Selective elimination of host cells harboring replication-competent human immunodeficiency virus reservoirs: a promising therapeutic strategy for HIV cure

In vitro inhibitory effect of maraviroc on the association of the simian immunodeficiency virus envelope glycoprotein with CCR5

(2021) Ignacio Giraudy et al.   VIRUS GENES

Effects of autophagy inhibitor 3-Methyladenine on ischemic stroke

(2021) Ao Zhang et al.   MEDICINE

Molecular basis of V-ATPase inhibition by bafilomycin A1

(2021) Rong Wang et al.   Nature Communications

The Interplay of HIV and Autophagy in Early Infection

(2021) Romina Cabrera-Rodríguez et al.   Frontiers in Microbiology

Are BET Inhibitors yet Promising Latency-Reversing Agents for HIV-1 Reactivation in AIDS Therapy?

(2021) Thanarat Salahong et al.   Viruses-Basel

Nicotinamide activates latent HIV-1 ex vivo in ART suppressed individuals, revealing higher potency than the association of two methyltransferase inhibitors, chaetocin and BIX01294

(2020) Sadia Samer et al.   Brazilian Journal of Infectious Diseases

Block-And-Lock Strategies to Cure HIV Infection

(2020) Gerlinde Vansant et al.   Viruses-Basel

Recent Advances in the Development of Integrase Inhibitors for HIV Treatment

(2020) Jay Trivedi et al.   Current HIV/AIDS Reports

New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19?

(2020) Christian A. Devaux et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Role of Extrinsic Apoptotic Signaling Pathway during Definitive Erythropoiesis in Normal Patients and in Patients with β-Thalassemia

(2020) Olga Raducka-Jaszul et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Prodrugs of PKC modulators show enhanced HIV latency reversal and an expanded therapeutic window

(2020) Jack L. Sloane et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gp41-targeted antibodies restore infectivity of a fusion-deficient HIV-1 envelope glycoprotein

(2020) Vinita R. Joshi et al.   PLoS Pathogens

Structure-Activity Relationship Analysis of Benzotriazine Analogues as HIV-1 Latency-Reversing Agents

(2020) Eric S. Sorensen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

CBF-1 Promotes the Establishment and Maintenance of HIV Latency by Recruiting Polycomb Repressive Complexes, PRC1 and PRC2, at HIV LTR

(2020) Adhikarimayum Lakhikumar Sharma et al.   Viruses-Basel

Reactivating latent HIV with PKC agonists induces resistance to apoptosis and is associated with phosphorylation and activation of BCL2

(2020) Andrea J. French et al.   PLoS Pathogens

Maraviroc reactivates HIV with potency similar to that of other latency reversing drugs without inducing toxicity in CD8 T cells

(2020) María Rosa López-Huertas et al.   BIOCHEMICAL PHARMACOLOGY

The histone deacetylase inhibitor chidamide induces intermittent viraemia in HIV‐infected patients on suppressive antiretroviral therapy

(2020) JH Li et al.   HIV MEDICINE

Long-acting cabotegravir and rilpivirine dosed every 2 months in adults with HIV-1 infection (ATLAS-2M), 48-week results: a randomised, multicentre, open-label, phase 3b, non-inferiority study

(2020) Edgar T Overton et al.   LANCET

Author Correction: Clearance of HIV infection by selective elimination of host cells capable of producing HIV

(2020) Min Li et al.   Nature Communications

HIV-1 reservoirs in urethral macrophages of patients under suppressive antiretroviral therapy

(2019) Yonatan Ganor et al.   Nature Microbiology

The inhibitor apoptosis protein antagonist Debio 1143 Is an attractive HIV-1 latency reversal candidate

(2019) Michael Bobardt et al.   PLoS One

HIV-1 remission following CCR5Δ32/Δ32 haematopoietic stem-cell transplantation

(2019) Ravindra K. Gupta et al.   NATURE

“Genetic evidence that Naïve T cells can contribute significantly to the HIV intact reservoir: time to re-evaluate their role”

(2019) Emmanuele Venanzi Rullo et al.   CLINICAL INFECTIOUS DISEASES

Heterogeneous HIV-1 Reactivation Patterns of Disulfiram and Combined Disulfiram+Romidepsin Treatments

(2019) Anna Kula et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Incidence and risk factors for liver enzyme elevation among naive HIV-1-infected patients receiving ART in the ICONA cohort

(2019) Lucia Taramasso et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Insights into the HIV Latency and the Role of Cytokines

(2019) Joseph Hokello et al.   Pathogens

HIV-1 Latency and Latency Reversal: Does Subtype Matter?

(2019) Indra Sarabia et al.   Viruses-Basel

Targeting Cellular and Tissue HIV Reservoirs With Toll-Like Receptor Agonists

(2019) Amanda B. Macedo et al.   Frontiers in Immunology

Sucrose Starvation Induces Microautophagy in Plant Root Cells

(2019) Shino Goto-Yamada et al.   Frontiers in Plant Science

Novel Latency Reversal Agents for HIV-1 Cure

(2018) Adam M. Spivak et al.   Annual Review of Medicine

Getting the “Kill” into “Shock and Kill”: Strategies to Eliminate Latent HIV

(2018) Youry Kim et al.   Cell Host & Microbe

Polypharmacology in HIV inhibition: can a drug with simultaneous action against two relevant targets be an alternative to combination therapy?

(2018) Sonia de Castro et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

An overview of tenofovir and renal disease for the HIV-treating clinician

(2018) Willem D.F. Venter et al.   SOUTHERN AFRICAN JOURNAL OF HIV MEDICINE

The Dual PI3K/mToR Inhibitor Omipalisib/GSK2126458 Inhibits Clonogenic Growth in Oncogenically-transformed Cells from Neurocutaneous Melanocytosis

(2018) DIPANJAN BASU et al.   Cancer Genomics & Proteomics

Treatment of HIV-Infected Individuals with the Histone Deacetylase Inhibitor Panobinostat Results in Increased Numbers of Regulatory T Cells and Limits Ex Vivo Lipopolysaccharide-Induced Inflammatory Responses

(2018) Christel Rothe Brinkmann et al.   mSphere

Design and synthesis of a luminescent iridium complex-peptide hybrid (IPH) that detects cancer cells and induces their apoptosis

(2018) Abdullah-Al Masum et al.   BIOORGANIC & MEDICINAL CHEMISTRY

OUP accepted manuscript

(2018)   CLINICAL INFECTIOUS DISEASES

Benzolactam-related compounds promote apoptosis of HIV-infected human cells via protein kinase C–induced HIV latency reversal

(2018) Kouki Matsuda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interferon Alpha Enhances NK Cell Function and the Suppressive Capacity of HIV-Specific CD8+ T Cells

(2018) Abena K. R. Kwaa et al.   JOURNAL OF VIROLOGY

The autophagy inhibitor spautin-1, either alone or combined with doxorubicin, decreases cell survival and colony formation in canine appendicular osteosarcoma cells

(2018) Courtney R. Schott et al.   PLoS One

Interval dosing with the HDAC inhibitor vorinostat effectively reverses HIV latency

(2017) Nancie M. Archin et al.   JOURNAL OF CLINICAL INVESTIGATION

Histone deacetylase inhibitors containing a benzamide functional group and a pyridyl cap are preferentially effective human immunodeficiency virus-1 latency-reversing agents in primary resting CD4+ T cells

(2017) Yoshifumi Kobayashi et al.   JOURNAL OF GENERAL VIROLOGY

Role of autophagy in HIV infection and pathogenesis

(2017) R. Nardacci et al.   JOURNAL OF INTERNAL MEDICINE

CD32a is a marker of a CD4 T-cell HIV reservoir harbouring replication-competent proviruses

(2017) Benjamin Descours et al.   NATURE

Natural killer cells migrate into and control simian immunodeficiency virus replication in lymph node follicles in African green monkeys

(2017) Nicolas Huot et al.   NATURE MEDICINE

Pore formation by dimeric Bak and Bax: an unusual pore?

(2017) Rachel T. Uren et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Identification of benzazole compounds that induce HIV-1 transcription

(2017) Jason D. Graci et al.   PLoS One

Emerging Mechanisms in Initiating and Terminating Autophagy

(2017) Manuela Antonioli et al.   TRENDS IN BIOCHEMICAL SCIENCES

Synergistic reactivation of latent HIV-1 provirus by PKA activator dibutyryl-cAMP in combination with an HDAC inhibitor

(2017) Hoyong Lim et al.   VIRUS RESEARCH

BET inhibitors RVX-208 and PFI-1 reactivate HIV-1 from latency

(2017) Panpan Lu et al.   Scientific Reports

Control of HIV Infection In Vivo Using Gene Therapy with a Secreted Entry Inhibitor

(2017) Alexander Falkenhagen et al.   Molecular Therapy-Nucleic Acids

Bictegravir versus dolutegravir, each with emtricitabine and tenofovir alafenamide, for initial treatment of HIV-1 infection: a randomised, double-blind, phase 2 trial

(2017) Paul E Sax et al.   Lancet HIV

Safety and tolerability of long-acting cabotegravir injections in HIV-uninfected men (ECLAIR): a multicentre, double-blind, randomised, placebo-controlled, phase 2a trial

(2017) Martin Markowitz et al.   Lancet HIV

Vorinostat Renders the Replication-Competent Latent Reservoir of Human Immunodeficiency Virus (HIV) Vulnerable to Clearance by CD8 T Cells

(2017) Julia A. Sung et al.   EBioMedicine

Autophagy and the Cell Cycle: A Complex Landscape

(2017) Søs Grønbæk Mathiassen et al.   Frontiers in Oncology

Antiviral Activity of Bictegravir (GS-9883), a Novel Potent HIV-1 Integrase Strand Transfer Inhibitor with an Improved Resistance Profile

(2016) Manuel Tsiang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Neuropsychiatric Effects of HIV Antiviral Medications

(2016) Glenn J. Treisman et al.   DRUG SAFETY

Functional Incompatibility between the Generic NF-κB Motif and a Subtype-Specific Sp1III Element Drives the Formation of the HIV-1 Subtype C Viral Promoter

(2016) Anjali Verma et al.   JOURNAL OF VIROLOGY

Prime, Shock, and Kill: Priming CD4 T Cells from HIV Patients with a BCL-2 Antagonist before HIV Reactivation Reduces HIV Reservoir Size

(2016) Nathan W. Cummins et al.   JOURNAL OF VIROLOGY

Residues in the gp41 Ectodomain Regulate HIV-1 Envelope Glycoprotein Conformational Transitions Induced by gp120-Directed Inhibitors

(2016) Beatriz Pacheco et al.   JOURNAL OF VIROLOGY

Activation and Inactivation of Primary Human Immunodeficiency Virus Envelope Glycoprotein Trimers by CD4-Mimetic Compounds

(2016) Navid Madani et al.   JOURNAL OF VIROLOGY

Cost Effectiveness of Potential ART Adherence Monitoring Interventions in Sub-Saharan Africa

(2016) Andrew N Phillips et al.   PLoS One

Latency reversal and viral clearance to cure HIV-1

(2016) D. M. Margolis et al.   SCIENCE

Ubiquitin-Dependent And Independent Signals In Selective Autophagy

(2016) Aliaksandr Khaminets et al.   TRENDS IN CELL BIOLOGY

TRIM11 Suppresses AIM2 Inflammasome by Degrading AIM2 via p62-Dependent Selective Autophagy

(2016) Tao Liu et al.   Cell Reports

Structure of the Human Autophagy Initiating Kinase ULK1 in Complex with Potent Inhibitors

(2015) Michael B. Lazarus et al.   ACS Chemical Biology

HIV-1 viral infectivity factor interacts with microtubule-associated protein light chain 3 and inhibits autophagy

(2015) Sophie Borel et al.   AIDS

BIRC2/cIAP1 Is a Negative Regulator of HIV-1 Transcription and Can Be Targeted by Smac Mimetics to Promote Reversal of Viral Latency

(2015) Lars Pache et al.   Cell Host & Microbe

Autophagy inhibitors

(2015) Benoit Pasquier   CELLULAR AND MOLECULAR LIFE SCIENCES

TBC1D14 regulates autophagy via the TRAPP complex and ATG9 traffic

(2015) C. A. Lamb et al.   EMBO JOURNAL

Dolutegravir and elvitegravir plasma concentrations following cessation of drug intake

(2015) Emilie Elliot et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Pharmacological Inhibition of ULK1 Kinase Blocks Mammalian Target of Rapamycin (mTOR)-dependent Autophagy

(2015) Katy J. Petherick et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synthesis and in Vitro Anticancer Activity of the First Class of Dual Inhibitors of REV-ERBβ and Autophagy

(2015) Esther Torrente et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cabotegravir plus rilpivirine, once a day, after induction with cabotegravir plus nucleoside reverse transcriptase inhibitors in antiretroviral-naive adults with HIV-1 infection (LATTE): a randomised, phase 2b, dose-ranging trial

(2015) David A Margolis et al.   LANCET INFECTIOUS DISEASES

IRGM Governs the Core Autophagy Machinery to Conduct Antimicrobial Defense

(2015) Santosh Chauhan et al.   MOLECULAR CELL

Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates

(2015) Daniel F. Egan et al.   MOLECULAR CELL

B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllers

(2015) Yoshinori Fukazawa et al.   NATURE MEDICINE

Reactivation of latent HIV-1 provirus via targeting protein phosphatase-1

(2015) Mudit Tyagi et al.   Retrovirology

Beclin orthologs: integrative hubs of cell signaling, membrane trafficking, and physiology

(2015) Beth Levine et al.   TRENDS IN CELL BIOLOGY

Human Immunodeficiency Virus Type 1 Nef Inhibits Autophagy through Transcription Factor EB Sequestration

(2015) Grant R. Campbell et al.   PLoS Pathogens

The Depsipeptide Romidepsin Reverses HIV-1 Latency In Vivo

(2015) Ole S. Søgaard et al.   PLoS Pathogens

Safety and efficacy of the HIV-1 attachment inhibitor prodrug BMS-663068 in treatment-experienced individuals: 24 week results of AI438011, a phase 2b, randomised controlled trial

(2015) Jacob P Lalezari et al.   Lancet HIV

Short-term administration of disulfiram for reversal of latent HIV infection: a phase 2 dose-escalation study

(2015) Julian H Elliott et al.   Lancet HIV

Once-daily dolutegravir versus darunavir plus ritonavir for treatment-naive adults with HIV-1 infection (FLAMINGO): 96 week results from a randomised, open-label, phase 3b study

(2015) Jean-Michel Molina et al.   Lancet HIV

Reactivation of HIV latency by a newly modified Ingenol derivative via protein kinase Cδ–NF-κB signaling

(2014) Guochun Jiang et al.   AIDS

Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase

(2014) Ruzica Bago et al.   BIOCHEMICAL JOURNAL

Old, new and emerging functions of caspases

(2014) S Shalini et al.   CELL DEATH AND DIFFERENTIATION

TRIM Proteins Regulate Autophagy and Can Target Autophagic Substrates by Direct Recognition

(2014) Michael A. Mandell et al.   DEVELOPMENTAL CELL

A cure for HIV: is it in sight?

(2014) Matthew Pace et al.   Expert Review of Anti-Infective Therapy

Interplay between viral Tat protein and c-Jun transcription factor in controlling LTR promoter activity in different human immunodeficiency virus type I subtypes

(2014) R. M. van der Sluis et al.   JOURNAL OF GENERAL VIROLOGY

Discovery of (2S)-8-[(3R)-3-Methylmorpholin-4-yl]-1-(3-methyl-2-oxobutyl)-2-(trifluoromethyl)-3,4-dihydro-2H-pyrimido[1,2-a]pyrimidin-6-one: A Novel Potent and Selective Inhibitor of Vps34 for the Treatment of Solid Tumors

(2014) Benoit Pasquier et al.   JOURNAL OF MEDICINAL CHEMISTRY

You eat what you are: autophagy inhibition as a therapeutic strategy in leukemia

(2014) A R Sehgal et al.   LEUKEMIA

Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo

(2014) William E. Dowdle et al.   NATURE CELL BIOLOGY

A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy

(2014) Baptiste Ronan et al.   Nature Chemical Biology

Dual inhibition of REV-ERBβ and autophagy as a novel pharmacological approach to induce cytotoxicity in cancer cells

(2014) C De Mei et al.   ONCOGENE

Discovery of a Small Molecule Agonist of Phosphatidylinositol 3-Kinase p110α That Reactivates Latent HIV-1

(2014) Geneviève Doyon et al.   PLoS One

Immunologic strategies for HIV-1 remission and eradication

(2014) D. H. Barouch et al.   SCIENCE

Pattern Recognition Receptors and Autophagy

(2014) Ji Eun Oh et al.   Frontiers in Immunology

Activity of the HIV-1 Attachment Inhibitor BMS-626529, the Active Component of the Prodrug BMS-663068, against CD4-Independent Viruses and HIV-1 Envelopes Resistant to Other Entry Inhibitors

(2013) Zhufang Li et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Replication-Competent Noninduced Proviruses in the Latent Reservoir Increase Barrier to HIV-1 Cure

(2013) Ya-Chi Ho et al.   CELL

Identification of a candidate therapeutic autophagy-inducing peptide

(2013) Sanae Shoji-Kawata et al.   NATURE

The autophagosome: origins unknown, biogenesis complex

(2013) Christopher A. Lamb et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

At the end of the autophagic road: an emerging understanding of lysosomal functions in autophagy

(2013) Han-Ming Shen et al.   TRENDS IN BIOCHEMICAL SCIENCES

HIV Latency

(2013) R. F. Siliciano et al.   Cold Spring Harbor Perspectives in Medicine

Blocking HIV-1 entry by a gp120 surface binding inhibitor

(2012) Lun K. Tsou et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Anti-malaria drug chloroquine is highly effective in treating avian influenza A H5N1 virus infection in an animal model

(2012) Yiwu Yan et al.   CELL RESEARCH

Redefining the Viral Reservoirs that Prevent HIV-1 Eradication

(2012) Evelyn Eisele et al.   IMMUNITY

Pharmacodynamics, Safety, and Pharmacokinetics of BMS-663068, an Oral HIV-1 Attachment Inhibitor in HIV-1-Infected Subjects

(2012) R. E. Nettles et al.   JOURNAL OF INFECTIOUS DISEASES

Reactivation of Latent HIV-1 by Inhibition of BRD4

(2012) Jian Zhu et al.   Cell Reports

Gold drug auranofin restricts the viral reservoir in the monkey AIDS model and induces containment of viral load following ART suspension

(2011) Mark G. Lewis et al.   AIDS

Specific functions of lysosomal proteases in endocytic and autophagic pathways

(2011) Sabrina Müller et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Beclin1 Controls the Levels of p53 by Regulating the Deubiquitination Activity of USP10 and USP13

(2011) Junli Liu et al.   CELL

Long-term Treatment With Raltegravir or Efavirenz Combined With Tenofovir/Emtricitabine for Treatment-Naive Human Immunodeficiency Virus-1–Infected Patients: 156-Week Results From STARTMRK

(2011) Jürgen K. Rockstroh et al.   CLINICAL INFECTIOUS DISEASES

Inhibition of autophagy by TAB2 and TAB3

(2011) Alfredo Criollo et al.   EMBO JOURNAL

Characterization of the R263K Mutation in HIV-1 Integrase That Confers Low-Level Resistance to the Second-Generation Integrase Strand Transfer Inhibitor Dolutegravir

(2011) P. K. Quashie et al.   JOURNAL OF VIROLOGY

Dual Role of 3-Methyladenine in Modulation of Autophagy via Different Temporal Patterns of Inhibition on Class I and III Phosphoinositide 3-Kinase

(2010) You-Tong Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Shaping Development of Autophagy Inhibitors with the Structure of the Lipid Kinase Vps34

(2010) S. Miller et al.   SCIENCE

TRAF6 and A20 Regulate Lysine 63-Linked Ubiquitination of Beclin-1 to Control TLR4-Induced Autophagy

(2010) C. S. Shi et al.   Science Signaling

Inhibitors of HIV-1 attachment. Part 4: A study of the effect of piperazine substitution patterns on antiviral potency in the context of indole-based derivatives

(2009) Tao Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages

(2009) George B. Kyei et al.   JOURNAL OF CELL BIOLOGY

Long-Term Control of HIV byCCR5Delta32/Delta32 Stem-Cell Transplantation

(2009) Gero Hütter et al.   NEW ENGLAND JOURNAL OF MEDICINE

"Shock and kill" effects of class I-selective histone deacetylase inhibitors in combination with the glutathione synthesis inhibitor buthionine sulfoximine in cell line models for HIV-1 quiescence

(2009) Andrea Savarino et al.   Retrovirology

ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor

(2008) C. Tse et al.   CANCER RESEARCH

Factors Controlling Chromatin Organization and Nucleosome Positioning for Establishment and Maintenance of HIV Latency

(2008) Ivan Sadowski et al.   CURRENT HIV RESEARCH

Discovery of Raltegravir, a Potent, Selective Orally Bioavailable HIV-Integrase Inhibitor for the Treatment of HIV-AIDS Infection

(2008) Vincenzo Summa et al.   JOURNAL OF MEDICINAL CHEMISTRY