Tim-3-Expressing CD4+ and CD8+ T Cells in Human Tuberculosis (TB) Exhibit Polarized Effector Memory Phenotypes and Stronger Anti-TB Effector Functions

Mycobacterium tuberculosis-Specific CD8+ T Cells Require Perforin to Kill Target Cells and Provide Protection In Vivo

(2014) J. S. Woodworth et al.   JOURNAL OF IMMUNOLOGY

Cell Surface Signaling Molecules in the Control of Immune Responses: A Tide Model

(2011) Yuwen Zhu et al.   IMMUNITY

Membrane-Bound IL-22 after De Novo Production in Tuberculosis and Anti-Mycobacterium tuberculosis Effector Function of IL-22+ CD4+ T Cells

(2011) G. Zeng et al.   JOURNAL OF IMMUNOLOGY

Elevated expression of Tim-3 on CD8 T cells correlates with disease severity of pulmonary tuberculosis

(2011) Xinjing Wang et al.   JOURNAL OF INFECTION

Virus Infection Stages and Distinct Th1 or Th17/Th22 T-Cell Responses in Malaria/SHIV Coinfection Correlate with Different Outcomes of Disease

(2011) Bridgett Ryan-Payseur et al.   JOURNAL OF INFECTIOUS DISEASES

Phosphotyrosine-Dependent Coupling of Tim-3 to T-Cell Receptor Signaling Pathways

(2011) J. Lee et al.   MOLECULAR AND CELLULAR BIOLOGY

Emerging Tim-3 functions in antimicrobial and tumor immunity

(2011) Kaori Sakuishi et al.   TRENDS IN IMMUNOLOGY

HCV-specific T cells in HCV/HIV co-infection show elevated frequencies of dual Tim-3/PD-1 expression that correlate with liver disease progression

(2010) Bahareh Vali et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Tim-3 expression on PD-1+ HCV-specific human CTLs is associated with viral persistence, and its blockade restores hepatocyte-directed in vitro cytotoxicity

(2010) Rachel H. McMahan et al.   JOURNAL OF CLINICAL INVESTIGATION

Tim3 binding to galectin-9 stimulates antimicrobial immunity

(2010) Pushpa Jayaraman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen–specific CD8+T cell dysfunction in melanoma patients

(2010) Julien Fourcade et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity

(2010) Kaori Sakuishi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

T cell immunoglobulin- and mucin-domain-containing molecule-3 (Tim-3) mediates natural killer cell suppression in chronic hepatitis B

(2010) Ying Ju et al.   JOURNAL OF HEPATOLOGY

Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection

(2010) H.-T. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differentiation, Distribution and γδ T Cell-Driven Regulation of IL-22-Producing T Cells in Tuberculosis

(2010) Shuyu Yao et al.   PLoS Pathogens

Cell-Mediated Immune Responses in Tuberculosis

(2009) Andrea M. Cooper   Annual Review of Immunology

Anti-TNF immunotherapy reduces CD8+ T cell–mediated antimicrobial activity against Mycobacterium tuberculosis in humans

(2009) Heiko Bruns et al.   JOURNAL OF CLINICAL INVESTIGATION

ESAT-6 Inhibits Production of IFN-  by Mycobacterium tuberculosis-Responsive Human T Cells

(2009) X. Wang et al.   JOURNAL OF IMMUNOLOGY

Negative Immune Regulator Tim-3 Is Overexpressed on T Cells in Hepatitis C Virus Infection and Its Blockade Rescues Dysfunctional CD4+ and CD8+ T Cells

(2009) L. Golden-Mason et al.   JOURNAL OF VIROLOGY

A Critical Role for CD8 T Cells in a Nonhuman Primate Model of Tuberculosis

(2009) Crystal Y. Chen et al.   PLoS Pathogens

Tumor Necrosis Factor Signaling Mediates Resistance to Mycobacteria by Inhibiting Bacterial Growth and Macrophage Death

(2008) Hilary Clay et al.   IMMUNITY

TIMs: central regulators of immune responses: Figure 1.

(2008) David A. Hafler et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection

(2008) R. Brad Jones et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Severe Tuberculosis Induces Unbalanced Up‐Regulation of Gene Networks and Overexpression ofIL‐22, MIP‐1α, CCL27, IP‐10, CCR4, CCR5, CXCR3, PD1, PDL2, IL‐3, IFN‐β, TIM1,andTLR2but Low Antigen‐Specific Cellular Responses

(2008) Liyou Qiu et al.   JOURNAL OF INFECTIOUS DISEASES