Emerging Role of TCA Cycle-Related Enzymes in Human Diseases

Mitochondrial DNA alterations underlie an irreversible shift to aerobic glycolysis in fumarate hydratase–deficient renal cancer

(2021) Daniel R. Crooks et al.   Science Signaling

Sperm-oocyte interplay: an overview of spermatozoon’s role in oocyte activation and current perspectives in diagnosis and fertility treatment

(2021) Mohammad Ishraq Zafar et al.   Cell and Bioscience

Gut microbial metabolites facilitate anticancer therapy efficacy by modulating cytotoxic CD8+ T cell immunity

(2021) Yao He et al.   Cell Metabolism

High CO2 levels drive the TCA cycle backwards towards autotrophy

(2021) Lydia Steffens et al.   NATURE

Highly accurate protein structure prediction with AlphaFold

(2021) John Jumper et al.   NATURE

Highly accurate protein structure prediction for the human proteome

(2021) Kathryn Tunyasuvunakool et al.   NATURE

Acetyl-CoA is produced by the citrate synthase homology module of ATP-citrate lyase

(2021) Kenneth Verstraete et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis

(2021) Daniel M. Kremer et al.   Nature Communications

Mitochondria: From Physiology to Pathology

(2021) Francesco Bruni   Life-Basel

Phospholipase C‐zeta levels are not correlated with fertilisation rates in infertile couples

(2021) Duru Aras‐Tosun et al.   ANDROLOGIA

Mitochondrial TCA cycle metabolites control physiology and disease

(2020) Inmaculada Martínez-Reyes et al.   Nature Communications

Dopamine-induced calcium signaling in olfactory bulb astrocytes

(2020) Timo Fischer et al.   Scientific Reports

The oxidative fumarase FumC is a key contributor for E. coli fitness under iron-limitation and during UTI

(2020) Stephanie D. Himpsl et al.   PLoS Pathogens

Mitochondrial aconitase controls adipogenesis through mediation of cellular ATP production

(2020) Yan Chen et al.   FASEB JOURNAL

Alteration of the Dopamine Receptors’ Expression in the Cerebellum of the Lysosomal Acid Phosphatase 2 Mutant (Naked–Ataxia (NAX)) Mouse

(2020) Mehdi Mehdizadeh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

IP3 mediated global Ca2+ signals arise through two temporally and spatially distinct modes of Ca2+ release

(2020) Jeffrey T Lock et al.   eLife

Thermal adaptation in the honeybee (Apis mellifera) via changes to the structure of malate dehydrogenase

(2020) Thitipan Meemongkolkiat et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Calcineurin

(2020) Trevor P. Creamer   Cell Communication and Signaling

The emerging role of targeting cancer metabolism for cancer therapy

(2020) Pegah Farhadi et al.   TUMOR BIOLOGY

The Mitochondrial Ca2+ Uptake and the Fine-Tuning of Aerobic Metabolism

(2020) Gaia Gherardi et al.   Frontiers in Physiology

Role of Sodium/Calcium Exchangers in Tumors

(2020) Barbora Chovancova et al.   Biomolecules

Macrophage ATP citrate lyase deficiency stabilizes atherosclerotic plaques

(2020) Jeroen Baardman et al.   Nature Communications

The role of glutamate oxaloacetate transaminases in sulfite biosynthesis and H2S metabolism

(2020) Anna-Theresa Mellis et al.   Redox Biology

The path toward using microbial metabolites as therapies

(2019) Hélène C. Descamps et al.   EBioMedicine

MDH1 deficiency is a metabolic disorder of the malate–aspartate shuttle associated with early onset severe encephalopathy

(2019) Melissa H. Broeks et al.   HUMAN GENETICS

Understanding the Mechanism of [4Fe-4S] Cluster Assembly on Eukaryotic Mitochondrial and Cytosolic Aconitase

(2019) Christine Wachnowsky et al.   INORGANIC CHEMISTRY

Extra-mitochondrial citrate synthase initiates calcium oscillation and suppresses age-dependent sperm dysfunction

(2019) Woojin Kang et al.   LABORATORY INVESTIGATION

Signaling and Regulation Through the NAD+ and NADP+ Networks

(2018) Ilmo E. Hassinen   ANTIOXIDANTS & REDOX SIGNALING

ME1 Regulates NADPH Homeostasis to Promote Gastric Cancer Growth and Metastasis

(2018) Yun-Xin Lu et al.   CANCER RESEARCH

Mitochondrial Aconitase in Neurodegenerative Disorders: Role of a Metabolism- related Molecule in Neurodegeneration

(2018) Fariba Khodagholi et al.   CURRENT DRUG TARGETS

Ca2+ Regulation of TRP Ion Channels

(2018) Raquibul Hasan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A primordial and reversible TCA cycle in a facultatively chemolithoautotrophic thermophile

(2018) Takuro Nunoura et al.   SCIENCE

Sperm-borne phospholipase C zeta-1 ensures monospermic fertilization in mice

(2018) Kaori Nozawa et al.   Scientific Reports

SDHA mutated paragangliomas may be at high risk of metastasis

(2017) Nicola Tufton et al.   ENDOCRINE-RELATED CANCER

A synergistic role of IRP1 and FBXL5 proteins in coordinating iron metabolism during cell proliferation

(2017) Nathan B. Johnson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intracellular calcium release channels: an update

(2017) Gaetano Santulli et al.   JOURNAL OF PHYSIOLOGY-LONDON

Intracellular Ca 2+ Sensing: Its Role in Calcium Homeostasis and Signaling

(2017) Rafaela Bagur et al.   MOLECULAR CELL

Plasma metabolomics reveals a diagnostic metabolic fingerprint for mitochondrial aconitase (ACO2) deficiency

(2017) Lucia Abela et al.   PLoS One

The Cerebellum: Adaptive Prediction for Movement and Cognition

(2017) Arseny A. Sokolov et al.   TRENDS IN COGNITIVE SCIENCES

Calcium influx and sperm-evoked calcium responses during oocyte maturation and egg activation

(2017) Ya-Ru Xu et al.   Oncotarget

Inhibition of malic enzyme 1 disrupts cellular metabolism and leads to vulnerability in cancer cells in glucose-restricted conditions

(2017) S Murai et al.   Oncogenesis

Sulfate radicals enable a non-enzymatic Krebs cycle precursor

(2017) Markus A. Keller et al.   Nature Ecology & Evolution

Metals promote sequences of the reverse Krebs cycle

(2017) Kamila B. Muchowska et al.   Nature Ecology & Evolution

TCA Cycle and Mitochondrial Membrane Potential Are Necessary for Diverse Biological Functions

(2016) Inmaculada Martínez-Reyes et al.   MOLECULAR CELL

Egg Activation at Fertilization by a Soluble Sperm Protein

(2016) Karl Swann et al.   PHYSIOLOGICAL REVIEWS

FUM2, a Cytosolic Fumarase, Is Essential for Acclimation to Low Temperature in Arabidopsis thaliana

(2016) Beth C. Dyson et al.   PLANT PHYSIOLOGY

The Warburg Effect: How Does it Benefit Cancer Cells?

(2016) Maria V. Liberti et al.   TRENDS IN BIOCHEMICAL SCIENCES

Identification of a novel inactivating mutation in Isocitrate Dehydrogenase 1 (IDH1-R314C) in a high grade astrocytoma

(2016) Sanne A. M. van Lith et al.   Scientific Reports

How cardiomyocyte excitation, calcium release and contraction become altered with age

(2015) Hirad A. Feridooni et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Expression and properties of the mitochondrial and cytosolic forms of fumarase in germinating maize seeds

(2014) Alexander T. Eprintsev et al.   PHYSIOLOGIA PLANTARUM

Calcium Influx and Male Fertility in the Context of the Sperm Proteome: An Update

(2014) Md Saidur Rahman et al.   Biomed Research International

The role of complex II in disease

(2012) Attje S. Hoekstra et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Calcium influx-mediated signaling is required for complete mouse egg activation

(2012) Y.-L. Miao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fusion and Fission: Interlinked Processes Critical for Mitochondrial Health

(2011) David C. Chan   Annual Review of Genetics

Extramitochondrial tricarboxylic acid cycle in retinal rod outer segments

(2011) Isabella Panfoli et al.   BIOCHIMIE

Revisiting the TCA cycle: signaling to tumor formation

(2011) Nuno Raimundo et al.   TRENDS IN MOLECULAR MEDICINE

The transient receptor potential family of ion channels

(2011) Bernd Nilius et al.   GENOME BIOLOGY

Both Forward and Reverse TCA Cycles Operate in Green Sulfur Bacteria

(2010) Kuo-Hsiang Tang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Single cell analysis: the new frontier in ‘omics’

(2010) Daojing Wang et al.   TRENDS IN BIOTECHNOLOGY

Calcium Oscillations

(2010) G. Dupont et al.   Cold Spring Harbor Perspectives in Biology

Fumarase: A Mitochondrial Metabolic Enzyme and a Cytosolic/Nuclear Component of the DNA Damage Response

(2010) Ohad Yogev et al.   PLOS BIOLOGY

Mitochondrial calcium as a key regulator of mitochondrial ATP production in mammalian cells

(2009) Elinor J. Griffiths et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Kinetic and Equilibrium Properties of Regulatory Calcium Sensors of NCX1 Protein

(2009) Liron Boyman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The triad of paragangliomas, gastric stromal tumours and pulmonary chondromas (Carney triad), and the dyad of paragangliomas and gastric stromal sarcomas (Carney-Stratakis syndrome): molecular genetics and clinical implications

(2009) C. A. Stratakis et al.   JOURNAL OF INTERNAL MEDICINE

Calcium signaling and neurodegenerative diseases

(2009) Ilya Bezprozvanny   TRENDS IN MOLECULAR MEDICINE

The Warburg Effect: Why and How Do Cancer Cells Activate Glycolysis in the Presence of Oxygen?

(2008) Miguel Lopez-Lazaro   Anti-Cancer Agents in Medicinal Chemistry

Differential metabolic consequences of fumarate hydratase and respiratory chain defects

(2008) Nuno Raimundo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Aging: An important factor for the pathogenesis of neurodegenerative diseases

(2008) Tahira Farooqui et al.   MECHANISMS OF AGEING AND DEVELOPMENT