Multitalented Synthetic Antimicrobial Peptides and Their Antibacterial, Antifungal and Antiviral Mechanisms

Recent advances in design of antimicrobial peptides and polypeptides toward clinical translation

(2021) Yunjiang Jiang et al.   ADVANCED DRUG DELIVERY REVIEWS

Rediscovery of antimicrobial peptides as therapeutic agents

(2021) Minkyung Ryu et al.   JOURNAL OF MICROBIOLOGY

Cross-linking peptide and repurposed drugs inhibit both entry pathways of SARS-CoV-2

(2021) Hanjun Zhao et al.   Nature Communications

Intracellular Redox-Modulated Pathways as Targets for Effective Approaches in the Treatment of Viral Infection

(2021) Alessandra Fraternale et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Compelling Evidence for the Activity of Antiviral Peptides against SARS-CoV-2

(2021) Miray Tonk et al.   Viruses-Basel

Redox regulation of immunity and the role of small molecular weight thiols

(2021) Pietro Ghezzi   Redox Biology

The antimicrobial peptide MK58911-NH2 acts on planktonic, biofilm and intramacrophage cells of Cryptococcus neoformans

(2021) Junya de Lacorte Singulani et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

An atomic perspective on improving daptomycin's activity

(2021) Pilar Blasco et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Polymyxin resistance in Enterobacterales: overview and epidemiology in the Americas

(2021) J. Rodríguez-Santiago et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Synthetic antimicrobial peptides: Characteristics, design, and potential as alternative molecules to overcome microbial resistance

(2021) Patrícia G. Lima et al.   LIFE SCIENCES

Emerging resistance mechanisms for 4 types of common anti-MRSA antibiotics in Staphylococcus aureus: A comprehensive review

(2021) Wan-Ting Liu et al.   MICROBIAL PATHOGENESIS

Biotechnological Insights on the Expression and Production of Antimicrobial Peptides in Plants

(2021) Balamurugan Shanmugaraj et al.   MOLECULES

Activity and Mechanism of Action of Antifungal Peptides from Microorganisms: A Review

(2021) Tianxi Li et al.   MOLECULES

Antibiofilm activity of host defence peptides: complexity provides opportunities

(2021) Robert E. W. Hancock et al.   NATURE REVIEWS MICROBIOLOGY

Antimicrobial Peptides and Proteins: From Nature’s Reservoir to the Laboratory and Beyond

(2021) Tanumoy Sarkar et al.   Frontiers in Chemistry

Current Update on Intrinsic and Acquired Colistin Resistance Mechanisms in Bacteria

(2021) Firdoos Ahmad Gogry et al.   Frontiers in Medicine

Recent Advances and Challenges in Nanodelivery Systems for Antimicrobial Peptides (AMPs)

(2021) Ziyan Tang et al.   Antibiotics-Basel

The lexicon of antimicrobial peptides: a complete set of arginine and tryptophan sequences

(2021) Sam Clark et al.   Communications Biology

Mechanism of Antimicrobial Peptides: Antimicrobial, Anti-Inflammatory and Antibiofilm Activities

(2021) Ying Luo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Treatment of multidrug-resistant Gram-negative skin and soft tissue infections

(2020) Jean-Francois Jabbour et al.   CURRENT OPINION IN INFECTIOUS DISEASES

PEGylation and Cell-Penetrating Peptides: Glimpse from Past and Prospects in Future

(2020) Sumit Kumar et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Computer-Aided Design of Antimicrobial Peptides: Are We Generating Effective Drug Candidates?

(2020) Marlon H. Cardoso et al.   Frontiers in Microbiology

Antibiofilm activities of ceragenins and antimicrobial peptides against fungal-bacterial mono and multispecies biofilms

(2020) Mayram Hacioglu et al.   JOURNAL OF ANTIBIOTICS

Methods to Enhance the Metabolic Stability of Peptide-Based PET Radiopharmaceuticals

(2020) Brendan J. Evans et al.   MOLECULES

Effect of helical kink in antimicrobial peptides on membrane pore formation

(2020) Alzbeta Tuerkova et al.   eLife

Endogenous Deficiency of Glutathione as the Most Likely Cause of Serious Manifestations and Death in COVID-19 Patients

(2020) Alexey Polonikov   ACS Infectious Diseases

Redox-Modulating Agents in the Treatment of Viral Infections

(2020) Paola Checconi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The value of antimicrobial peptides in the age of resistance

(2020) Maria Magana et al.   LANCET INFECTIOUS DISEASES

Colistin Resistance in Environmental Isolates of Acinetobacter baumannii

(2020) Branko Jovcic et al.   Microbial Drug Resistance

Assessing the Potential for Staphylococcus aureus to Evolve Resistance to XF-73

(2020) R. Craig MacLean   TRENDS IN MICROBIOLOGY

Establishing the Structure–Activity Relationship of Daptomycin

(2020) Hoi Yee Chow et al.   ACS Medicinal Chemistry Letters

Multidrug-resistant gram-negative organisms: a review of recently approved antibiotics and novel pipeline agents

(2020) A. Provenzani et al.   International Journal of Clinical Pharmacy

A Novel Antimicrobial Peptide Scyreprocin From Mud Crab Scylla paramamosain Showing Potent Antifungal and Anti-biofilm Activity

(2020) Ying Yang et al.   Frontiers in Microbiology

Expression and Roles of Antimicrobial Peptides in Innate Defense of Airway Mucosa: Potential Implication in Cystic Fibrosis

(2020) Regina Geitani et al.   Frontiers in Immunology

DAPTOMYCIN, its membrane-active mechanism vs. that of other antimicrobial peptides

(2020) Huey W. Huang   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

A broad-spectrum virus- and host-targeting peptide against respiratory viruses including influenza virus and SARS-CoV-2

(2020) Hanjun Zhao et al.   Nature Communications

Antimicrobial Peptides: Classification, Design, Application and Research Progress in Multiple Fields

(2020) Yuchen Huan et al.   Frontiers in Microbiology

(p)ppGpp Metabolism and Antimicrobial Resistance in Bacterial Pathogens

(2020) Bhabatosh Das et al.   Frontiers in Microbiology

The Potential of Antiviral Peptides as COVID-19 Therapeutics

(2020) Arun Suria Karnan Mahendran et al.   Frontiers in Pharmacology

The Anti-Microbial Peptide (Lin-SB056-1)2-K Reduces Pro-Inflammatory Cytokine Release through Interaction with Pseudomonas aeruginosa Lipopolysaccharide

(2020) Lucia Grassi et al.   Antibiotics-Basel

Peptide and peptide-based inhibitors of SARS-CoV-2 entry

(2020) Desiree Schütz et al.   ADVANCED DRUG DELIVERY REVIEWS

Oral decontamination with colistin plus neomycin in solid organ transplant recipients colonized by multidrug-resistant Enterobacterales: a multicentre, randomized, controlled, open-label, parallel-group clinical trial

(2020) Maria Carmen Fariñas et al.   CLINICAL MICROBIOLOGY AND INFECTION

Antimicrobial peptides (AMPs): a patent review (2015–2020)

(2020) Giannamaria Annunziato et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Lipidation of Antimicrobial Peptides as a Design Strategy for Future Alternatives to Antibiotics

(2020) Taylor Rounds et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Temporin-Like Peptides Show Antimicrobial and Anti-Biofilm Activities against Streptococcus mutans with Reduced Hemolysis

(2020) Hanqi Wei et al.   MOLECULES

(Re)Defining the Proline-Rich Antimicrobial Peptide Family and the Identification of Putative New Members

(2020) Nicholas G. Welch et al.   Frontiers in Chemistry

Structural mechanism of transcription inhibition by lasso peptides microcin J25 and capistruin

(2019) Nathaniel R. Braffman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Antimicrobial Peptide lin-SB056-1 and Its Dendrimeric Derivative Prevent Pseudomonas aeruginosa Biofilm Formation in Physiologically Relevant Models of Chronic Infections

(2019) Lucia Grassi et al.   Frontiers in Microbiology

HIV-1 anchor inhibitors and membrane fusion inhibitors target distinct but overlapping steps in virus entry

(2019) Dirk Eggink et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recent Advances in the Exploration of Therapeutic Analogues of Gramicidin S, an Old but Still Potent Antimicrobial Peptide

(2019) Qinkun Guan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Emerging and reemerging fungal infections

(2019) Shawn R. Lockhart et al.   SEMINARS IN DIAGNOSTIC PATHOLOGY

Antiviral peptides as promising therapeutic drugs

(2019) Liana Costa Pereira Vilas Boas et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

ASP2397 Is a Novel Natural Compound That Exhibits Rapid and Potent Fungicidal Activity against Aspergillus Species through a Specific Transporter

(2019) Ikuko Nakamura et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mini review on Antimicrobial Peptides, Sources, Mechanism and Recent Applications

(2019) Jaspreet Kaur Boparai et al.   PROTEIN AND PEPTIDE LETTERS

C16-Fengycin A affect the growth of Candida albicans by destroying its cell wall and accumulating reactive oxygen species

(2019) Yanan Liu et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Antimicrobial Peptides: Features, Action, and Their Resistance Mechanisms in Bacteria

(2018) Hoda Moravej et al.   Microbial Drug Resistance

Tryptophan-Rich and Proline-Rich Antimicrobial Peptides

(2018) Awdhesh Mishra et al.   MOLECULES

Modulation of toll-like receptor signaling by antimicrobial peptides

(2018) Ernest Y. Lee et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Design and Assessment of Anti-Biofilm Peptides: Steps Toward Clinical Application

(2018) Melanie Dostert et al.   Journal of Innate Immunity

Peptide-guided functionalization and macrocyclization of bioactive peptidosulfonamides by Pd(II)-catalyzed late-stage C–H activation

(2018) Jian Tang et al.   Nature Communications

Antifungal and anti-biofilm activity of the first cryptic antimicrobial peptide from an archaeal protein against Candida spp. clinical isolates

(2018) Emanuela Roscetto et al.   Scientific Reports

Short Symmetric-End Antimicrobial Peptides Centered on β-Turn Amino Acids Unit Improve Selectivity and Stability

(2018) Na Dong et al.   Frontiers in Microbiology

Proline-rich antimicrobial peptides show a long-lasting post-antibiotic effect on Enterobacteriaceae and Pseudomonas aeruginosa

(2017) Luzia Holfeld et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

DNA replication proteins as potential targets for antimicrobials in drug-resistant bacterial pathogens

(2017) Erika van Eijk et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Second Generation Triple-Helical Peptide Inhibitors of Matrix Metalloproteinases

(2017) Manishabrata Bhowmick et al.   JOURNAL OF MEDICINAL CHEMISTRY

An antimicrobial peptide that inhibits translation by trapping release factors on the ribosome

(2017) Tanja Florin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Enterococcus faecalisbacteriocin EntV inhibits hyphal morphogenesis, biofilm formation, and virulence ofCandida albicans

(2017) Carrie E. Graham et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Releasable and traceless PEGylation of arginine-rich antimicrobial peptides

(2017) Y. Gong et al.   Chemical Science

An antimicrobial peptide that inhibits translation by trapping release factors on the ribosome

(2017) Tanja Florin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Strategies to Fabricate Polypeptide-Based Structures via Ring-Opening Polymerization of N-Carboxyanhydrides

(2017) Carmen M. González-Henríquez et al.   Polymers

Membrane Active Antimicrobial Peptides: Translating Mechanistic Insights to Design

(2017) Jianguo Li et al.   Frontiers in Neuroscience

Antimicrobial peptides and their interaction with biofilms of medically relevant bacteria

(2016) Giovanna Batoni et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Peptides Derived from Glycoproteins H and B of Herpes Simplex Virus Type 1 and Herpes Simplex Virus Type 2 Are Capable of Blocking Herpetic Infection in vitro

(2016) Abraham Cetina-Corona et al.   INTERVIROLOGY

Systematic Analysis of Intracellular-targeting Antimicrobial Peptides, Bactenecin 7, Hybrid of Pleurocidin and Dermaseptin, Proline–Arginine-rich Peptide, and Lactoferricin B, by UsingEscherichia coliProteome Microarrays

(2016) Yu-Hsuan Ho et al.   MOLECULAR & CELLULAR PROTEOMICS

Bacterial strategies of resistance to antimicrobial peptides

(2016) Hwang-Soo Joo et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Proline-rich Antimicrobial Peptides Optimized for Binding to Escherichia coli Chaperone DnaK

(2016) Daniel Knappe et al.   PROTEIN AND PEPTIDE LETTERS

Evaluation of short synthetic antimicrobial peptides for treatment of drug-resistant and intracellular Staphylococcus aureus

(2016) Mohamed F. Mohamed et al.   Scientific Reports

Visualizing Attack of Escherichia coli by the Antimicrobial Peptide Human Defensin 5

(2015) Haritha R. Chileveru et al.   BIOCHEMISTRY

Defensive remodeling: How bacterial surface properties and biofilm formation promote resistance to antimicrobial peptides

(2015) Reut Nuri et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The Lantibiotic Nisin Induces Lipid II Aggregation, Causing Membrane Instability and Vesicle Budding

(2015) Katharina M. Scherer et al.   BIOPHYSICAL JOURNAL

Non-Membrane Permeabilizing Modes of Action of Antimicrobial Peptides on Bacteria

(2015) Marco Scocchi et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Immunogenicity and pharmacokinetics of short, proline-rich antimicrobial peptides

(2015) Luzia Holfeld et al.   Future Medicinal Chemistry

Matrix Metalloproteinase Inhibitor as an Antimicrobial Agent to Eradicate Enterococcus faecalis Biofilm

(2015) Chiew Xsia Tay et al.   JOURNAL OF ENDODONTICS

Broad-spectrum antivirals against viral fusion

(2015) Frederic Vigant et al.   NATURE REVIEWS MICROBIOLOGY

Peptide-based antifungal therapies against emerging infections

(2015) A. Matejuk et al.   DRUGS OF THE FUTURE

Site-specific pegylation of an antimicrobial peptide increases resistance to Pseudomonas aeruginosa elastase

(2014) Chiara Falciani et al.   AMINO ACIDS

Identification of Inhibitors of a Bacterial Sigma Factor Using a New High-Throughput Screening Assay

(2014) S. A. El-Mowafi et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Peptide:lipid ratio and membrane surface charge determine the mechanism of action of the antimicrobial peptide BP100. Conformational and functional studies

(2014) Mariana C. Manzini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Peptide entry inhibitors of enveloped viruses: The importance of interfacial hydrophobicity

(2014) Hussain Badani et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The bacterial lipopeptide iturins induceVerticillium dahliaecell death by affecting fungal signalling pathways and mediate plant defence responses involved in pathogen-associated molecular pattern-triggered immunity

(2014) Qin Han et al.   ENVIRONMENTAL MICROBIOLOGY

How Does It Kill?: Understanding the Candidacidal Mechanism of Salivary Histatin 5

(2014) Sumant Puri et al.   EUKARYOTIC CELL

Dendrimers: synthesis, applications, and properties

(2014) Elham Abbasi et al.   Nanoscale Research Letters

Identification and Mechanism of Action of the Plant Defensin NaD1 as a New Member of the Antifungal Drug Arsenal against Candida albicans

(2013) Brigitte M. E. Hayes et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

AVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses

(2013) Abid Qureshi et al.   NUCLEIC ACIDS RESEARCH

Gastric Antimicrobial Peptides Fail to Eradicate Helicobacter pylori Infection Due to Selective Induction and Resistance

(2013) Sabine Nuding et al.   PLoS One

Does cholesterol suppress the antimicrobial peptide induced disruption of lipid raft containing membranes?

(2012) Austin J. McHenry et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Glutathione synthesis

(2012) Shelly C. Lu   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Release of Dengue Virus Genome Induced by a Peptide Inhibitor

(2012) Shee-Mei Lok et al.   PLoS One

Hidden Killers: Human Fungal Infections

(2012) G. D. Brown et al.   Science Translational Medicine

Beyond natural antimicrobial peptides: multimeric peptides and other peptidomimetic approaches

(2011) Andrea Giuliani et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Characterization of environmental chemicals with potential for DNA damage using isogenic DNA repair-deficient chicken DT40 cell lines

(2011) Kimiyo N. Yamamoto et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Antimicrobial and cell-penetrating peptides induce lipid vesicle fusion by folding and aggregation

(2011) Parvesh Wadhwani et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Antimicrobial Peptides: Old Molecules with New Ideas

(2011) Teruaki Nakatsuji et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Describing the Mechanism of Antimicrobial Peptide Action with the Interfacial Activity Model

(2010) William C. Wimley   ACS Chemical Biology

Antimicrobial β-Peptides and α-Peptoids

(2010) Troels Godballe et al.   Chemical Biology & Drug Design

In vitro activity of XF-73, a novel antibacterial agent, against antibiotic-sensitive and -resistant Gram-positive and Gram-negative bacterial species

(2010) David J. Farrell et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Prodrug Approach for Increasing Cellular Glutathione Levels

(2010) Ivana Cacciatore et al.   MOLECULES

Synthesis, characterization, antimicrobial activity and LPS-interaction properties of SB041, a novel dendrimeric peptide with antimicrobial properties

(2010) Michela Bruschi et al.   PEPTIDES

The Bacterial Cell Envelope

(2010) T. J. Silhavy et al.   Cold Spring Harbor Perspectives in Biology

The Roles of Antimicrobial Peptides in Innate Host Defense

(2009) Gill Diamond et al.   CURRENT PHARMACEUTICAL DESIGN

Anionic Antimicrobial Peptides from Eukaryotic Organisms

(2009) Frederick Harris et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Rhesus Theta-Defensin Prevents Death in a Mouse Model of Severe Acute Respiratory Syndrome Coronavirus Pulmonary Disease

(2009) C. L. Wohlford-Lenane et al.   JOURNAL OF VIROLOGY

Inhibition of Inositol Phosphorylceramide Synthase by the Cyclic Peptide Aureobasidin A

(2008) P. A. Aeed et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Toroidal pores formed by antimicrobial peptides show significant disorder

(2008) Durba Sengupta et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Synthetic Mimic of Antimicrobial Peptide with Nonmembrane-Disrupting Antibacterial Properties

(2008) Gregory J. Gabriel et al.   BIOMACROMOLECULES

GSH and analogs in antiviral therapy

(2008) Alessandra Fraternale et al.   MOLECULAR ASPECTS OF MEDICINE