The Notch signaling pathway regulates macrophage polarization in liver diseases

Inhibition of Notch1 signaling reduces hepatocyte injury in nonalcoholic fatty liver disease via autophagy

(2021) Min Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mechanisms of Fibrosis Development in NASH

(2020) Robert F. Schwabe et al.   GASTROENTEROLOGY

Endothelial Notch activation promotes neutrophil transmigration via downregulating endomucin to aggravate hepatic ischemia/reperfusion injury

(2020) Peiran Zhang et al.   Science China-Life Sciences

TSG-6 Inhibits Oxidative Stress and Induces M2 Polarization of Hepatic Macrophages in Mice With Alcoholic Hepatitis via Suppression of STAT3 Activation

(2020) Yue-Meng Wan et al.   Frontiers in Pharmacology

Macrophage Phenotype and Function in Liver Disorder

(2020) Lang Dou et al.   Frontiers in Immunology

The Role of Notch Signaling in Macrophages during Inflammation and Infection: Implication in Rheumatoid Arthritis?

(2020) Esra’a Keewan et al.   Cells

Targeted Delivery of Notch Inhibitor Attenuates Obesity-Induced Glucose Intolerance and Liver Fibrosis

(2020) Lauren R. Richter et al.   ACS Nano

Notch-1 Signaling Modulates Macrophage Polarization and Immune Defense against Mycobacterium avium paratuberculosis Infection in Inflammatory Diseases

(2020) Esra’a Keewan et al.   Microorganisms

Onco-fetal Reprogramming of Endothelial Cells Drives Immunosuppressive Macrophages in Hepatocellular Carcinoma

(2020) Ankur Sharma et al.   CELL

Capsaicin attenuates liver fibrosis by targeting Notch signaling to inhibit TNF-α secretion from M1 macrophages

(2020) Jianping Sheng et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Ursodeoxycholic Acid Regulates Hepatic Energy Homeostasis and White Adipose Tissue Macrophages Polarization in Leptin-Deficiency Obese Mice

(2019) Yu-Sheng Chen et al.   Cells

Notch signaling via Wnt regulates the proliferation of alternative, CCR2-independent tumor-associated macrophages in hepatocellular carcinoma

(2019) Yu-Chen Ye et al.   CANCER RESEARCH

Notch Signaling Regulates Immune Responses in Atherosclerosis

(2019) Francesco Vieceli Dalla Sega et al.   Frontiers in Immunology

Salidroside Inhibits Lipopolysaccharide-ethanol-induced Activation of Proinflammatory Macrophages via Notch Signaling Pathway

(2019) Jian-sha Li et al.   Current Medical Science

Diversity, Mechanisms, and Significance of Macrophage Plasticity

(2019) Massimo Locati et al.   Annual Review of Pathology-Mechanisms of Disease

The Crosstalk of miRNA and Oxidative Stress in the Liver: From Physiology to Pathology and Clinical Implications

(2019) Klieser et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Decoding the Notch signal

(2019) Julia Falo‐Sanjuan et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Newly excysted juveniles (NEJs) of Fasciola gigantica induce mice liver fibrosis and M2 macrophage-like phenotype in vivo

(2019) Yaoyao Zhang et al.   MICROBIAL PATHOGENESIS

Novel Insights on Notch signaling pathways in liver fibrosis

(2018) Ming-ming Ni et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Implications of macrophage polarization in autoimmunity

(2018) Samanta C. Funes et al.   IMMUNOLOGY

Notch Signaling Regulates Microglial Activation and Inflammatory Reactions in a Rat Model of Temporal Lobe Epilepsy

(2018) Lei Wu et al.   NEUROCHEMICAL RESEARCH

Notch signaling regulates the responses of lipopolysaccharide-stimulated macrophages in the presence of immune complexes

(2018) Wipawee Wongchana et al.   PLoS One

M2-polarized tumor-associated macrophages facilitated migration and epithelial-mesenchymal transition of HCC cells via the TLR4/STAT3 signaling pathway

(2018) Rong-Rong Yao et al.   World Journal of Surgical Oncology

Mesenchymal stem cells attenuate sepsis-induced liver injury via inhibiting M1 polarization of Kupffer cells

(2018) Xujing Liang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

M1-/M2-macrophage Polarization-based Hepatotoxicity in d-galactosamine-induced Acute Liver Injury in Rats

(2018) Nahid Rahman et al.   TOXICOLOGIC PATHOLOGY

Regulation of periostin expression by Notch signaling in hepatocytes and liver cancer cell lines

(2018) Pornrat Kongkavitoon et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

iNOS promotes CD24+CD133+ liver cancer stem cell phenotype through a TACE/ADAM17-dependent Notch signaling pathway

(2018) Ronghua Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hepatocyte Notch activation induces liver fibrosis in nonalcoholic steatohepatitis

(2018) Changyu Zhu et al.   Science Translational Medicine

Repression of the Notch pathway prevents liver damage in streptozotocin-induced diabetic mice

(2017) Eda Acikgoz et al.   FOLIA HISTOCHEMICA ET CYTOBIOLOGICA

Blockade of Notch signaling promotes acetaminophen-induced liver injury

(2017) Longfeng Jiang et al.   IMMUNOLOGIC RESEARCH

Liver inflammation and fibrosis

(2017) Yukinori Koyama et al.   JOURNAL OF CLINICAL INVESTIGATION

The role of Kupffer cells in hepatic diseases

(2017) Peizhi Li et al.   MOLECULAR IMMUNOLOGY

Notch Signaling in Development, Tissue Homeostasis, and Disease

(2017) Chris Siebel et al.   PHYSIOLOGICAL REVIEWS

Immunology in the liver — from homeostasis to disease

(2016) Felix Heymann et al.   Nature Reviews Gastroenterology & Hepatology

Notch Signaling Contributes to Liver Inflammation by Regulation of Interleukin-22-Producing Cells in Hepatitis B Virus Infection

(2016) Xin Wei et al.   Frontiers in Cellular and Infection Microbiology

Inhibition of Notch Signaling Attenuates Schistosomiasis Hepatic Fibrosis via Blocking Macrophage M2 Polarization

(2016) Shaoping Zheng et al.   PLoS One

Kupffer cells induce Notch-mediated hepatocyte conversion in a common mouse model of intrahepatic cholangiocarcinoma

(2016) Maiko Terada et al.   Scientific Reports

Modulation of Notch Signaling as a Therapeutic Approach for Liver Cancer

(2015) Guang Wu et al.   CURRENT GENE THERAPY

NOTCH reprograms mitochondrial metabolism for proinflammatory macrophage activation

(2015) Jun Xu et al.   JOURNAL OF CLINICAL INVESTIGATION

Krüppel-like factor 4 is a transcriptional regulator of M1/M2 macrophage polarization in alcoholic liver disease

(2015) Banishree Saha et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Notch signaling and M1 macrophage activation in obesity-alcohol synergism

(2015) Jun Xu et al.   Clinics and Research in Hepatology and Gastroenterology

The interplay of the Notch signaling in hepatic stellate cells and macrophages determines the fate of liver fibrogenesis

(2015) Ruchi Bansal et al.   Scientific Reports

The NOTCH signaling pathway in normal and malignant blood cell production

(2015) Sukanya Suresh et al.   Journal of Cell Communication and Signaling

M1- and M2-macrophage polarization in rat liver cirrhosis induced by thioacetamide (TAA), focusing on Iba1 and galectin-3

(2014) Kavindra Kumara Wijesundera et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Macrophage heterogeneity in liver injury and fibrosis

(2014) Frank Tacke et al.   JOURNAL OF HEPATOLOGY

Macrophage polarization and function with emphasis on the evolving roles of coordinated regulation of cellular signaling pathways

(2013) Dexi Zhou et al.   CELLULAR SIGNALLING

Notch signaling and new therapeutic options in liver disease

(2013) Carola Maria Morell et al.   JOURNAL OF HEPATOLOGY

Macrophage plasticity and polarization in tissue repair and remodelling

(2012) Alberto Mantovani et al.   JOURNAL OF PATHOLOGY

Notch–RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization

(2012) Haixia Xu et al.   NATURE IMMUNOLOGY

Notch Signaling Determines the M1 versus M2 Polarization of Macrophages in Antitumor Immune Responses

(2010) Yao-Chun Wang et al.   CANCER RESEARCH