Altered serum protein levels in frontotemporal dementia and amyotrophic lateral sclerosis indicate calcium and immunity dysregulation

Uncovering pathophysiological changes in frontotemporal dementia using serum lipids

(2020) Katherine Phan et al.   Scientific Reports

Novel CSF biomarkers in genetic frontotemporal dementia identified by proteomics

(2019) Emma L. van der Ende et al.   Annals of Clinical and Translational Neurology

Genome-wide analyses as part of the international FTLD-TDP whole-genome sequencing consortium reveals novel disease risk factors and increases support for immune dysfunction in FTLD

(2019) Cyril Pottier et al.   ACTA NEUROPATHOLOGICA

Altered calcium dynamics and glutamate receptor properties in iPSC derived motor neurons from ALS patients with C9orf72, FUS, SOD1 or TDP43 mutations

(2019) Franziska Bursch et al.   HUMAN MOLECULAR GENETICS

Immune Signaling in Neurodegeneration

(2019) Timothy R. Hammond et al.   IMMUNITY

Calcium-Binding Proteins as Determinants of Central Nervous System Neuronal Vulnerability to Disease

(2019) Richard Fairless et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Searching for novel cerebrospinal fluid biomarkers of tau pathology in frontotemporal dementia: an elusive quest

(2019) Martha S Foiani et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

A new normalization for Nanostring nCounter gene expression data

(2019) Ramyar Molania et al.   NUCLEIC ACIDS RESEARCH

Deep undepleted human serum proteome profiling toward biomarker discovery for Alzheimer’s disease

(2019) Kaushik Kumar Dey et al.   Clinical Proteomics

Neuroinflammation in frontotemporal dementia

(2019) Fiona Bright et al.   Nature Reviews Neurology

Prognosis for patients with amyotrophic lateral sclerosis: development and validation of a personalised prediction model

(2018) Henk-Jan Westeneng et al.   LANCET NEUROLOGY

Towards a TDP-43-Based Biomarker for ALS and FTLD

(2018) Emily Feneberg et al.   MOLECULAR NEUROBIOLOGY

Functional and structural damage of neurons by innate immune mechanisms during neurodegeneration

(2018) Christina Ising et al.   Cell Death & Disease

Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies

(2018) Iris Broce et al.   PLOS MEDICINE

Mass spectrometry analysis of plasma from amyotrophic lateral sclerosis and control subjects

(2018) Zhouwei Xu et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Plasma Gelsolin: Indicator of Inflammation and Its Potential as a Diagnostic Tool and Therapeutic Target

(2018) Ewelina Piktel et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Different neuroinflammatory profile in amyotrophic lateral sclerosis and frontotemporal dementia is linked to the clinical phase

(2018) Patrick Oeckl et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Inflammation in ALS/FTD pathogenesis

(2018) Madelyn E. McCauley et al.   ACTA NEUROPATHOLOGICA

Neurofilament light chain in serum for the diagnosis of amyotrophic lateral sclerosis

(2018) Federico Verde et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Tissue-enhanced plasma proteomic analysis for disease stratification in amyotrophic lateral sclerosis

(2018) Irene Zubiri et al.   Molecular Neurodegeneration

STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

(2018) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Machine Learning Reveals Protein Signatures in CSF and Plasma Fluids of Clinical Value for ALS

(2018) Michael S. Bereman et al.   Scientific Reports

Proteomic studies in the discovery of cerebrospinal fluid biomarkers for amyotrophic lateral sclerosis

(2017) Peggy Barschke et al.   Expert Review of Proteomics

Role of Neuroinflammation in Amyotrophic Lateral Sclerosis: Cellular Mechanisms and Therapeutic Implications

(2017) Jia Liu et al.   Frontiers in Immunology

A novel network analysis approach reveals DNA damage, oxidative stress and calcium/cAMP homeostasis-associated biomarkers in frontotemporal dementia

(2017) Fernando Palluzzi et al.   PLoS One

Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation

(2016) Hansen Lui et al.   CELL

The frontotemporal dementia-motor neuron disease continuum

(2016) James R Burrell et al.   LANCET

Amyotrophic lateral sclerosis: moving towards a new classification system

(2016) Ammar Al-Chalabi et al.   LANCET NEUROLOGY

Serum neurofilament light chain protein is a measure of disease intensity in frontotemporal dementia

(2016) Jonathan D. Rohrer et al.   NEUROLOGY

C9orf72 Hexanucleotide Expansions Are Associated with Altered Endoplasmic Reticulum Calcium Homeostasis and Stress Granule Formation in Induced Pluripotent Stem Cell-Derived Neurons from Patients with Amyotrophic Lateral Sclerosis and Frontotemporal Demen

(2016) Ruxandra Dafinca et al.   STEM CELLS

Calcium dysregulation contributes to neurodegeneration in FTLD patient iPSC-derived neurons

(2016) Keiko Imamura et al.   Scientific Reports

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Elevation of the terminal complement activation products C5a and C5b-9 in ALS patient blood

(2014) S. Mantovani et al.   JOURNAL OF NEUROIMMUNOLOGY

TDP-43 Toxicity Proceeds via Calcium Dysregulation and Necrosis in Aging Caenorhabditis elegans Motor Neurons

(2014) D. Aggad et al.   JOURNAL OF NEUROSCIENCE

Frontotemporal dementia and its subtypes: a genome-wide association study

(2014) Raffaele Ferrari et al.   LANCET NEUROLOGY

Systemic metabolism in frontotemporal dementia

(2014) R. M. Ahmed et al.   NEUROLOGY

Elevated levels of cerebrospinal fluid neuron-specific enolase (NSE) in Alzheimer's disease

(2014) Frank Martin Schmidt et al.   NEUROSCIENCE LETTERS

Role for terminal complement activation in amyotrophic lateral sclerosis disease progression

(2014) T. M. Woodruff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Calcium dysregulation and neuroinflammation: Discrete and integrated mechanisms for age-related synaptic dysfunction

(2013) Diana M. Sama et al.   AGEING RESEARCH REVIEWS

Pathophysiological insights into ALS with C9ORF72 expansions

(2013) K. L. Williams et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

A Dramatic Increase of C1q Protein in the CNS during Normal Aging

(2013) A. H. Stephan et al.   JOURNAL OF NEUROSCIENCE

Patterns of microglial cell activation in frontotemporal lobar degeneration

(2013) Suzannah B. Lant et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Role of fibulin-3 in lung cancer: In vivo and in vitro analyses

(2013) SHUN XU et al.   ONCOLOGY REPORTS

Molecular Imaging of Microglial Activation in Amyotrophic Lateral Sclerosis

(2013) Philippe Corcia et al.   PLoS One

Frontotemporal lobar degeneration and amyotrophic lateral sclerosis: Molecular similarities and differences

(2013) M. Neumann   REVUE NEUROLOGIQUE

The Complement System: An Unexpected Role in Synaptic Pruning During Development and Disease

(2012) Alexander H. Stephan et al.   Annual Review of Neuroscience

Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia

(2011) Katya Rascovsky et al.   BRAIN

Combination of neurofilament heavy chain and complement C3 as CSF biomarkers for ALS

(2011) Jeban Ganesalingam et al.   JOURNAL OF NEUROCHEMISTRY

Misfolded superoxide dismutase-1 in CSF from amyotrophic lateral sclerosis patients

(2011) Per Zetterström et al.   JOURNAL OF NEUROCHEMISTRY

Amyotrophic lateral sclerosis

(2011) Matthew C Kiernan et al.   LANCET

Calcium signalling in astroglia

(2011) Alexei Verkhratsky et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

MS3 eliminates ratio distortion in isobaric multiplexed quantitative proteomics

(2011) Lily Ting et al.   NATURE METHODS

BioProfiling.de: analytical web portal for high-throughput cell biology

(2011) A. V. Antonov   NUCLEIC ACIDS RESEARCH

Calcium Control of Neurotransmitter Release

(2011) T. C. Sudhof   Cold Spring Harbor Perspectives in Biology

Calcium Dysregulation and Homeostasis of Neural Calcium in the Molecular Mechanisms of Neurodegenerative Diseases Provide Multiple Targets for Neuroprotection

(2010) Gregor Zündorf et al.   ANTIOXIDANTS & REDOX SIGNALING

Calcium dysregulation in amyotrophic lateral sclerosis

(2010) Julian Grosskreutz et al.   CELL CALCIUM

Gene expression profiling in peripheral blood mononuclear cells from patients with sporadic amyotrophic lateral sclerosis (sALS)

(2010) Rongzhen Zhang et al.   JOURNAL OF NEUROIMMUNOLOGY

Behavioural-variant frontotemporal dementia: diagnosis, clinical staging, and management

(2010) Olivier Piguet et al.   LANCET NEUROLOGY

Extracellular Calcium Controls Background Current and Neuronal Excitability via an UNC79-UNC80-NALCN Cation Channel Complex

(2010) Boxun Lu et al.   NEURON

Focus on molecules: Fibulin-3 (EFEMP1)

(2009) Youwen Zhang et al.   EXPERIMENTAL EYE RESEARCH

FUS mutations in amyotrophic lateral sclerosis: clinical, pathological, neurophysiological and genetic analysis

(2009) I. P. Blair et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY

Combination of affinity depletion of abundant proteins and reversed-phase fractionation in proteomic analysis of human plasma/serum

(2007) Nina Zolotarjova et al.   JOURNAL OF CHROMATOGRAPHY A