The ECM: To Scaffold, or Not to Scaffold, That Is the Question

Oxygen-Releasing Biomaterials: Current Challenges and Future Applications

(2021) Niels G.A. Willemen et al.   TRENDS IN BIOTECHNOLOGY

Engineering organoids

(2021) Moritz Hofer et al.   Nature Reviews Materials

Human pluripotent stem cell-derived alveolar organoids for modeling pulmonary fibrosis and drug testing

(2021) Jung-Hyun Kim et al.   Cell Death Discovery

Organotypic 3D decellularized matrix tumor spheroids for high-throughput drug screening

(2021) Luís P. Ferreira et al.   BIOMATERIALS

Biomaterial-Assisted Regenerative Medicine

(2021) Teruki Nii et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Synthetic extracellular matrices with tailored adhesiveness and degradability support lumen formation during angiogenic sprouting

(2021) Jifeng Liu et al.   Nature Communications

Extra Cellular Matrix Deposition and Assembly in Dermis Spheroids

(2021) Francesca Rescigno et al.   Clinical Cosmetic and Investigational Dermatology

Human pluripotent stem cell-derived cartilaginous organoids promote scaffold-free healing of critical size long bone defects

(2021) Wai Long Tam et al.   Stem Cell Research & Therapy

Pre-culture of Mesenchymal Stem Cells within RGD-modified Hyaluronic Acid Hydrogel Improves their Resilience to Ischaemic Conditions

(2020) Laura B. Gallagher et al.   Acta Biomaterialia

Integrin Signaling in Glioma Pathogenesis: From Biology to Therapy

(2020) Aleksandra Ellert-Miklaszewska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Osteopontin up-regulates Col IV expression through repressing miR-29a in human retinal capillary endothelial cells

(2020) Ping Duan et al.   Molecular Therapy-Nucleic Acids

Growth Factor Engineering Strategies for Regenerative Medicine Applications

(2020) Xiaochen Ren et al.   Frontiers in Bioengineering and Biotechnology

Three-dimensional bioprinted hepatorganoids prolong survival of mice with liver failure

(2020) Huayu Yang et al.   GUT

Laminin-511 and α6 integrins regulate the expression of CXCR4 to promote endothelial morphogenesis

(2020) Hao Xu et al.   JOURNAL OF CELL SCIENCE

CRISPR screens in cancer spheroids identify 3D growth-specific vulnerabilities

(2020) Kyuho Han et al.   NATURE

Human-scale lung regeneration based on decellularized matrix scaffolds as a biologic platform

(2020) Keiji Ohata et al.   SURGERY TODAY

Development of a tunable method to generate various three-dimensional microstructures by replenishing macromolecules such as extracellular matrix components and polysaccharides

(2020) Fumiya Tao et al.   Scientific Reports

Synthetic alternatives to Matrigel

(2020) Elizabeth A. Aisenbrey et al.   Nature Reviews Materials

Angiogenesis in Tissue Engineering: As Nature Intended?

(2020) Valeria Mastrullo et al.   Frontiers in Bioengineering and Biotechnology

Synthetic ECM: Bioactive synthetic hydrogels for 3D tissue engineering

(2020) Asli Unal et al.   BIOCONJUGATE CHEMISTRY

Organoid Models of Tumor Immunology

(2020) Kanako Yuki et al.   TRENDS IN IMMUNOLOGY

High-throughput automated organoid culture via stem-cell aggregation in microcavity arrays

(2020) Nathalie Brandenberg et al.   Nature Biomedical Engineering

3D Cell Culture Models Demonstrate a Role for FGF and WNT Signaling in Regulation of Lung Epithelial Cell Fate and Morphogenesis

(2020) Anas Rabata et al.   Frontiers in Cell and Developmental Biology

Human Lung Adenocarcinoma-Derived Organoid Models for Drug Screening

(2020) Zhichao Li et al.   iScience

The role of integrins in inflammation and angiogenesis

(2020) Olachi J. Mezu-Ndubuisi et al.   PEDIATRIC RESEARCH

Three-Dimensional Culture System of Cancer Cells Combined with Biomaterials for Drug Screening

(2020) Teruki Nii et al.   Cancers

Cellular extrusion bioprinting improves kidney organoid reproducibility and conformation

(2020) Kynan T. Lawlor et al.   NATURE MATERIALS

Tumour-associated macrophages drive stromal cell-dependent collagen crosslinking and stiffening to promote breast cancer aggression

(2020) Ori Maller et al.   NATURE MATERIALS

Soluble matrix protein is a potent modulator of mesenchymal stem cell performance

(2019) Giselle C. Yeo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tissue Engineering: Then, Now and the Future

(2019) Arnold I Caplan   TISSUE ENGINEERING PART A

Cell population balance of cardiovascular spheroids derived from human induced pluripotent stem cells

(2019) Yuanwei Yan et al.   Scientific Reports

Fine tuning the extracellular environment accelerates the derivation of kidney organoids from human pluripotent stem cells

(2019) Elena Garreta et al.   NATURE MATERIALS

Nuclear ERK: Mechanism of Translocation, Substrates, and Role in Cancer

(2019) Galia Maik-Rachline et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Integrin Signaling in Cancer: Mechanotransduction, Stemness, Epithelial Plasticity, and Therapeutic Resistance

(2019) Jonathan Cooper et al.   CANCER CELL

Oral mucosal organoids as a potential platform for personalized cancer therapy

(2019) Else Driehuis et al.   Cancer Discovery

Application of Cancer Organoid Model for Drug Screening and Personalized Therapy

(2019) Jumpei Kondo et al.   Cells

Targeting the complexity of Src signalling in the tumour microenvironment of pancreatic cancer: from mechanism to therapy

(2019) Ashleigh Parkin et al.   FEBS Journal

The Hippo Pathway, YAP/TAZ, and the Plasma Membrane

(2019) Valentina Rausch et al.   TRENDS IN CELL BIOLOGY

Advances in Biomaterials for Drug Delivery

(2018) Owen S. Fenton et al.   ADVANCED MATERIALS

The extracellular matrix as a key regulator of intracellular signalling networks

(2018) Jordan F Hastings et al.   BRITISH JOURNAL OF PHARMACOLOGY

Involvement of Advanced Glycation End Products in the Pathogenesis of Diabetic Retinopathy

(2018) Jing Xu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Multi-size spheroid formation using microfluidic funnels

(2018) M. Marimuthu et al.   LAB ON A CHIP

Injectable Hydrogels for Cardiac Tissue Engineering

(2018) Brisa Peña et al.   MACROMOLECULAR BIOSCIENCE

The WNT signaling pathways in wound healing and fibrosis

(2018) Olivier Burgy et al.   MATRIX BIOLOGY

Extracellular matrix-driven congenital muscular dystrophies

(2018) Payam Mohassel et al.   MATRIX BIOLOGY

The Synergy of Scaffold-Based and Scaffold-Free Tissue Engineering Strategies

(2018) Aleksandr Ovsianikov et al.   TRENDS IN BIOTECHNOLOGY

The Microwell-mesh: A high-throughput 3D prostate cancer spheroid and drug-testing platform

(2018) E. O. Mosaad et al.   Scientific Reports

Scaffold-free trachea regeneration by tissue engineering with bio-3D printing†

(2018) Daisuke Taniguchi et al.   Interactive Cardiovascular and Thoracic Surgery

Identification of a novel anoikis signalling pathway using the fungal virulence factor gliotoxin

(2018) Florian Haun et al.   Nature Communications

Improved phosphoproteomic analysis for phosphosignaling and active-kinome profiling in Matrigel-embedded spheroids and patient-derived organoids

(2018) Yuichi Abe et al.   Scientific Reports

Cellular response to collagen-elastin composite materials

(2018) Daniel V. Bax et al.   Acta Biomaterialia

YAP/TAZ Signaling as a Molecular Link between Fibrosis and Cancer

(2018) Satoshi Noguchi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hippo–YAP/TAZ signalling in organ regeneration and regenerative medicine

(2018) Iván M. Moya et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A reproducible scaffold-free 3D organoid model to study neoplastic progression in breast cancer

(2018) Sabra I. Djomehri et al.   Journal of Cell Communication and Signaling

Patterned cell and matrix dynamics in branching morphogenesis

(2017) Shaohe Wang et al.   JOURNAL OF CELL BIOLOGY

Life is 3D: Boosting Spheroid Function for Tissue Engineering

(2017) Matthias W. Laschke et al.   TRENDS IN BIOTECHNOLOGY

Targeting the Tumor Stroma: the Biology and Clinical Development of Pegylated Recombinant Human Hyaluronidase (PEGPH20)

(2017) Kit Man Wong et al.   Current Oncology Reports

Phase I Clinical Trial of Autologous Stem Cell–Sheet Transplantation Therapy for Treating Cardiomyopathy

(2017) Shigeru Miyagawa et al.   Journal of the American Heart Association

Recellularization of decellularized heart valves: Progress toward the tissue-engineered heart valve

(2017) Mitchell C VeDepo et al.   Journal of Tissue Engineering

A micro-architecturally biomimetic collagen template for mesenchymal condensation based cartilage regeneration

(2016) Mousa Younesi et al.   Acta Biomaterialia

Novel human hepatic organoid model enables testing of drug-induced liver fibrosis in vitro

(2016) Sofia B. Leite et al.   BIOMATERIALS

Extracellular matrix-based biomaterial scaffolds and the host response

(2016) Joseph M. Aamodt et al.   BIOMATERIALS

A Three-Dimensional Organoid Culture System Derived from Human Glioblastomas Recapitulates the Hypoxic Gradients and Cancer Stem Cell Heterogeneity of Tumors Found In Vivo

(2016) Christopher G. Hubert et al.   CANCER RESEARCH

Modeling Development and Disease with Organoids

(2016) Hans Clevers   CELL

Extracellular matrix motion and early morphogenesis

(2016) Rajprasad Loganathan et al.   DEVELOPMENT

Fibroblast spheroids as a model to study sustained fibroblast quiescence and their crosstalk with tumor cells

(2016) Pertteli Salmenperä et al.   EXPERIMENTAL CELL RESEARCH

Alterations in the epithelial stem cell compartment could contribute to permanent changes in the mucosa of patients with ulcerative colitis

(2016) Isabella Dotti et al.   GUT

Designer matrices for intestinal stem cell and organoid culture

(2016) Nikolce Gjorevski et al.   NATURE

A practical guide to hydrogels for cell culture

(2016) Steven R Caliari et al.   NATURE METHODS

TGF-β: the master regulator of fibrosis

(2016) Xiao-ming Meng et al.   Nature Reviews Nephrology

Delivery of Human Adipose Stem Cells Spheroids into Lockyballs

(2016) Karina R. Silva et al.   PLoS One

Zika virus impairs growth in human neurospheres and brain organoids

(2016) P. P. Garcez et al.   SCIENCE

Characterizing responses to CFTR-modulating drugs using rectal organoids derived from subjects with cystic fibrosis

(2016) Johanna F. Dekkers et al.   Science Translational Medicine

Physiologically Low Oxygen Enhances Biomolecule Production and Stemness of Mesenchymal Stem Cell Spheroids

(2016) Emily Shearier et al.   TISSUE ENGINEERING PART C-METHODS

3D Bioprinting of Spatially Heterogeneous Collagen Constructs for Cartilage Tissue Engineering

(2016) Stephanie Rhee et al.   ACS Biomaterials-Science & Engineering

3D Bioprinting of Spatially Heterogeneous Collagen Constructs for Cartilage Tissue Engineering

(2016) Stephanie Rhee et al.   ACS Biomaterials Science & Engineering

Designing hydrogels for controlled drug delivery

(2016) Jianyu Li et al.   Nature Reviews Materials

Three Dimensional Human Neuro-Spheroid Model of Alzheimer’s Disease Based on Differentiated Induced Pluripotent Stem Cells

(2016) Han-Kyu Lee et al.   PLoS One

Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease

(2016) Catherine C. Bell et al.   Scientific Reports

FOXG1-Dependent Dysregulation of GABA/Glutamate Neuron Differentiation in Autism Spectrum Disorders

(2015) Jessica Mariani et al.   CELL

The endoderm and myocardium join forces to drive early heart tube assembly

(2015) Anastasiia Aleksandrova et al.   DEVELOPMENTAL BIOLOGY

Adhesion to fibronectin regulates Hippo signaling via the FAK–Src–PI3K pathway

(2015) Nam-Gyun Kim et al.   JOURNAL OF CELL BIOLOGY

Pivotal preclinical trial of the spheroid reservoir bioartificial liver

(2015) Jaime M. Glorioso et al.   JOURNAL OF HEPATOLOGY

Cell-sized condensed collagen microparticles for preparing microengineered composite spheroids of primary hepatocytes

(2015) Masumi Yamada et al.   LAB ON A CHIP

Sequential cancer mutations in cultured human intestinal stem cells

(2015) Jarno Drost et al.   NATURE

Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell– and patient-derived tumor organoids

(2015) Ling Huang et al.   NATURE MEDICINE

Tension tests on mammalian collagen fibrils

(2015) Yehe Liu et al.   Interface Focus

Switching between self-renewal and lineage commitment of human induced pluripotent stem cells via cell–substrate and cell–cell interactions on a dendrimer-immobilized surface

(2014) Mee-Hae Kim et al.   BIOMATERIALS

Enhanced reseeding of decellularized rodent lungs with mouse embryonic stem cells

(2014) Shimon Lecht et al.   BIOMATERIALS

Matrix as an Interstitial Transport System

(2014) Dong Fan et al.   CIRCULATION RESEARCH

The Hippo-YAP signaling pathway and contact inhibition of growth

(2014) Barry M. Gumbiner et al.   JOURNAL OF CELL SCIENCE

Conformational remodeling of the fibronectin matrix selectively regulates VEGF signaling

(2014) A. Ambesi et al.   JOURNAL OF CELL SCIENCE

Integrins and epithelial cell polarity

(2014) Jessica L. Lee et al.   JOURNAL OF CELL SCIENCE

Biology of the Extracellular Matrix

(2014) Beatrice Yue   JOURNAL OF GLAUCOMA

A Novel Proteolytic Cascade Generates an Extracellular Matrix-Derived Chemoattractant in Chronic Neutrophilic Inflammation

(2014) A. Gaggar et al.   JOURNAL OF IMMUNOLOGY

Remodelling the extracellular matrix in development and disease

(2014) Caroline Bonnans et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Extracellular Matrix Modulates Angiogenesis in Physiological and Pathological Conditions

(2014) Anna Neve et al.   Biomed Research International

25th Anniversary Article: Rational Design and Applications of Hydrogels in Regenerative Medicine

(2013) Nasim Annabi et al.   ADVANCED MATERIALS

Anoikis molecular pathways and its role in cancer progression

(2013) Paolo Paoli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Enhancement of tenogenic differentiation of human adipose stem cells by tendon-derived extracellular matrix

(2013) Guang Yang et al.   BIOMATERIALS

Three-dimensional assembly of tissue-engineered cartilage constructs results in cartilaginous tissue formation without retainment of zonal characteristics

(2013) W. Schuurman et al.   Journal of Tissue Engineering and Regenerative Medicine

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

Spheroid culture as a tool for creating 3D complex tissues

(2013) Eelco Fennema et al.   TRENDS IN BIOTECHNOLOGY

Functional Diversity of Laminins

(2012) Anna Domogatskaya et al.   Annual Review of Cell and Developmental Biology

Mechanical Properties of the Extracellular Matrix of the Aorta Studied by Enzymatic Treatments

(2012) Jan-Willem M. Beenakker et al.   BIOPHYSICAL JOURNAL

Sonic Hedgehog–Modified Human CD34+ Cells Preserve Cardiac Function After Acute Myocardial Infarction

(2012) Alexander R. Mackie et al.   CIRCULATION RESEARCH

Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis

(2012) B. Zhao et al.   GENES & DEVELOPMENT

Mechanisms of fibrosis: therapeutic translation for fibrotic disease

(2012) Thomas A Wynn et al.   NATURE MEDICINE

Analysis of Adhesion Molecules and Basement Membrane Contributions to Synaptic Adhesion at the Drosophila Embryonic NMJ

(2012) Andre Koper et al.   PLoS One

Imaging Key Biomarkers of Tumor Angiogenesis

(2012) Marina V. Backer et al.   Theranostics

Skin tissue engineering — In vivo and in vitro applications

(2011) Florian Groeber et al.   ADVANCED DRUG DELIVERY REVIEWS

The effect of matrix stiffness on the differentiation of mesenchymal stem cells in response to TGF-β

(2011) Jennifer S. Park et al.   BIOMATERIALS

Extracellular matrix and cell signalling: the dynamic cooperation of integrin, proteoglycan and growth factor receptor

(2011) Soo-Hyun Kim et al.   JOURNAL OF ENDOCRINOLOGY

Mechanisms by Which the Extracellular Matrix and Integrin Signaling Act to Regulate the Switch Between Tumor Suppression and Tumor Promotion

(2011) Patricia J. Keely   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma

(2011) J. D. Arroyo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular Matrix Degradation and Remodeling in Development and Disease

(2011) P. Lu et al.   Cold Spring Harbor Perspectives in Biology

Hierarchically Assembled Mesenchymal Stem Cell Spheroids Using Biomimicking Nanofilaments and Microstructured Scaffolds for Vascularized Adipose Tissue Engineering

(2010) Taek Gyoung Kim et al.   ADVANCED FUNCTIONAL MATERIALS

Enhanced proteolytic degradation of molecularly engineered PEG hydrogels in response to MMP-1 and MMP-2

(2010) J. Patterson et al.   BIOMATERIALS

Basement membrane components are key players in specialized extracellular matrices

(2010) Jenny Kruegel et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Dynamic interplay between the collagen scaffold and tumor evolution

(2010) Mikala Egeblad et al.   CURRENT OPINION IN CELL BIOLOGY

The extracellular matrix at a glance

(2010) C. Frantz et al.   JOURNAL OF CELL SCIENCE

Matrigel: A complex protein mixture required for optimal growth of cell culture

(2010) Chris S. Hughes et al.   PROTEOMICS

Development of porous PEG hydrogels that enable efficient, uniform cell-seeding and permit early neural process extension

(2009) R.M. Namba et al.   Acta Biomaterialia

Homogeneous and organized differentiation within embryoid bodies induced by microsphere-mediated delivery of small molecules

(2009) Richard L. Carpenedo et al.   BIOMATERIALS

The effect of mean pore size on cell attachment, proliferation and migration in collagen–glycosaminoglycan scaffolds for bone tissue engineering

(2009) Ciara M. Murphy et al.   BIOMATERIALS

Integrins

(2009) Malgorzata Barczyk et al.   CELL AND TISSUE RESEARCH

Type VII Collagen: The Anchoring Fibril Protein at Fault in Dystrophic Epidermolysis Bullosa

(2009) Hye Jin Chung et al.   DERMATOLOGIC CLINICS

The extracellular matrix in development and morphogenesis: A dynamic view

(2009) Tania Rozario et al.   DEVELOPMENTAL BIOLOGY

Nemosis, a novel way of fibroblast activation, in inflammation and cancer

(2009) Antti Vaheri et al.   EXPERIMENTAL CELL RESEARCH

Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment

(2009) Zachary T. Schafer et al.   NATURE

Extracellular Matrix Molecules: Potential Targets in Pharmacotherapy

(2009) H. Jarvelainen et al.   PHARMACOLOGICAL REVIEWS

The Extracellular Matrix: Not Just Pretty Fibrils

(2009) R. O. Hynes   SCIENCE

Extracellular matrix as a biological scaffold material: Structure and function

(2008) S BADYLAK et al.   Acta Biomaterialia

Formation and activation of fibroblast spheroids depend on fibronectin–integrin interaction

(2008) Pertteli Salmenperä et al.   EXPERIMENTAL CELL RESEARCH

Tissue engineering: strategies, stem cells and scaffolds

(2008) Daniel Howard et al.   JOURNAL OF ANATOMY

Mechanical and Failure Properties of Extracellular Matrix Sheets as a Function of Structural Protein Composition

(2007) Lauren D. Black et al.   BIOPHYSICAL JOURNAL