Targetable Pathways for Alleviating Mitochondrial Dysfunction in Neurodegeneration of Metabolic and Non-Metabolic Diseases

Different Fumaric Acid Esters Elicit Distinct Pharmacologic Responses

(2021) Brian T. Wipke et al.   Neurology-Neuroimmunology & Neuroinflammation

Alpha-synuclein-induced mitochondrial dysfunction is mediated via a sirtuin 3-dependent pathway

(2020) Jae-Hyeon Park et al.   Molecular Neurodegeneration

Impaired mitophagy links mitochondrial disease to epithelial stress in methylmalonyl-CoA mutase deficiency

(2020) Alessandro Luciani et al.   Nature Communications

Advances in drug therapy for mitochondrial diseases

(2020) Lufei Zhang et al.   Annals of Translational Medicine

Characterization of More Selective Central Nervous System Nrf2-Activating Novel Vinyl Sulfoximine Compounds Compared to Dimethyl Fumarate

(2020) Karl E. Carlström et al.   Neurotherapeutics

PGC-1α, Inflammation, and Oxidative Stress: An Integrative View in Metabolism

(2020) Sergio Rius-Pérez et al.   Oxidative Medicine and Cellular Longevity

Mechanism of Action of Ketogenic Diet Treatment: Impact of Decanoic Acid and Beta—Hydroxybutyrate on Sirtuins and Energy Metabolism in Hippocampal Murine Neurons

(2020) Partha Dabke et al.   Nutrients

Decanoic Acid and Not Octanoic Acid Stimulates Fatty Acid Synthesis in U87MG Glioblastoma Cells: A Metabolomics Study

(2020) Fabrizio Damiano et al.   Frontiers in Neuroscience

Mechanisms of Mitochondrial Dysfunction in Lysosomal Storage Disorders: A Review

(2020) Karolina M. Stepien et al.   Journal of Clinical Medicine

USP14 as a Therapeutic Target Against Neurodegeneration: A Rat Brain Perspective

(2020) Chayan Banerjee et al.   Frontiers in Cell and Developmental Biology

Mitochondrial Dysfunction, Oxidative Stress, and Neuroinflammation: Intertwined Roads to Neurodegeneration

(2020) Anna Picca et al.   Antioxidants

Pyrroloquinoline quinone promotes mitochondrial biogenesis in rotenone-induced Parkinson’s disease model via AMPK activation

(2020) Qiong Cheng et al.   ACTA PHARMACOLOGICA SINICA

Lysosomal storage disorders – challenges, concepts and avenues for therapy: beyond rare diseases

(2019) André R. A. Marques et al.   JOURNAL OF CELL SCIENCE

Idebenone Alleviates Neuroinflammation and Modulates Microglial Polarization in LPS-Stimulated BV2 Cells and MPTP-Induced Parkinson’s Disease Mice

(2019) Aijuan Yan et al.   Frontiers in Cellular Neuroscience

Insight into the mechanism of action of dimethyl fumarate in multiple sclerosis

(2019) Sudhir Kumar Yadav et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Mitochondrial dysfunction in neurodegenerative diseases and the potential countermeasure

(2019) Yan Wang et al.   CNS Neuroscience & Therapeutics

Mitochondria in Neuroprotection by Phytochemicals: Bioactive Polyphenols Modulate Mitochondrial Apoptosis System, Function and Structure

(2019) Makoto Naoi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Oxidative Stress in Neurodegenerative Diseases: From a Mitochondrial Point of View

(2019) Giovanna Cenini et al.   Oxidative Medicine and Cellular Longevity

Regulation of Mitochondrial Biogenesis as a Way for Active Longevity: Interaction Between the Nrf2 and PGC-1α Signaling Pathways

(2019) Artem P. Gureev et al.   Frontiers in Genetics

Activators and Inhibitors of NRF2: A Review of Their Potential for Clinical Development

(2019) Natalia Robledinos-Antón et al.   Oxidative Medicine and Cellular Longevity

Effect of Trehalose on Manganese‐induced Mitochondrial Dysfunction and Neuronal Cells Damage in Mice

(2019) Kuan Liu et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Systemic Oxidative Stress: A Key Point in Neurodegeneration — A Review

(2019) E. E. Martínez Leo et al.   Journal of Nutrition Health & Aging

GBA mutation promotes early mitochondrial dysfunction in 3D neurosphere models

(2019) Constanza Morén et al.   Aging-US

Interplay between MicroRNAs and Oxidative Stress in Neurodegenerative Diseases

(2019) Konovalova et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Autophagy Signaling Pathway: A Potential Multifunctional Therapeutic Target of Curcumin in Neurological and Neuromuscular Diseases

(2019) Lorena Perrone et al.   Nutrients

Neuroprotective potential of chrysin in Parkinson's disease: Molecular mechanisms and clinical implications

(2019) Efthalia Angelopoulou et al.   NEUROCHEMISTRY INTERNATIONAL

CoQ10 enhances PGC1α and increases expression of mitochondrial antioxidant proteins in chronically ischemic swine myocardium

(2019) Laura Hocum Stone et al.   Nutrition & Metabolism

Trehalose reduces retinal degeneration, neuroinflammation and storage burden caused by a lysosomal hydrolase deficiency

(2018) Parisa Lotfi et al.   Autophagy

Mitochondrial Dysfunction in Parkinson’s Disease: New Mechanistic Insights and Therapeutic Perspectives

(2018) Jin-Sung Park et al.   Current Neurology and Neuroscience Reports

Mitochondria: Targeting mitochondrial reactive oxygen species with mitochondriotropic polyphenolic-based antioxidants

(2018) José Teixeira et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Cellular neurometabolism: a tentative to connect cell biology and metabolism in neurology

(2018) Àngels García-Cazorla et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Altered Redox Homeostasis in Branched-Chain Amino Acid Disorders, Organic Acidurias, and Homocystinuria

(2018) Eva Richard et al.   Oxidative Medicine and Cellular Longevity

Idebenone: Novel Strategies to Improve Its Systemic and Local Efficacy

(2018) Lucia Montenegro et al.   Nanomaterials

Small molecule inhibitors reveal allosteric regulation of USP14 via steric blockade

(2018) Yiwei Wang et al.   CELL RESEARCH

USP14 inhibition corrects an in vivo model of impaired mitophagy

(2018) Joy Chakraborty et al.   EMBO Molecular Medicine

Resveratrol: from enhanced biosynthesis and bioavailability to multitargeting chronic diseases

(2018) Naveet Pannu et al.   BIOMEDICINE & PHARMACOTHERAPY

Mitochondria as a therapeutic target for common pathologies

(2018) Michael P. Murphy et al.   NATURE REVIEWS DRUG DISCOVERY

Neuronal decanoic acid oxidation is markedly lower than that of octanoic acid: A mechanistic insight into the medium-chain triglyceride ketogenic diet

(2017) Aziza Khabbush et al.   EPILEPSIA

Mitochondrial biogenesis in neurodegeneration

(2017) P. Andy Li et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Trehalose Inhibits A53T Mutant α-Synuclein Overexpression and Neurotoxicity in Transduced PC12 Cells

(2017) Juan Zhao et al.   MOLECULES

Mitochondrial Dysfunction and Neurodegeneration in Lysosomal Storage Disorders

(2017) Nicoletta Plotegher et al.   TRENDS IN MOLECULAR MEDICINE

Mechanistic Investigations of the Mitochondrial Complex I Inhibitor Rotenone in the Context of Pharmacological and Safety Evaluation

(2017) Sabrina Heinz et al.   Scientific Reports

Neuronal Mitophagy in Neurodegenerative Diseases

(2017) Marta Martinez-Vicente   Frontiers in Molecular Neuroscience

Mitochondria and α-Synuclein: Friends or Foes in the Pathogenesis of Parkinson’s Disease?

(2017) Gaia Faustini et al.   Genes

Evidence of Oxidative Stress and Secondary Mitochondrial Dysfunction in Metabolic and Non-Metabolic Disorders

(2017) Karolina M. Stepien et al.   Journal of Clinical Medicine

Mitochondrial Biogenesis as a Pharmacological Target: A New Approach to Acute and Chronic Diseases

(2016) Ryan M. Whitaker et al.   Annual Review of Pharmacology and Toxicology

Repurposing the NRF2 Activator Dimethyl Fumarate as Therapy Against Synucleinopathy in Parkinson's Disease

(2016) Isabel Lastres-Becker et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial dysfunction in fibroblasts derived from patients with Niemann-Pick type C disease

(2016) Marcin Woś et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Chrysin exerts neuroprotective effects against 3-Nitropropionic acid induced behavioral despair—Mitochondrial dysfunction and striatal apoptosis via upregulating Bcl-2 gene and downregulating Bax—Bad genes in male wistar rats

(2016) Sumathi Thangarajan et al.   BIOMEDICINE & PHARMACOTHERAPY

Antioxidant effects of resveratrol in the cardiovascular system

(2016) Ning Xia et al.   BRITISH JOURNAL OF PHARMACOLOGY

Paraoxonases, mitochondrial dysfunction and non-communicable diseases

(2016) Jordi Camps et al.   CHEMICO-BIOLOGICAL INTERACTIONS

PPARγ as a therapeutic target to rescue mitochondrial function in neurological disease

(2016) Juan Carlos Corona et al.   FREE RADICAL BIOLOGY AND MEDICINE

USP14 regulates autophagy by suppressing K63 ubiquitination of Beclin 1

(2016) Daichao Xu et al.   GENES & DEVELOPMENT

Development of Therapeutics That Induce Mitochondrial Biogenesis for the Treatment of Acute and Chronic Degenerative Diseases

(2016) Robert B. Cameron et al.   JOURNAL OF MEDICINAL CHEMISTRY

Distinct Nrf2 Signaling Mechanisms of Fumaric Acid Esters and Their Role in Neuroprotection against 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Experimental Parkinson's-Like Disease

(2016) M. Ahuja et al.   JOURNAL OF NEUROSCIENCE

Oxidative stress and metabolic disorders: Pathogenesis and therapeutic strategies

(2016) Vibha Rani et al.   LIFE SCIENCES

Curcumin Rescues a PINK1 Knock Down SH-SY5Y Cellular Model of Parkinson’s Disease from Mitochondrial Dysfunction and Cell Death

(2016) Celia van der Merwe et al.   MOLECULAR NEUROBIOLOGY

Parkin and PINK1 Patient iPSC-Derived Midbrain Dopamine Neurons Exhibit Mitochondrial Dysfunction and α-Synuclein Accumulation

(2016) Sun Young Chung et al.   Stem Cell Reports

Molecular mechanisms underlying PINK1 and Parkin catalyzed ubiquitylation of substrates on damaged mitochondria

(2015) Fumika Koyano et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Congenital disorders of autophagy: an emerging novel class of inborn errors of neuro-metabolism

(2015) Darius Ebrahimi-Fakhari et al.   BRAIN

Parkin maintains mitochondrial levels of the protective Parkinson’s disease-related enzyme 17-β hydroxysteroid dehydrogenase type 10

(2015) G Bertolin et al.   CELL DEATH AND DIFFERENTIATION

Current disease modifying approaches to treat Parkinson’s disease

(2015) Dan Lindholm et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Molecular Mechanisms of Mitochondrial Autophagy/Mitophagy in the Heart

(2015) T. Saito et al.   CIRCULATION RESEARCH

Deubiquitinases and the new therapeutic opportunities offered to cancer

(2015) R. Pfoh et al.   ENDOCRINE-RELATED CANCER

Curcumin Attenuates Gentamicin-Induced Kidney Mitochondrial Alterations: Possible Role of a Mitochondrial Biogenesis Mechanism

(2015) Mario Negrette-Guzmán et al.   Evidence-based Complementary and Alternative Medicine

Examining the neuroprotective effects of protocatechuic acid and chrysin on in vitro and in vivo models of Parkinson disease

(2015) Zaijun Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

(2015) Michael Lazarou et al.   NATURE

The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease

(2015) Alicia M. Pickrell et al.   NEURON

The importance of antioxidants which play the role in cellular response against oxidative/nitrosative stress: current state

(2015) Ergul Belge Kurutas   Nutrition Journal

Resveratrol: A Focus on Several Neurodegenerative Diseases

(2015) Ester Tellone et al.   Oxidative Medicine and Cellular Longevity

Mitochondrial dysfunction and mitophagy in Parkinson's: from familial to sporadic disease

(2015) Brent J. Ryan et al.   TRENDS IN BIOCHEMICAL SCIENCES

Aggregated α-synuclein and complex I deficiency: exploration of their relationship in differentiated neurons

(2015) A K Reeve et al.   Cell Death & Disease

Pharmacological Chaperones and Coenzyme Q10 Treatment Improves Mutant β-Glucocerebrosidase Activity and Mitochondrial Function in Neuronopathic Forms of Gaucher Disease

(2015) Mario de la Mata et al.   Scientific Reports

A review on mitochondrial restorative mechanism of antioxidants in Alzheimer’s disease and other neurological conditions

(2015) Anil Kumar et al.   Frontiers in Pharmacology

Oxidative stress: a concept in redox biology and medicine

(2015) Helmut Sies   Redox Biology

Resveratrol Directly Binds to Mitochondrial Complex I and Increases Oxidative Stress in Brain Mitochondria of Aged Mice

(2015) Naïg Gueguen et al.   PLoS One

Effect of resveratrol on mitochondrial function: Implications in parkin-associated familiar Parkinson's disease

(2014) Anna Ferretta et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Autophagy of Mitochondria: A Promising Therapeutic Target for Neurodegenerative Disease

(2014) Pradip K. Kamat et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Genetic Insights into Sporadic Parkinson's Disease Pathogenesis

(2014) Chou Chai et al.   CURRENT GENOMICS

Mitochondrial Biogenesis: A Therapeutic Target for Neurodevelopmental Disorders and Neurodegenerative Diseases

(2014) Martine Uittenbogaard et al.   CURRENT PHARMACEUTICAL DESIGN

Altered levels of α-synuclein and sphingolipids in Batten disease lymphoblast cells

(2014) Sunyang Kang et al.   GENE

Soluble, Prefibrillar α-Synuclein Oligomers Promote Complex I-dependent, Ca2+-induced Mitochondrial Dysfunction

(2014) Eric S. Luth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The ketogenic diet component decanoic acid increases mitochondrial citrate synthase and complex I activity in neuronal cells

(2014) Sean David Hughes et al.   JOURNAL OF NEUROCHEMISTRY

The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy

(2014) Baris Bingol et al.   NATURE

Improved neuroprotection using miglustat, curcumin and ibuprofen as a triple combination therapy in Niemann–Pick disease type C1 mice

(2014) Ian M. Williams et al.   NEUROBIOLOGY OF DISEASE

Increased plasma oligomeric alpha-synuclein in patients with lysosomal storage diseases

(2014) S.N. Pchelina et al.   NEUROSCIENCE LETTERS

Comparative absorption of curcumin formulations

(2014) Ralf Jäger et al.   Nutrition Journal

Ubiquinol-10 Supplementation Activates Mitochondria Functions to Decelerate Senescence in Senescence-Accelerated Mice

(2013) Geng Tian et al.   ANTIOXIDANTS & REDOX SIGNALING

Isogenic Human iPSC Parkinson’s Model Shows Nitrosative Stress-Induced Dysfunction in MEF2-PGC1α Transcription

(2013) Scott D. Ryan et al.   CELL

Complexity of dopamine metabolism

(2013) Johannes Meiser et al.   Cell Communication and Signaling

Mitochondria and Quality Control Defects in a Mouse Model of Gaucher Disease—Links to Parkinson’s Disease

(2013) Laura D. Osellame et al.   Cell Metabolism

Dietary pyrroloquinoline quinone (PQQ) alters indicators of inflammation and mitochondrial-related metabolism in human subjects

(2013) Calliandra B. Harris et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

PPARγ signaling and metabolism: the good, the bad and the future

(2013) Maryam Ahmadian et al.   NATURE MEDICINE

Mitochondrial dysfunction and oxidative stress in Parkinson's disease

(2013) Sudhakar Raja Subramaniam et al.   PROGRESS IN NEUROBIOLOGY

Inhibition of oxidative stress by coenzyme Q10 increases mitochondrial mass and improves bioenergetic function in optic nerve head astrocytes

(2013) Y H Noh et al.   Cell Death & Disease

Natural polyphenols against neurodegenerative disorders: Potentials and pitfalls

(2012) Azadeh Ebrahimi et al.   AGEING RESEARCH REVIEWS

Resveratrol Produces Neurotrophic Effects on Cultured Dopaminergic Neurons through Prompting Astroglial BDNF and GDNF Release

(2012) Feng Zhang et al.   Evidence-based Complementary and Alternative Medicine

Lysosomal storage disorders: The cellular impact of lysosomal dysfunction

(2012) Frances M. Platt et al.   JOURNAL OF CELL BIOLOGY

PINK1- and Parkin-mediated mitophagy at a glance

(2012) Seok Min Jin et al.   JOURNAL OF CELL SCIENCE

Reactive oxygen/nitrogen species and their functional correlations in neurodegenerative diseases

(2012) Mahesh Ramalingam et al.   JOURNAL OF NEURAL TRANSMISSION

Mitochondria, oxidative stress and neurodegeneration

(2012) Antonio Federico et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Mitochondrial diseases

(2012) Anthony HV Schapira   LANCET

Peroxisome Proliferator-Activated Receptor Gamma (PPAR-γ) and Neurodegenerative Disorders

(2012) Yu-Chang Chen et al.   MOLECULAR NEUROBIOLOGY

Glucocerebrosidase inhibition causes mitochondrial dysfunction and free radical damage

(2012) Michael W.J. Cleeter et al.   NEUROCHEMISTRY INTERNATIONAL

Pgc-1α Overexpression Downregulates Pitx3 and Increases Susceptibility to MPTP Toxicity Associated with Decreased Bdnf

(2012) Joanne Clark et al.   PLoS One

Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue

(2012) Yoichi Imaizumi et al.   Molecular Brain

Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis

(2011) Pablo J Fernandez-Marcos et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

PARK6 PINK1 mutants are defective in maintaining mitochondrial membrane potential and inhibiting ROS formation of substantia nigra dopaminergic neurons

(2011) Hung-Li Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mitochondrial energy metabolism in neurodegeneration associated with methylmalonic acidemia

(2011) Daniela R. Melo et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Mutant A53T α-Synuclein Induces Neuronal Death by Increasing Mitochondrial Autophagy

(2011) Vinay Choubey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aggregation of α-synuclein in brain samples from subjects with glucocerebrosidase mutations

(2011) Jae Hyuk Choi et al.   MOLECULAR GENETICS AND METABOLISM

Identification of the target proteins of rosiglitazone in 3T3-L1 adipocytes through proteomic analysis of cytosolic and secreted proteins

(2011) Hyun-Ho Hwang et al.   MOLECULES AND CELLS

Resveratrol-Activated AMPK/SIRT1/Autophagy in Cellular Models of Parkinson’s Disease

(2011) Yuncheng Wu et al.   NEUROSIGNALS

Curcumin protects against A53T alpha-synuclein-induced toxicity in a PC12 inducible cell model for Parkinsonism

(2011) Zhaohui Liu et al.   PHARMACOLOGICAL RESEARCH

Glucocerebrosidase is present in α-synuclein inclusions in Lewy body disorders

(2010) Ozlem Goker-Alpan et al.   ACTA NEUROPATHOLOGICA

Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network

(2010) Richard C. Scarpulla   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Curcumin reduces α-synuclein induced cytotoxicity in Parkinson's disease cell model

(2010) Min S Wang et al.   BMC NEUROSCIENCE

The sites and topology of mitochondrial superoxide production

(2010) Martin D. Brand   EXPERIMENTAL GERONTOLOGY

PINK1 cleavage at position A103 by the mitochondrial protease PARL

(2010) Emma Deas et al.   HUMAN MOLECULAR GENETICS

Curcumin attenuates 6-hydroxydopamine-induced cytotoxicity by anti-oxidation and nuclear factor-kappaB modulation in MES23.5 cells

(2009) Jun Wang et al.   BIOCHEMICAL PHARMACOLOGY

Mitochondria: A therapeutic target in neurodegeneration

(2009) Paula I. Moreira et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

PINK1 function in health and disease

(2009) Emma Deas et al.   EMBO Molecular Medicine

Pyrroloquinoline Quinone Stimulates Mitochondrial Biogenesis through cAMP Response Element-binding Protein Phosphorylation and Increased PGC-1α Expression

(2009) Winyoo Chowanadisai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PPARγ stimulation promotes mitochondrial biogenesis and prevents glucose deprivation-induced neuronal cell loss

(2009) Gianluca Miglio et al.   NEUROCHEMISTRY INTERNATIONAL

Parkinson Phenotype in Aged PINK1-Deficient Mice Is Accompanied by Progressive Mitochondrial Dysfunction in Absence of Neurodegeneration

(2009) Suzana Gispert et al.   PLoS One

Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease: Critical role for the astrocyte

(2009) Pei-Chun Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inherited disorders affecting mitochondrial function are associated with glutathione deficiency and hypocitrullinemia

(2009) K. R. Atkuri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dietary resveratrol administration increases MnSOD expression and activity in mouse brain

(2008) Ellen L. Robb et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Transcriptional control of mitochondrial biogenesis: the central role of PGC-1 

(2008) R. Ventura-Clapier et al.   CARDIOVASCULAR RESEARCH

Oxidative Stress and Neurotoxicity

(2007) Lawrence M. Sayre et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Alterations in mitochondrial respiratory functions, redox metabolism and apoptosis by oxidant 4-hydroxynonenal and antioxidants curcumin and melatonin in PC12 cells

(2007) Haider Raza et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY