Idebenone Alleviates Neuroinflammation and Modulates Microglial Polarization in LPS-Stimulated BV2 Cells and MPTP-Induced Parkinson’s Disease Mice

PPARß/δ agonist alleviates NLRP3 inflammasome-mediated neuroinflammation in the MPTP mouse model of Parkinson’s disease

(2018) Linfang Chen et al.   BEHAVIOURAL BRAIN RESEARCH

Thromboxane A2 receptor antagonist SQ29548 attenuates SH‑SY5Y neuroblastoma cell impairments induced by oxidative stress

(2018) Gaoyu Cai et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Aucubin alleviates glial cell activation and preserves dopaminergic neurons in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonian mice

(2018) Ying-Li Zhu et al.   NEUROREPORT

Partial Depletion of Peripheral M1 Macrophages Reverses Motor Deficits in MPTP-Treated Mouse by Suppressing Neuroinflammation and Dopaminergic Neurodegeneration

(2018) Aijuan Yan et al.   Frontiers in Aging Neuroscience

TOPK Promotes Microglia/Macrophage Polarization towards M2 Phenotype via Inhibition of HDAC1 and HDAC2 Activity after Transient Cerebral Ischemia

(2018) Ziping Han et al.   Aging and Disease

Aged Mice are More Resistant to Influenza Virus Infection due to Reduced Inflammation and Lung Pathology

(2018) Jiao Lu et al.   Aging and Disease

Thromboxane A2 receptor antagonist SQ29548 suppresses the LPS-induced release of inflammatory cytokines in BV2 microglia cells via suppressing MAPK and NF-κB signaling pathways

(2017) Aijuan Yan et al.   Molecular Medicine Reports

Pharmacological Modulation of Functional Phenotypes of Microglia in Neurodegenerative Diseases

(2017) Gyun Jee Song et al.   Frontiers in Aging Neuroscience

Neurochemical and Behavior Deficits in Rats with Iron and Rotenone Co-treatment: Role of Redox Imbalance and Neuroprotection by Biochanin A

(2017) Lijia Yu et al.   Frontiers in Neuroscience

Pharmacological effect of a new idebenone formulation in a model of carrageenan-induced inflammatory pain

(2016) Filomena Lauro et al.   PHARMACOLOGICAL RESEARCH

Thromboxane A2 receptor antagonist SQ29548 reduces ischemic stroke-induced microglia/macrophages activation and enrichment, and ameliorates brain injury

(2016) Aijuan Yan et al.   Scientific Reports

Thromboxane A2 Receptor Stimulation Enhances Microglial Interleukin-1β and NO Biosynthesis Mediated by the Activation of ERK Pathway

(2016) Wanlin Yang et al.   Frontiers in Aging Neuroscience

Microglia-Mediated Inflammation and Neurodegenerative Disease

(2015) Ling Xu et al.   MOLECULAR NEUROBIOLOGY

Capillarisin Suppresses Lipopolysaccharide-Induced Inflammatory Mediators in BV2 Microglial Cells by Suppressing TLR4-Mediated NF-κB and MAPKs Signaling Pathway

(2015) Zhen Yu et al.   NEUROCHEMICAL RESEARCH

Idebenone and neuroprotection: antioxidant, pro-oxidant, or electron carrier?

(2014) Sausan Jaber et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

EOP, a Newly Synthesized Ethyl Pyruvate Derivative, Attenuates the Production of Inflammatory Mediators via p38, ERK and NF-κB Pathways in Lipopolysaccharide-Activated BV-2 Microglial Cells

(2014) Soon Min et al.   MOLECULES

Co-enzyme Q10and idebenone use in Friedreich's ataxia

(2013) Michael H Parkinson et al.   JOURNAL OF NEUROCHEMISTRY

The antioxidant idebenone fails to prevent or attenuate chronic experimental autoimmune encephalomyelitis in the mouse

(2013) Sebastian M. Fiebiger et al.   JOURNAL OF NEUROIMMUNOLOGY

Targeting the Shift from M1 to M2 Macrophages in Experimental Autoimmune Encephalomyelitis Mice Treated with Fasudil

(2013) Chunyun Liu et al.   PLoS One

LLDT-67 attenuates MPTP-induced neurotoxicity in mice by up-regulating NGF expression

(2012) Dong-dong Wu et al.   ACTA PHARMACOLOGICA SINICA

Assessing Activation States in Microglia

(2012) Carol A. Colton et al.   CNS & Neurological Disorders-Drug Targets

Adjudin attenuates lipopolysaccharide (LPS)- and ischemia-induced microglial activation

(2012) Jiaxiang Shao et al.   JOURNAL OF NEUROIMMUNOLOGY

Lipopolysaccharide-induced interleukin (IL)-4 receptor-α expression and corresponding sensitivity to the M2 promoting effects of IL-4 are impaired in microglia of aged mice

(2011) Ashley M. Fenn et al.   BRAIN BEHAVIOR AND IMMUNITY

Nitric oxide pros and cons: The role of l-arginine, a nitric oxide precursor, and idebenone, a coenzyme-Q analogue in ameliorating cerebral hypoxia in rat

(2010) Nayira A. Abdel Baky et al.   BRAIN RESEARCH BULLETIN

A Nurr1/CoREST Pathway in Microglia and Astrocytes Protects Dopaminergic Neurons from Inflammation-Induced Death

(2009) Kaoru Saijo et al.   CELL

Heterogeneity of Microglial Activation in the Innate Immune Response in the Brain

(2009) Carol A. Colton   Journal of Neuroimmune Pharmacology

Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease

(2008) Vanessa Brochard et al.   JOURNAL OF CLINICAL INVESTIGATION

Inflammation as a causative factor in the aetiology of Parkinson's disease

(2007) P S Whitton   BRITISH JOURNAL OF PHARMACOLOGY