The Bioinorganic Chemistry of Mammalian Metallothioneins

Zinc transporters and their functional integration in mammalian cells

(2021) Taiho Kambe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Principles and practice of determining metal–protein affinities

(2021) Tessa R. Young et al.   BIOCHEMICAL JOURNAL

Spontaneous, synchronous zinc spikes oscillate with neural excitability and calcium spikes in primary hippocampal neuron culture

(2021) Chen Zhang et al.   JOURNAL OF NEUROCHEMISTRY

Emerging Roles of Metallothioneins in Beta Cell Pathophysiology: Beyond and above Metal Homeostasis and Antioxidant Response

(2021) Mohammed Bensellam et al.   Biology-Basel

Phytochelatins as a Dynamic System for Cd(II) Buffering from the Micro- to Femtomolar Range

(2021) Joanna Wątły et al.   INORGANIC CHEMISTRY

The Enigmatic Metallothioneins: A Case of Upward-Looking Research

(2021) Ahmad Yaman Abdin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

An Integrated Mass Spectrometry and Molecular Dynamics Simulations Approach Reveals the Spatial Organization Impact of Metal-Binding Sites on the Stability of Metal-Depleted Metallothionein-2 Species

(2021) Manuel David Peris-Díaz et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The glutathione/metallothionein system challenges the design of efficient O2-activating Cu-complexes

(2020) Alice Santoro et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Metallothionein Isoforms as Double Agents - Their Roles in Carcinogenesis, Cancer Progression and Chemoresistance

(2020) Miguel Angel Merlos Rodrigo et al.   DRUG RESISTANCE UPDATES

Stochastic or Not? Method To Predict and Quantify the Stochastic Effects on the Association Reaction Equilibria in Nanoscopic Systems

(2020) Wojciech Goch et al.   JOURNAL OF PHYSICAL CHEMISTRY A

Advances in visualization of copper in mammalian systems using X-ray fluorescence microscopy

(2020) Scot C. Leary et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Metalation: nature’s challenge in bioinorganic chemistry

(2020) Nigel J. Robinson et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Metallothioneins regulate ATP7A trafficking and control cell viability during copper deficiency and excess

(2020) Nikita Gudekar et al.   Scientific Reports

Ag+ Ion Binding to Human Metallothionein-2A Is Cooperative and Domain Specific

(2020) Shiyu Dong et al.   ANALYTICAL CHEMISTRY

Metal and affinity-specific dual labeling of cysteine-rich proteins for identification of metal-binding sites

(2020) Manuel David Peris-Diaz et al.   ANALYTICAL CHEMISTRY

Mass Spectrometry-Based Structural Analysis of Cysteine-Rich Metal-Binding Sites in Proteins with MetaOdysseus R Software

(2020) Manuel David Peris-Díaz et al.   JOURNAL OF PROTEOME RESEARCH

Galvanization of Protein–Protein Interactions in a Dynamic Zinc Interactome

(2020) Anna Kocyła et al.   TRENDS IN BIOCHEMICAL SCIENCES

Metallothionein-3 as a multifunctional player in the control of cellular processes and diseases

(2020) Jae-Young Koh et al.   Molecular Brain

Zinc shapes the folding landscape of p53 and establishes a pathway for reactivating structurally diverse cancer mutants

(2020) Adam R Blanden et al.   eLife

Bacterial sensors define intracellular free energies for correct enzyme metalation

(2019) Deenah Osman et al.   Nature Chemical Biology

Channels, transporters and receptors for cadmium and cadmium complexes in eukaryotic cells: myths and facts

(2019) Frank Thévenod et al.   BIOMETALS

Copper–zinc superoxide dismutase (Sod1) activation terminates interaction between its copper chaperone (Ccs) and the cytosolic metal-binding domain of the copper importer Ctr1

(2019) Amélie Skopp et al.   BIOMETALS

The EMBL-EBI search and sequence analysis tools APIs in 2019

(2019) Fábio Madeira et al.   NUCLEIC ACIDS RESEARCH

Ratiometric two-photon microscopy reveals attomolar copper buffering in normal and Menkes mutant cells

(2019) M. Thomas Morgan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intracellular Zn2+ transients modulate global gene expression in dissociated rat hippocampal neurons

(2019) Lynn Sanford et al.   Scientific Reports

Activity-based ratiometric FRET probe reveals oncogene-driven changes in labile copper pools induced by altered glutathione metabolism

(2019) Clive Yik-Sham Chung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiple Mechanisms of Zinc-Mediated Inhibition for the Apoptotic Caspases-3, -6, -7, and -8

(2018) Scott J. Eron et al.   ACS Chemical Biology

Stabilization of Aliphatic Phosphines by Auxiliary Phosphine Sulfides Offers Zeptomolar Affinity and Unprecedented Selectivity for Probing Biological CuI

(2018) M. Thomas Morgan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Metal binding properties, stability and reactivity of zinc fingers

(2018) Katarzyna Kluska et al.   COORDINATION CHEMISTRY REVIEWS

Unravelling the mechanistic details of metal binding to mammalian metallothioneins from stoichiometric, kinetic, and binding affinity data

(2018) Judith S. Scheller et al.   DALTON TRANSACTIONS

Interdependence of free zinc changes and protein complex assembly – insights into zinc signal regulation

(2018) Anna Kocyła et al.   Metallomics

Crosstalk of the structural and zinc buffering properties of mammalian metallothionein-2

(2018) Agnieszka Drozd et al.   Metallomics

Metal binding properties of zinc fingers with a naturally altered metal binding site

(2018) Katarzyna Kluska et al.   Metallomics

Short oligopeptides with three cystein residues as models of sulphur-rich Cu(I)- and Hg(II)-binding sites in proteins≈

(2018) Edit Mesterházy et al.   Metallomics

Copper(I)-binding properties of de-coppering drugs for the treatment of Wilson disease. α-Lipoic acid as a potential anti-copper agent

(2018) Julia Smirnova et al.   Scientific Reports

Collision-Induced Unfolding of Partially Metalated Metallothionein-2A: Tracking Unfolding Reactions of Gas Phase Ions

(2018) Shiyu Dong et al.   ANALYTICAL CHEMISTRY

The roles of metallothioneins in carcinogenesis

(2018) Manfei Si et al.   Journal of Hematology & Oncology

Side-chain moieties from the N-terminal region of Aβ are Involved in an oligomer-stabilizing network of interactions

(2018) Kaja Przygońska et al.   PLoS One

Correction to: Copper signalling: causes and consequences

(2018) Julianna Kardos et al.   Cell Communication and Signaling

The Functions of Metamorphic Metallothioneins in Zinc and Copper Metabolism

(2017) Artur Krężel et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Zinc in Cellular Regulation: The Nature and Significance of “Zinc Signals”

(2017) Wolfgang Maret   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Function of Metallothionein-3 in Neuronal Cells: Do Metal Ions Alter Expression Levels of MT3?

(2017) Jamie Bousleiman et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Copper metallothioneins

(2017) Jenifer Calvo et al.   IUBMB LIFE

Glutathione limits aquacopper(I) to sub-femtomolar concentrations through cooperative assembly of a tetranuclear cluster

(2017) M. Thomas Morgan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Copper signaling in the brain and beyond

(2017) Cheri M. Ackerman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Defining the human copper proteome and analysis of its expression variation in cancers

(2017) S. Blockhuys et al.   Metallomics

Stepwise copper(i) binding to metallothionein: a mixed cooperative and non-cooperative mechanism for all 20 copper ions

(2017) Judith S. Scheller et al.   Metallomics

Eukaryotic Rad50 functions as a rod-shaped dimer

(2017) Young Bong Park et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Eukaryotic Rad50 functions as a rod-shaped dimer

(2017) Young Bong Park et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A molecular chaperone activity of CCS restores the maturation of SOD1 fALS mutants

(2017) Enrico Luchinat et al.   Scientific Reports

Resistance of Cu(Aβ4- 16) to Copper Capture by Metallothionein-3 Supports a Function for the Aβ4- 42 Peptide as a Synaptic CuII Scavenger

(2016) Nina E. Wezynfeld et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The metal face of protein tyrosine phosphatase 1B

(2016) Elisa Bellomo et al.   COORDINATION CHEMISTRY REVIEWS

A Quantitative Scale of Oxophilicity and Thiophilicity

(2016) Kasper P. Kepp   INORGANIC CHEMISTRY

Thermodynamics of Pb(ii) and Zn(ii) binding to MT-3, a neurologically important metallothionein

(2016) M. C. Carpenter et al.   Metallomics

Zinc sensing by metal-responsive transcription factor 1 (MTF1) controls metallothionein and ZnT1 expression to buffer the sensitivity of the transcriptome response to zinc

(2016) J. E. J. Hardyman et al.   Metallomics

Defining the metal binding pathways of human metallothionein 1a: balancing zinc availability and cadmium seclusion

(2016) Gordon W. Irvine et al.   Metallomics

Copper regulates cyclic-AMP-dependent lipolysis

(2016) Lakshmi Krishnamoorthy et al.   Nature Chemical Biology

Molecular Basis for Subtype Specificity and High-Affinity Zinc Inhibition in the GluN1-GluN2A NMDA Receptor Amino-Terminal Domain

(2016) Annabel Romero-Hernandez et al.   NEURON

Metal-coupled folding as the driving force for the extreme stability of Rad50 zinc hook dimer assembly

(2016) Tomasz Kochańczyk et al.   Scientific Reports

IL-4 Induces Metallothionein 3- and SLC30A4-Dependent Increase in Intracellular Zn 2+ that Promotes Pathogen Persistence in Macrophages

(2016) Kavitha Subramanian Vignesh et al.   Cell Reports

Supermetallization of peptides and proteins during electrospray ionization

(2015) Yury Kostyukevich et al.   JOURNAL OF MASS SPECTROMETRY

Highly Efficient Luminescence of Cu(I) Compounds: Thermally Activated Delayed Fluorescence Combined with Short-Lived Phosphorescence

(2015) Thomas Hofbeck et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

How Closely Related Are Conformations of Protein Ions Sampled by IM-MS to Native Solution Structures?

(2015) Shu-Hua Chen et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Genetically-encoded FRET-based sensors for monitoring Zn2+ in living cells

(2015) Anne M. Hessels et al.   Metallomics

Relationship between the architecture of zinc coordination and zinc binding affinity in proteins – insights into zinc regulation

(2015) Tomasz Kochańczyk et al.   Metallomics

Analyzing free zinc(ii) ion concentrations in cell biology with fluorescent chelating molecules

(2015) Wolfgang Maret   Metallomics

Searching for harmony in transition-metal signaling

(2015) Christopher J Chang   Nature Chemical Biology

Positive and negative regulators of the metallothionein gene (Review)

(2015) SHINICHIRO TAKAHASHI   Molecular Medicine Reports

The Zinc Balance: Competitive Zinc Metalation of Carbonic Anhydrase and Metallothionein 1A

(2014) Tyler B. J. Pinter et al.   BIOCHEMISTRY

Fluorescent Sensors for Measuring Metal Ions in Living Systems

(2014) Kyle P. Carter et al.   CHEMICAL REVIEWS

Copper as a key regulator of cell signalling pathways

(2014) Alexandra Grubman et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

In vivo-folded metal-metallothionein 3 complexes reveal the Cu-thionein rather than Zn-thionein character of this brain-specific mammalian metallothionein

(2014) Ester Artells et al.   FEBS Journal

Metal Preferences and Metallation

(2014) Andrew W. Foster et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Evolution and Functional Divergence of the Metallothionein Gene Family in Vertebrates

(2014) Nina Serén et al.   JOURNAL OF MOLECULAR EVOLUTION

Metal-Induced Conformational Changes of Human Metallothionein-2A: A Combined Theoretical and Experimental Study of Metal-Free and Partially Metalated Intermediates

(2014) Shu-Hua Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Metal binding properties of the zinc finger metallome – insights into variations in stability

(2014) Anna Miłoch et al.   Metallomics

Membrane proteins bind lipids selectively to modulate their structure and function

(2014) Arthur Laganowsky et al.   NATURE

Cross-omics gene and protein expression profiling in juvenile female mice highlights disruption of calcium and zinc signalling in the brain following dietary exposure to CB-153, BDE-47, HBCD or TCDD

(2014) J.D. Rasinger et al.   TOXICOLOGY

Cellular glutathione plays a key role in copper uptake mediated by human copper transporter 1

(2013) Edward B. Maryon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Combining Chemical Labeling, Bottom-Up and Top-Down Ion-Mobility Mass Spectrometry To Identify Metal-Binding Sites of Partially Metalated Metallothionein

(2013) Shu-Hua Chen et al.   ANALYTICAL CHEMISTRY

Probing the Conformational Diversity of Cancer-Associated Mutations in p53 with Ion-Mobility Mass Spectrometry

(2013) Ewa Jurneczko et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Evolution of metallotionein isoforms complexes in hepatic cells of Mus musculus along cadmium exposure

(2013) R. Jara-Biedma et al.   BIOMETALS

Inhibitory zinc sites in enzymes

(2013) Wolfgang Maret   BIOMETALS

Optimization of Triazine Nitriles as Rhodesain Inhibitors: Structure-Activity Relationships, Bioisosteric Imidazopyridine Nitriles, and X-ray Crystal Structure Analysis with Human Cathepsin L

(2013) Veronika Ehmke et al.   ChemMedChem

Robust Affinity Standards for Cu(I) Biochemistry

(2013) Pritha Bagchi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Metal ion release from metallothioneins: proteolysis as an alternative to oxidation

(2013) Estevão A. Peroza et al.   Metallomics

Metallothionein polymorphisms in pathological processes

(2013) Martina Raudenska et al.   Metallomics

MAFFT Multiple Sequence Alignment Software Version 7: Improvements in Performance and Usability

(2013) K. Katoh et al.   MOLECULAR BIOLOGY AND EVOLUTION

The aryl hydrocarbon receptor and glucocorticoid receptor interact to activate human metallothionein 2A

(2013) Shoko Sato et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Zinc Biochemistry: From a Single Zinc Enzyme to a Key Element of Life

(2013) Wolfgang Maret   Advances in Nutrition

Unraveling the Mechanism of Electrospray Ionization

(2012) Lars Konermann et al.   ANALYTICAL CHEMISTRY

Intrinsically Disordered p53 and Its Complexes Populate Compact Conformations in the Gas Phase

(2012) Kevin Pagel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structural properties of metal-free apometallothioneins

(2012) Kelly L. Summers et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The taste of heavy metals: Gene regulation by MTF-1

(2012) Viola Günther et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Metallothionein primary structure in amphibians: Insights from comparative evolutionary analysis in vertebrates

(2012) Francesca Trinchella et al.   COMPTES RENDUS BIOLOGIES

Human Metallothionein Expression under Normal and Pathological Conditions: Mechanisms of Gene Regulation Based on In silico Promoter Analysis

(2012) Debby Laukens et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Picomolar Concentrations of Free Zinc(II) Ions Regulate Receptor Protein-tyrosine Phosphatase β Activity

(2012) Matthew Wilson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Stoichiometric Transition from Zn6Cu1-Metallothionein to Zn7-Metallothionein Underlies the Up-regulation of Metallothionein (MT) Expression

(2012) Lydia Alvarez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Femtomolar Zn2+ affinity of LIM domain of PDLIM1 protein uncovers crucial contribution of protein–protein interactions to protein stability

(2012) Małgorzata Sikorska et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Solution Structure of MSL2 CXC Domain Reveals an Unusual Zn3Cys9 Cluster and Similarity to Pre-SET Domains of Histone Lysine Methyltransferases

(2012) Sanduo Zheng et al.   PLoS One

Java bioinformatics analysis web services for multiple sequence alignment--JABAWS:MSA

(2011) P. V. Troshin et al.   BIOINFORMATICS

Promiscuity and preferences of metallothioneins: the cell rules

(2011) Andrew W Foster et al.   BMC BIOLOGY

Ferritin and metallothionein: dangerous liaisons

(2011) Ruben Orihuela et al.   CHEMICAL COMMUNICATIONS

Crystal Structure of the Human Histone Methyltransferase ASH1L Catalytic Domain and Its Implications for the Regulatory Mechanism

(2011) Sojin An et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Preparation and reactivity of a tetranuclear Fe(II) core in the metallothionein α-domain

(2011) Yohei Sano et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

New perspectives of zinc coordination environments in proteins

(2011) Wolfgang Maret   JOURNAL OF INORGANIC BIOCHEMISTRY

The Amyloid Formation Mechanism in Human IAPP: Dimers Have β-Strand Monomer−Monomer Interfaces

(2011) Nicholas F. Dupuis et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The “magic numbers” of metallothionein

(2011) Duncan E. K. Sutherland et al.   Metallomics

MTF-1-Mediated Repression of the Zinc Transporter Zip10 Is Alleviated by Zinc Restriction

(2011) Louis A. Lichten et al.   PLoS One

Role of metallothionein in cadmium traffic and toxicity in kidneys and other mammalian organs

(2010) Ivan Sabolić et al.   BIOMETALS

Metallothionein-3 regulates lysosomal function in cultured astrocytes under both normal and oxidative conditions

(2010) Sook-Jeong Lee et al.   GLIA

Coordination Properties of Zinc Finger Peptides Revisited: Ligand Competition Studies Reveal Higher Affinities for Zinc and Cobalt

(2010) Olivier Sénèque et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cytosolic zinc buffering and muffling: Their role in intracellular zinc homeostasis

(2010) Robert A. Colvin et al.   Metallomics

The challenges of determining metal–protein affinities

(2010) Zhiguang Xiao et al.   NATURAL PRODUCT REPORTS

Metallothioneins: unparalleled diversity in structures and functions for metal ion homeostasis and more

(2010) Claudia A. Blindauer et al.   NATURAL PRODUCT REPORTS

Affinity gradients drive copper to cellular destinations

(2010) Lucia Banci et al.   NATURE

Structural Biology of Human H3K9 Methyltransferases

(2010) Hong Wu et al.   PLoS One

Electrospray ionization mass spectrometry of zinc, cadmium, and copper metallothioneins: Evidence for metal-binding cooperativity

(2010) Peter M. Gehrig et al.   PROTEIN SCIENCE

Coordination Dynamics of Zinc in Proteins

(2009) Wolfgang Maret et al.   CHEMICAL REVIEWS

Reaction of the zinc sensor FluoZin-3 with Zn7-metallothionein: Inquiry into the existence of a proposed weak binding site

(2009) Mohammad Ali Namdarghanbari et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Influence of {\text{NH - }}\text{S^\gamma } bonding interactions on the structure and dynamics of metallothioneins

(2009) Núria Romero-Isart et al.   JOURNAL OF MOLECULAR MODELING

Protein kinase C regulation of neuronal zinc signaling mediates survival during preconditioning

(2009) Mandar A. Aras et al.   JOURNAL OF NEUROCHEMISTRY

Zinc deposition during ESI-MS analysis of peptide-zinc complexes

(2009) Haritha Mattapalli et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Metallothionein is upregulated by hypoxia and stabilizes hypoxia-inducible factor in the kidney

(2009) Ichiro Kojima et al.   KIDNEY INTERNATIONAL

The plant metallothionein 2 from Cicer arietinum forms a single metal–thiolate cluster

(2009) Xiaoqiong Wan et al.   Metallomics

Covalent arylation of metallothionein by oxidized dopamine products: A possible mechanism for zinc-mediated enhancement of dopaminergic neuron survival

(2009) Michelle A. Gauthier et al.   NEUROTOXICITY RESEARCH

Three-dimensional solution structure of mouse [Cd7]-metallothionein-l by homonuclear and heteronuclear NMR spectroscopy

(2009) Klaus Zangger et al.   PROTEIN SCIENCE

Metallothionein protection of cadmium toxicity

(2009) Curtis D. Klaassen et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

PCR arrays identify metallothionein-3 as a highly hypoxia-inducible gene in human adipocytes

(2008) Bohan Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Partial oxidation and oxidative polymerization of metallothionein

(2008) Hajo Haase et al.   ELECTROPHORESIS

Human metallothionein metallomics

(2008) Yuan Li et al.   JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY

Redefining the Role of Metallothionein within the Injured Brain

(2008) Roger S. Chung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metallothionein Induction by Hypoxia Involves Cooperative Interactions between Metal-Responsive Transcription Factor-1 and Hypoxia-Inducible Transcription Factor-1 

(2008) B. J. Murphy et al.   MOLECULAR CANCER RESEARCH

Protein-folding location can regulate manganese-binding versus copper- or zinc-binding

(2008) Steve Tottey et al.   NATURE

Metal swap between Zn7-metallothionein-3 and amyloid-β–Cu protects against amyloid-β toxicity

(2008) Gabriele Meloni et al.   Nature Chemical Biology

Stepwise evolution of protein native structure with electrospray into the gas phase, 10-12 to 102 s

(2008) K. Breuker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

S-Glutathionylation of metallothioneins by nitrosative/oxidative stress

(2007) Manuela Casadei et al.   EXPERIMENTAL GERONTOLOGY

Metallothionein redox biology in the cytoprotective and cytotoxic functions of zinc

(2007) Wolfgang Maret   EXPERIMENTAL GERONTOLOGY