling exceptional RNA genomes
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- One severe acute respiratory syndrome coronavirus protein complex integrates processive RNA polymerase and exonuclease activities
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- RNA 3'-end mismatch excision by the severe acute respiratory syndrome coronavirus nonstructural protein nsp10/nsp14 exoribonuclease complex
- (2012) M. Bouvet et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Features and development ofCoot
- (2010) P. Emsley et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- electronic Ligand Builder and Optimization Workbench(eLBOW): a tool for ligand coordinate and restraint generation
- (2009) Nigel W. Moriarty et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Binding of 2′-Amino-2′-Deoxycytidine-5′-Triphosphate to Norovirus Polymerase Induces Rearrangement of the Active Site
- (2009) Dmitry F. Zamyatkin et al. JOURNAL OF MOLECULAR BIOLOGY
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