Metal ion coordination delays amyloid-β peptide self-assembly by forming an aggregation–inert complex

Structural analysis of copper(I) interaction with amyloid β peptide

(2019) Giuseppe De Gregorio et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Effects of Cu(II) on the aggregation of amyloid-β

(2019) Martina G. M. Weibull et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Mercury and Alzheimer’s Disease: Hg(II) Ions Display Specific Binding to the Amyloid-β Peptide and Hinder Its Fibrillization

(2019) Cecilia Wallin et al.   Biomolecules

Distinct thermodynamic signatures of oligomer generation in the aggregation of the amyloid-β peptide

(2018) Samuel I. A. Cohen et al.   Nature Chemistry

On the role of sidechain size and charge in the aggregation of Aβ42 with familial mutations

(2018) Xiaoting Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulation of electrostatic interactions to reveal a reaction network unifying the aggregation behaviour of the Aβ42 peptide and its variants

(2017) Georg Meisl et al.   Chemical Science

Bri2 BRICHOS client specificity and chaperone activity are governed by assembly state

(2017) Gefei Chen et al.   Nature Communications

Alzheimer’s disease and cigarette smoke components: effects of nicotine, PAHs, and Cd(II), Cr(III), Pb(II), Pb(IV) ions on amyloid-β peptide aggregation

(2017) Cecilia Wallin et al.   Scientific Reports

Thioflavin T as an amyloid dye: fibril quantification, optimal concentration and effect on aggregation

(2017) Christine Xue et al.   Royal Society Open Science

Monomeric Aβ1–40 and Aβ1–42 Peptides in Solution Adopt Very Similar Ramachandran Map Distributions That Closely Resemble Random Coil

(2016) Julien Roche et al.   BIOCHEMISTRY

The Amyloid-β Peptide in Amyloid Formation Processes: Interactions with Blood Proteins and Naturally Occurring Metal Ions

(2016) Cecilia Wallin et al.   ISRAEL JOURNAL OF CHEMISTRY

Specific Binding of Cu(II) Ions to Amyloid-Beta Peptides Bound to Aggregation-Inhibiting Molecules or SDS Micelles Creates Complexes that Generate Radical Oxygen Species

(2016) Ann Tiiman et al.   JOURNAL OF ALZHEIMERS DISEASE

Specific binding modes of Cu(I) and Ag(I) with neurotoxic domain of the human prion protein

(2016) Daniela Valensin et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Ionic Strength Modulation of the Free Energy Landscape of Aβ40 Peptide Fibril Formation

(2016) Axel Abelein et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Characterization of Mn(II) ion binding to the amyloid-β peptide in Alzheimer⿿s disease

(2016) Cecilia Wallin et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Molecular mechanisms of protein aggregation from global fitting of kinetic models

(2016) Georg Meisl et al.   Nature Protocols

Kinetic analysis reveals the diversity of microscopic mechanisms through which molecular chaperones suppress amyloid formation

(2016) Paolo Arosio et al.   Nature Communications

Quantitative analysis of intrinsic and extrinsic factors in the aggregation mechanism of Alzheimer-associated Aβ-peptide

(2016) Georg Meisl et al.   Scientific Reports

XAS Investigation of Silver(I) Coordination in Copper(I) Biological Binding Sites

(2015) Giulia Veronesi et al.   INORGANIC CHEMISTRY

A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers

(2015) Samuel I A Cohen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Zinc as chaperone-mimicking agent for retardation of amyloid β peptide fibril formation

(2015) Axel Abelein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers

(2015) Samuel I A Cohen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Metal Ions and Intrinsically Disordered Proteins and Peptides: From Cu/Zn Amyloid-β to General Principles

(2014) Peter Faller et al.   ACCOUNTS OF CHEMICAL RESEARCH

NMR investigations of metal interactions with unstructured soluble protein domains

(2014) Riccardo De Ricco et al.   COORDINATION CHEMISTRY REVIEWS

The amyloid state and its association with protein misfolding diseases

(2014) Tuomas P. J. Knowles et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The tachykinin peptide neurokinin B binds copper(I) and silver(I) and undergoes quasi-reversible electrochemistry: Towards a new function for the peptide in the brain

(2014) Aidan B. Grosas et al.   NEUROCHEMISTRY INTERNATIONAL

Biometals and Their Therapeutic Implications in Alzheimer’s Disease

(2014) Scott Ayton et al.   Neurotherapeutics

Differences in nucleation behavior underlie the contrasting aggregation kinetics of the Aβ40 and Aβ42 peptides

(2014) Georg Meisl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chemical kinetics for drug discovery to combat protein aggregation diseases

(2014) Paolo Arosio et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Biophysical Studies of the Amyloid β-Peptide: Interactions with Metal Ions and Small Molecules

(2013) Sebastian Wärmländer et al.   CHEMBIOCHEM

Nanobio Silver: Its Interactions with Peptides and Bacteria, and Its Uses in Medicine

(2013) Sonja Eckhardt et al.   CHEMICAL REVIEWS

Role of Metal Ions in the Self-assembly of the Alzheimer’s Amyloid-β Peptide

(2013) Peter Faller et al.   INORGANIC CHEMISTRY

Proliferation of amyloid- 42 aggregates occurs through a secondary nucleation mechanism

(2013) S. I. A. Cohen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Using chemical shift perturbation to characterise ligand binding

(2013) Mike P. Williamson   PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY

The Amyloid State of Proteins in Human Diseases

(2012) David Eisenberg et al.   CELL

Transient small molecule interactions kinetically modulate amyloid β peptide self-assembly

(2012) Axel Abelein et al.   FEBS LETTERS

Metallostasis in Alzheimer's disease

(2012) Scott Ayton et al.   FREE RADICAL BIOLOGY AND MEDICINE

A Label-Free Oligonucleotide Based Thioflavin-T Fluorescent Switch for Ag+ Detection with low Background Emission

(2012) Yongxiang Wang et al.   JOURNAL OF FLUORESCENCE

From Macroscopic Measurements to Microscopic Mechanisms of Protein Aggregation

(2012) Samuel I.A. Cohen et al.   JOURNAL OF MOLECULAR BIOLOGY

Rapid Formation of a Preoligomeric Peptide-Metal-Peptide Complex Following Copper(II) Binding to Amyloid β Peptides

(2011) Jeppe T. Pedersen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Effect of Zinc Binding on β-Amyloid Structure and Dynamics: Implications for Aβ Aggregation

(2011) Nasrollah Rezaei-Ghaleh et al.   BIOPHYSICAL JOURNAL

A modified Stokes-Einstein equation for Aβ aggregation

(2011) Srisairam Achuthan et al.   BMC BIOINFORMATICS

Iron(II) Binding to Amyloid-β, the Alzheimer’s Peptide

(2011) Fatima Bousejra-ElGarah et al.   INORGANIC CHEMISTRY

Nucleated polymerization with secondary pathways. I. Time evolution of the principal moments

(2011) Samuel I. A. Cohen et al.   JOURNAL OF CHEMICAL PHYSICS

Synthesis of a library of oligothiophenes and their utilization as fluorescent ligands for spectral assignment of protein aggregates

(2011) Therése Klingstedt et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Molecular mechanism of Thioflavin-T binding to amyloid fibrils

(2010) Matthew Biancalana et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

N-terminal engineering of amyloid-β-binding Affibody molecules yields improved chemical synthesis and higher binding affinity

(2010) Joel Lindgren et al.   PROTEIN SCIENCE

Amyloid β-Protein Aggregation Produces Highly Reproducible Kinetic Data and Occurs by a Two-Phase Process

(2009) Erik Hellstrand et al.   ACS Chemical Neuroscience

Copper and Zinc Binding to Amyloid-β: Coordination, Dynamics, Aggregation, Reactivity and Metal-Ion Transfer

(2009) Peter Faller   CHEMBIOCHEM

Zn(II)- and Cu(II)-induced non-fibrillar aggregates of amyloid-β (1-42) peptide are transformed to amyloid fibrils, both spontaneously and under the influence of metal chelators

(2009) Vello Tõugu et al.   JOURNAL OF NEUROCHEMISTRY

An Analytical Solution to the Kinetics of Breakable Filament Assembly

(2009) T. P. J. Knowles et al.   SCIENCE

Metal Binding Affinity and Selectivity in Metalloproteins: Insights from Computational Studies

(2008) Todor Dudev et al.   Annual Review of Biophysics

Metals in Alzheimer's and Parkinson's Diseases

(2008) Kevin J Barnham et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Bioinorganic chemistry of copper and zinc ions coordinated to amyloid-β peptide

(2008) Peter Faller et al.   DALTON TRANSACTIONS

Identifying the Minimal Copper- and Zinc-binding Site Sequence in Amyloid-β Peptides

(2008) Velia Minicozzi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY