Compelling Evidence for the Activity of Antiviral Peptides against SARS-CoV-2

Intranasal fusion inhibitory lipopeptide prevents direct-contact SARS-CoV-2 transmission in ferrets

(2021) Rory D. de Vries et al.   SCIENCE

Fusion mechanism of 2019-nCoV and fusion inhibitors targeting HR1 domain in spike protein

(2020) Shuai Xia et al.   Cellular & Molecular Immunology

The emergence of a novel coronavirus (SARS-CoV-2), their biology and therapeutic options

(2020) Suliman Khan et al.   JOURNAL OF CLINICAL MICROBIOLOGY

A Novel Coronavirus from Patients with Pneumonia in China, 2019

(2020) Na Zhu et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Use of Chloroquine and Hydroxychloroquine in COVID-19 and Cardiovascular Implications: Understanding Safety Discrepancies to Improve Interpretation and Design of Clinical Trials

(2020) Ohad Oren et al.   Circulation-Arrhythmia and Electrophysiology

Human Intestinal Defensin 5 Inhibits SARS-CoV-2 Invasion by Cloaking ACE2

(2020) Cheng Wang et al.   GASTROENTEROLOGY

Cytokine release syndrome in severe COVID-19: interleukin-6 receptor antagonist tocilizumab may be the key to reduce mortality

(2020) Chi Zhang et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Antiviral Peptides: Identification and Validation

(2020) Garima Agarwal et al.   International Journal of Peptide Research and Therapeutics

The effect of corticosteroid treatment on patients with coronavirus infection: a systematic review and meta-analysis

(2020) Zhenwei Yang et al.   JOURNAL OF INFECTION

Novel coronavirus treatment with ribavirin: Groundwork for an evaluation concerning COVID-19

(2020) Jahan S. Khalili et al.   JOURNAL OF MEDICAL VIROLOGY

Remdesivir: A Review of Its Discovery and Development Leading to Emergency Use Authorization for Treatment of COVID-19

(2020) Richard T. Eastman et al.   ACS Central Science

COVID-19 treatment: close to a cure? A rapid review of pharmacotherapies for the novel coronavirus (SARS-CoV-2)

(2020) Yang Song et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Early administration of Interleukin-6 inhibitors for patients with severe Covid-19 disease is associated with decreased intubation, reduced mortality, and increased discharge

(2020) Pranay Sinha et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Clinical characteristics of coronavirus disease 2019 (COVID-19) in China: A systematic review and meta-analysis

(2020) Leiwen Fu et al.   JOURNAL OF INFECTION

The ten reasons why corticosteroid therapy reduces mortality in severe COVID-19

(2020) Yaseen M. Arabi et al.   INTENSIVE CARE MEDICINE

A broad-spectrum virus- and host-targeting peptide against respiratory viruses including influenza virus and SARS-CoV-2

(2020) Hanjun Zhao et al.   Nature Communications

Preemptive interleukin-6 blockade in patients with COVID-19

(2020) Lucía Guillén et al.   Scientific Reports

The Potential of Antiviral Peptides as COVID-19 Therapeutics

(2020) Arun Suria Karnan Mahendran et al.   Frontiers in Pharmacology

Neutralizing monoclonal antibodies for COVID-19 treatment and prevention

(2020) Juan Pablo Jaworski   Biomedical Journal

Antiviral Activity of Synthetic Peptides Derived from Physiological Proteins

(2019) Arianna Sala et al.   INTERVIROLOGY

A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike

(2019) Shuai Xia et al.   Science Advances

Antiviral peptides as promising therapeutic drugs

(2019) Liana Costa Pereira Vilas Boas et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Synthetic surfactin analogues have improved anti-PEDV properties

(2019) Lvfeng Yuan et al.   PLoS One

Towards the Application of Human Defensins as Antivirals

(2018) Mee Sook Park et al.   Biomolecules & Therapeutics

Designing improved active peptides for therapeutic approaches against infectious diseases

(2018) Bárbara Gomes et al.   BIOTECHNOLOGY ADVANCES

Mining the tree of life: Host defense peptides as antiviral therapeutics

(2018) Jessica R. Shartouny et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Dual-functional peptide with defective interfering genes effectively protects mice against avian and seasonal influenza

(2018) Hanjun Zhao et al.   Nature Communications

A scorpion venom peptide Ev37 restricts viral late entry by alkalizing acidic organelles

(2018) Fangfang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Amphibian Host Defense Peptide Is Virucidal for Human H1 Hemagglutinin-Bearing Influenza Viruses

(2017) David J. Holthausen et al.   IMMUNITY

A peptide-based viral inactivator inhibits Zika virus infection in pregnant mice and fetuses

(2017) Yufeng Yu et al.   Nature Communications

Drug resistance in influenza A virus: the epidemiology and management

(2017) Mazhar Hussain et al.   Infection and Drug Resistance

Inhibition of highly pathogenic avian influenza (HPAI) virus by a peptide derived from vFLIP through its direct destabilization of viruses

(2017) Ho-Jin Moon et al.   Scientific Reports

Identification of innate immune antiretroviral factors during in vivo and in vitro exposure to HIV-1

(2016) Wildeman Zapata et al.   MICROBES AND INFECTION

Virucidal activity of Haemaphysalis longicornis longicin P4 peptide against tick-borne encephalitis virus surrogate Langat virus

(2016) Melbourne Rio Talactac et al.   Parasites & Vectors

A novel peptide with potent and broad-spectrum antiviral activities against multiple respiratory viruses

(2016) Hanjun Zhao et al.   Scientific Reports

Engineering a Therapeutic Lectin by Uncoupling Mitogenicity from Antiviral Activity

(2015) Michael D. Swanson et al.   CELL

The Phyre2 web portal for protein modeling, prediction and analysis

(2015) Lawrence A Kelley et al.   Nature Protocols

Strategic Approaches to Optimizing Peptide ADME Properties

(2014) Li Di   AAPS Journal

Current progress in antiviral strategies

(2014) Zhiyong Lou et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Structure-based discovery of Middle East respiratory syndrome coronavirus fusion inhibitor

(2014) Lu Lu et al.   Nature Communications

Cationic Host Defence Peptides: Potential as Antiviral Therapeutics

(2013) Emily Gwyer Findlay et al.   BIODRUGS

Defensins in innate immunity

(2013) Le Zhao et al.   CURRENT OPINION IN HEMATOLOGY

Antiviral Mechanisms of Human Defensins

(2013) Sarah S. Wilson et al.   JOURNAL OF MOLECULAR BIOLOGY

Peptide inhibitors against herpes simplex virus infections

(2013) Stefania Galdiero et al.   JOURNAL OF PEPTIDE SCIENCE

VIRsiRNApred: a web server for predicting inhibition efficacy of siRNAs targeting human viruses

(2013) Abid Qureshi et al.   Journal of Translational Medicine

A mastoparan-derived peptide has broad-spectrum antiviral activity against enveloped viruses

(2013) Christopher J. Sample et al.   PEPTIDES

Analysis and Prediction of Highly Effective Antiviral Peptides Based on Random Forests

(2013) Kuan Y. Chang et al.   PLoS One

Current scenario of peptide-based drugs: the key roles of cationic antitumor and antiviral peptides

(2013) Kelly C. L. Mulder et al.   Frontiers in Microbiology

Antivirals: Past, present and future

(2012) Erik De Clercq   BIOCHEMICAL PHARMACOLOGY

Novel Cyclotides and Uncyclotides with Highly Shortened Precursors fromChassalia chartaceaand Effects of Methionine Oxidation on Bioactivities

(2012) Giang Kien Truc Nguyen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multifaceted Mechanisms of HIV-1 Entry Inhibition by Human α-Defensin

(2012) Lusine H. Demirkhanyan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rethinking amide bond synthesis

(2011) Vijaya R. Pattabiraman et al.   NATURE

Virucidal activity of a scorpion venom peptide variant mucroporin-M1 against measles, SARS-CoV and influenza H5N1 viruses

(2011) Qiaoli Li et al.   PEPTIDES

Describing the Mechanism of Antimicrobial Peptide Action with the Interfacial Activity Model

(2010) William C. Wimley   ACS Chemical Biology

Discovering and improving novel peptide therapeutics

(2008) D MCGREGOR   CURRENT OPINION IN PHARMACOLOGY