Article
Environmental Sciences
Are S. Bruvold, Andre Marcel Bienfait, Torunn Kringlen Ervik, Katrin Loeschner, Stig Valdersnes
Summary: Due to the challenges in detecting and quantifying nanoparticles in seawater, limited data is available on their distributions in the marine environment. A new method utilizing single particle inductively coupled plasma mass spectrometry (SP-ICP-MS) was developed to investigate the horizontal and vertical distributions of inorganic nanoparticles and trace elements in a pristine Norwegian fjord. The method allowed for the determination of individual inorganic nanoparticles at environmentally relevant concentrations. The study found particulate aluminum, iron, manganese, lead, silicon, and titanium in surface sea water.
MARINE ENVIRONMENTAL RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Besnik Muqaku, Patrick Oeckl
Summary: Mass spectrometry is an important technique for analyzing biomolecules, especially in the field of neurodegenerative diseases where peptidomics analysis of cerebrospinal fluid samples has played a crucial role.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yulia A. Maksimova, Alexander S. Dubenskiy, Lyudmila A. Pavlova, Ilya Shigapov, Dmitry M. Korshunov, Irina F. Seregina, Vadim A. Davankov, Mikhail A. Bolshov
Summary: In this paper, a combined procedure for noble metal determination is proposed, which involves fire assay, acid digestion, and reversible dynamic sorptive preconcentration, followed by flow-injection ICP-MS analysis. The reversible preconcentration of noble metals is achieved using a new PVBC-VP sorbent and elution with a specific mixture, resulting in high recovery rates.
Article
Biochemistry & Molecular Biology
Bernhard Michalke, Achim Berthele, Vivek Venkataramani
Summary: Transition metals play an important role in brain metabolism of neurologic healthy patients, showing specific concentration patterns. High molecular weight metal species are decreased in CSF, while certain metal fractions are relatively increased.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Geriatrics & Gerontology
Nicolas Delcourt, Alix-Marie Pouget, Alicia Grivaud, Leonor Nogueira, Frederic Larvor, Philippe Marchand, Eric Schmidt, Bruno Le Bizec
Summary: This study found that PFAS compounds, widely used in various products, are present in human cerebrospinal fluid and are associated with clinical and biological markers of Alzheimer's disease.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ivanilce Cristina Guimaraes, Luis Fernando Tofoli, Alessandra Sussulini
Summary: This study aimed to determine the elemental composition of ready-to-consume ayahuasca samples produced in Brazil and evaluate their safety. The results showed that the elemental concentrations in the samples were lower than the recommended or tolerable limits, indicating safe administration levels of ayahuasca in terms of total elemental content.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Biology
Ivan Dolanc, Lejla Ferhatovic Hamzic, Tatjana Orct, Vedran Micek, Iva Sunic, Antonija Jonjic, Jasna Jurasovic, Sasa Missoni, Miran Coklo, Sandra Kraljevic Pavelic
Summary: Human activities have increased levels of poisonous chemicals, including heavy metals, in the environment. Clinoptilolite, a volcanic stone, can capture heavy metals and be used as a food supplement for detox purposes. Clinical studies have shown its detoxifying, antioxidant, and anti-inflammatory effects. In an experiment with rats, activated clinoptilolite was found to release metallic toxicants from organs to the bloodstream, indicating a detoxification process.
Article
Agriculture, Multidisciplinary
Natalia Platosz, Natalia Baczek, Joanna Topolska, Dorota Szawara-Nowak, Wieslaw Wiczkowski
Summary: This study aimed to verify the ability of different types of anthocyanins to cross the blood-cerebrospinal fluid barrier in sheep. The results showed that the penetration potential of chokeberry anthocyanins was higher than that of red cabbage anthocyanins, which could be largely attributed to the type and number of substituents as well as the size of the molecule.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Geochemistry & Geophysics
Eszter Sendula, Benjamin C. Gill, J. Donald Rimstidt, Tim K. Lowenstein, Mebrahtu F. Weldeghebriel, Javier Garcia-Veigas, Robert J. Bodnar
Summary: Previous studies have confirmed that primary fluid inclusions in halite can record and preserve information about the major ion chemistry of seawater. In this study, the ratios of redox sensitive trace metals in primary fluid inclusions in halite from two boreholes in the Polish sector of the European Southern Permian Basin were determined. The results show that the trace metal abundances in fluid inclusions vary in response to changes in seawater redox conditions, indicating their potential as a redox proxy.
Article
Food Science & Technology
Emanuela Bacchi, Gaetano Cammilleri, Marina Tortorici, Francesco Giuseppe Galluzzo, Licia Pantano, Vittorio Calabrese, Antonio Vella, Andrea Macaluso, Gianluigi Maria Lo Dico, Vincenzo Ferrantelli, Mariagrazia Brunone
Summary: We examined the levels of As, Cr, Cd, and Pb in farmed East Asian bullfrog samples from Vietnam and Thailand using ICP-MS. The results showed high levels of As, with no significant differences between production areas. Cd was not detected in any of the samples, and the Pb concentrations were within the permitted levels set by the European Commission. The Cr and Pb contents were higher in bullfrogs produced in Vietnam compared to Thailand. The consumption of this type of food may pose carcinogenic and non-carcinogenic risks due to the elevated levels of As.
Article
Environmental Sciences
Valentina Cumbo, Francesco Giuseppe Galluzzo, Gaetano Cammilleri, Antonietta Mascetti, Giovanni Lo Cascio, Innocenzo Ezio Giangrosso, Andrea Pulvirenti, Salvatore Seminara, Vincenzo Ferrantelli
Summary: Marine Pollution Monitoring: Calonectris diomedea breeds on Mediterranean islands, and the stomach oil produced may reflect the composition of prey ingested and contaminants uptake.
Feeding Ecology Study: Through the examination of trace elements concentration, variability in trace metals found in stomach oil of Scopoli's shearwater colony on Linosa Island was revealed.
MARINE POLLUTION BULLETIN
(2022)
Article
Chemistry, Analytical
Dong Xiang, Tinghui Zhao, Jue Wang, Yang Cao, Qiuxia Yu, Lu Liu, Hengyi Yu, Xiping Li, Ninghong Li, Yang Yi, Xuepeng Gong
Summary: A sensitive and robust LC-MS/MS method was developed and validated for the quantification of olverembatinib in human plasma and cerebrospinal fluid (CSF). The method involved liquid-liquid extraction and precipitation enrichment for plasma and CSF pretreatment, respectively. The detection was performed by electrospray ionization in a positive ion mode using multiple reaction monitoring. The method proved to be accurate and precise, with a successful application in measuring olverembatinib concentrations in plasma and CSF from chronic myeloid leukemia patients.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Chemistry, Applied
Natalia Platosz, Natalia Baczek, Joanna Topolska, Dorota Szawara-Nowak, Janina Skipor, Stanislaw Milewski, Wieslaw Wiczkowski
Summary: The study found that anthocyanins could penetrate the blood-cerebrospinal fluid barrier in sheep after chokeberry administration, mainly in the form of methylated, glucuronidated, and sulfated derivatives in body fluids. The profile and concentration changes of chokeberry anthocyanins in cerebrospinal fluid were influenced by their fluctuations in blood plasma concentrations, as well as the chemical structure of various cyanidin derivatives present in the CSF.
Article
Biochemistry & Molecular Biology
Federica Romano, Giovanni Iaderosa, Matteo Corana, Stefano Perotto, Giacomo Baima, Federica Di Scipio, Giuliana Abbadessa, Giulia Maria Mariani, Mario Aimetti, Giovanni Nicolao Berta
Summary: This study analyzed the elemental composition of gingival crevicular fluid (GCF) and saliva and found differences in their content that could be used to diagnose periodontitis and periodontal health. GCF showed higher clustering potential than saliva.
Article
Biochemistry & Molecular Biology
Melissa Baerenfaenger, Merel A. Post, Pieter Langerhorst, Karin Huijben, Fokje Zijlstra, Joannes F. M. Jacobs, Marcel M. Verbeek, Hans J. C. T. Wessels, Dirk J. Lefeber
Summary: The glycosylation of proteins plays an important role in neurological development and disease. Glycoproteomic studies on CSF provide valuable insights into brain glycosylation. However, it is important to consider that CSF proteins mainly originate from the blood, not reflecting brain glycosylation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Petr Dusek, Per M. Roos, Tomasz Litwin, Susanne A. Schneider, Trond Peder Flaten, Jan Aaseth
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2015)
Article
Biochemistry & Molecular Biology
Klaus Thanke Aspli, Trond Peder Flaten, Per M. Roos, Trygve Holmoy, Jon H. Skogholt, Jan Aaseth
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2015)
Review
Public, Environmental & Occupational Health
Caroline Ingre, Per M. Roos, Fredrik Piehl, Freya Kamel, Fang Fang
CLINICAL EPIDEMIOLOGY
(2015)
Article
Biochemistry & Molecular Biology
Jan Aaseth, Jan Alexander, Geir Bjorklund, Knut Hestad, Petr Dusek, Per M. Roos, Urban Alehagen
Article
Neurosciences
Ann Tiiman, Jinghui Luo, Cecilia Wallin, Lisa Olsson, Joel Lindgren, Juri Jarvet, Per Roose, Sabrina B. Sholts, Shai Rahimipour, Jan Pieter Abrahams, Amelie Eriksson Karlstrom, Astrid Graslund, Sebastian K. T. S. Warmlander
JOURNAL OF ALZHEIMERS DISEASE
(2016)
Article
Biochemistry & Molecular Biology
Cecilia Wallin, Yashraj S. Kulkarni, Axel Abelein, Juri Jarvet, Qinghua Liao, Birgit Strodel, Lisa Olsson, Jinghui Luo, Jan Pieter Abrahams, Sabrina B. Sholts, Per M. Roos, Shina C. L. Kamerlin, Astrid Graslund, Sebastian K. T. S. Warmlander
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2016)
Article
Clinical Neurology
Elin Roos, Daniela Mariosa, Caroline Ingre, Cecilia Lundholm, Karin Wirdefeldt, Per M. Roos, Fang Fang
Article
Multidisciplinary Sciences
Cecilia Wallin, Sabrina B. Sholts, Nicklas Osterlund, Jinghui Luo, Juri Jarvet, Per M. Roos, Leopold Ilag, Astrid Graslund, Sebastian K. T. S. Warmlander
SCIENTIFIC REPORTS
(2017)
Review
Biochemistry & Molecular Biology
Jan Aaseth, Petr Dusek, Per M. Roos
Article
Biochemistry & Molecular Biology
Per M. Roos, Olof Vesterberg, Tore Syversen, Trond Peder Flaten, Monica Nordberg
BIOLOGICAL TRACE ELEMENT RESEARCH
(2013)
Article
Medicine, Research & Experimental
Per M. Roos, Syverin Lierhagen, Trond Peder Flaten, Tore Syversen, Olof Vesterberg, Monica Nordberg
EXPERIMENTAL BIOLOGY AND MEDICINE
(2012)
Article
Biochemistry & Molecular Biology
Per M. Roos
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2014)
Review
Biochemistry & Molecular Biology
Lassi Koski, Cecilia Ronnevi, Elina Berntsson, Sebastian K. T. S. Warmlander, Per M. Roos
Summary: ALS, Alzheimer's disease, Parkinson's disease and other neurodegenerative disorders have a significant impact on patients, caregivers, and society due to the aggregation of proteins in nerve cells. TDP-43 seems to play a specific role in ALS pathogenesis, and further research is needed on the role of metals in TDP-43 aggregation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Petr Dusek, Tim Hofer, Jan Alexander, Per M. Roos, Jan O. Aaseth
Summary: Disruption of cerebral iron regulation is linked to aging and various neurodegenerative disorders, with iron accumulation potentially causing oxidative stress, ferroptosis, and inflammation. Different diseases display distinct patterns of iron accumulation, implicating inflammatory changes and blood-brain barrier disruption. Strategies to reduce brain iron uptake may be important in preventing neurodegenerative disorders.
Article
Biochemistry & Molecular Biology
Sadia Anjum, Hamile Ali, Faiza Naseer, Maisa S. Abduh, Halima Qadir, Salik Kakar, Yasir Waheed, Tahir Ahmad
Summary: This study demonstrates that avocado and papaya fruit juices can reduce the accumulation of cadmium in the liver, kidney, and hippocampal tissues, and upregulate the expression of antioxidant enzymes while reducing lipid peroxidation. Compared to avocado, papaya has a stronger potential for improving memory and learning, as well as reducing lipid peroxidation in various tissues.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Celio Junior da C. Fernandes, Gerson Santos de Almeida, Patricia Fretes Wood, Anderson M. Gomes, Fabio J. Bezerra, Jose C. S. Vieira, Pedro M. Padilha, Willian F. Zambuzzi
Summary: This study demonstrates the role of mechanosignaling in the promotion of an osteoblastic phenotype in response to zirconia exposure. The release of angiocrine factors modulated by mechanosignaling is crucial in creating a microenvironment that promotes wound healing and osseointegration. These findings highlight the importance of considering endothelial cell mechanosignaling in bone healing and osseointegration in the context of blood vessel effects.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Rehab I. Abdel-Karim, Rania K. Hashish, Dahlia I. Badran, Sally S. Mohammed, Noha A. Salem
Summary: The study found that chlorpyrifos has hepatotoxicity, while cerium oxide nanoparticles can alleviate this toxicity. Cerium oxide nanoparticles can protect the liver by reducing the expression of inflammatory and apoptotic proteins and increasing the activity of antioxidant enzymes.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Tahani El Ayari, Raja Ben Ahmed, Zaineb Hammemi, Abdessalem Kouki, Emna Chelb, Salwa Nechi, Najoua Trigui El Menif
Summary: This study assessed the effects of samarium doped zinc oxide nanoparticles (Sm doped ZnO NPs) on the edible mussel Mytilus galloprovincialis and found that it led to a decrease in filtration rates and histopathological alterations in the gills, digestive glands, and gonads.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Shanshan Niu, Zhangmin Wang, Xuebin Yin, Xiaodong Liu, Liqiang Qin, Muhammad Raza Farooq, Ofori Prince Danso, Zezhou Zhang, Qin Luo, Chenlu Sun, Jiaping Song
Summary: This study investigated the transport of selenium through the soil-crop-human chain in regions with different selenium levels. It found that the residents' dietary selenium intake was related to the selenium content in soil, with one village within the WHO recommended intake range while the other village was at risk of selenium deficiency. There were significant positive correlations between residents' dietary selenium intake and the three selenium biomarkers.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Sanaz Salaramoli, Hamid Reza Joshaghani, Ali Shoeibi, Seyed Isaac Hashemy
Summary: The study suggests that serum levels of selenium and selenoprotein P may serve as biomarkers or risk factors for Parkinson's disease. Additionally, there is a correlation between alpha-synuclein levels and disease stage. Further research is needed to understand the role of selenoprotein S in reducing alpha-synuclein aggregation.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Motozumi Ando, Keiko Suzuki, Riko Kitamoto, Ayako Nakayama, Norio Watanabe, Masami Kawahara
Summary: C57BL/6 mice and BALB/c mice showed different expression profiles of selenoprotein P after a high-fat diet (HFD). C57BL/6 mice in the HFD group had higher body weight, fasting plasma glucose levels, and plasma selenoprotein P levels compared to the ND group. However, BALB/c mice did not show significant differences in fasting plasma selenoprotein P levels between the HFD and ND groups.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Ruihan Song, Huanhuan Chen, Runqing Zhan, Miaomiao Han, Longzhu Zhao, Xiaoli Shen
Summary: This study aims to investigate the protective effects of Vitamin E (Vit E) on manganese (Mn)-induced nigrostriatal system lesions. The results demonstrate that Vit E improves behavioral disorders, attenuates the loss of nigral dopaminergic neurons, and restores mitochondrial function. Additionally, the protective effect of Vit E may be associated with the upregulation of CHRM1 and KCNJ4 mRNA.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Jose Luan da Paixao Teixeira, Ana Paula Rebellato, Maria Isabel Andrekowisk Fioravanti, Raquel Fernanda Milani, Marcelo Antonio Morgano
Summary: The study aimed to determine the total Se content and bioaccessibility in commercial plant-based beverages, with results showing that only one beverage made from organic cashew nuts could meet the recommended Se intake for different populations. High bioacessibility percentages were observed in the beverages.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Andreas F. Lehner, Sarah Rebolloso, Paul P. Calle, Karen Ingerman, Gregory A. Lewbart, Juan Pablo Munoz-Perez, Carlos A. Valle, John P. Buchweitz
Summary: The dried blood spot (DBS) technology is useful for storing blood samples from wildlife, and this study developed methods for measuring several important elements in DBS and used them for health assessments of Galapagos land iguanas. The results showed that the DBS samples accurately reflected the concentrations of various elements compared to plasma samples, with some divergences observed between different species.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Zhou, Chunbei Zhou, Jun Xie, Fei Luo, Ning Yao
Summary: The study illustrates the changes in iodized salt usage, goiter rate, and median urinary iodine concentration in school-aged children in Chongqing over the past 21 years. Adequate iodized salt consumption can eliminate iodine deficiency disorders in children, but excessive iodine intake from salt can lead to high urinary iodine excretion and even goiter. Continuous monitoring and adjustment of iodine fortification levels in household table salt is crucial.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Agustin B. Actis Dato, Valeria R. Martinez, Jorge O. Velez Rueda, Enrique L. Portiansky, Veronica De Giustu, Evelina G. Ferrer, Patricia A. M. Williams
Summary: The zinc coordination complex ZnMD, synthesized in this study, showed promising effects in treating hypertension and cardiac hypertrophy. It was more effective than the antihypertensive drug MD in reducing blood pressure and preventing myocardial hypertrophy. ZnMD also exhibited protective effects on the heart by reducing oxidative damage and regulating the expression of oxidative enzymes. These findings suggest that ZnMD has the potential to be developed as a therapeutic drug for hypertension and cardiac dysfunction.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Mina Sarani, Maryam Roostaee, Mahboubeh Adeli-Sardou, Davood Kalantar-Neyestanaki, Seyed Amin Ayatollahi Mousavi, Azam Amanizadeh, Mahmood Barani, Alireza Amirbeigi
Summary: This study successfully synthesized nano bismuth oxide using green synthesis methods. The nano particles doped with silver and copper demonstrated excellent antibacterial properties and selective cytotoxicity against cancer cells. These findings have important implications for biomedical and therapeutic applications.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Mona Abdel-Rahman, Heba M. Elmasry, Omar A. Ahmed-Farid, Sherein M. Hegazy, Mohamed M. Rezk
Summary: This study investigates the neuro effects of lanthanides on different brain areas in rats and finds that they can distribute and accumulate in various brain regions. Treatment with cerium nanoparticles or lanthanum causes a significant decrease in norepinephrine, dopamine, serotonin, and GABA, accompanied by a significant increase in 5-hydroxyl indoleacetic acid levels. Moreover, cerium nanoparticles exhibit high activity in scavenging free radicals.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Mahshid Deldar Abad Paskeh, Nahid Babaei, Mehrdad Hashemi, Abbas Doosti, Kiavash Hushmandi, Maliheh Entezari, Saeed Samarghandian
Summary: The combination of curcumin, vitamins D and E with Fe2O3-NPs and MnO2-NPs has shown to improve semen parameters and reduce apoptosis in germ cells in rats with testicular hyperthermia. This study suggests that this combination therapy may have a positive effect on fertility and decreasing the toxic effects of nanoparticles.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2024)