Ca2+ Regulation of TRP Ion Channels

A Novel Mechanism for Calmodulin-Dependent Inactivation of Transient Receptor Potential Vanilloid 6

(2018) Neil Bate et al.   BIOCHEMISTRY

TRPM4 and TRPM5 are both required for normal signaling in taste receptor cells

(2018) Debarghya Dutta Banik et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A TRP channel trio mediates acute noxious heat sensing

(2018) Ine Vandewauw et al.   NATURE

Structure of the human TRPM4 ion channel in a lipid nanodisc

(2017) Henriette E. Autzen et al.   SCIENCE

Regulation of Pain and Itch by TRP Channels

(2017) Carlene Moore et al.   Neuroscience Bulletin

Calmodulin is responsible for Ca2+-dependent regulation of TRPA1 Channels

(2017) Raquibul Hasan et al.   Scientific Reports

G protein βγ subunits inhibit TRPM3 ion channels in sensory neurons

(2017) Talisia Quallo et al.   eLife

Inhibition of Transient Receptor Potential Melastatin 3 ion channels by G-protein βγ subunits

(2017) Doreen Badheka et al.   eLife

Anti-nociceptive action of peripheral mu-opioid receptors by G-beta-gamma protein-mediated inhibition of TRPM3 channels

(2017) Sandeep Dembla et al.   eLife

Structural studies of the C-terminal tail of polycystin-2 (PC2) reveal insights into the mechanisms used for the functional regulation of PC2

(2016) Yifei Yang et al.   JOURNAL OF PHYSIOLOGY-LONDON

Phospholipase C δ4 regulates cold sensitivity in mice

(2016) Yevgen Yudin et al.   JOURNAL OF PHYSIOLOGY-LONDON

The TRPM2 ion channel is required for sensitivity to warmth

(2016) Chun-Hsiang Tan et al.   NATURE

Crystal structure of the epithelial calcium channel TRPV6

(2016) Kei Saotome et al.   NATURE

The TRPM2 channel is a hypothalamic heat sensor that limits fever and can drive hypothermia

(2016) K. Song et al.   SCIENCE

The role of TRPMLs in endolysosomal trafficking and function

(2015) Kartik Venkatachalam et al.   CELL CALCIUM

Molecular sensors and modulators of thermoreception

(2015) Xuming Zhang   Channels

GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation

(2015) Makoto Shigeto et al.   JOURNAL OF CLINICAL INVESTIGATION

Tmem100 Is a Regulator of TRPA1-TRPV1 Complex and Contributes to Persistent Pain

(2015) Hao-Jui Weng et al.   NEURON

A channelopathy mechanism revealed by direct calmodulin activation of TrpV4

(2015) Stephen H. Loukin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Towards a Unified Theory of Calmodulin Regulation (Calmodulation) of Voltage-Gated Calcium and Sodium Channels

(2015) Manu Ben-Johny et al.   Current Molecular Pharmacology

Conservation of Ca2+/Calmodulin Regulation across Na and Ca2+ Channels

(2014) Manu Ben-Johny et al.   CELL

Negatively Charged Amino Acids Near and in Transient Receptor Potential (TRP) Domain of TRPM4 Channel Are One Determinant of Its Ca2+Sensitivity

(2014) Soichiro Yamaguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Determinants of Phosphatidylinositol 4,5-Bisphosphate (PI(4,5)P2) Binding to Transient Receptor Potential V1 (TRPV1) Channels

(2014) Horacio Poblete et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Basal Thermal Sensitivity of the TRPV1 Ion Channel Is Determined by PKC II

(2014) L. Li et al.   JOURNAL OF NEUROSCIENCE

Targeting TRP ion channels for itch relief

(2014) Xuming Zhang   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

A dynamic set point for thermal adaptation requires phospholipase C-mediated regulation of TRPM8 in vivo

(2014) Daniel S. Brenner et al.   PAIN

Acute Heat-Evoked Temperature Sensation Is Impaired but Not Abolished in Mice Lacking TRPV1 and TRPV3 Channels

(2014) Irène Marics et al.   PLoS One

Preassociated apocalmodulin mediates Ca2+-dependent sensitization of activation and inactivation of TMEM16A/16B Ca2+-gated Cl−channels

(2014) Tingting Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRPV4 channel activity is modulated by direct interaction of the ankyrin domain to PI(4,5)P2

(2014) Nobuaki Takahashi et al.   Nature Communications

TRP Channels and Pain

(2013) David Julius   Annual Review of Cell and Developmental Biology

What do we know about the transient receptor potential vanilloid 2 (TRPV2) ion channel?

(2013) Alex Perálvarez-Marín et al.   FEBS Journal

Interplay between Calmodulin and Phosphatidylinositol 4,5-Bisphosphate in Ca2+-induced Inactivation of Transient Receptor Potential Vanilloid 6 Channels

(2013) Chike Cao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinctive Changes in Plasma Membrane Phosphoinositides Underlie Differential Regulation of TRPV1 in Nociceptive Neurons

(2013) V. Lukacs et al.   JOURNAL OF NEUROSCIENCE

TRPV3: time to decipher a poorly understood family member!

(2013) Bernd Nilius et al.   JOURNAL OF PHYSIOLOGY-LONDON

Structure of the TRPV1 ion channel determined by electron cryo-microscopy

(2013) Maofu Liao et al.   NATURE

TRPA1: A Gatekeeper for Inflammation

(2012) Diana M. Bautista et al.   Annual Review of Physiology

C-terminal Acidic Cluster Is Involved in Ca2+-induced Regulation of Human Transient Receptor Potential Ankyrin 1 Channel

(2012) Lucie Sura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calmodulin and S100A1 Protein Interact with N Terminus of TRPM3 Channel

(2012) Blanka Holakovska et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calcium-induced Conformational Changes in C-terminal Tail of Polycystin-2 Are Necessary for Channel Gating

(2012) Andjelka S. Ćelić et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct properties of Ca2+–calmodulin binding to N- and C-terminal regulatory regions of the TRPV1 channel

(2012) Sze-Yi Lau et al.   JOURNAL OF GENERAL PHYSIOLOGY

TRP Vanilloid 2 Knock-Out Mice Are Susceptible to Perinatal Lethality But Display Normal Thermal and Mechanical Nociception

(2011) U. Park et al.   JOURNAL OF NEUROSCIENCE

Decrease in phosphatidylinositol 4,5-bisphosphate levels mediates desensitization of the cold sensor TRPM8 channels

(2011) Yevgen Yudin et al.   JOURNAL OF PHYSIOLOGY-LONDON

Molecular Mechanisms of Calmodulin Action on TRPV5 and Modulation by Parathyroid Hormone

(2011) T. de Groot et al.   MOLECULAR AND CELLULAR BIOLOGY

TRPV3 and TRPV4 Ion Channels are Not Major Contributors to Mouse Heat Sensation

(2011) Susan M Huang et al.   Molecular Pain

TRPM3 Is a Nociceptor Channel Involved in the Detection of Noxious Heat

(2011) Joris Vriens et al.   NEURON

Cytoplasmic ankyrin repeats of transient receptor potential A1 (TRPA1) dictate sensitivity to thermal and chemical stimuli

(2011) J. F. Cordero-Morales et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The transient receptor potential family of ion channels

(2011) Bernd Nilius et al.   GENOME BIOLOGY

Characterization of calmodulin binding domains in TRPV2 and TRPV5 C-tails

(2010) Blanka Holakovska et al.   AMINO ACIDS

PP2B/calcineurin-mediated desensitization of TRPV1 does not require AKAP150

(2010) Elaine D. Por et al.   BIOCHEMICAL JOURNAL

TRPV4-mediated channelopathies

(2010) Pratibha Verma et al.   Channels

Lack of TRPM2 Impaired Insulin Secretion and Glucose Metabolisms in Mice

(2010) K. Uchida et al.   DIABETES

Ca2+-Dependent Desensitization of TRPV2 Channels Is Mediated by Hydrolysis of Phosphatidylinositol 4,5-Bisphosphate

(2010) J. Mercado et al.   JOURNAL OF NEUROSCIENCE

TRPV2 has a pivotal role in macrophage particle binding and phagocytosis

(2010) Tiffany M Link et al.   NATURE IMMUNOLOGY

Interdomain Interactions Control Ca2+-Dependent Potentiation in the Cation Channel TRPV4

(2010) Rainer Strotmann et al.   PLoS One

Structure of the EF-hand domain of polycystin-2 suggests a mechanism for Ca2+-dependent regulation of polycystin-2 channel activity

(2010) E. T. Petri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential Regulation of TRPV1, TRPV3, and TRPV4 Sensitivity through a Conserved Binding Site on the Ankyrin Repeat Domain

(2009) Christopher B. Phelps et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intracellular calcium activates TRPM2 and its alternative spliced isoforms

(2009) J. Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ionic interactions are essential for TRPV1 C-terminus binding to calmodulin

(2008) Lenka Grycova et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Activity of the Neuronal Cold Sensor TRPM8 Is Regulated by Phospholipase C via the Phospholipid Phosphoinositol 4,5-Bisphosphate

(2008) Richard L. Daniels et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Domain Mapping of the Polycystin-2 C-terminal Tail Usingde NovoMolecular Modeling and Biophysical Analysis

(2008) Andjelka Ćelić et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hydrolysis of Phosphatidylinositol 4,5-Bisphosphate Mediates Calcium-induced Inactivation of TRPV6 Channels

(2008) Baskaran Thyagarajan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calcium Plays a Central Role in the Sensitization of TRPV3 Channel to Repetitive Stimulations

(2008) Rui Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IP3Receptor Binds to and Sensitizes TRPV4 Channel to Osmotic Stimuli via a Calmodulin-binding Site

(2008) Anna Garcia-Elias et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Nociceptor Ion Channel TRPA1 Is Potentiated and Inactivated by Permeating Calcium Ions

(2008) Yuanyuan Y. Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phospholipase C-Mediated Regulation of Transient Receptor Potential Vanilloid 6 Channels: Implications in Active Intestinal Ca2+ Transport

(2008) B. Thyagarajan et al.   MOLECULAR PHARMACOLOGY

Proinflammatory Mediators Modulate the Heat-Activated Ion Channel TRPV1 via the Scaffolding Protein AKAP79/150

(2008) Xuming Zhang et al.   NEURON