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Title
TIM-3: An update on immunotherapy
Authors
Keywords
TIM-3, Gal-9, Autoimmune diseases, Tumors
Journal
INTERNATIONAL IMMUNOPHARMACOLOGY
Volume 99, Issue -, Pages 107933
Publisher
Elsevier BV
Online
2021-07-03
DOI
10.1016/j.intimp.2021.107933
References
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Related references
Note: Only part of the references are listed.- Galectin-9 interacts with PD-1 and TIM-3 to regulate T cell death and is a target for cancer immunotherapy
- (2021) Riyao Yang et al. Nature Communications
- Differential expression of Tim-3, PD-1, and CCR5 on peripheral T and B lymphocytes in hepatitis C virus-related hepatocellular carcinoma and their impact on treatment outcomes
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- Loss of the Major Phosphatidylserine or Phosphatidylethanolamine Flippases Differentially Affect Phagocytosis
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- Transforming growth factor beta type 1 (TGF-β) and hypoxia-inducible factor 1 (HIF-1) transcription complex as master regulators of the immunosuppressive protein galectin-9 expression in human cancer and embryonic cells
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- Correction: Tim-3 Expression in Cervical Cancer Promotes Tumor Metastasis
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- MicroRNA-155 regulates interferon-γproduction in natural killer cells via Tim-3 signalling in chronic hepatitis C virus infection
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- Nivolumab and Ipilimumab versus Ipilimumab in Untreated Melanoma
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- PD-1 Blockade with Nivolumab in Relapsed or Refractory Hodgkin's Lymphoma
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- Galectin-9-CD44 Interaction Enhances Stability and Function of Adaptive Regulatory T Cells
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- Lack of TIM-3 Immunoregulation in Multiple Sclerosis
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- Galectin-9 Increases Tim-3+ Dendritic Cells and CD8+ T Cells and Enhances Antitumor Immunity via Galectin-9-Tim-3 Interactions
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- CEACAM1 regulates TIM-3-mediated tolerance and exhaustion
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- Enhanced Virus-Specific CD8+ T Cell Responses by Listeria monocytogenes-Infected Dendritic Cells in the Context of Tim-3 Blockade
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- Tim-3 expression is increased on peripheral T cells from diffuse large B cell lymphoma
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- VISTA Is a Novel Broad-Spectrum Negative Checkpoint Regulator for Cancer Immunotherapy
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- Prognostic Value of T Cell Immunoglobulin Mucin-3 in Prostate Cancer
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- HIV Infection Deregulates Tim-3 Expression on Innate Cells
- (2013) Constance A.M. Finney et al. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
- The Tim-3/galectin-9 pathway involves in the homeostasis of hepatic Tregs in a mouse model of concanavalin A-induced hepatitis
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- Tim-3 Expression in Cervical Cancer Promotes Tumor Metastasis
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- Tim-3 Expression Defines Regulatory T Cells in Human Tumors
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- Anti-CTLA-4 Antibodies of IgG2a Isotype Enhance Antitumor Activity through Reduction of Intratumoral Regulatory T Cells
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- TIM3+FOXP3+regulatory T cells are tissue-specific promoters of T-cell dysfunction in cancer
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- Tim-3 marks human natural killer cell maturation and suppresses cell-mediated cytotoxicity
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- Tim-3 is an inducible human natural killer cell receptor that enhances interferon gamma production in response to galectin-9
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- HCV-infected hepatocytes drive CD4+CD25+Foxp3+regulatory T-cell development through the Tim-3/Gal-9 pathway
- (2012) Xiao J. Ji et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Blockade of Tim-3 signaling restores the virus-specific CD8+T-cell response in patients with chronic hepatitis B
- (2012) Wei Wu et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Tim-3/galectin-9 signaling pathway mediates T-cell dysfunction and predicts poor prognosis in patients with hepatitis B virus-associated hepatocellular carcinoma
- (2012) Hang Li et al. HEPATOLOGY
- IL-12 upregulates TIM-3 expression and induces T cell exhaustion in patients with follicular B cell non-Hodgkin lymphoma
- (2012) Zhi-Zhang Yang et al. JOURNAL OF CLINICAL INVESTIGATION
- Tumor immunity times out: TIM-3 and HMGB1
- (2012) Daolin Tang et al. NATURE IMMUNOLOGY
- Tumor-infiltrating DCs suppress nucleic acid–mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1
- (2012) Shigeki Chiba et al. NATURE IMMUNOLOGY
- Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer
- (2012) Suzanne L. Topalian et al. NEW ENGLAND JOURNAL OF MEDICINE
- TIM-3 Expression Characterizes Regulatory T Cells in Tumor Tissues and Is Associated with Lung Cancer Progression
- (2012) Xin Gao et al. PLoS One
- Tim-3-Expressing CD4+ and CD8+ T Cells in Human Tuberculosis (TB) Exhibit Polarized Effector Memory Phenotypes and Stronger Anti-TB Effector Functions
- (2012) Yueqin Qiu et al. PLoS Pathogens
- The Emerging Role of the TIM Molecules in Transplantation
- (2011) M. Y. Yeung et al. AMERICAN JOURNAL OF TRANSPLANTATION
- Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia
- (2011) Q. Zhou et al. BLOOD
- Anti-TIM3 Antibody Promotes T Cell IFN- -Mediated Antitumor Immunity and Suppresses Established Tumors
- (2011) S. F. Ngiow et al. CANCER RESEARCH
- The −1541 C>T and +4259 G>T of TIM-3 polymorphisms are associated with rheumatoid arthritis susceptibility in a Chinese Hui population
- (2011) J. Xu et al. International Journal of Immunogenetics
- Phosphotyrosine-Dependent Coupling of Tim-3 to T-Cell Receptor Signaling Pathways
- (2011) J. Lee et al. MOLECULAR AND CELLULAR BIOLOGY
- Ipilimumab plus Dacarbazine for Previously Untreated Metastatic Melanoma
- (2011) Caroline Robert et al. NEW ENGLAND JOURNAL OF MEDICINE
- Expression of human TIM-3 and its correlation with disease activity in rheumatoid arthritis
- (2011) J Lee et al. SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
- Tim-3 expression on peripheral T cell subsets correlates with disease progression in hepatitis B infection
- (2011) Wei Wu et al. Virology Journal
- Genetic variations and haplotypes in TIM-3 gene and the risk of gastric cancer
- (2010) Bangwei Cao et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Blockade of Tim-3 Pathway Ameliorates Interferon-γ Production from Hepatic CD8+ T Cells in a Mouse Model of Hepatitis B Virus Infection
- (2010) Ying Ju et al. Cellular & Molecular Immunology
- Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity
- (2010) Kaori Sakuishi et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Tim-3/Galectin-9 Pathway: Regulation of Th1 Immunity through Promotion of CD11b+Ly-6G+ Myeloid Cells
- (2010) V. Dardalhon et al. JOURNAL OF IMMUNOLOGY
- T Cell/Transmembrane, Ig, and Mucin-3 Allelic Variants Differentially Recognize Phosphatidylserine and Mediate Phagocytosis of Apoptotic Cells
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- Improved Survival with Ipilimumab in Patients with Metastatic Melanoma
- (2010) F. Stephen Hodi et al. NEW ENGLAND JOURNAL OF MEDICINE
- Tim-3 mediates phagocytosis of apoptotic cells and cross-presentation
- (2009) M. Nakayama et al. BLOOD
- TIM-3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines
- (2009) William D. Hastings et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Negative Immune Regulator Tim-3 Is Overexpressed on T Cells in Hepatitis C Virus Infection and Its Blockade Rescues Dysfunctional CD4+ and CD8+ T Cells
- (2009) L. Golden-Mason et al. JOURNAL OF VIROLOGY
- Blood diffusion and Th1-suppressive effects of galectin-9-containing exosomes released by Epstein-Barr virus-infected nasopharyngeal carcinoma cells
- (2008) J. Klibi et al. BLOOD
- Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection
- (2008) R. Brad Jones et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Structural Analysis of the Human Galectin-9 N-terminal Carbohydrate Recognition Domain Reveals Unexpected Properties that Differ from the Mouse Orthologue
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