Article
Medicine, Research & Experimental
Qi-Yue Chen, Xiao-Bo Huang, Ya-Jun Zhao, Hua-Gen Wang, Jia-Bin Wang, Li-Chao Liu, Ling-Qian Wang, Qing Zhong, Jian-Wei Xie, Jian-Xian Lin, Jun Lu, Long-Long Cao, Mi Lin, Ru-Hong Tu, Chao-Hui Zheng, Ping Li, Chang-Ming Huang
Summary: This study identified a decrease in FABP4 expression as a potential marker for gastric cancer (GC) metastasis and poor prognosis. Mechanistically, FABP4 inhibited GC metastasis by binding with PPAR-gamma and suppressing CADM3 transcription. The antidiabetic drug rosiglitazone showed therapeutic potential in restoring PPAR-gamma/CADM3 activation in FABP4-deficient GC cells.
Article
Biochemistry & Molecular Biology
Daiane Boff, Remo Castro Russo, Helena Crijns, Vivian Louise Soares de Oliveira, Matheus Silverio Mattos, Pedro Elias Marques, Gustavo Batista Menezes, Angelica Thomaz Vieira, Mauro Martins Teixeira, Paul Proost, Flavio Almeida Amaral
Summary: This study tested the anti-inflammatory effect of CXCL9(74-103) in Klebsiella pneumoniae-induced pneumonia. The treatment with CXCL9(74-103) reduced neutrophil migration, decreased the production of IL-1 beta, and improved lung function in infected mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Respiratory System
Ivan Ramirez-Moral, Bianca Lima Ferreira, Alex F. de Vos, Tom van der Poll
Summary: PPAR-γ agonist pioglitazone administered 6 or 8 hours after infection with a highly virulent strain of Klebsiella pneumoniae in mice resulted in reduced lung cytokine levels and bacterial growth at 24 hours post-infection, as well as decreased dissemination to distant organs at 42 hours post-infection. These findings suggest that pioglitazone may be a promising agent in the treatment of Klebsiella pneumonia.
RESPIRATORY RESEARCH
(2021)
Article
Medicine, Research & Experimental
Ching-Chun Yang, Chih-Hsing Wu, Ta-Chun Lin, Yi-Ning Cheng, Chin-Sung Chang, Kuo-Ting Lee, Pei-Jane Tsai, Yau-Sheng Tsai
Summary: The study reveals an additional anti-inflammatory role for PPAR gamma in suppressing NLRP3 inflammasome activation through interaction with NLRP3.
Article
Pharmacology & Pharmacy
Jialing Ma, Peng Zeng, Lipei Liu, Mengmeng Zhu, Juan Zheng, Chengyi Wang, Xiaokang Zhao, Wenquan Hu, Xiaoxiao Yang, Yajun Duan, Jihong Han, Qing R. Miao, Yuanli Chen
Summary: This study found that PPAR gamma ligands can enhance the expression of NGBR in the liver and reduce ER stress and inflammation by selectively activating PPAR gamma. These findings reveal the potential mechanism of NGBR in regulating insulin sensitivity.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Karima El-Sayed, Dina A. Ali, Shymaa Ahmed Maher, Dalia Ghareeb, Samy Selim, Sarah Albogami, Eman Fayad, Eman Kolieb
Summary: This study demonstrates that PIO20 provides protection against gentamycin-induced testicular damage, exerting its effects through anti-oxidant, anti-inflammatory, and anti-apoptotic mechanisms.
Article
Pharmacology & Pharmacy
Hui Niu, Tianli Yang, Jin Wang, Rui Wang, Yun Cai
Summary: Pre-administration of colistin can attenuate excessive immune reactions and protect the lungs from MRSA-associated damages, but these effects cannot be reversed solely by blocking the p38/MAPK pathway. Further exploration of the mechanism underlying the immunoregulatory effects of colistin in mammals is necessary.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Peripheral Vascular Disease
Brooke Grimaldi, Hamid-Reza Kohan-Ghadr, Chidambra D. Halari, Pinki Nandi, John C. Kingdom, Sascha Drewlo
Summary: Activation of PPAR gamma in the preeclampsia placenta promotes cell growth and antioxidative stress pathways. Rosiglitazone restores HO1 signaling in a PPAR gamma-dependent manner, offering a potential therapeutic pathway to reverse placental damage and reduce maternal sequelae. Future research should focus on understanding impaired PPAR gamma signaling in the human placenta and identifying safe compounds for preventing severe perinatal morbidity and mortality.
Article
Biochemistry & Molecular Biology
Shao-Ling Huang, Melanie R. Moody, Xing Yin, David D. McPherson, Hyunggun Kim
Summary: Atherosclerosis is a complex disease characterized by pathological changes in the vascular wall. Liposomes loaded with nitric oxide and rosiglitazone were prepared and delivered via intra-arterial administration in a rabbit model of acute arterial injury. The co-delivery system demonstrated anti-inflammatory and anti-proliferative effects, reducing intimal thickening.
Article
Pharmacology & Pharmacy
Xuemei Cao, Min Mao, Junlin Diao, Yi Hou, Hong Su, Yongjun Gan, Jibin Li, Xiaoyong Tong, Chaodong Wu, Zhong Zuo, Xiaoqiu Xiao
Summary: The study showed that the partial agonist CMHX008 had a more beneficial impact on cardiac function and morphology compared to rosiglitazone, as it improved heart function without causing cardiac hypertrophy.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Reproductive Biology
Fariborz Moghadam, Mehdi Hajian, Shiva Rouhollahi Varnosfaderani, Farnoosh Jafarpour, Mohammad Hossein Nasr Esfahani
Summary: The study showed that LPS significantly reduced developmental competence of mouse embryos, while the PPAR gamma agonist RGZ could ameliorate the toxic effect of LPS, and this effect was reversed by the PPARy antagonist GW9662.
Article
Immunology
Hongbo Zhang, Taylor Alford, Shuangquan Liu, Dongming Zhou, Jieru Wang
Summary: Influenza virus infection decreases the expression of PPAR gamma in macrophages, leading to inflammation and lung injury.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Haoshen Feng, Yan Yin, Rui Zheng, Jian Kang
Summary: The study demonstrated that Rosiglitazone significantly alleviated lung inflammation and emphysema induced by cigarette smoke exposure by inhibiting M1 macrophage polarization, mainly through the activation of PPAR gamma and RXR alpha.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Behavioral Sciences
Chenglei Chao, Yinghui Li, Quan Li, Guofeng Wu
Summary: Rosiglitazone attenuates inflammation in intracerebral hemorrhage by inhibiting microglia M1 polarization.
BRAIN AND BEHAVIOR
(2023)
Article
Cell Biology
Mengle Shao, Qianbin Zhang, Ashley Truong, Bo Shan, Lavanya Vishvanath, Lin Li, Patrick Seale, Rana K. Gupta
Summary: The protein-protein interaction between ZFP423 and EBF2 plays a crucial role in maintaining the identity of white adipocytes and preventing browning. Disruption of this interaction leads to widespread browning of WAT. ZFP423 controls the thermogenic plasticity of adipocytes by regulating EBF2 coactivator recruitment and PPAR gamma occupancy.
GENES & DEVELOPMENT
(2021)
Article
Allergy
Jessica Reyes-Angel, Yueh-Ying Han, Franziska Rosser, Erick Forno, Edna Acosta-Perez, Glorisa Canino, Juan C. Celedon
Summary: Unhealthy diet is associated with asthma and severe asthma exacerbations in Puerto Rican youth, but not with changes in lung function.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)
Review
Allergy
Matthew Wong, Erick Forno, Juan C. Celedon
Summary: There is evidence of interactions between obesity and indoor and outdoor pollutants that increase the risk of asthma, but the specific mechanisms need further research. Limited evidence suggests that obesity may affect the impact of depression or anxiety on asthma, while the interactions between obesity and sex hormone levels or dietary patterns are still unclear.
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2022)
Article
Biochemical Research Methods
Manqi Cai, Molin Yue, Tianmeng Chen, Jinling Liu, Erick Forno, Xinghua Lu, Timothy Billiar, Juan Celedon, Chris McKennan, Wei Chen, Jiebiao Wang
Summary: This study focuses on using cellular deconvolution methods to extract cell-type-specific signals from tissue-level omics data. However, different methods produce different results under various real data settings. The study proposes EnsDeconv, an ensemble deconvolution method that synthesizes the results from multiple single deconvolution methods to achieve robust and accurate estimation of cellular fractions.
Article
Allergy
Michael S. Freedman, Erick Forno
Summary: This study aimed to identify early predictive factors associated with pediatric intensive care unit (PICU) admission. The study found that higher heart rates and respiratory rates, and lower SpO2 within the first hour of emergency department (ED) presentation were independently associated with PICU admission. A binary predictive index using 1-hour vitals accurately predicted PICU admission, and in combination with a secondary standardized clinical asthma distress score, the positive predictive value increased significantly.
Editorial Material
Critical Care Medicine
Erick Forno, Paul D. Robinson
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Franziska J. Rosser, Scott D. Rothenberger, Yueh-Ying Han, Erick Forno, Juan C. Celedon
Summary: This study examined the effects of adding the Air Quality Index and recommendations to asthma action plans for children with asthma. The results showed that adding the Air Quality Index led to improved asthma control, but may decrease outdoor activity.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2023)
Article
Critical Care Medicine
Nirav R. Bhakta, Christian Bime, David A. Kaminsky, Meredith C. McCormack, Neeta Thakur, Sanja Stanojevic, Aaron D. Baugh, Lundy Braun, Stephanie Lovinsky-Desir, Rosemary Adamson, Jonathan Witonsky, Robert A. Wise, Sean D. Levy, Robert Brown, Erick Forno, Robyn T. Cohen, Meshell Johnson, John Balmes, Yolanda Mageto, Cathryn T. Lee, Refiloe Masekela, Daniel J. Weiner, Charlie G. Irvin, Erik R. Swenson, Margaret Rosenfeld, Richard M. Schwartzstein, Anurag Agrawal, Enid Neptune, Juan P. Wisnivesky, Victor E. Ortega, Peter Burney
Summary: The use of race and ethnicity in pulmonary function test (PFT) interpretation is being questioned due to concerns of perpetuating false fixed differences between races and masking the effects of differential exposures. The American Thoracic Society (ATS) recommended replacing race and ethnicity-specific reference equations with race-neutral average equations, accompanied by a broader re-evaluation of how PFTs are used in clinical, employment, and insurance decisions. Further research and education are also recommended to better understand the impact of this change and improve the evidence for PFT use.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Allergy
Amanda Gutwein, Yueh-Ying Han, Angel Colon-Semidey, Maria Alvarez, Edna Acosta-Perez, Erick Forno, Glorisa Canino, Andrea Apter, Juan C. Celedon
Summary: This study investigates the association between low parental numeracy and childhood asthma exacerbations. The results show that persistently low parental numeracy is associated with asthma exacerbations in Puerto Rican youth. However, there is no significant correlation between low numeracy and changes in lung function.
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2023)
Article
Pediatrics
Kristina Gaietto, Yueh-Ying Han, Erick Forno, Edna Acosta-Perez, Anna Marsland, Gregory E. Miller, Franziska J. Rosser, Wei Chen, Glorisa Canino, Juan C. Celedon
Summary: Exposure to violence (ETV) and violence-related distress are associated with an increased risk of asthma in children and adolescents with high Th2 immunity. These findings suggest that ETV and violence-related distress may be important determinants of asthma in youth with high Th2 immunity.
PEDIATRIC PULMONOLOGY
(2023)
Article
Multidisciplinary Sciences
Raimon Rios, Thiago Magalhaes da Silva, Agostino Strina, Erick Forno, Ryan Costa, Juan C. Celedon, Mauricio L. Barreto, Camila Alexandrina Figueiredo
Summary: Genetic variants in filaggrin (FLG) are associated with eczema, and the association is modified by African ancestry. The T allele of SNP rs6587666 in FLG is negatively associated with eczema, and this association is influenced by the degree of African ancestry.
Review
Pediatrics
Carlos E. E. Rodriguez-Martinez, Monica P. P. Sossa-Briceno, Erick Forno
Summary: The objective of this review was to systematically identify and evaluate the composite predictive models developed for predicting which children are at high risk for future asthma exacerbations or asthma deterioration. A total of 17 composite predictive models were identified, of which 41.2% fulfilled all the quality criteria. These models can help clinicians identify high-risk children and target specific interventions to prevent exacerbations or deterioration of asthma.
PEDIATRIC PULMONOLOGY
(2023)
Article
Pediatrics
Kristina Gaietto, Nicholas Bergum, Franziska Rosser, Oliver Snyder, Natalia Acevedo-Torres, Leigh Anne DiCicco, Gabriella Butler, Sherry Rauenswinter, Jennifer Iagnemma, David Wolfson, Yueh-Ying Han, Traci M. Kazmerski, Erick Forno
Summary: This study aimed to determine the association of COVID-19 variant waves with asthma exacerbations in children. The proportion of children with asthma experiencing an asthma exacerbation was higher during the Omicron wave compared to prior waves. These findings provide additional support for vaccination and prevention efforts.
PEDIATRIC PULMONOLOGY
(2023)
Meeting Abstract
Critical Care Medicine
F. J. Rosser, Y. Han, S. D. Rothenberger, E. Forno, J. C. Celedon
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Meeting Abstract
Critical Care Medicine
S. Kim, E. Forno, Z. Xu, M. Yue, H. Park, Q. Yan, M. L. Manni, E. Acosta-Perez, G. Canino, W. Chen, J. C. Celedon
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Meeting Abstract
Critical Care Medicine
Z. Xu, E. Forno, Y. Han, M. L. Manni, W. Chen, J. C. Celedon
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)