Targeting of NLRP3 inflammasome with gene editing for the amelioration of inflammatory diseases

A Single Administration of CRISPR/Cas9 Lipid Nanoparticles Achieves Robust and Persistent In Vivo Genome Editing

(2018) Jonathan D. Finn et al.   Cell Reports

Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders

(2017) Hua Jiang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing

(2017) Hao Yin et al.   NATURE BIOTECHNOLOGY

Unexpected mutations after CRISPR–Cas9 editing in vivo

(2017) Kellie A Schaefer et al.   NATURE METHODS

Delivery technologies for genome editing

(2017) Hao Yin et al.   NATURE REVIEWS DRUG DISCOVERY

Hit-and-run programming of therapeutic cytoreagents using mRNA nanocarriers

(2017) H. F. Moffett et al.   Nature Communications

Nanoparticle delivery of Cas9 ribonucleoprotein and donor DNA in vivo induces homology-directed DNA repair

(2017) Kunwoo Lee et al.   Nature Biomedical Engineering

Artificial Virus Delivers CRISPR-Cas9 System for Genome Editing of Cells in Mice

(2016) Ling Li et al.   ACS Nano

Non-Viral CRISPR/Cas Gene Editing In Vitro and In Vivo Enabled by Synthetic Nanoparticle Co-Delivery of Cas9 mRNA and sgRNA

(2016) Jason B. Miller et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Tumor acidity-sensitive linkage-bridged block copolymer for therapeutic siRNA delivery

(2016) Cong-Fei Xu et al.   BIOMATERIALS

Deletion ofNlrp3Augments Survival during Polymicrobial Sepsis by Decreasing Autophagy and Enhancing Phagocytosis

(2016) Liliang Jin et al.   JOURNAL OF IMMUNOLOGY

CRISPR gene-editing tested in a person for the first time

(2016) David Cyranoski   NATURE

Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo

(2016) Hao Yin et al.   NATURE BIOTECHNOLOGY

Mechanism and Regulation of NLRP3 Inflammasome Activation

(2016) Yuan He et al.   TRENDS IN BIOCHEMICAL SCIENCES

Chromatin-remodelling factor Brg1 regulates myocardial proliferation and regeneration in zebrafish

(2016) Chenglu Xiao et al.   Nature Communications

Self-Assembled DNA Nanoclews for the Efficient Delivery of CRISPR-Cas9 for Genome Editing

(2015) Wujin Sun et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Dopamine Controls Systemic Inflammation through Inhibition of NLRP3 Inflammasome

(2015) Yiqing Yan et al.   CELL

In vivo genome editing using Staphylococcus aureus Cas9

(2015) F. Ann Ran et al.   NATURE

Principles of nanoparticle design for overcoming biological barriers to drug delivery

(2015) Elvin Blanco et al.   NATURE BIOTECHNOLOGY

The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease

(2015) Yun-Hee Youm et al.   NATURE MEDICINE

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

(2015) Rebecca C Coll et al.   NATURE MEDICINE

Inflammasomes: mechanism of action, role in disease and therapeutics

(2015) Haitao Guo et al.   NATURE MEDICINE

The isolation of an RNA aptamer targeting to p53 protein with single amino acid mutation

(2015) Liang Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vivo gene editing in dystrophic mouse muscle and muscle stem cells

(2015) M. Tabebordbar et al.   SCIENCE

In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy

(2015) C. E. Nelson et al.   SCIENCE

Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo

(2014) John A Zuris et al.   NATURE BIOTECHNOLOGY

CRISPR-Cas systems for editing, regulating and targeting genomes

(2014) Jeffry D Sander et al.   NATURE BIOTECHNOLOGY

Nanoparticles encapsulating hepatitis B virus cytosine-phosphate-guanosine induce therapeutic immunity against HBV infection

(2013) Shujuan Lv et al.   HEPATOLOGY

Mechanisms of NOD-like Receptor-Associated Inflammasome Activation

(2013) Haitao Wen et al.   IMMUNITY

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

RNA-Guided Human Genome Engineering via Cas9

(2013) P. Mali et al.   SCIENCE

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

PEGylated PRINT Nanoparticles: The Impact of PEG Density on Protein Binding, Macrophage Association, Biodistribution, and Pharmacokinetics

(2012) Jillian L. Perry et al.   NANO LETTERS

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases

(2012) Charles A. Dinarello et al.   NATURE REVIEWS DRUG DISCOVERY

NLRP3 inflammasome induces chemotactic immune cell migration to the CNS in experimental autoimmune encephalomyelitis

(2012) M. Inoue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

(2012) M. Jinek et al.   SCIENCE

The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases

(2011) Beckley K. Davis et al.   Annual Review of Immunology

The effect of surface charge on in vivo biodistribution of PEG-oligocholic acid based micellar nanoparticles

(2011) Kai Xiao et al.   BIOMATERIALS

Systemic delivery of siRNA with cationic lipid assisted PEG-PLA nanoparticles for cancer therapy

(2011) Xian-Zhu Yang et al.   JOURNAL OF CONTROLLED RELEASE

Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

(2011) Haitao Wen et al.   NATURE IMMUNOLOGY

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

NLRP3 inflammasomes link inflammation and metabolic disease

(2011) Dominic De Nardo et al.   TRENDS IN IMMUNOLOGY

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Strategies in the design of nanoparticles for therapeutic applications

(2010) Robby A. Petros et al.   NATURE REVIEWS DRUG DISCOVERY

The Inflammasomes: Guardians of the Body

(2009) Fabio Martinon et al.   Annual Review of Immunology

Glyburide inhibits the Cryopyrin/Nalp3 inflammasome

(2009) Mohamed Lamkanfi et al.   JOURNAL OF CELL BIOLOGY

IL-1 trap go-ahead

(2008) Mark Ratner   NATURE BIOTECHNOLOGY