Metals in ALS TDP-43 Pathology

The cytotoxic effect of α‐synuclein aggregates

(2021) Francisco Melo et al.   CHEMPHYSCHEM

TDP-43 aggregation induced by oxidative stress causes global mitochondrial imbalance in ALS

(2021) Xinxin Zuo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Lithium ions display weak interaction with amyloid-beta (Aβ) peptides and have minor effects on their aggregation

(2021) Elina Berntsson et al.   ACTA BIOCHIMICA POLONICA

Cryo‐electron Microscopy Imaging of Alzheimer's Amyloid‐beta 42 Oligomer Displayed on a Functionally and Structurally Relevant Scaffold

(2021) Jinming Wu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Amyotrophic lateral sclerosis with speech apraxia, predominant upper motor neuron signs, and prominent iron accumulation in the frontal operculum and precentral gyrus

(2021) Tomoki T. Mitani et al.   NEUROPATHOLOGY

Zn(II) binding causes interdomain changes in the structure and flexibility of the human prion protein

(2021) Maciej Gielnik et al.   Scientific Reports

Metal ion coordination delays amyloid-β peptide self-assembly by forming an aggregation–inert complex

(2020) Cecilia Wallin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LATE: Nicht jede Demenz ist Alzheimer – Diskussion einer neuen Krankheitsentität am Fallbeispiel

(2020) Doreen Görß et al.   NERVENARZT

Altered serum protein levels in frontotemporal dementia and amyotrophic lateral sclerosis indicate calcium and immunity dysregulation

(2020) Jared S. Katzeff et al.   Scientific Reports

Interactions between the Intrinsically Disordered Regions of hnRNP-A2 and TDP-43 Accelerate TDP-43′s Conformational Transition

(2020) Wan-Chin Chiang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ALS Genetics: Gains, Losses, and Implications for Future Therapies

(2020) Garam Kim et al.   NEURON

Multifunctional roles of zinc in Alzheimer’s disease

(2020) Zhuoya Xie et al.   NEUROTOXICOLOGY

Molecular and Cellular Mechanisms Affected in ALS

(2020) Laura Le Gall et al.   Journal of Personalized Medicine

Amyotrophic Lateral Sclerosis After Exposure to Manganese from Traditional Medicine Procedures in Kenya

(2020) Elin Roos et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Zinc Binds to RRM2 Peptide of TDP-43

(2020) Andrey V. Golovin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A novel hypothesis on metal dyshomeostasis and mitochondrial dysfunction in amyotrophic lateral sclerosis: Potential pathogenetic mechanism and therapeutic implications

(2020) Yutaka Nakagawa et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Molecular Mechanisms of TDP-43 Misfolding and Pathology in Amyotrophic Lateral Sclerosis

(2019) Archana Prasad et al.   Frontiers in Molecular Neuroscience

The debated toxic role of aggregated TDP-43 in amyotrophic lateral sclerosis: a resolution in sight?

(2019) Rudolf C Hergesheimer et al.   BRAIN

The Pathobiology of TDP-43 C-Terminal Fragments in ALS and FTLD

(2019) Britt A. Berning et al.   Frontiers in Neuroscience

Metal binding to the amyloid-β peptides in the presence of biomembranes: potential mechanisms of cell toxicity

(2019) Sebastian K. T. S. Wärmländer et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

TDP-43 proteinopathy and mitochondrial abnormalities in neurodegeneration

(2019) Ju Gao et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Could Lifetime Lead Exposure Play a Role in Limbic-predominant Age-related TDP-43 Encephalopathy (LATE)?

(2019) Esme Fuller-Thomson et al.   JOURNAL OF ALZHEIMERS DISEASE

Structural Insights Into TDP-43 and Effects of Post-translational Modifications

(2019) Liberty François-Moutal et al.   Frontiers in Molecular Neuroscience

Mercury and Alzheimer’s Disease: Hg(II) Ions Display Specific Binding to the Amyloid-β Peptide and Hinder Its Fibrillization

(2019) Cecilia Wallin et al.   Biomolecules

Alzheimer’s disease pathology propagation by exosomes containing toxic amyloid-beta oligomers

(2018) Maitrayee Sardar Sinha et al.   ACTA NEUROPATHOLOGICA

Pathomechanisms of TDP-43 in neurodegeneration

(2018) Ju Gao et al.   JOURNAL OF NEUROCHEMISTRY

The Neuronal Tau Protein Blocks in Vitro Fibrillation of the Amyloid-β (Aβ) Peptide at the Oligomeric Stage

(2018) Cecilia Wallin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Novel genes associated with amyotrophic lateral sclerosis: diagnostic and clinical implications

(2018) Ruth Chia et al.   LANCET NEUROLOGY

Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

(2018) Melanie D. Sweeney et al.   Nature Reviews Neurology

Redox metals homeostasis in multiple sclerosis and amyotrophic lateral sclerosis: a review

(2018) Sahar Sheykhansari et al.   Cell Death & Disease

Heavy Metal Neurotoxicants Induce ALS-Linked TDP-43 Pathology

(2018) Peter E A Ash et al.   TOXICOLOGICAL SCIENCES

Machine Learning Reveals Protein Signatures in CSF and Plasma Fluids of Clinical Value for ALS

(2018) Michael S. Bereman et al.   Scientific Reports

Ultraclean paired sampling for metal analysis in neurodegenerative disorders

(2018) Per M. Roos   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Amyotrophic lateral sclerosis

(2017) Michael A van Es et al.   LANCET

Oxidative stress and mitochondrial damage in the pathogenesis of ALS: New perspectives

(2017) F. Bozzo et al.   NEUROSCIENCE LETTERS

Modeling U-shaped dose-response curves for manganese using categorical regression

(2017) Brittany Milton et al.   NEUROTOXICOLOGY

Amyotrophic Lateral Sclerosis

(2017) Robert H. Brown et al.   NEW ENGLAND JOURNAL OF MEDICINE

Functional and dynamic polymerization of the ALS-linked protein TDP-43 antagonizes its pathologic aggregation

(2017) Tariq Afroz et al.   Nature Communications

Alzheimer’s disease and cigarette smoke components: effects of nicotine, PAHs, and Cd(II), Cr(III), Pb(II), Pb(IV) ions on amyloid-β peptide aggregation

(2017) Cecilia Wallin et al.   Scientific Reports

Zinc binding to RNA recognition motif of TDP-43 induces the formation of amyloid-like aggregates

(2017) Cyrille Garnier et al.   Scientific Reports

TDP-43 Prions

(2017) Takashi Nonaka et al.   Cold Spring Harbor Perspectives in Medicine

Reactive Astrocytes Promote ALS-like Degeneration and Intracellular Protein Aggregation in Human Motor Neurons by Disrupting Autophagy through TGF-β1

(2017) Pratibha Tripathi et al.   Stem Cell Reports

Healing of Amyotrophic Lateral Sclerosis: A Case Report

(2017) Inge Mangelsdorf et al.   Complementary Medicine Research

Reciprocal Molecular Interactions between the Aβ Peptide Linked to Alzheimer’s Disease and Insulin Linked to Diabetes Mellitus Type II

(2016) Jinghui Luo et al.   ACS Chemical Neuroscience

Protein folding alterations in amyotrophic lateral sclerosis

(2016) Sonam Parakh et al.   BRAIN RESEARCH

Mechanisms of prion-induced neurodegeneration

(2016) Paula Saá et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

The TDP-43 N-terminal domain structure at high resolution

(2016) Miguel Mompeán et al.   FEBS Journal

Cross-interactions between the Alzheimer Disease Amyloid-β Peptide and Other Amyloid Proteins: A Further Aspect of the Amyloid Cascade Hypothesis

(2016) Jinghui Luo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Physiological functions and pathobiology of TDP-43 and FUS/TLS proteins

(2016) Antonia Ratti et al.   JOURNAL OF NEUROCHEMISTRY

Characterization of Mn(II) ion binding to the amyloid-β peptide in Alzheimer⿿s disease

(2016) Cecilia Wallin et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Amyotrophic lateral sclerosis: moving towards a new classification system

(2016) Ammar Al-Chalabi et al.   LANCET NEUROLOGY

Occupational exposures and the risk of amyotrophic lateral sclerosis

(2016) Tracy L Peters et al.   OCCUPATIONAL AND ENVIRONMENTAL MEDICINE

Zinc as chaperone-mimicking agent for retardation of amyloid β peptide fibril formation

(2015) Axel Abelein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Risk factors for amyotrophic lateral sclerosis

(2015) Fang Fang et al.   Clinical Epidemiology

Alzheimer Peptides Aggregate into Transient Nanoglobules That Nucleate Fibrils

(2014) Jinghui Luo et al.   BIOCHEMISTRY

Non-chaperone Proteins Can Inhibit Aggregation and Cytotoxicity of Alzheimer Amyloid β Peptide

(2014) Jinghui Luo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The hairpin conformation of the amyloid β peptide is an important structural motif along the aggregation pathway

(2014) Axel Abelein et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Blood Lead, Manganese, and Aluminum Levels in a Regional Italian Cohort of ALS Patients

(2014) Elpidio Maria Garzillo et al.   JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE

Increased metal content in the TDP-43A315T transgenic mouse model of frontotemporal lobar degeneration and amyotrophic lateral sclerosis

(2014) Theresa N. T. Dang et al.   Frontiers in Aging Neuroscience

Protein aggregation in amyotrophic lateral sclerosis

(2013) Anna M. Blokhuis et al.   ACTA NEUROPATHOLOGICA

Biophysical Studies of the Amyloid β-Peptide: Interactions with Metal Ions and Small Molecules

(2013) Sebastian Wärmländer et al.   CHEMBIOCHEM

Human lysozyme inhibits the in vitro aggregation of Aβ peptides, which in vivo are associated with Alzheimer's disease

(2013) Jinghui Luo et al.   CHEMICAL COMMUNICATIONS

The dual functions of the extreme N-terminus of TDP-43 in regulating its biological activity and inclusion formation

(2013) Yong-Jie Zhang et al.   HUMAN MOLECULAR GENETICS

Structural Transformation of the Amyloidogenic Core Region of TDP-43 Protein Initiates Its Aggregation and Cytoplasmic Inclusion

(2013) Lei-Lei Jiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aberrant Assembly of RNA Recognition Motif 1 Links to Pathogenic Conversion of TAR DNA-binding Protein of 43 kDa (TDP-43)

(2013) Akemi Shodai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular basis of UG-rich RNA recognition by the human splicing factor TDP-43

(2013) Peter J Lukavsky et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dysregulation of intracellular copper homeostasis is common to transgenic mice expressing human mutant superoxide dismutase-1s regardless of their copper-binding abilities

(2013) Eiichi Tokuda et al.   NEUROBIOLOGY OF DISEASE

Cerebrospinal fluid of newly diagnosed amyotrophic lateral sclerosis patients exhibits abnormal levels of selenium species including elevated selenite

(2013) Marco Vinceti et al.   NEUROTOXICOLOGY

The C9orf72 GGGGCC Repeat Is Translated into Aggregating Dipeptide-Repeat Proteins in FTLD/ALS

(2013) K. Mori et al.   SCIENCE

TDP-43 skeins show properties of amyloid in a subset of ALS cases

(2012) John L. Robinson et al.   ACTA NEUROPATHOLOGICA

Lead Poisoning Mimicking Amyotrophic Lateral Sclerosis: An Adverse Effect of Rituals

(2012) Claude Bachmeyer et al.   AMERICAN JOURNAL OF MEDICINE

Mercury in the Spinal Cord After Inhalation of Mercury

(2012) Per M. Roos et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

The N-terminus of TDP-43 promotes its oligomerization and enhances DNA binding affinity

(2012) Chung-ke Chang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Metal Concentrations in Cerebrospinal Fluid and Blood Plasma from Patients with Amyotrophic Lateral Sclerosis

(2012) Per M. Roos et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

The Amyloid State of Proteins in Human Diseases

(2012) David Eisenberg et al.   CELL

Protein Aggregation and Defective RNA Metabolism as Mechanisms for Motor Neuron Damage

(2012) N. Ticozzi et al.   CNS & Neurological Disorders-Drug Targets

Manganese in cerebrospinal fluid and blood plasma of patients with amyotrophic lateral sclerosis

(2012) Per M Roos et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Early Steps in Oxidation-Induced SOD1 Misfolding: Implications for Non-Amyloid Protein Aggregation in Familial ALS

(2012) Vikram Khipple Mulligan et al.   JOURNAL OF MOLECULAR BIOLOGY

Inhibition of TDP-43 Accumulation by Bis(thiosemicarbazonato)-Copper Complexes

(2012) Sarah J. Parker et al.   PLoS One

Delineation of the Core Aggregation Sequences of TDP-43 C-Terminal Fragment

(2011) Akash Saini et al.   CHEMBIOCHEM

Role of manganese in neurodegenerative diseases

(2011) Aaron B. Bowman et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Amyotrophic lateral sclerosis

(2011) Matthew C Kiernan et al.   LANCET

The C-Terminal TDP-43 Fragments Have a High Aggregation Propensity and Harm Neurons by a Dominant-Negative Mechanism

(2011) Chunxing Yang et al.   PLoS One

Association Between Blood Lead and the Risk of Amyotrophic Lateral Sclerosis

(2010) F. Fang et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Zinc induces depletion and aggregation of endogenous TDP-43

(2010) Aphrodite Caragounis et al.   FREE RADICAL BIOLOGY AND MEDICINE

Inorganic mercury within motor neurons does not cause the TDP-43 changes seen in sporadic ALS

(2010) Roger Pamphlett et al.   TOXICOLOGY LETTERS

Mercury exposure in sporadic amyotrophic lateral sclerosis patients from Ganga plain region in India: A retrospective study

(2010) Alok Kumar et al.   TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY

Exposure to chemicals and metals and risk of amyotrophic lateral sclerosis: A systematic review

(2009) Nadia A. Sutedja et al.   Amyotrophic Lateral Sclerosis

TDP-43 Dimerizes in Human Cells in Culture

(2009) Yuki Shiina et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

CSF neurofilament protein analysis in the differential diagnosis of ALS

(2009) Thierry S. Reijn et al.   JOURNAL OF NEUROLOGY

The role of environmental mercury, lead and pesticide exposure in development of amyotrophic lateral sclerosis

(2009) Frank O. Johnson et al.   NEUROTOXICOLOGY

Structural insights into TDP-43 in nucleic-acid binding and domain interactions

(2009) P.-H. Kuo et al.   NUCLEIC ACIDS RESEARCH

Isomerization of the Asp7 Residue Results in Zinc‐Induced Oligomerization of Alzheimer’s Disease Amyloid β(1–16) Peptide

(2008) Philipp O. Tsvetkov et al.   CHEMBIOCHEM

Bioinorganic chemistry of copper and zinc ions coordinated to amyloid-β peptide

(2008) Peter Faller et al.   DALTON TRANSACTIONS

Disturbance of Nuclear and Cytoplasmic TAR DNA-binding Protein (TDP-43) Induces Disease-like Redistribution, Sequestration, and Aggregate Formation

(2008) Matthew J. Winton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A CSF biomarker panel for identification of patients with amyotrophic lateral sclerosis

(2008) R. M. Mitchell et al.   NEUROLOGY

TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis

(2008) J. Sreedharan et al.   SCIENCE