The Emerging Role of the TIM Molecules in Transplantation

TIMgenes: a family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity

(2015) Gordon J. Freeman et al.   IMMUNOLOGICAL REVIEWS

TIM-4 Expressed on APCs Induces T Cell Expansion and Survival

(2014) R. Rodriguez-Manzanet et al.   JOURNAL OF IMMUNOLOGY

T Cell Ig and Mucin Domain-1-Mediated T Cell Activation Requires Recruitment and Activation of Phosphoinositide 3-Kinase

(2014) A. J. de Souza et al.   JOURNAL OF IMMUNOLOGY

Tim-1 Signaling Substitutes for Conventional Signal 1 and Requires Costimulation to Induce T Cell Proliferation

(2014) C. Mariat et al.   JOURNAL OF IMMUNOLOGY

Regulatory B cells are identified by expression of TIM-1 and can be induced through TIM-1 ligation to promote tolerance in mice

(2011) Qing Ding et al.   JOURNAL OF CLINICAL INVESTIGATION

Urinary Expression of Kidney Injury Markers in Renal Transplant Recipients

(2010) C.-C. Szeto et al.   Clinical Journal of the American Society of Nephrology

T-Cell Immunoglobulin Mucin-3 Determines Severity of Liver Ischemia/Reperfusion Injury in Mice in a TLR4-Dependent Manner

(2010) Yoichiro Uchida et al.   GASTROENTEROLOGY

Apoptotic Cells Activate NKT Cells through T Cell Ig-Like Mucin-Like-1 Resulting in Airway Hyperreactivity

(2010) H.-H. Lee et al.   JOURNAL OF IMMUNOLOGY

TIM-4, a Receptor for Phosphatidylserine, Controls Adaptive Immunity by Regulating the Removal of Antigen-Specific T Cells

(2010) L. A. Albacker et al.   JOURNAL OF IMMUNOLOGY

TIM-3: A Novel Regulatory Molecule of Alloimmune Activation

(2010) O. Boenisch et al.   JOURNAL OF IMMUNOLOGY

Kidney Injury Molecule-1 is an Early Noninvasive Indicator for Donor Brain Death-Induced Injury Prior to Kidney Transplantation

(2009) W. N. Nijboer et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Tim-3 mediates phagocytosis of apoptotic cells and cross-presentation

(2009) M. Nakayama et al.   BLOOD

TIM-3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines

(2009) William D. Hastings et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The costimulatory role of TIM molecules

(2009) Roselynn Rodriguez-Manzanet et al.   IMMUNOLOGICAL REVIEWS

Tubular Expression of KIM-1 Does not Predict Delayed Function After Transplantation

(2009) B. Schroppel et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

IL-18 and Urinary NGAL Predict Dialysis and Graft Recovery after Kidney Transplantation

(2009) I. E. Hall et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Targeting Tim-1 to overcome resistance to transplantation tolerance mediated by CD8 T17 cells

(2009) X. Yuan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Galectin-9 Significantly Prolongs the Survival of Fully Mismatched Cardiac Allografts in Mice

(2009) Wentao He et al.   TRANSPLANTATION

Galectin-9 suppresses the generation of Th17, promotes the induction of regulatory T cells, and regulates experimental autoimmune arthritis

(2008) Masako Seki et al.   CLINICAL IMMUNOLOGY

Increased T cell immunoglobulin mucin-3 and its ligand in acquired aplastic anemia

(2008) Jian Zhang et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Tim-3-Galectin-9 pathway involves the suppression induced by CD4+CD25+ regulatory T cells

(2008) Feng Wang et al.   IMMUNOBIOLOGY

Bimodal regulation of T cell-mediated immune responses by TIM-4

(2008) M. Mizui et al.   INTERNATIONAL IMMUNOLOGY

Disruption of T-cell immunoglobulin and mucin domain molecule (TIM)–1/TIM4 interaction as a therapeutic strategy in a dendritic cell–induced peanut allergy model

(2008) Bai-Sui Feng et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The emerging role of T cell Ig mucin 1 in alloimmune responses in an experimental mouse transplant model

(2008) Takuya Ueno et al.   JOURNAL OF CLINICAL INVESTIGATION

Immunostimulatory Tim-1–specific antibody deprograms Tregs and prevents transplant tolerance in mice

(2008) Nicolas Degauque et al.   JOURNAL OF CLINICAL INVESTIGATION

Kidney injury molecule–1 is a phosphatidylserine receptor that confers a phagocytic phenotype on epithelial cells

(2008) Takaharu Ichimura et al.   JOURNAL OF CLINICAL INVESTIGATION

Activation of Tim-3–Galectin-9 pathway improves survival of fully allogeneic skin grafts

(2008) Feng Wang et al.   TRANSPLANT IMMUNOLOGY

In primed allo-tolerance, TIM-3-Ig rapidly suppresses TGFβ, but has no immediate effect on Foxp3

(2008) Poorni A. D. S. Muthukumarana et al.   TRANSPLANT INTERNATIONAL

Noninvasive Tim-3 Messenger RNA Evaluation in Renal Transplant Recipients With Graft Dysfunction

(2008) Roberto C. Manfro et al.   TRANSPLANTATION