期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 22, 期 21, 页码 -出版社
MDPI
DOI: 10.3390/ijms222111822
关键词
asthma; T cell; eosinophil; neutrophil; microbiota; commensal; dysbiosis
资金
- National Research Foundation of Korea [NRF-2019R1A2C2087490, NRF-2021M3A9D3026428, NRF-2021M3A9H3015688]
- Ministry of Science and ICT of Korea (Sejong-si, Korea)
- National Research Foundation of Korea (Daejeon, Korea) [NRF-2019H1A2A1076865]
- National Research Foundation of Korea [2021M3A9H3015688, 2021M3A9D3026428, 2019H1A2A1076865] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Asthma presents with two phenotypes: eosinophilic and neutrophilic, each with different prognosis and drug responsiveness. CD4(+) T cells are crucial for determining asthma phenotype. Commensal bacteria play a key role in asthma pathogenesis, with beneficial bacteria suppressing asthma and harmful bacteria exacerbating it.
Asthma, a chronic respiratory disease involving variable airflow limitations, exhibits two phenotypes: eosinophilic and neutrophilic. The asthma phenotype must be considered because the prognosis and drug responsiveness of eosinophilic and neutrophilic asthma differ. CD4(+) T cells are the main determinant of asthma phenotype. Th2, Th9 and Tfh cells mediate the development of eosinophilic asthma, whereas Th1 and Th17 cells mediate the development of neutrophilic asthma. Elucidating the biological roles of CD4(+) T cells is thus essential for developing effective asthma treatments and predicting a patient's prognosis. Commensal bacteria also play a key role in the pathogenesis of asthma. Beneficial bacteria within the host act to suppress asthma, whereas harmful bacteria exacerbate asthma. Recent literature indicates that imbalances between beneficial and harmful bacteria affect the differentiation of CD4(+) T cells, leading to the development of asthma. Correcting bacterial imbalances using probiotics reportedly improves asthma symptoms. In this review, we investigate the effects of crosstalk between the microbiota and CD4(+) T cells on the development of asthma.
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