Pathogenesis and Treatment of Cytokine Storm Induced by Infectious Diseases

Predictive immunogenetic markers in COVID-19

(2021) Mauro de Meira Leite et al.   HUMAN IMMUNOLOGY

Therapeutic plasma exchange for coronavirus disease-2019 triggered cytokine release syndrome; a retrospective propensity matched control study

(2021) Sultan Mehmood Kamran et al.   PLoS One

TLR9 and COVID-19: A Multidisciplinary Theory of a Multifaceted Therapeutic Target

(2021) Gillina F. G. Bezemer et al.   Frontiers in Pharmacology

IL-1 Receptor Antagonist Anakinra in the Treatment of COVID-19 Acute Respiratory Distress Syndrome: A Retrospective, Observational Study

(2021) Marco Franzetti et al.   JOURNAL OF IMMUNOLOGY

Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19

(2021)   NEW ENGLAND JOURNAL OF MEDICINE

SARS-CoV-2 Disease Adjuvant Therapies and Supplements Breakthrough for the Infection Prevention

(2021) Alessio Danilo Inchingolo et al.   Microorganisms

Combination therapy of Tocilizumab and steroid for management of COVID-19 associated cytokine release syndrome

(2021) Ameet Dravid et al.   MEDICINE

Combination of natural antivirals and potent immune invigorators: A natural remedy to combat COVID ‐19

(2021) Muhammad Ajmal Shah et al.   PHYTOTHERAPY RESEARCH

The Mechanism behind Influenza Virus Cytokine Storm

(2021) Yinuo Gu et al.   Viruses-Basel

Regulatory B cells in infection, inflammation, and autoimmunity

(2020) Subhajit Dasgupta et al.   CELLULAR IMMUNOLOGY

Levels of pro- and anti-inflammatory cytokines in cystic fibrosis patients with or without gingivitis

(2020) Onurcem Duruel et al.   CYTOKINE

Epidemiologic Features and Clinical Course of Patients Infected With SARS-CoV-2 in Singapore

(2020) Barnaby Edward Young et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China

(2020) Dawei Wang et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

An immune-cell signature of bacterial sepsis

(2020) Miguel Reyes et al.   NATURE MEDICINE

Safety of bacteriophage therapy in severe Staphylococcus aureus infection

(2020) Aleksandra Petrovic Fabijan et al.   Nature Microbiology

Immune response to SARS‐CoV‐2 and mechanisms of immunopathological changes in COVID‐19

(2020) Ahmet Kursat Azkur et al.   ALLERGY

Hematological findings and complications of COVID ‐19

(2020) Evangelos Terpos et al.   AMERICAN JOURNAL OF HEMATOLOGY

Weathering the COVID-19 storm: Lessons from hematologic cytokine syndromes

(2020) James T. England et al.   BLOOD REVIEWS

COVID-19: A New Virus, but a Familiar Receptor and Cytokine Release Syndrome

(2020) Toshio Hirano et al.   IMMUNITY

TH17 responses in cytokine storm of COVID-19: An emerging target of JAK2 inhibitor Fedratinib

(2020) Dandan Wu et al.   JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION

COVID-19: consider cytokine storm syndromes and immunosuppression

(2020) Puja Mehta et al.   LANCET

Virological assessment of hospitalized patients with COVID-2019

(2020) Roman Wölfel et al.   NATURE

Effective treatment of severe COVID-19 patients with tocilizumab

(2020) Xiaoling Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytokine release syndrome in severe COVID-19

(2020) John B. Moore et al.   SCIENCE

Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China

(2020) Chaomin Wu et al.   JAMA Internal Medicine

High-Dose Intravenous Immunoglobulin as a Therapeutic Option for Deteriorating Patients With Coronavirus Disease 2019

(2020) Wei Cao et al.   Open Forum Infectious Diseases

Historically controlled comparison of glucocorticoids with or without tocilizumab versus supportive care only in patients with COVID-19-associated cytokine storm syndrome: results of the CHIC study

(2020) Sofia Ramiro et al.   ANNALS OF THE RHEUMATIC DISEASES

Cytokine Storms: Understanding COVID-19

(2020) Nilam Mangalmurti et al.   IMMUNITY

Selective inhibition of interleukin-1 receptor-associated kinase 1 ameliorates lipopolysaccharide-induced sepsis in mice

(2020) Bin Pan et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Anti-IL-6 receptor antibody treatment for severe COVID-19 and the potential implication of IL-6 gene polymorphisms in novel coronavirus pneumonia

(2020) Zulvikar Syambani Ulhaq et al.   MEDICINA CLINICA

Early IL-1 receptor blockade in severe inflammatory respiratory failure complicating COVID-19

(2020) Raphaël Cauchois et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting JAK-STAT Signaling to Control Cytokine Release Syndrome in COVID-19

(2020) Wei Luo et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Apoptotic cell therapy for cytokine storm associated with acute severe sepsis

(2020) Netanel Karbian et al.   Cell Death & Disease

Marked T cell activation, senescence, exhaustion and skewing towards TH17 in patients with COVID-19 pneumonia

(2020) Sara De Biasi et al.   Nature Communications

Intravenous high-dose vitamin C for the treatment of severe COVID-19: study protocol for a multicentre randomised controlled trial

(2020) Fang Liu et al.   BMJ Open

Sepsis-associated severe interleukin-6 storm in critical coronavirus disease 2019

(2020) Lan Huang et al.   Cellular & Molecular Immunology

Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19

(2020) et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

IL-6 serum levels predict severity and response to tocilizumab in COVID-19: An observational study

(2020) José María Galván-Román et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

An inflammatory cytokine signature predicts COVID-19 severity and survival

(2020) Diane Marie Del Valle et al.   NATURE MEDICINE

IL-6 trans-signaling induces plasminogen activator inhibitor-1 from vascular endothelial cells in cytokine release syndrome

(2020) Sujin Kang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes

(2020) Rajendra Karki et al.   CELL

Treg cell therapy: How cell heterogeneity can make the difference

(2020) Giulio Giganti et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Discovery of HIV entry inhibitors via a hybrid CXCR4 and CCR5 receptor pharmacophore‐based virtual screening approach

(2020) Muhammad Usman Mirza et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Toll-like receptors in sepsis-associated cytokine storm and their endogenous negative regulators as future immunomodulatory targets

(2020) V. Kumar   INTERNATIONAL IMMUNOPHARMACOLOGY

Defining IL‐6 levels in healthy individuals: A meta‐analysis

(2020) Elias A. Said et al.   JOURNAL OF MEDICAL VIROLOGY

Cytokine Storm

(2020) David C. Fajgenbaum et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Neutralizing Monoclonal Antibody for Hospitalized Patients with Covid-19

(2020)   NEW ENGLAND JOURNAL OF MEDICINE

Efficacy of therapeutic plasma exchange in the treatment of penn class 3 and 4 cytokine release syndrome complicating COVID-19

(2020) W. Larry Gluck et al.   RESPIRATORY MEDICINE

Putative roles of vitamin D in modulating immune response and immunopathology associated with COVID-19

(2020) Raman Kumar et al.   VIRUS RESEARCH

Development of CpG-adjuvanted stable prefusion SARS-CoV-2 spike antigen as a subunit vaccine against COVID-19

(2020) Tsun-Yung Kuo et al.   Scientific Reports

Influenza infection, SARS, MERS and COVID-19: Cytokine storm – The common denominator and the lessons to be learned

(2020) Varvara A. Ryabkova et al.   CLINICAL IMMUNOLOGY

Inhibition of autophagy protects against sepsis by concurrently attenuating the cytokine storm and vascular leakage

(2019) Liang-Hsuan Lu et al.   JOURNAL OF INFECTION

Gpr174-deficient regulatory T cells decrease cytokine storm in septic mice

(2019) Dongze Qiu et al.   Cell Death & Disease

Diagnostic accuracy of a rapid RT-PCR assay for point-of-care detection of influenza A/B virus at emergency department admission: A prospective evaluation during the 2017/2018 influenza season

(2019) Maxime Maignan et al.   PLoS One

Role of the Innate Cytokine Storm Induced by the Influenza A Virus

(2019) Yinuo Gu et al.   VIRAL IMMUNOLOGY

Effects of early enteral nutrition on Th17/Treg cells and IL-23/IL-17 in septic patients

(2019) Jia-Kui Sun et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) Suppresses Inflammation and Bacterial Clearance during Influenza-Bacterial Super-Infection

(2019) Radha Gopal et al.   Viruses-Basel

IFN-γ drives inflammatory bowel disease pathogenesis through VE-cadherin–directed vascular barrier disruption

(2019) Victoria Langer et al.   JOURNAL OF CLINICAL INVESTIGATION

The primacy of gastrointestinal tract antigen-presenting cells in lethal graft-versus-host disease

(2019) Motoko Koyama et al.   BLOOD

Short or Long Antibiotic Regimes in Orthopaedics (SOLARIO): a randomised controlled open-label non-inferiority trial of duration of systemic antibiotics in adults with orthopaedic infection treated operatively with local antibiotic therapy

(2019) Maria Dudareva et al.   Trials

Metabolic Pathways Involved in Regulatory T Cell Functionality

(2019) Rosalie W. M. Kempkes et al.   Frontiers in Immunology

Plasma proteomics identifies a ‘chemokine storm’ in idiopathic multicentric Castleman disease

(2018) Sheila K. Pierson et al.   AMERICAN JOURNAL OF HEMATOLOGY

Mortality Benefit of Recombinant Human Interleukin-1 Receptor Antagonist for Sepsis Varies by Initial Interleukin-1 Receptor Antagonist Plasma Concentration*

(2018) Nuala J. Meyer et al.   CRITICAL CARE MEDICINE

A guide to chemokines and their receptors

(2018) Catherine E. Hughes et al.   FEBS Journal

Anti-sepsis protection of Xuebijing injection is mediated by differential regulation of pro- and anti-inflammatory Th17 and T regulatory cells in a murine model of polymicrobial sepsis

(2018) Xi Chen et al.   JOURNAL OF ETHNOPHARMACOLOGY

Monocyte-derived IL-1 and IL-6 are differentially required for cytokine-release syndrome and neurotoxicity due to CAR T cells

(2018) Margherita Norelli et al.   NATURE MEDICINE

Exotoxins and endotoxins: Inducers of inflammatory cytokines

(2018) Jean-Marc Cavaillon   TOXICON

Early immune anergy towards recall antigens and mitogens in patients at onset of septic shock

(2018) M. Feuerecker et al.   Scientific Reports

Cytokine release syndrome

(2018) Alexander Shimabukuro-Vornhagen et al.   Journal for ImmunoTherapy of Cancer

The clinical importance of a cytokine network in the acute phase of sepsis

(2018) Hisatake Matsumoto et al.   Scientific Reports

Cytokine release syndrome and neurotoxicity after CD19 chimeric antigen receptor-modified (CAR-) T cell therapy

(2018) Kevin A. Hay   BRITISH JOURNAL OF HAEMATOLOGY

MiR-590-3p Attenuates Acute Kidney Injury by Inhibiting Tumor Necrosis Factor Receptor-Associated Factor 6 in Septic Mice

(2018) Jing Ma et al.   INFLAMMATION

Inflammation induced by influenza virus impairs human innate immune control of pneumococcus

(2018) Simon P. Jochems et al.   NATURE IMMUNOLOGY

Mechanisms Underlying Microbial-Mediated Changes in Social Behavior in Mouse Models of Autism Spectrum Disorder

(2018) Martina Sgritta et al.   NEURON

Cytokine storm and sepsis disease pathogenesis

(2017) Benjamin G. Chousterman et al.   Seminars in Immunopathology

Cytokine storms in infectious diseases

(2017) John R. Teijaro   Seminars in Immunopathology

Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology

(2017) Rudragouda Channappanavar et al.   Seminars in Immunopathology

Review: Cytokine Storm Syndrome: Looking Toward the Precision Medicine Era

(2017) Edward M. Behrens et al.   Arthritis & Rheumatology

Chronic Recurrent Multifocal Osteomyelitis (CRMO): Presentation, Pathogenesis, and Treatment

(2017) Sigrun R. Hofmann et al.   Current Osteoporosis Reports

Dysregulated Type I Interferon and Inflammatory Monocyte-Macrophage Responses Cause Lethal Pneumonia in SARS-CoV-Infected Mice

(2016) Rudragouda Channappanavar et al.   Cell Host & Microbe

Interleukin-1 Receptor Blockade Is Associated With Reduced Mortality in Sepsis Patients With Features of Macrophage Activation Syndrome

(2016) Bita Shakoory et al.   CRITICAL CARE MEDICINE

Immunotherapeutic implications of IL-6 blockade for cytokine storm

(2016) Toshio Tanaka et al.   Immunotherapy

Understanding host–pathogen interaction

(2016) K. Asehnoune et al.   INTENSIVE CARE MEDICINE

Interactions between the microbiota and pathogenic bacteria in the gut

(2016) Andreas J. Bäumler et al.   NATURE

The cytokine storm of severe influenza and development of immunomodulatory therapy

(2015) Qiang Liu et al.   Cellular & Molecular Immunology

Neutrophil trails guide influenza-specific CD8+ T cells in the airways

(2015) K. Lim et al.   SCIENCE

Interleukin-3 amplifies acute inflammation and is a potential therapeutic target in sepsis

(2015) G. F. Weber et al.   SCIENCE

Peptide 19-2.5 Inhibits Heparan Sulfate-Triggered Inflammation in Murine Cardiomyocytes Stimulated with Human Sepsis Serum

(2015) Lukas Martin et al.   PLoS One

Current concepts in the diagnosis and management of cytokine release syndrome

(2014) D. W. Lee et al.   BLOOD

Role of IL-10-Producing Regulatory B Cells in Chronic Hepatitis B Virus Infection

(2014) Yanping Gong et al.   DIGESTIVE DISEASES AND SCIENCES

TLR-2 and TLR-4 expression in monocytes of newborns with late-onset sepsis

(2014) Ana C.C. Redondo et al.   Jornal de Pediatria

The Effects of Oral Antibiotics on Infection Prophylaxis in Traumatic Wounds

(2014) Bulent Erbil et al.   Ulusal Travma ve Acil Cerrahi Dergisi-Turkish Journal of Trauma & Emergency Surgery

Cytokine markers as predictors of type of respiratory infection in patients during the influenza season

(2013) John Patrick Haran et al.   AMERICAN JOURNAL OF EMERGENCY MEDICINE

Targeting the “Cytokine Storm” for Therapeutic Benefit

(2013) Riccardo V. D'Elia et al.   Clinical and Vaccine Immunology

Clinical Findings in 111 Cases of Influenza A (H7N9) Virus Infection

(2013) Hai-Nv Gao et al.   NEW ENGLAND JOURNAL OF MEDICINE

Chimeric Antigen Receptor–Modified T Cells for Acute Lymphoid Leukemia

(2013) Stephan A. Grupp et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structure of the CCR5 Chemokine Receptor-HIV Entry Inhibitor Maraviroc Complex

(2013) Q. Tan et al.   SCIENCE

Early Host Cell Targets of Yersinia pestis during Primary Pneumonic Plague

(2013) Roger D. Pechous et al.   PLoS Pathogens

IL-10-Producing Regulatory B Cells in the Pathogenesis of Chronic Hepatitis B Virus Infection

(2012) A. Das et al.   JOURNAL OF IMMUNOLOGY

Gene expression profiling reveals the defining features of monocytes from septic patients with compensatory anti-inflammatory response syndrome

(2012) Ping-bo Xu et al.   JOURNAL OF INFECTION

Into the Eye of the Cytokine Storm

(2012) J. R. Tisoncik et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

TLR2, TLR4 and the MYD88 Signaling Pathway Are Crucial for Neutrophil Migration in Acute Kidney Injury Induced by Sepsis

(2012) Angela Castoldi et al.   PLoS One

Endothelial Cells Are Central Orchestrators of Cytokine Amplification during Influenza Virus Infection

(2011) John R. Teijaro et al.   CELL

Multiplex cytokine profiling in patients with sepsis

(2010) SIMONA MERA et al.   APMIS

Case Report of a Serious Adverse Event Following the Administration of T Cells Transduced With a Chimeric Antigen Receptor Recognizing ERBB2

(2010) Richard A Morgan et al.   MOLECULAR THERAPY

The safety and side effects of monoclonal antibodies

(2010) Trevor T. Hansel et al.   NATURE REVIEWS DRUG DISCOVERY

Bacteriophages as potential new therapeutics to replace or supplement antibiotics

(2010) Mzia Kutateladze et al.   TRENDS IN BIOTECHNOLOGY

Host–pathogen interactions in sepsis

(2007) Tom van der Poll et al.   LANCET INFECTIOUS DISEASES