Proline-rich antimicrobial peptides show a long-lasting post-antibiotic effect on Enterobacteriaceae and Pseudomonas aeruginosa

Proline-rich antimicrobial peptides targeting protein synthesis

(2017) Michael Graf et al.   NATURAL PRODUCT REPORTS

An antimicrobial peptide that inhibits translation by trapping release factors on the ribosome

(2017) Tanja Florin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

An antimicrobial peptide that inhibits translation by trapping release factors on the ribosome

(2017) Tanja Florin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Racing on the Wrong Track

(2017) Laszlo Otvos   Frontiers in Chemistry

In vivo Efficacy and Pharmacokinetics of Optimized Apidaecin Analogs

(2017) Rico Schmidt et al.   Frontiers in Chemistry

The antibiotic pipeline for multi-drug resistant gram negative bacteria: what can we expect?

(2016) Matthew E. Falagas et al.   Expert Review of Anti-Infective Therapy

Pharmacokinetics andin vivoefficacy of optimized oncocin derivatives

(2016) Rico Schmidt et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Structures of proline-rich peptides bound to the ribosome reveal a common mechanism of protein synthesis inhibition

(2016) Matthieu G. Gagnon et al.   NUCLEIC ACIDS RESEARCH

Structure of the mammalian antimicrobial peptide Bac7(1–16) bound within the exit tunnel of a bacterial ribosome

(2016) A. Carolin Seefeldt et al.   NUCLEIC ACIDS RESEARCH

Optimization of oncocin for antibacterial activity using a SPOT synthesis approach: extending the pathogen spectrum to Staphylococcus aureus

(2015) Daniel Knappe et al.   AMINO ACIDS

Influence of theyjiL-mdtMGene Cluster on the Antibacterial Activity of Proline-Rich Antimicrobial Peptides Overcoming Escherichia coli Resistance Induced by the Missing SbmA Transporter System

(2015) Andor Krizsan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Oncocin Onc72 is efficacious against antibiotic-susceptibleKlebsiella pneumoniaeATCC 43816 in a murine thigh infection model

(2015) Daniel Knappe et al.   BIOPOLYMERS

Short Proline-Rich Antimicrobial Peptides Inhibit Either the Bacterial 70S Ribosome or the Assembly of its Large 50S Subunit

(2015) Andor Krizsan et al.   CHEMBIOCHEM

Non-Membrane Permeabilizing Modes of Action of Antimicrobial Peptides on Bacteria

(2015) Marco Scocchi et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Therapeutic utility of antibacterial peptides in wound healing

(2015) Laszlo Otvos et al.   Expert Review of Anti-Infective Therapy

Identification of Api88 Binding Partners in Escherichia coli Using a Photoaffinity-Cross-Link Strategy and Label-Free Quantification

(2015) Daniela Volke et al.   JOURNAL OF PROTEOME RESEARCH

The proline-rich antimicrobial peptide Onc112 inhibits translation by blocking and destabilizing the initiation complex

(2015) A Carolin Seefeldt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The mechanism of inhibition of protein synthesis by the proline-rich peptide oncocin

(2015) Raktim N Roy et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The proline-rich antimicrobial peptide Onc112 inhibits translation by blocking and destabilizing the initiation complex

(2015) A Carolin Seefeldt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The mechanism of inhibition of protein synthesis by the proline-rich peptide oncocin

(2015) Raktim N Roy et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Insect-Derived Proline-Rich Antimicrobial Peptides Kill Bacteria by Inhibiting Bacterial Protein Translation at the 70 S Ribosome

(2014) Andor Krizsan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Hydroxyproline Substitutions Stabilize Non-Glycosylated Drosocin Against Serum Proteases Without Challenging its Antibacterial Activity

(2014) Daniel Knappe et al.   PROTEIN AND PEPTIDE LETTERS

In Vivo Activity of Optimized Apidaecin and Oncocin Peptides Against a Multiresistant, KPC-Producing Klebsiella pneumoniae Strain

(2014) Eszter Ostorhazi et al.   PROTEIN AND PEPTIDE LETTERS

Cellular Uptake of Apidaecin 1b and Related Analogs in Gram-negative Bacteria Reveals Novel Antibacterial Mechanism for Proline-rich Antimicrobial Peptides

(2014) Nicole Berthold et al.   PROTEIN AND PEPTIDE LETTERS

Rapid systemic and local treatments with the antibacterial peptide dimer A3-APO and its monomeric metabolite eliminate bacteria and reduce inflammation in intradermal lesions infected with Propionibacterium acnes and meticillin-resistant Staphylococcus aureus

(2013) Eszter Ostorhazi et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Api88 Is a Novel Antibacterial Designer Peptide To Treat Systemic Infections with Multidrug-Resistant Gram-Negative Pathogens

(2012) Patricia Czihal et al.   ACS Chemical Biology

Effect of antimicrobial peptides from Apis mellifera hemolymph and its optimized version Api88 on biological activities of human monocytes and mast cells

(2012) Ulrike Keitel et al.   Innate Immunity

Oncocin derivative Onc72 is highly active against Escherichia coli in a systemic septicaemia infection mouse model

(2012) D. Knappe et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Absence ofin vitroinnate immunomodulation by insect-derived short proline-rich antimicrobial peptides points to direct antibacterial actionin vivo

(2012) Stefanie Fritsche et al.   JOURNAL OF PEPTIDE SCIENCE

Broad-spectrum antimicrobial efficacy of peptide A3-APO in mouse models of multidrug-resistant wound and lung infections cannot be explained by in vitro activity against the pathogens involved

(2011) Eszter Ostorhazi et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

The Honeybee Antimicrobial Peptide Apidaecin Differentially Immunomodulates Human Macrophages, Monocytes and Dendritic Cells

(2011) Regina Tavano et al.   Journal of Innate Immunity

Intramuscularly administered peptide A3-APO is effective against carbapenem-resistant Acinetobacter baumannii in mouse models of systemic infections

(2010) Eszter Ostorhazi et al.   BIOPOLYMERS

The proline-rich peptide Bac7(1-35) reduces mortality from Salmonella typhimurium in a mouse model of infection

(2010) Monica Benincasa et al.   BMC MICROBIOLOGY

Bactericidal oncocin derivatives with superior serum stabilities

(2010) Daniel Knappe et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Preclinical advantages of intramuscularly administered peptide A3-APO over existing therapies in Acinetobacter baumannii wound infections

(2010) E. Ostorhazi et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Oncocin (VDKPPYLPRPRPPRRIYNR-NH2): A Novel Antibacterial Peptide Optimized against Gram-Negative Human Pathogens

(2010) Daniel Knappe et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pharmacokinetics and Pharmacodynamics of Antibacterial Agents

(2009) Matthew E. Levison et al.   INFECTIOUS DISEASE CLINICS OF NORTH AMERICA

The designer proline-rich antibacterial peptide A3-APO is effective against systemic Escherichia coli infections in different mouse models

(2009) Dora Szabo et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS