The Influence of the Microbiome on Early-Life Severe Viral Lower Respiratory Infections and Asthma—Food for Thought?

Features of the bronchial bacterial microbiome associated with atopy, asthma, and responsiveness to inhaled corticosteroid treatment

(2017) Juliana Durack et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Serum cathelicidin, nasopharyngeal microbiota, and disease severity among infants hospitalized with bronchiolitis

(2017) Kohei Hasegawa et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Bacterial microbiota of the upper respiratory tract and childhood asthma

(2017) Martin Depner et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Nasopharyngeal Microbiome in Respiratory Syncytial Virus Resembles Profile Associated with Increased Childhood Asthma Risk

(2016) Christian Rosas-Salazar et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Microbiome and the Respiratory Tract

(2016) Robert P. Dickson et al.   Annual Review of Physiology

A Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Barrier and Enhances Pathogen Susceptibility

(2016) Mahesh S. Desai et al.   CELL

The Human Microbiome before Birth

(2016) Martin J. Blaser et al.   Cell Host & Microbe

Perinatal Activation of the Interleukin-33 Pathway Promotes Type 2 Immunity in the Developing Lung

(2016) Ismé M. de Kleer et al.   IMMUNITY

Aeroallergen-induced IL-33 predisposes to respiratory virus–induced asthma by dampening antiviral immunity

(2016) Jason P. Lynch et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Respiratory syncytial virus and rhinovirus severe bronchiolitis are associated with distinct nasopharyngeal microbiota

(2016) Jonathan M. Mansbach et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Development of the gut microbiota and mucosal IgA responses in twins and gnotobiotic mice

(2016) Joseph D. Planer et al.   NATURE

Normalizing the environment recapitulates adult human immune traits in laboratory mice

(2016) Lalit K. Beura et al.   NATURE

Gut microbiome–derived metabolites modulate intestinal epithelial cell damage and mitigate graft-versus-host disease

(2016) Nathan D Mathewson et al.   NATURE IMMUNOLOGY

Viral Bronchiolitis in Children

(2016) H. Cody Meissner   NEW ENGLAND JOURNAL OF MEDICINE

Innate Immunity and Asthma Risk in Amish and Hutterite Farm Children

(2016) Michelle M. Stein et al.   NEW ENGLAND JOURNAL OF MEDICINE

Airway Microbiota in Severe Asthma and Relationship to Asthma Severity and Phenotypes

(2016) Qingling Zhang et al.   PLoS One

Natural history of the infant gut microbiome and impact of antibiotic treatment on bacterial strain diversity and stability

(2016) Moran Yassour et al.   Science Translational Medicine

Antibiotics, birth mode, and diet shape microbiome maturation during early life

(2016) Nicholas A. Bokulich et al.   Science Translational Medicine

The Role of Short-Chain Fatty Acids, Produced by Anaerobic Bacteria, in the Cystic Fibrosis Airway

(2015) Bojana Mirković et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Toward Primary Prevention of Asthma. Reviewing the Evidence for Early-Life Respiratory Viral Infections as Modifiable Risk Factors to Prevent Childhood Asthma

(2015) Amy S. Feldman et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Admission to hospital for bronchiolitis in England: trends over five decades, geographical variation and association with perinatal characteristics and subsequent asthma

(2015) Christopher A Green et al.   ARCHIVES OF DISEASE IN CHILDHOOD

Changes in microbiota during experimental human Rhinovirus infection

(2015) J. J. Hofstra et al.   BMC INFECTIOUS DISEASES

The Infant Nasopharyngeal Microbiome Impacts Severity of Lower Respiratory Infection and Risk of Asthma Development

(2015) Shu Mei Teo et al.   Cell Host & Microbe

Airway dysbiosis:Haemophilus influenzaeandTropherymain poorly controlled asthma

(2015) Jodie L. Simpson et al.   EUROPEAN RESPIRATORY JOURNAL

Asthma phenotypes and the use of biologic medications in asthma and allergic disease: The next steps toward personalized care

(2015) Merritt L. Fajt et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

TLR4 genotype and environmental LPS mediate RSV bronchiolitis through Th2 polarization

(2015) Mauricio T. Caballero et al.   JOURNAL OF CLINICAL INVESTIGATION

Group 2 innate lymphoid cells license dendritic cells to potentiate memory TH2 cell responses

(2015) Timotheus Y F Halim et al.   NATURE IMMUNOLOGY

Innate immunological function of TH2 cells in vivo

(2015) Liying Guo et al.   NATURE IMMUNOLOGY

The immunology of asthma

(2015) Bart N Lambrecht et al.   NATURE IMMUNOLOGY

Innate lymphoid cells in the initiation, regulation and resolution of inflammation

(2015) Gregory F Sonnenberg et al.   NATURE MEDICINE

Farm dust and endotoxin protect against allergy through A20 induction in lung epithelial cells

(2015) M. J. Schuijs et al.   SCIENCE

Early infancy microbial and metabolic alterations affect risk of childhood asthma

(2015) Marie-Claire Arrieta et al.   Science Translational Medicine

Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites

(2015) Alison N. Thorburn et al.   Nature Communications

Neonatal Streptococcus pneumoniae Infection May Aggravate Adulthood Allergic Airways Disease in Association with IL-17A

(2015) Baohui Yang et al.   PLoS One

IRF-3, IRF-7, and IPS-1 Promote Host Defense against Acute Human Metapneumovirus Infection in Neonatal Mice

(2014) Kirsten M. Spann et al.   AMERICAN JOURNAL OF PATHOLOGY

Depletion of Circulating Regulatory T Cells during Severe Respiratory Syncytial Virus Infection in Young Children

(2014) Silvina Raiden et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Defective Respiratory Tract Immune Surveillance in Asthma

(2014) Patrick G. Holt et al.   CHEST

The Nasal and Sinus Microbiome in Health and Disease

(2014) Michael T. Wilson et al.   CURRENT ALLERGY AND ASTHMA REPORTS

MHCII-Mediated Dialog between Group 2 Innate Lymphoid Cells and CD4+ T Cells Potentiates Type 2 Immunity and Promotes Parasitic Helminth Expulsion

(2014) Christopher J. Oliphant et al.   IMMUNITY

Receptor for advanced glycation end products and its ligand high-mobility group box-1 mediate allergic airway sensitization and airway inflammation

(2014) Md Ashik Ullah et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Detection of pathogenic bacteria during rhinovirus infection is associated with increased respiratory symptoms and asthma exacerbations

(2014) Kirsten M. Kloepfer et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis

(2014) Aurélien Trompette et al.   NATURE MEDICINE

Potentially Pathogenic Airway Bacteria and Neutrophilic Inflammation in Treatment Resistant Severe Asthma

(2014) Benjamin J. Green et al.   PLoS One

The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition

(2014) Pamela V. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macronutrients during Pregnancy and Life-Threatening Respiratory Syncytial Virus Infections in Children

(2013) F. Martín Ferolla et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Effects of Airway Microbiome on Corticosteroid Responsiveness in Asthma

(2013) Elena Goleva et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Low gut microbiota diversity in early infancy precedes asthma at school age

(2013) T. R. Abrahamsson et al.   CLINICAL AND EXPERIMENTAL ALLERGY

The plasmacytoid dendritic cell: at the cross-roads in asthma

(2013) J. P. Lynch et al.   EUROPEAN RESPIRATORY JOURNAL

Immunobiotic Lactobacillus rhamnosus improves resistance of infant mice against respiratory syncytial virus infection

(2013) Eriko Chiba et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Biphasic assembly of the murine intestinal microbiota during early development

(2013) Ida Gisela Pantoja-Feliciano et al.   ISME Journal

Risk of childhood asthma following infant bronchiolitis during the respiratory syncytial virus season

(2013) Kristina M. James et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Toll-like receptor 7 gene deficiency and early-life Pneumovirus infection interact to predispose toward the development of asthma-like pathology in mice

(2013) Gerard E. Kaiko et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Prebiotic and probiotic supplementation prevents rhinovirus infections in preterm infants: A randomized, placebo-controlled trial

(2013) Raakel Luoto et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Regulatory T Cells Prevent Th2 Immune Responses and Pulmonary Eosinophilia during Respiratory Syncytial Virus Infection in Mice

(2013) L. R. Durant et al.   JOURNAL OF VIROLOGY

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

(2013) Yukihiro Furusawa et al.   NATURE

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

(2013) Nicholas Arpaia et al.   NATURE

Respiratory Syncytial Virus and Recurrent Wheeze in Healthy Preterm Infants

(2013) Maarten O. Blanken et al.   NEW ENGLAND JOURNAL OF MEDICINE

The combined effects of family size and farm exposure on childhood hay fever and atopy

(2013) Jon Genuneit et al.   PEDIATRIC ALLERGY AND IMMUNOLOGY

Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation

(2013) Jennifer L. Pluznick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis

(2013) P. M. Smith et al.   SCIENCE

Human milk oligosaccharides: Every baby needs a sugar mama

(2012) L. Bode   GLYCOBIOLOGY

Interleukin-1α controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33

(2012) Monique A.M. Willart et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Innate IFNs and Plasmacytoid Dendritic Cells Constrain Th2 Cytokine Responses to Rhinovirus: A Regulatory Mechanism with Relevance to Asthma

(2012) A. L. Pritchard et al.   JOURNAL OF IMMUNOLOGY

Allergic host defences

(2012) Noah W. Palm et al.   NATURE

Human gut microbiome viewed across age and geography

(2012) Tanya Yatsunenko et al.   NATURE

Viral infections and atopy in asthma pathogenesis: new rationales for asthma prevention and treatment

(2012) Patrick G Holt et al.   NATURE MEDICINE

Respiratory Syncytial Virus Promotes Moraxella catarrhalis-Induced Ascending Experimental Otitis Media

(2012) M. Elizabeth Brockson et al.   PLoS One

Microbial Exposure During Early Life Has Persistent Effects on Natural Killer T Cell Function

(2012) T. Olszak et al.   SCIENCE

Interactions Between the Microbiota and the Immune System

(2012) L. V. Hooper et al.   SCIENCE

Asthma Prevention byLactobacillus Rhamnosusin a Mouse Model is Associated With CD4+CD25+Foxp3+T Cells

(2012) Seong-Ok Jang et al.   Allergy Asthma & Immunology Research

Effect of Breast and Formula Feeding on Gut Microbiota Shaping in Newborns

(2012) Federica Guaraldi et al.   Frontiers in Cellular and Infection Microbiology

Short-chain free fatty acid receptors FFA2/GPR43 and FFA3/GPR41 as new potential therapeutic targets

(2012) Trond Ulven   Frontiers in Endocrinology

Maternal intestinal flora and wheeze in early childhood

(2011) N. E. Lange et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Infant antibiotic use and wheeze and asthma risk: a systematic review and meta-analysis

(2011) J. Penders et al.   EUROPEAN RESPIRATORY JOURNAL

Febrile respiratory illnesses in infancy and atopy are risk factors for persistent asthma and wheeze

(2011) M.M.H. Kusel et al.   EUROPEAN RESPIRATORY JOURNAL

House dust mite sensitization in toddlers predicts current wheeze at age 12 years

(2011) Caroline J. Lodge et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Induction and maintenance of allergen-specific FOXP3+ Treg cells in human tonsils as potential first-line organs of oral tolerance

(2011) Oscar Palomares et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Selective Orthosteric Free Fatty Acid Receptor 2 (FFA2) Agonists

(2011) Johannes Schmidt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plasmacytoid Dendritic Cells Promote Host Defense against Acute Pneumovirus Infection via the TLR7-MyD88-Dependent Signaling Pathway

(2011) S. Davidson et al.   JOURNAL OF IMMUNOLOGY

Human Milk Probiotic Lactobacillus fermentum CECT5716 Reduces the Incidence of Gastrointestinal and Upper Respiratory Tract Infections in Infants

(2011) José Maldonado et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Characteristics of atopic children with pandemic H1N1 influenza viral infection: Pandemic H1N1 influenza reveals ‘occult’ asthma of childhood

(2011) Shunji Hasegawa et al.   PEDIATRIC ALLERGY AND IMMUNOLOGY

Natural Aryl Hydrocarbon Receptor Ligands Control Organogenesis of Intestinal Lymphoid Follicles

(2011) E. A. Kiss et al.   SCIENCE

Evolution of Th2 Immunity: A Rapid Repair Response to Tissue Destructive Pathogens

(2011) Judith E. Allen et al.   PLoS Pathogens

Synbiotics reduce allergen-induced T-helper 2 response and improve peak expiratory flow in allergic asthmatics

(2010) M. A. Van De Pol et al.   ALLERGY

Probiotics for the treatment of allergic rhinitis and asthma: systematic review of randomized controlled trials

(2010) Harissios Vliagoftis et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Recurrent Wheezing in the Third Year of Life Among Children Born at 32 Weeks' Gestation or Later

(2010) Gabriel J. Escobar et al.   ARCHIVES OF PEDIATRICS & ADOLESCENT MEDICINE

The effect of enteral supplementation of a prebiotic mixture of non-human milk galacto-, fructo- and acidic oligosaccharides on intestinal permeability in preterm infants

(2010) Elisabeth A. M. Westerbeek et al.   BRITISH JOURNAL OF NUTRITION

Bifidobacterium animalis subsp. lactis BB-12 in reducing the risk of infections in infancy

(2010) Teemu Taipale et al.   BRITISH JOURNAL OF NUTRITION

Update on Infection and Antibiotics in Asthma

(2010) Donald R. Rollins et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Acetate, the key modulator of inflammatory responses in acute alcoholic hepatitis

(2010) Stuart F. W. Kendrick et al.   HEPATOLOGY

Man's best friend? The effect of pet ownership on house dust microbial communities

(2010) Kei E. Fujimura et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The effect of respiratory syncytial virus on subsequent recurrent wheezing in atopic and nonatopic children

(2010) Eric A.F. Simões et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Airway microbiota and bronchial hyperresponsiveness in patients with suboptimally controlled asthma

(2010) Yvonne J. Huang et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Blockade of Dendritic Cell Development by Bacterial Fermentation Products Butyrate and Propionate through a Transporter (Slc5a8)-dependent Inhibition of Histone Deacetylases

(2010) Nagendra Singh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Suppressive effect of short-chain fatty acids on production of proinflammatory mediators by neutrophils

(2010) Marco A.R. Vinolo et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Boosting airway T-regulatory cells by gastrointestinal stimulation as a strategy for asthma control

(2010) D H Strickland et al.   Mucosal Immunology

Randomized placebo-controlled trial of lactobacillus on asthmatic children with allergic rhinitis

(2010) Yue-Sheng Chen et al.   PEDIATRIC PULMONOLOGY

Disordered Microbial Communities in Asthmatic Airways

(2010) Markus Hilty et al.   PLoS One

Succession of microbial consortia in the developing infant gut microbiome

(2010) J. E. Koenig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns

(2010) M. G. Dominguez-Bello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reversible Microbial Colonization of Germ-Free Mice Reveals the Dynamics of IgA Immune Responses

(2010) S. Hapfelmeier et al.   SCIENCE

Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species

(2010) K. Atarashi et al.   SCIENCE

Asthma and allergy patterns over 18 years after severe RSV bronchiolitis in the first year of life

(2010) N. Sigurs et al.   THORAX

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

(2009) Kendle M. Maslowski et al.   NATURE

Breastfeeding reduces the severity of respiratory syncytial virus infection among young infants: A multi-center prospective study

(2009) Tatsuo Nishimura et al.   PEDIATRICS INTERNATIONAL

Breast feeding, parental allergy and asthma in children followed for 8 years. The PIAMA birth cohort study

(2009) S Scholtens et al.   THORAX

Wheezing Rhinovirus Illnesses in Early Life Predict Asthma Development in High-Risk Children

(2008) Daniel J. Jackson et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Evidence of a Causal Role of Winter Virus Infection during Infancy in Early Childhood Asthma

(2008) Pingsheng Wu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Lactobacillus reuteri–induced Regulatory T cells Protect against an Allergic Airway Response in Mice

(2008) Khalil Karimi et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Specific probiotics in reducing the risk of acute infections in infancy – a randomised, double-blind, placebo-controlled study

(2008) Samuli Rautava et al.   BRITISH JOURNAL OF NUTRITION

New targets for drug development in asthma

(2008) Ian M Adcock et al.   LANCET

Breast milk–mediated transfer of an antigen induces tolerance and protection from allergic asthma

(2008) Valérie Verhasselt et al.   NATURE MEDICINE

Butyrate and trichostatin A attenuate nuclear factor κB activation and tumor necrosis factor α secretion and increase prostaglandin E2 secretion in human peripheral blood mononuclear cells

(2008) Makoto Usami et al.   NUTRITION RESEARCH

Ribavirin for respiratory syncytial virus bronchiolitis reduced the risk of asthma and allergen sensitization

(2008) Chien-Han Chen et al.   PEDIATRIC ALLERGY AND IMMUNOLOGY

Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface

(2008) S. Vaishnava et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA