Peptide and peptide-based inhibitors of SARS-CoV-2 entry

Fusion mechanism of 2019-nCoV and fusion inhibitors targeting HR1 domain in spike protein

(2020) Shuai Xia et al.   Cellular & Molecular Immunology

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

Structural basis for the recognition of the SARS-CoV-2 by full-length human ACE2

(2020) Renhong Yan et al.   SCIENCE

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

(2020) Daniel Wrapp et al.   SCIENCE

Return of the Coronavirus: 2019-nCoV

(2020) Lisa E. Gralinski et al.   Viruses-Basel

Subunit Vaccines Against Emerging Pathogenic Human Coronaviruses

(2020) Ning Wang et al.   Frontiers in Microbiology

The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2

(2020)   Nature Microbiology

Computational Design of ACE2-Based Peptide Inhibitors of SARS-CoV-2

(2020) Yanxiao Han et al.   ACS Nano

Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2

(2020) Qihui Wang et al.   CELL

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

(2020) Alexandra C. Walls et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion

(2020) Shuai Xia et al.   CELL RESEARCH

The pivotal link between ACE2 deficiency and SARS-CoV-2 infection

(2020) Paolo Verdecchia et al.   European Journal of Internal Medicine

Human Intestinal Defensin 5 Inhibits SARS-CoV-2 Invasion by Cloaking ACE2

(2020) Cheng Wang et al.   GASTROENTEROLOGY

Phylogenetic Analysis and Structural Modeling of SARS-CoV-2 Spike Protein Reveals an Evolutionary Distinct and Proteolytically Sensitive Activation Loop

(2020) Javier A. Jaimes et al.   JOURNAL OF MOLECULAR BIOLOGY

Design of potent membrane fusion inhibitors against SARS-CoV-2, an emerging coronavirus with high fusogenic activity

(2020) Yuanmei Zhu et al.   JOURNAL OF VIROLOGY

A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells

(2020) Markus Hoffmann et al.   MOLECULAR CELL

Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor

(2020) Jun Lan et al.   NATURE

Structural basis of receptor recognition by SARS-CoV-2

(2020) Jian Shang et al.   NATURE

Virological assessment of hospitalized patients with COVID-2019

(2020) Roman Wölfel et al.   NATURE

Compassionate Use of Remdesivir for Patients with Severe Covid-19

(2020) Jonathan Grein et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cathepsin L-selective inhibitors: A potentially promising treatment for COVID-19 patients

(2020) Tianxiao Liu et al.   PHARMACOLOGY & THERAPEUTICS

Cell entry mechanisms of SARS-CoV-2

(2020) Jian Shang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV

(2020) Xiuyuan Ou et al.   Nature Communications

TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes

(2020) Ruochen Zang et al.   Science Immunology

De novo design of protein peptides to block association of the SARS-CoV-2 spike protein with human ACE2

(2020) Xiaoqiang Huang et al.   Aging-US

Extrapulmonary manifestations of COVID-19

(2020) Aakriti Gupta et al.   NATURE MEDICINE

SARS-CoV-2 and bat RaTG13 spike glycoprotein structures inform on virus evolution and furin-cleavage effects

(2020) Antoni G. Wrobel et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

In silico design of antiviral peptides targeting the spike protein of SARS-CoV-2

(2020) Rongsong Ling et al.   PEPTIDES

Identification of a Potential Peptide Inhibitor of SARS-CoV-2 Targeting its Entry into the Host Cells

(2020) Mirza S. Baig et al.   DRUGS IN R&D

TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells

(2020) Dorothea Bestle et al.   Life Science Alliance

An enzyme-based immunodetection assay to quantify SARS-CoV-2 infection

(2020) Carina Conzelmann et al.   ANTIVIRAL RESEARCH

Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant

(2020) Leonid Yurkovetskiy et al.   CELL

Superinfections in patients treated with Teicoplanin as anti‐SARS‐CoV‐2 agent

(2020) Giancarlo Ceccarelli et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Conformational transition of SARS-CoV-2 spike glycoprotein between its closed and open states

(2020) Mert Gur et al.   JOURNAL OF CHEMICAL PHYSICS

Antiviral Peptides as Promising Therapeutics against SARS-CoV-2

(2020) Surid Mohammad Chowdhury et al.   JOURNAL OF PHYSICAL CHEMISTRY B

In-silico design of a potential inhibitor of SARS-CoV-2 S protein

(2020) Grijesh Jaiswal et al.   PLoS One

De novo design of picomolar SARS-CoV-2 miniprotein inhibitors

(2020) Longxing Cao et al.   SCIENCE

A broad-spectrum virus- and host-targeting peptide against respiratory viruses including influenza virus and SARS-CoV-2

(2020) Hanjun Zhao et al.   Nature Communications

Dynamics of the ACE2–SARS-CoV-2/SARS-CoV spike protein interface reveal unique mechanisms

(2020) Amanat Ali et al.   Scientific Reports

Beyond Shielding: The Roles of Glycans in the SARS-CoV-2 Spike Protein

(2020) Lorenzo Casalino et al.   ACS Central Science

Screening and evaluation of approved drugs as inhibitors of main protease of SARS-CoV-2

(2020) Praveen Kumar Tripathi et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

TMPRSS2 contributes to virus spread and immunopathology in the airways of murine models after coronavirus infection

(2019) Naoko Iwata-Yoshikawa et al.   JOURNAL OF VIROLOGY

BacMam production and crystal structure of nonglycosylated apo human furin at 1.89 Å resolution

(2019) Kenneth H. Pearce et al.   Acta Crystallographica Section F-Structural Biology Communications

The SIRAH 2.0 Force Field: Altius, Fortius, Citius

(2019) Matías R. Machado et al.   Journal of Chemical Theory and Computation

HIV-1 anchor inhibitors and membrane fusion inhibitors target distinct but overlapping steps in virus entry

(2019) Dirk Eggink et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike

(2019) Shuai Xia et al.   Science Advances

Antiviral peptides as promising therapeutic drugs

(2019) Liana Costa Pereira Vilas Boas et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

ATN-161 reduces virus proliferation in PHEV-infected mice by inhibiting the integrin α5β1-FAK signaling pathway

(2019) Xiaoling Lv et al.   VETERINARY MICROBIOLOGY

Why are vaccines against many human viral diseases still unavailable; an historic perspective?

(2019) Gregory A. Tannock et al.   JOURNAL OF MEDICAL VIROLOGY

Therapeutic peptides: Historical perspectives, current development trends, and future directions

(2018) Jolene L. Lau et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Designing inhaled protein therapeutics for topical lung delivery: what are the next steps?

(2018) Elsa Bodier-Montagutelli et al.   Expert Opinion on Drug Delivery

Peptide-Based Membrane Fusion Inhibitors Targeting HCoV-229E Spike Protein HR1 and HR2 Domains

(2018) Shuai Xia et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

HPEPDOCK: a web server for blind peptide–protein docking based on a hierarchical algorithm

(2018) Pei Zhou et al.   NUCLEIC ACIDS RESEARCH

SWISS-MODEL: homology modelling of protein structures and complexes

(2018) Andrew Waterhouse et al.   NUCLEIC ACIDS RESEARCH

Wild-type human coronaviruses prefer cell-surface TMPRSS2 to endosomal cathepsins for cell entry

(2018) Kazuya Shirato et al.   VIROLOGY

Immunosilencing peptides by stereochemical inversion and sequence reversal: retro-D-peptides

(2018) Pol Arranz-Gibert et al.   Scientific Reports

De novo design of a fluorescence-activating β-barrel

(2018) Jiayi Dou et al.   NATURE

Select gp120 V2 domain specific antibodies derived from HIV and SIV infection and vaccination inhibit gp120 binding to α4β7

(2018) Sakaorat Lertjuthaporn et al.   PLoS Pathogens

Functional analysis of potential cleavage sites in the MERS-coronavirus spike protein

(2018) Hannah Kleine-Weber et al.   Scientific Reports

A Lipopeptide HIV-1/2 Fusion Inhibitor with Highly Potent In Vitro , Ex Vivo , and In Vivo Antiviral Activity

(2017) Huihui Chong et al.   JOURNAL OF VIROLOGY

The ClusPro web server for protein–protein docking

(2017) Dima Kozakov et al.   Nature Protocols

Identification of a Novel Inhibitor against Middle East Respiratory Syndrome Coronavirus

(2017) Yaping Sun et al.   Viruses-Basel

Alpha-1-antitrypsin interacts with gp41 to block HIV-1 entry into CD4+ T lymphocytes

(2016) Xueyuan Zhou et al.   BMC MICROBIOLOGY

Glycopeptide Antibiotics Potently Inhibit Cathepsin L in the Late Endosome/Lysosome and Block the Entry of Ebola Virus, Middle East Respiratory Syndrome Coronavirus (MERS-CoV), and Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)

(2016) Nan Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

First-in-human application of the novel hepatitis B and hepatitis D virus entry inhibitor myrcludex B

(2016) Antje Blank et al.   JOURNAL OF HEPATOLOGY

The HADDOCK2.2 Web Server: User-Friendly Integrative Modeling of Biomolecular Complexes

(2016) G.C.P. van Zundert et al.   JOURNAL OF MOLECULAR BIOLOGY

Clinical Isolates of Human Coronavirus 229E Bypass the Endosome for Cell Entry

(2016) Kazuya Shirato et al.   JOURNAL OF VIROLOGY

The SWISS-MODEL Repository—new features and functionality

(2016) Stefan Bienert et al.   NUCLEIC ACIDS RESEARCH

A novel peptide with potent and broad-spectrum antiviral activities against multiple respiratory viruses

(2016) Hanjun Zhao et al.   Scientific Reports

Beyond RGD: virus interactions with integrins

(2015) Hosni A. M. Hussein et al.   ARCHIVES OF VIROLOGY

MDTraj: A Modern Open Library for the Analysis of Molecular Dynamics Trajectories

(2015) Robert T. McGibbon et al.   BIOPHYSICAL JOURNAL

AVP-IC50Pred: Multiple machine learning techniques-based prediction of peptide antiviral activity in terms of half maximal inhibitory concentration (IC50)

(2015) Abid Qureshi et al.   BIOPOLYMERS

Peptide therapeutics: current status and future directions

(2015) Keld Fosgerau et al.   DRUG DISCOVERY TODAY

Design of a Potent Antibiotic Peptide Based on the Active Region of Human Defensin 5

(2015) Cheng Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

The I-TASSER Suite: protein structure and function prediction

(2015) Jianyi Yang et al.   NATURE METHODS

Antiviral Activity of the Human Cathelicidin, LL-37, and Derived Peptides on Seasonal and Pandemic Influenza A Viruses

(2015) Shweta Tripathi et al.   PLoS One

EPI-X4, a novel endogenous antagonist of CXCR4

(2015) Christian Buske et al.   Oncotarget

Improved Pharmacological and Structural Properties of HIV Fusion Inhibitor AP3 over Enfuvirtide: Highlighting Advantages of Artificial Peptide Strategy

(2015) Xiaojie Zhu et al.   Scientific Reports

Inhibitory activity and molecular mechanism of protegrin-1 against porcine reproductive and respiratory syndrome virus in vitro

(2014) Chunhe Guo et al.   ANTIVIRAL THERAPY

Cholesterol-conjugated peptide antivirals: a path to a rapid response to emerging viral diseases

(2014) Antonello Pessi   JOURNAL OF PEPTIDE SCIENCE

Structure-based discovery of Middle East respiratory syndrome coronavirus fusion inhibitor

(2014) Lu Lu et al.   Nature Communications

Teicoplanin for treating MRSA pneumonia

(2014) J. Mukhopadhyay   BMJ-British Medical Journal

Identification of the first synthetic inhibitors of the type II transmembrane serine protease TMPRSS2 suitable for inhibition of influenza virus activation

(2013) Daniela Meyer et al.   BIOCHEMICAL JOURNAL

Hepatitis B and D Viruses Exploit Sodium Taurocholate Co-transporting Polypeptide for Species-Specific Entry into Hepatocytes

(2013) Yi Ni et al.   GASTROENTEROLOGY

Antiviral Mechanisms of Human Defensins

(2013) Sarah S. Wilson et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure of the Fusion Core and Inhibition of Fusion by a Heptad Repeat Peptide Derived from the S Protein of Middle East Respiratory Syndrome Coronavirus

(2013) J. Gao et al.   JOURNAL OF VIROLOGY

AVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses

(2013) Abid Qureshi et al.   NUCLEIC ACIDS RESEARCH

In Silico Approach for Predicting Toxicity of Peptides and Proteins

(2013) Sudheer Gupta et al.   PLoS One

Activation of influenza viruses by proteases from host cells and bacteria in the human airway epithelium

(2013) Eva Böttcher-Friebertshäuser et al.   Pathogens and Disease

A Rationally Engineered Anti-HIV Peptide Fusion Inhibitor with Greatly Reduced Immunogenicity

(2012) F. Brauer et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A hexapeptide of the receptor-binding domain of SARS corona virus spike protein blocks viral entry into host cells via the human receptor ACE2

(2012) Anna-Winona Struck et al.   ANTIVIRAL RESEARCH

Airway delivery of peptides and proteins using nanoparticles

(2012) Christophe Y. Dombu et al.   BIOMATERIALS

The biology and therapeutic targeting of the proprotein convertases

(2012) Nabil G. Seidah et al.   NATURE REVIEWS DRUG DISCOVERY

Aprotinin and similar protease inhibitors as drugs against influenza

(2011) O.P. Zhirnov et al.   ANTIVIRAL RESEARCH

Halogen Bonding at the Active Sites of Human Cathepsin L and MEK1 Kinase: Efficient Interactions in Different Environments

(2011) Leo A. Hardegger et al.   ChemMedChem

The VSGB 2.0 model: A next generation energy model for high resolution protein structure modeling

(2011) Jianing Li et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Drug resistance in HIV-1

(2011) Daniel R Kuritzkes   Current Opinion in Virology

Development of Peptide and Small-Molecule HIV-1 Fusion Inhibitors that Target gp41

(2010) Lifeng Cai et al.   ChemMedChem

Two-Year Safety and Virologic Efficacy of Maraviroc in Treatment-Experienced Patients With CCR5-Tropic HIV-1 Infection: 96-Week Combined Analysis of MOTIVATE 1 and 2

(2010) W David Hardy et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Novel insights into proteolytic cleavage of influenza virus hemagglutinin

(2010) Stephanie Bertram et al.   REVIEWS IN MEDICAL VIROLOGY

Potent Inhibitors of Furin and Furin-like Proprotein Convertases Containing Decarboxylated P1 Arginine Mimetics

(2009) Gero L. Becker et al.   JOURNAL OF MEDICINAL CHEMISTRY

Fine Mapping of Pre-S Sequence Requirements for Hepatitis B Virus Large Envelope Protein-Mediated Receptor Interaction

(2009) A. Schulze et al.   JOURNAL OF VIROLOGY

The spike protein of SARS-CoV — a target for vaccine and therapeutic development

(2009) Lanying Du et al.   NATURE REVIEWS MICROBIOLOGY

Structures and Mechanisms of Viral Membrane Fusion Proteins: Multiple Variations on a Common Theme

(2008) Judith M. White et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Peptidomimetics, a synthetic tool of drug discovery

(2008) Josef Vagner et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Fusion core structure of the severe acute respiratory syndrome coronavirus (SARS-CoV): In search of potent SARS-CoV entry inhibitors

(2008) Ling-Hon Matthew Chu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

CHARMM-GUI: A web-based graphical user interface for CHARMM

(2008) Sunhwan Jo et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Cathepsin L Functionally Cleaves the Severe Acute Respiratory Syndrome Coronavirus Class I Fusion Protein Upstream of Rather than Adjacent to the Fusion Peptide

(2008) B. J. Bosch et al.   JOURNAL OF VIROLOGY