Mercury and Alzheimer’s Disease: Hg(II) Ions Display Specific Binding to the Amyloid-β Peptide and Hinder Its Fibrillization

Concentration-dependent effects of mercury and lead on Aβ42: possible implications for Alzheimer’s disease

(2019) Daniela Meleleo et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Insights into the Potential Role of Mercury in Alzheimer’s Disease

(2019) Geir Bjørklund et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Native Ion Mobility-Mass Spectrometry reveals the formation of β-barrel shaped Amyloid-β hexamers in a membrane-mimicking environment

(2019) Nicklas Österlund et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Molecular Targets in Alzheimer’s Disease

(2019) Geir Bjørklund et al.   MOLECULAR NEUROBIOLOGY

Metal binding to the amyloid-β peptides in the presence of biomembranes: potential mechanisms of cell toxicity

(2019) Sebastian K. T. S. Wärmländer et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Amyloid-β Peptide Interactions with Amphiphilic Surfactants: Electrostatic and Hydrophobic Effects

(2018) Nicklas Österlund et al.   ACS Chemical Neuroscience

Alzheimer’s disease pathology propagation by exosomes containing toxic amyloid-beta oligomers

(2018) Maitrayee Sardar Sinha et al.   ACTA NEUROPATHOLOGICA

Inorganic mercury in human astrocytes, oligodendrocytes, corticomotoneurons and the locus ceruleus: implications for multiple sclerosis, neurodegenerative disorders and gliomas

(2018) Roger Pamphlett et al.   BIOMETALS

Tau filaments in neurodegenerative diseases

(2018) Michel Goedert   FEBS LETTERS

The Neuronal Tau Protein Blocks in Vitro Fibrillation of the Amyloid-β (Aβ) Peptide at the Oligomeric Stage

(2018) Cecilia Wallin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Zinc ion rapidly induces toxic, off-pathway amyloid-β oligomers distinct from amyloid-β derived diffusible ligands in Alzheimer’s disease

(2018) Ming-Che Lee et al.   Scientific Reports

Oxidative stress and the amyloid beta peptide in Alzheimer’s disease

(2018) C. Cheignon et al.   Redox Biology

Niacin prevents mitochondrial oxidative stress caused by sub-chronic exposure to methylmercury

(2018) Lílian Cristina Pereira et al.   DRUG AND CHEMICAL TOXICOLOGY

Neuroinflammation, Hyperphosphorylated Tau, Diffuse Amyloid Plaques, and Down-Regulation of the Cellular Prion Protein in Air Pollution Exposed Children and Young Adults

(2018) Lilian Calderón-Garcidueñas et al.   JOURNAL OF ALZHEIMERS DISEASE

Clinicopathologic Study of Alzheimer's Disease: Alzheimer Mimics

(2018) Yong S. Shim et al.   JOURNAL OF ALZHEIMERS DISEASE

Mechanisms of Cell-to-Cell Transmission of Pathological Tau

(2018) Garrett S. Gibbons et al.   JAMA Neurology

Membrane-mimetic systems for biophysical studies of the amyloid-β peptide

(2018) Nicklas Österlund et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Ultraclean paired sampling for metal analysis in neurodegenerative disorders

(2018) Per M. Roos   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Prenatal mercury exposure, neurodevelopment and apolipoprotein E genetic polymorphism

(2017) Janja Snoj Tratnik et al.   ENVIRONMENTAL RESEARCH

Strategic roadmap for an early diagnosis of Alzheimer's disease based on biomarkers

(2017) Giovanni B Frisoni et al.   LANCET NEUROLOGY

Mercury exposure and Alzheimer's disease in India - An imminent threat?

(2017) Parthasarathi Chakraborty   SCIENCE OF THE TOTAL ENVIRONMENT

Alzheimer’s disease and cigarette smoke components: effects of nicotine, PAHs, and Cd(II), Cr(III), Pb(II), Pb(IV) ions on amyloid-β peptide aggregation

(2017) Cecilia Wallin et al.   Scientific Reports

Structure and Synaptic Function of Metal Binding to the Amyloid Precursor Protein and its Proteolytic Fragments

(2017) Klemens Wild et al.   Frontiers in Molecular Neuroscience

Cigarette Smoking is a Risk Factor for Alzheimer's Disease: An Analysis Controlling for Tobacco Industry Affiliation

(2017) Janine K. Cataldo et al.   JOURNAL OF ALZHEIMERS DISEASE

Does Inorganic Mercury Play a Role in Alzheimer's Disease? A Systematic Review and an Integrated Molecular Mechanism

(2017) Joachim Mutter et al.   JOURNAL OF ALZHEIMERS DISEASE

Oxidative stress affects processing of amyloid precursor protein in vascular endothelial cells

(2017) Abebe Muche et al.   PLoS One

Reciprocal Molecular Interactions between the Aβ Peptide Linked to Alzheimer’s Disease and Insulin Linked to Diabetes Mellitus Type II

(2016) Jinghui Luo et al.   ACS Chemical Neuroscience

Efficacy of lifestyle interventions on clinical and neuroimaging outcomes in elderly

(2016) Elena Rolandi et al.   AGEING RESEARCH REVIEWS

Monomeric Aβ1–40 and Aβ1–42 Peptides in Solution Adopt Very Similar Ramachandran Map Distributions That Closely Resemble Random Coil

(2016) Julien Roche et al.   BIOCHEMISTRY

Challenges in studying the structures of metal-amyloid oligomers related to type 2 diabetes, Parkinson's disease, and Alzheimer's disease

(2016) Vered Wineman-Fisher et al.   COORDINATION CHEMISTRY REVIEWS

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

A review of toxicity and mechanisms of individual and mixtures of heavy metals in the environment

(2016) Xiangyang Wu et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Association of Seafood Consumption, Brain Mercury Level, and APOE ε4 Status With Brain Neuropathology in Older Adults

(2016) Martha Clare Morris et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Specific Binding of Cu(II) Ions to Amyloid-Beta Peptides Bound to Aggregation-Inhibiting Molecules or SDS Micelles Creates Complexes that Generate Radical Oxygen Species

(2016) Ann Tiiman et al.   JOURNAL OF ALZHEIMERS DISEASE

Cross-interactions between the Alzheimer Disease Amyloid-β Peptide and Other Amyloid Proteins: A Further Aspect of the Amyloid Cascade Hypothesis

(2016) Jinghui Luo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of Mn(II) ion binding to the amyloid-β peptide in Alzheimer⿿s disease

(2016) Cecilia Wallin et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Late running is not too late against Alzheimer's pathology

(2016) Arne Herring et al.   NEUROBIOLOGY OF DISEASE

Chronic exposure to aluminum and risk of Alzheimer’s disease: A meta-analysis

(2016) Zengjin Wang et al.   NEUROSCIENCE LETTERS

Aβ42 assembles into specific β-barrel pore-forming oligomers in membrane-mimicking environments

(2016) Montserrat Serra-Batiste et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Magnetite pollution nanoparticles in the human brain

(2016) Barbara A. Maher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Role of Amyloid-β Oligomers in Toxicity, Propagation, and Immunotherapy

(2016) Urmi Sengupta et al.   EBioMedicine

Nucleus basalis of Meynert revisited: anatomy, history and differential involvement in Alzheimer’s and Parkinson’s disease

(2015) Alan King Lun Liu et al.   ACTA NEUROPATHOLOGICA

Mercury, APOE, and child behavior

(2015) Sharon Ng et al.   CHEMOSPHERE

Silver nanoparticles affect on gene expression of inflammatory and neurodegenerative responses in mouse brain neural cells

(2015) Chin-Lin Huang et al.   ENVIRONMENTAL RESEARCH

Meta-analysis of modifiable risk factors for Alzheimer's disease

(2015) Wei Xu et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Zinc as chaperone-mimicking agent for retardation of amyloid β peptide fibril formation

(2015) Axel Abelein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparison of Metal Levels between Postmortem Brain and Ventricular Fluid in Alzheimer’s Disease and Nondemented Elderly Controls

(2015) Steven T. Szabo et al.   TOXICOLOGICAL SCIENCES

Environmental pollutants as risk factors for neurodegenerative disorders: Alzheimer and Parkinson diseases

(2015) Miguel Chin-Chan et al.   Frontiers in Cellular Neuroscience

Amyloid domains in the cell nucleus controlled by nucleoskeletal protein lamin B1 reveal a new pathway of mercury neurotoxicity

(2015) Florian Arnhold et al.   PeerJ

Smoking and increased Alzheimer's disease risk: A review of potential mechanisms

(2014) Timothy C. Durazzo et al.   Alzheimers & Dementia

Amyloid-β efflux from the central nervous system into the plasma

(2014) Kaleigh Filisa Roberts et al.   ANNALS OF NEUROLOGY

Heavy metals, organic solvents, and multiple sclerosis: An exploratory look at gene-environment interactions

(2014) Melanie D. Napier et al.   Archives of Environmental & Occupational Health

Alzheimer Peptides Aggregate into Transient Nanoglobules That Nucleate Fibrils

(2014) Jinghui Luo et al.   BIOCHEMISTRY

Endogenous Polyamines Reduce the Toxicity of Soluble Aβ Peptide Aggregates Associated with Alzheimer’s Disease

(2014) Jinghui Luo et al.   BIOMACROMOLECULES

Non-chaperone Proteins Can Inhibit Aggregation and Cytotoxicity of Alzheimer Amyloid β Peptide

(2014) Jinghui Luo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The hairpin conformation of the amyloid β peptide is an important structural motif along the aggregation pathway

(2014) Axel Abelein et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Mercury-induced amyloid-beta (Aβ) accumulation in the brain is mediated by disruption of Aβ transport

(2014) Dong-Kyeong Kim et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Potential for primary prevention of Alzheimer's disease: an analysis of population-based data

(2014) Sam Norton et al.   LANCET NEUROLOGY

Exposure to As-, Cd-, and Pb-Mixture Induces Aβ, Amyloidogenic APP Processing and Cognitive Impairments via Oxidative Stress-Dependent Neuroinflammation in Young Rats

(2014) Anushruti Ashok et al.   TOXICOLOGICAL SCIENCES

Role of early life exposure and environment on neurodegeneration: implications on brain disorders

(2014) Shweta Modgil et al.   Translational Neurodegeneration

Cellular Polyamines Promote Amyloid-Beta (Aβ) Peptide Fibrillation and Modulate the Aggregation Pathways

(2013) Jinghui Luo et al.   ACS Chemical Neuroscience

The role of pro-inflammatory S100A9 in Alzheimer’s disease amyloid-neuroinflammatory cascade

(2013) Chao Wang et al.   ACTA NEUROPATHOLOGICA

Serum Trace Metal Levels in Alzheimer’s Disease and Normal Control Groups

(2013) Jun-Hyun Park et al.   American Journal of Alzheimers Disease and Other Dementias

Oxidative stress and mitochondrial dysfunction in Alzheimer's disease

(2013) Xinglong Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Biophysical Studies of the Amyloid β-Peptide: Interactions with Metal Ions and Small Molecules

(2013) Sebastian Wärmländer et al.   CHEMBIOCHEM

Human lysozyme inhibits the in vitro aggregation of Aβ peptides, which in vivo are associated with Alzheimer's disease

(2013) Jinghui Luo et al.   CHEMICAL COMMUNICATIONS

Inhibiting and Reversing Amyloid-β Peptide (1-40) Fibril Formation with Gramicidin S and Engineered Analogues

(2013) Jinghui Luo et al.   CHEMISTRY-A EUROPEAN JOURNAL

Long term neurocognitive impact of low dose prenatal methylmercury exposure in Hong Kong

(2013) Hugh Simon Lam et al.   ENVIRONMENT INTERNATIONAL

Role of Metal Ions in the Self-assembly of the Alzheimer’s Amyloid-β Peptide

(2013) Peter Faller et al.   INORGANIC CHEMISTRY

Why Mercury Prefers Soft Ligands

(2013) Demian Riccardi et al.   Journal of Physical Chemistry Letters

In Vitro and Mechanistic Studies of an Antiamyloidogenic Self-Assembled Cyclic d,l-α-Peptide Architecture

(2013) Michal Richman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Oxidation and methylation of dissolved elemental mercury by anaerobic bacteria

(2013) Haiyan Hu et al.   Nature Geoscience

The missing link in the amyloid cascade of Alzheimer’s disease – Metal ions

(2013) Ann Tiiman et al.   NEUROCHEMISTRY INTERNATIONAL

Mercury, APOE, and children's neurodevelopment

(2013) Sharon Ng et al.   NEUROTOXICOLOGY

Low levels of copper disrupt brain amyloid-β homeostasis by altering its production and clearance

(2013) Itender Singh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Using chemical shift perturbation to characterise ligand binding

(2013) Mike P. Williamson   PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY

Mercury distribution and speciation in different brain regions of beluga whales (Delphinapterus leucas)

(2013) Sonja K. Ostertag et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Epidemiology of Alzheimer Disease

(2013) R. Mayeux et al.   Cold Spring Harbor Perspectives in Medicine

A central role for dityrosine crosslinking of Amyloid-β in Alzheimer’s disease

(2013) Youssra K Al-Hilaly et al.   Acta Neuropathologica Communications

Familial Alzheimer’s Disease Mutations Differentially Alter Amyloid β-Protein Oligomerization

(2012) Megan Murray Gessel et al.   ACS Chemical Neuroscience

Cu(II) Affinity for the Alzheimer’s Peptide: Tyrosine Fluorescence Studies Revisited

(2012) Bruno Alies et al.   ANALYTICAL CHEMISTRY

pH-dependence of the specific binding of Cu(II) and Zn(II) ions to the amyloid-β peptide

(2012) Leila Ghalebani et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ca2+enhances Aβ polymerization rate and fibrillar stability in a dynamic manner

(2012) Kristoffer Brännström et al.   BIOCHEMICAL JOURNAL

The Amyloid State of Proteins in Human Diseases

(2012) David Eisenberg et al.   CELL

Neurodegenerative diseases and exposure to the environmental metals Mn, Pb, and Hg

(2012) Laurent Charlet et al.   COORDINATION CHEMISTRY REVIEWS

Metallostasis in Alzheimer's disease

(2012) Scott Ayton et al.   FREE RADICAL BIOLOGY AND MEDICINE

Engineered non-fluorescent Affibody molecules facilitate studies of the amyloid-beta (Aβ) peptide in monomeric form: Low pH was found to reduce Aβ/Cu(II) binding affinity

(2012) Joel Lindgren et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Nanoprobing of the Effect of Cu2+ Cations on Misfolding, Interaction and Aggregation of Amyloid β Peptide

(2012) Zhengjian Lv et al.   Journal of Neuroimmune Pharmacology

Spreading of Neurodegenerative Pathology via Neuron-to-Neuron Transmission of  -Amyloid

(2012) S. Nath et al.   JOURNAL OF NEUROSCIENCE

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

(2012) Thorlakur Jonsson et al.   NATURE

Traumatic brain injury: A risk factor for Alzheimer's disease

(2012) Thamil Mani Sivanandam et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

The effect of cadmium on Aβ levels in APP/PS1 transgenic mice

(2012) XIAOLING LI et al.   Experimental and Therapeutic Medicine

Mercury-induced toxicity of rat cortical neurons is mediated through N-methyl-D-Aspartate receptors

(2012) Fenglian Xu et al.   Molecular Brain

All-Time Releases of Mercury to the Atmosphere from Human Activities

(2011) David G. Streets et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Transient formation of intermediate conformational states of amyloid-β peptide revealed by heteronuclear magnetic resonance spectroscopy

(2011) Takahiro Yamaguchi et al.   FEBS LETTERS

Metals in alzheimer's disease: a systemic perspective

(2011) Rosanna Squitti   Frontiers in Bioscience-Landmark

Iron(II) Binding to Amyloid-β, the Alzheimer’s Peptide

(2011) Fatima Bousejra-ElGarah et al.   INORGANIC CHEMISTRY

Cerebrospinal fluid/plasma quotients of essential and non-essential metals in patients with Alzheimer’s disease

(2011) Lars Gerhardsson et al.   JOURNAL OF NEURAL TRANSMISSION

The projected effect of risk factor reduction on Alzheimer's disease prevalence

(2011) Deborah E Barnes et al.   LANCET NEUROLOGY

Vascular risk factors promote conversion from mild cognitive impairment to Alzheimer disease

(2011) J. Li et al.   NEUROLOGY

Amyloidogenic Protein-Membrane Interactions: Mechanistic Insight from Model Systems

(2010) Sara M. Butterfield et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mercury(II) promotes the in vitro aggregation of tau fragment corresponding to the second repeat of microtubule-binding domain: Coordination and conformational transition

(2010) Dan-Jing Yang et al.   BIOPOLYMERS

Stabilization of neurotoxic Alzheimer amyloid-  oligomers by protein engineering

(2010) A. Sandberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Zinc ions promote Alzheimer A  aggregation via population shift of polymorphic states

(2010) Y. Miller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

N-terminal engineering of amyloid-β-binding Affibody molecules yields improved chemical synthesis and higher binding affinity

(2010) Joel Lindgren et al.   PROTEIN SCIENCE

In Silico Analysis of the Apolipoprotein E and the Amyloid β Peptide Interaction: Misfolding Induced by Frustration of the Salt Bridge Network

(2010) Jinghui Luo et al.   PLoS Computational Biology

Amyloid β-Protein Aggregation Produces Highly Reproducible Kinetic Data and Occurs by a Two-Phase Process

(2009) Erik Hellstrand et al.   ACS Chemical Neuroscience

Copper and Zinc Binding to Amyloid-β: Coordination, Dynamics, Aggregation, Reactivity and Metal-Ion Transfer

(2009) Peter Faller   CHEMBIOCHEM

Chronic copper exposure exacerbates both amyloid and tau pathology and selectively dysregulates cdk5 in a mouse model of AD

(2009) Masashi Kitazawa et al.   JOURNAL OF NEUROCHEMISTRY

Zn(II)- and Cu(II)-induced non-fibrillar aggregates of amyloid-β (1-42) peptide are transformed to amyloid fibrils, both spontaneously and under the influence of metal chelators

(2009) Vello Tõugu et al.   JOURNAL OF NEUROCHEMISTRY

The Role of Apolipoprotein E in Alzheimer's Disease

(2009) Jungsu Kim et al.   NEURON

Heavy metal ions are potent inhibitors of protein folding

(2008) Sandeep K. Sharma et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Efficiency of Histidine-Associating Compounds for Blocking the Alzheimer's Aβ Channel Activity and Cytotoxicity

(2008) Nelson Arispe et al.   BIOPHYSICAL JOURNAL

Bioinorganic chemistry of copper and zinc ions coordinated to amyloid-β peptide

(2008) Peter Faller et al.   DALTON TRANSACTIONS

Metal Concentrations in Plasma and Cerebrospinal Fluid in Patients with Alzheimer’s Disease

(2008) Lars Gerhardsson et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Exposure to metal ions regulates mRNA levels of APP and BACE1 in PC12 cells: Blockage by curcumin

(2008) Raozhou Lin et al.   NEUROSCIENCE LETTERS

The amyloid  -peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae

(2008) C. A. Hansson Petersen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Binding of zinc(II) and copper(II) to the full-length Alzheimer’s amyloid-β peptide

(2007) Vello Tõugu et al.   JOURNAL OF NEUROCHEMISTRY