Article
Infectious Diseases
Matthew J. Fisher, Luis A. Marcos Raymundo, Melinda Monteforte, Erin M. Taub, Roderick Go
Summary: This study evaluated the clinical outcomes of critically ill COVID-19 patients treated with tocilizumab and found that there was no reduction in mortality associated with tocilizumab treatment. Additionally, there was no observed increased risk of secondary infection in patients given tocilizumab. Further studies are needed to determine the role of tocilizumab in the treatment of COVID-19.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Muhammad Z. Mushtaq, Saad B. Z. Mahmood, Aysha Almas, Syed Ather Wasti, Syed Ahsan Ali
Summary: This study examined the response of tocilizumab in COVID-19 patients by analyzing clinical parameters and inflammatory markers. The results showed that tocilizumab can decrease the need for mechanical ventilation and improve inflammatory markers and neutrophil to lymphocyte ratio. However, it is associated with adverse events including bacterial and fungal infections.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Emna Abidi, Wasim S. El Nekidy, Eman Alefishat, Nadeem Rahman, Georg A. Petroianu, Rania El-Lababidi, Jihad Mallat
Summary: Elevated IL-6 levels play a key role in COVID-19 immune impairment, with tocilizumab being investigated as a potential treatment by targeting IL-6 receptor antagonism. While early observational studies show benefits, subsequent randomized trials have produced conflicting results regarding tocilizumab's efficacy as a standard therapy for COVID-19 pneumonia.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Oncology
Heinz Ludwig, Evangelos Terpos, Niels van de Donk, Maria -Victoria Mateos, Philippe Moreau, Melitios-Athanasios Dimopoulos, Michel Delforge, Paula Rodriguez -Otero, Jesus San-Miguel, Kwee Yong, Francesca Gay, Hermann Einsele, Roberto Mina, Jo Caers, Christoph Driessen, Pellegrino Musto, Sonja Zweegman, Monika Engelhardt, Gordon Cook, Katja Weisel, Annemiek Broijl, Meral Beksac, Jelena Bila, Fredrik Schjesvold, Michele Cavo, Roman Hajek, Cyrille Touzeau, Mario Boccadoro, Pieter Sonneveld
Summary: This Policy Review provides a consensus on the prevention and management of adverse events caused by T-cell redirecting bispecific antibodies (BsAbs) and chimeric antigen receptor T cells (CAR T cells) in multiple myeloma therapy. Recommended measures include premedication, regular assessment of symptoms and severity, step-up dosing, corticosteroids, tocilizumab, and other additional drugs. Preventive measures against infections and treatment of complications are also addressed.
Editorial Material
Biochemistry & Molecular Biology
Randy Q. Cron, Roberto Caricchio, W. Winn Chatham
Summary: Cytokine blockade can improve the survival rate of COVID-19 patients at risk of respiratory failure, with timing and patient selection being crucial factors.
Article
Microbiology
Christian Matthias Zobel, Werner Wenzel, Jan Philipp Krueger, Ulrich Baumgarten, Tobias Wageloehner, Nino Neumann, Behruz Foroutan, Rico Mueller, Annette Mueller, Dominic Rauschning, Meike Schuessler, Lorenz Scheit, Felix Weinreich, Klaas Oltmanns, Franziska Keidel, Maria Koch, Sebastian Spethmann, Maximilian Schreiner
Summary: This observational study included 135 hospitalized patients with COVID-19 pneumonia in four German hospitals. It found that elevated levels of IL-6, PCT, and CRP at hospital admission were significantly associated with a higher risk of ventilator requirement or death within 30 days of symptom onset.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Allergy
Jose Maria Galvan-Roman, Sebastian C. Rodriguez-Garcia, Emilia Roy-Vallejo, Ana Marcos-Jimenez, Santiago Sanchez-Alonso, Carlos Fernandez-Diaz, Ana Alcaraz-Serna, Tamara Mateu-Albero, Pablo Rodriguez-Cortes, Ildefonso Sanchez-Cerrillo, Laura Esparcia, Pedro Martinez-Fleta, Celia Lopez-Sanz, Ligia Gabrie, Luciana del Campo Guerola, Carmen Suarez-Fernandez, Julio Ancochea, Alfonso Canabal, Patricia Albert, Diego A. Rodriguez-Serrano, Juan Mariano Aguilar, Carmen del Arco, Ignacio de los Santos, Lucio Garcia-Fraile, Rafael de la Camara, Jose Maria Serra, Esther Ramirez, Tamara Alonso, Pedro Landete, Joan B. Soriano, Enrique Martin-Gayo, Arturo Fraile Torres, Nelly Daniela Zurita Cruz, Rosario Garcia-Vicuna, Laura Cardenoso, Francisco Sanchez-Madrid, Arantzazu Alfranca, Cecilia Munoz-Calleja, Isidoro Gonzalez-Alvaro
Summary: Baseline IL-6 greater than 30 pg/mL predicts the need for IMV in COVID-19 patients, and early TCZ treatment can improve oxygenation. Patients with high IL-6 not treated with TCZ show high mortality.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Health Care Sciences & Services
Gabriele Melegari, Enrico Giuliani, Chiara Dallai, Lucia Veronesi, Elisabetta Bertellini, Suela Osmenaj, Alberto Barbieri
Summary: This study describes the one-year survival of ICU patients treated with tocilizumab, with results showing a lower one-year mortality rate in the tocilizumab treatment group and a weaker impact on quality of life.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Anna Lebedeva, Ivan Molodtsov, Alexandra Anisimova, Anastasia Berestovskaya, Oleg Dukhin, Antonina Elizarova, Wendy Fitzgerald, Darya Fomina, Kseniya Glebova, Oxana Ivanova, Anna Kalinskaya, Anastasia Lebedeva, Maryana Lysenko, Elena Maryukhnich, Elena Misyurina, Denis Protsenko, Alexander Rosin, Olga Sapozhnikova, Denis Sokorev, Alexander Shpektor, Daria Vorobyeva, Elena Vasilieva, Leonid Margolis
Summary: COVID-19 patients with cytokine storm syndrome (CSS) and those without formed distinct clusters based on their cytokine concentrations. However, the administration of tocilizumab therapy did not fully correspond to these CSS clusters. IL-1RA was found to be prognostically significant in both groups and may be useful in defining the onset of a cytokine storm and indicating anti-cytokine therapy in COVID-19.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Infectious Diseases
Zubia Jamil, Fahad N. Almajhdi, Samreen Khalid, Muhammad Asghar, Jamal Ahmed, Yasir Waheed
Summary: The study compared the effects of different formulations and dosages of steroids on the 30-day in-hospital clinical outcome of patients with severe COVID-19 infection, finding that low-dose Dexamethasone (6 mg/day) was more effective in improving survival outcomes than high-dose Dexamethasone and Methylprednisolone.
Article
Public, Environmental & Occupational Health
Di Hu, Jinpeng Li, Rongfen Gao, Shipei Wang, Qianqian Li, Sichao Chen, Jianglong Huang, Yihui Huang, Man Li, Wei Long, Zeming Liu, Liang Guo, Xiaohui Wu
Summary: This study found a correlation between decreased CO2 levels and increased mortality risk in COVID-19 patients based on clinical data analysis from Leishenshan Hospital in Wuhan. The findings suggest that hyperventilation during mechanical ventilation may be a contributing factor.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Medicine, General & Internal
Antonio Ramon, Marta Zaragoza, Ana Maria Torres, Joaquin Cascon, Pilar Blasco, Javier Milara, Jorge Mateo
Summary: This study aimed to predict poor outcomes in COVID-19 patients treated with tocilizumab using machine learning techniques. The results showed that requiring invasive mechanical ventilation and hyperferritinemia were the main factors predicting worse clinical outcomes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Infectious Diseases
Edmund Huang, Sharon Isonaka, Haoshu Yang, Erin Salce, Elisa Rosales, Stanley C. Jordan
Summary: This retrospective study compared outcomes among critically ill COVID-19 patients treated with tocilizumab and those who were not. The results showed that tocilizumab treatment was associated with lower mortality rates, especially in patients requiring mechanical ventilation.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Hector Corominas, Ivan Castellvi, Virginia Pomar, Rosa Antonijoan, Isabel Mur, Laia Matas, Ignasi Gich, Natividad de Benito, Ana Laiz, Diego Castillo, Laura Villamarin, David Filella, Ana Milena Mill, Maria Angeles Quijada, Mireia Puig, Jordi Casademont, Pere Domingo
Summary: This study assessed the efficacy and safety of tocilizumab in treating COVID-19 patients, showing a potential to prevent acute lung injury and adult respiratory distress syndrome with lower mortality rates. Early administration of IL6-R antagonists may be a safe and effective treatment to prevent ICU admission and further complications in patients with impending hyperinflammatory response.
CLINICAL IMMUNOLOGY
(2021)
Article
Immunology
Jianbo Tian, Ming Zhang, Meng Jin, Fengqin Zhang, Qian Chu, Xiaoyang Wang, Can Chen, Huihui Yue, Li Zhang, Ronghui Du, Dong Zhao, Zhaofu Zeng, Yang Zhao, Kui Liu, Mengmei Wang, Ke Hu, Xiaoping Miao, Huilan Zhang
Summary: This study found that tocilizumab treatment in COVID-19 patients can lower the risk of in-hospital death and acute respiratory distress syndrome. Patients had heightened inflammation and dysregulated immune cells before treatment, but these indicators improved after tocilizumab administration.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Urology & Nephrology
Peter Chang, Andrew A. Wagner, Meredith M. Regan, Joseph A. Smith, Christopher S. Saigal, Mark S. Litwin, Jim C. Hu, Matthew R. Cooperberg, Peter R. Carroll, Eric A. Klein, Adam S. Kibel, Gerald L. Andriole, Misop Han, Alan W. Partin, David P. Wood, Catrina M. Crociani, Thomas K. Greenfield, Dattatraya Patil, Larry A. Hembroff, Kyle Davis, Linda Stork, Daniel E. Spratt, John T. Wei, Martin G. Sanda
Summary: In high-volume academic centers, patients undergoing robot-assisted laparoscopic prostatectomy (RALP) and open radical prostatectomy (ORP) can expect similar long-term health-related quality of life outcomes. Overall, RALP patients experience fewer post-surgical complications, less pain, and shorter hospital stays compared to ORP.
JOURNAL OF UROLOGY
(2022)
Article
Biology
Ziyi Li, Yijian Huang, Dattatraya Patil, Martin G. Sanda
Summary: Continuous biomarkers are commonly used in disease screening and diagnosis. Specificity at a controlled sensitivity level is an important performance metric. Covariate adjustment is crucial in biomarker evaluation. This paper proposes a parsimonious quantile regression model for local modeling, and assesses specificity with covariate-specific control of sensitivity. The proposed method demonstrates computational efficiency and restores the inherent monotonicity in the estimated covariate-adjusted ROC curve.
Article
Urology & Nephrology
Tad A. Manalo, Henry D. Biermann, Dattatraya H. Patil, Akanksha Mehta
Summary: This study explores the temporal association between depression, anxiety, and erectile dysfunction (ED) in young men, revealing a high incidence and prevalence of depression and anxiety in those diagnosed with ED. The research underscores the importance of normalizing mental health screenings and routine psychiatric follow-up in this population. The study also highlights the need for further investigation into the relationship between mental illnesses and ED in younger men.
JOURNAL OF SEXUAL MEDICINE
(2022)
Article
Pediatrics
Charlotte Q. Wu, Emily S. Blum, Dattatraya Patil, H. Stella Shin, Edwin A. Smith
Summary: The study found that the creatinine nadir within 6 weeks after primary valve ablation in infants can predict the severity of childhood chronic kidney disease with high accuracy and acceptability. These findings can be used for patient counseling and risk stratification.
PEDIATRIC NEPHROLOGY
(2022)
Article
Urology & Nephrology
Julie M. Shabto, Dattatraya Patil, Katherine Poulose, Mackenzie P. Bennett, Angel X. Xiao, Heather S. Hipp, Jennifer F. Kawwass, Akanksha Mehta
Summary: This study evaluated the management of male factor infertility in fertility clinics, including website educational content and factors related to referral for urologic evaluation and care. The findings showed that variability in patient-facing education, infertility practice setting, and size influenced access to urologic care for couples with male factor infertility.
Article
Urology & Nephrology
Grace Moxley Saxon, Dattatraya Patil, Jessica Hammett
Summary: The study aimed to determine the prevalence of urologic malignancy in women evaluated for microhematuria and describe the clinical features shared by these women. The results showed that the incidence of urologic malignancy was very low among women with microhematuria, and repeat evaluations had low yield in detecting malignancy for stable microhematuria patients.
Article
Urology & Nephrology
Margaret F. Meagher, Dattatraya Patil, Kazutaka Saito, Juan F. Javier-Desloges, Aaron W. Bradshaw, Sunil H. Patel, Brittney H. Cotta, Yosuke Yasuda, Ahmed Eldefrawy, Fady Ghali, Ryan Nasseri, Fang Wan, Yasuhisa Fujii, Viraj Master, Ithaar H. Derweesh
Summary: This study investigated the association between African-American race and survival in patients with Renal Cell Carcinoma (RCC). The results showed that despite having more indolent histology and lower stage, African-Americans had a greater risk of diminished survival. They had worse overall survival for all stages and worse cancer-specific survival for stage III/IV RCC.
Article
Oncology
Amir Ishaq Khan, Sarah P. Psutka, Dattatraya H. Patil, Gordon Hong, Milton A. Williams, Mehmet A. Bilen, Aarti Sekhar, Haydn T. Kissick, Vikram M. Narayan, Shreyas S. Joshi, Kenneth Ogan, Viraj A. Master
Summary: Sarcopenia and high systemic inflammation are independently associated with poor OS after CN, providing potential use in preoperative risk stratification.
Article
Oncology
Masahiro Toide, Kazutaka Saito, Yosuke Yasuda, Hajime Tanaka, Shohei Fukuda, Dattatraya Patil, Brittney H. Cotta, Sunil H. Patel, Viraj A. Master, Ithaar H. Derweesh, Yasuhisa Fujii
Summary: This study evaluated the prognostic value of C-reactive protein in patients with non-metastatic papillary renal cell carcinoma and found a significant association between C-reactive protein and poor recurrence-free survival. C-reactive protein can serve as a useful adjunct biomarker for screening patients at high risk of recurrence.
CLINICAL GENITOURINARY CANCER
(2022)
Article
Endocrinology & Metabolism
Kerri R. Beckmann, Chris H. Bangma, Jozien Helleman, Anders Bjartell, Peter R. Carroll, Todd Morgan, Daan Nieboer, Aida Santaolalla, Bruce J. Trock, Riccardo Valdagni, Monique J. Roobol
Summary: This study examined the impact of repeat biopsy interval on the risk of prostate cancer upgrading and conversion to treatment during active surveillance. The results suggest that more frequent biopsies may increase the risk of conversion to treatment, but do not affect the risk of upgrading.
Article
Medicine, General & Internal
Eric L. Walton, Timothy P. Quinn, Evan Mulloy, Dattatraya Patil, Akanksha Mehta
Summary: This study compared the trends of intralesional injections and surgical treatment for Peyronie's disease (PD) and assessed the contemporary cost of treatment using Collagenase Clostridium histolyticum (CCH) versus surgical intervention. The results showed that the use of CCH has significantly increased since its FDA approval in 2013, with similar out-of-pocket patient contribution compared to surgical therapy despite higher total treatment costs.
Article
Urology & Nephrology
Mimi Nguyen, Arman Walia, Ava Saidian, Dhruv Puri, Margaret F. Meagher, Kevin Hakimi, Hajime Tanaka, Dattatraya Patil, Yosuke Yasuda, Kazutaka Saito, Sohail Dhanji, Clara Cerrato, Rekha Narasimhan, John Perry, Viraj Master, Yasuhisa Fujii, Ithaar H. Derweesh
Summary: This study evaluated the impact of worsening surgically induced chronic kidney disease on survival outcomes in renal cell carcinoma patients. It found that decline in kidney function was associated with increased all-cause mortality and non-cancer mortality, but not cancer-specific mortality. The decision to preserve nephrons should be individualized based on oncological risk and the risk of functional decline.
Article
Oncology
Benjamin N. Schmeusser, Dattatraya H. Patil, Edouard H. Nicaise, Manuel Armas-Phan, Reza Nebavizadeh, Vikram M. Narayan, Shreyas S. Joshi, Kenneth Ogan, Adeboye O. Osunkoya, Mehmet A. Bilen, Viraj A. Master
Summary: This study externally validated the 2018 Leibovich RCC prognostic model and found optimal performance, especially for clear cell RCC. The results were consistent in a large representation of Black patients. This work is important for ensuring the model's applicability to all patient populations.
Article
Urology & Nephrology
Jonathan Olivier, Weiyu Li, Daan Nieboer, Jozien Helleman, Monique Roobol, Vincent Gnanapragasam, Mark Frydenberg, Mikio Sugimoto, Peter Carroll, Todd M. Morgan, Riccardo Valdagni, Jose Rubio-Briones, Gregoire Robert, Phillip Stricker, Andrew Hayen, Ivo Schoots, Masoom Haider, Caroline M. Moore, Brian Denton, Arnauld Villers
Summary: Patients with suspicious lesions on baseline MRI are more likely to require active treatment, exhibit histological progression, and discontinue AS compared to those without suspicious lesions.
EUROPEAN UROLOGY OPEN SCIENCE
(2022)
Article
Genetics & Heredity
Yu Jiang, Travis J. Meyers, Adaeze A. Emeka, Lauren Folgosa Cooley, Phillip R. Cooper, Nicola Lancki, Irene Helenowski, Linda Kachuri, Daniel W. Lin, Janet L. Stanford, Lisa F. Newcomb, Suzanne Kolb, Antonio Finelli, Neil E. Fleshner, Maria Komisarenko, James A. Eastham, Behfar Ehdaie, Nicole Benfante, Christopher J. Logothetis, Justin R. Gregg, Cherie A. Perez, Sergio Garza, Jeri Kim, Leonard S. Marks, Merdie Delfin, Danielle Barsa, Danny Vesprini, Laurence H. Klotz, Andrew Loblaw, Alexandre Mamedov, S. Larry Goldenberg, Celestia S. Higano, Maria Spillane, Eugenia Wu, H. Ballentine Carter, Christian P. Pavlovich, Mufaddal Mamawala, Tricia Landis, Peter R. Carroll, June M. Chan, Matthew R. Cooperberg, Janet E. Cowan, Todd M. Morgan, Javed Siddiqui, Rabia Martin, Eric A. Klein, Karen Brittain, Paige Gotwald, Daniel A. Barocas, Jeremiah R. Dallmer, Jennifer B. Gordetsky, Pam Steele, Shilajit D. Kundu, Jazmine Stockdale, Monique J. Roobol, Lionne D. F. Venderbos, Martin G. Sanda, Rebecca Arnold, Dattatraya Patil, Christopher P. Evans, Marc A. Dall'Era, Anjali Vij, Anthony J. Costello, Ken Chow, Niall M. Corcoran, Soroush Rais-Bahrami, Courtney Phares, Douglas S. Scherr, Thomas Flynn, R. Jeffrey Karnes, Michael Koch, Courtney Rose Dhondt, Joel B. Nelson, Dawn McBride, Michael S. Cookson, Kelly L. Stratton, Stephen Farriester, Erin Hemken, Walter M. Stadler, Tuula Pera, Deimante Banionyte, Fernando J. Bianco, Isabel H. Lopez, Stacy Loeb, Samir S. Taneja, Nataliya Byrne, Christopher L. Amling, Ann Martinez, Luc Boileau, Franklin D. Gaylis, Jacqueline Petkewicz, Nicholas Kirwen, Brian T. Helfand, Jianfeng Xu, Denise M. Scholtens, William J. Catalona, John S. Witte
Summary: Men diagnosed with low-risk prostate cancer who initially choose active surveillance may eventually convert to active treatment due to genetic factors that predispose to aggressive tumors. This study identified genetic variants associated with conversion from active surveillance to active treatment, suggesting that germline genetics may help individualize management decisions for low-risk prostate cancer.
HUMAN GENETICS AND GENOMICS ADVANCES
(2022)