Emerging Roles of Metallothioneins in Beta Cell Pathophysiology: Beyond and above Metal Homeostasis and Antioxidant Response

Nutrient-Induced Metabolic Stress, Adaptation, Detoxification, and Toxicity in the Pancreatic β-Cell

(2020) Marc Prentki et al.   DIABETES

Endothelial Overexpression of Metallothionein Prevents Diabetes Mellitus-Induced Impairment in Ischemia Angiogenesis via Preservation of HIF-1α/SDF-1/VEGF Signaling in Endothelial Progenitor Cells

(2020) Kai Wang et al.   DIABETES

Early beta cell dysfunction vs insulin hypersecretion as the primary event in the pathogenesis of dysglycaemia

(2020) Nathalie Esser et al.   DIABETOLOGIA

Zinc Deficiency is Associated with Poor Glycemic Control

(2019) Muhammad Farooq   JCPSP-Journal of the College of Physicians and Surgeons Pakistan

Macrophage alterations in islets of obese mice linked to beta cell disruption in diabetes

(2019) Jeng Yie Chan et al.   DIABETOLOGIA

Interactions between plasma copper concentrations and SOD1 gene polymorphism for impaired glucose regulation and type 2 diabetes

(2019) Jiawei Yin et al.   Redox Biology

Metallothionein 1 negatively regulates glucose-stimulated insulin secretion and is differentially expressed in conditions of beta cell compensation and failure in mice and humans

(2019) Mohammed Bensellam et al.   DIABETOLOGIA

Nutrient Metabolism, Subcellular Redox State, and Oxidative Stress in Pancreatic Islets and β-Cells

(2019) Leticia P. Roma et al.   JOURNAL OF MOLECULAR BIOLOGY

Serum copper profile in patients with type 1 diabetes in comparison to other metals

(2019) Rosanna Squitti et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Metallothioneins are neuroprotective agents in lysosomal storage disorders

(2018) Eleonora Cavalca et al.   ANNALS OF NEUROLOGY

Glucose Acutely Reduces Cytosolic and Mitochondrial H2O2 in Rat Pancreatic Beta Cells

(2018) Jean-Philippe Deglasse et al.   ANTIOXIDANTS & REDOX SIGNALING

Identification of early biological changes in palmitate-treated isolated human islets

(2018) Ernest Sargsyan et al.   BMC GENOMICS

Contribution of oxidative stress and impaired biogenesis of pancreatic β-cells to type 2 diabetes

(2018) Petr Jezek et al.   ANTIOXIDANTS & REDOX SIGNALING

Metallothioneins: Emerging Modulators in Immunity and Infection

(2017) Kavitha Subramanian Vignesh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mechanisms of β-cell dedifferentiation in diabetes: recent findings and future research directions

(2017) Mohammed Bensellam et al.   JOURNAL OF ENDOCRINOLOGY

Chronic high fat feeding restricts islet mRNA translation initiation independently of ER stress via DNA damage and p53 activation

(2017) Masayuki Hatanaka et al.   Scientific Reports

Immunomodulation of cell-penetrating tat-metallothionein for successful outcome of xenotransplanted pancreatic islet

(2016) Min Jun Kim et al.   JOURNAL OF DRUG TARGETING

Comprehensive alpha, beta and delta cell transcriptomes reveal that ghrelin selectively activates delta cells and promotes somatostatin release from pancreatic islets

(2016) Michael R. DiGruccio et al.   Molecular Metabolism

Glucokinase activation is beneficial or toxic to cultured rat pancreatic islets depending on the prevailing glucose concentration

(2015) Leticia P. Roma et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Novel Observations From Next-Generation RNA Sequencing of Highly Purified Human Adult and Fetal Islet Cell Subsets

(2015) David M. Blodgett et al.   DIABETES

Dual Opposing Roles of Metallothionein Overexpression in C57BL/6J Mouse Pancreatic β-Cells

(2015) Suqin Chen et al.   PLoS One

Intracellular zinc in insulin secretion and action: a determinant of diabetes risk?

(2015) Guy A. Rutter et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

Insulin secretory granules control autophagy in pancreatic   cells

(2015) A. Goginashvili et al.   SCIENCE

Low alpha-synuclein levels in the blood are associated with insulin resistance

(2015) Gerardo Rodriguez-Araujo et al.   Scientific Reports

Positive and negative regulators of the metallothionein gene (Review)

(2015) SHINICHIRO TAKAHASHI   Molecular Medicine Reports

Calcium signaling in pancreatic β-cells in health and in Type 2 diabetes

(2014) Patrick Gilon et al.   CELL CALCIUM

Metallothionein and stress combine to affect multiple organ systems

(2014) Michael A. Lynes et al.   CELL STRESS & CHAPERONES

Hypoxia lowers SLC30A8/ZnT8 expression and free cytosolic Zn2+ in pancreatic beta cells

(2014) Philipp A. Gerber et al.   DIABETOLOGIA

Role of metallothioneins as danger signals in the pathogenesis of colitis

(2014) Lindsey Devisscher et al.   JOURNAL OF PATHOLOGY

The role of metallothionein-3 in streptozotocin-induced beta-islet cell death and diabetes in mice

(2014) Hyae-Ran Byun et al.   Metallomics

Alterations of Pancreatic Islet Structure, Metabolism and Gene Expression in Diet-Induced Obese C57BL/6J Mice

(2014) Regan Roat et al.   PLoS One

Lipotoxic endoplasmic reticulum stress, β cell failure, and type 2 diabetes mellitus

(2014) Trevor J. Biden et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Oxidative stress and DNA repair and detoxification gene expression in adolescents exposed to heavy metals living in the Milazzo-Valle del Mela area (Sicily, Italy)

(2014) Gabriele Pizzino et al.   Redox Biology

The Type 2 Diabetes-Associated Gene Ide Is Required for Insulin Secretion and Suppression of  -Synuclein Levels in  -Cells

(2013) P. Steneberg et al.   DIABETES

Hypoxic resistance of hypodermically transplanted pancreatic islets by using cell-absorbable antioxidant Tat-metallothionein

(2013) Hae Song Jung et al.   JOURNAL OF CONTROLLED RELEASE

Mammalian MT1 and MT2 metallothioneins differ in their metal binding abilities

(2013) Ester Artells et al.   Metallomics

Metallothionein polymorphisms in pathological processes

(2013) Martina Raudenska et al.   Metallomics

Zinc, pancreatic islet cell function and diabetes: new insights into an old story

(2013) Fabrice Chimienti   NUTRITION RESEARCH REVIEWS

Accumulation of cadmium in insulin-producing β cells

(2013) Malek El Muayed et al.   Islets

Zinc Biochemistry: From a Single Zinc Enzyme to a Key Element of Life

(2013) Wolfgang Maret   Advances in Nutrition

Zinc, Copper, Iron, and Chromium Concentrations in Young Patients with Type 2 Diabetes Mellitus

(2012) M. Basaki et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Divalent Metal Transporter 1 Regulates Iron-Mediated ROS and Pancreatic β Cell Fate in Response to Cytokines

(2012) Jakob Bondo Hansen et al.   Cell Metabolism

Human Metallothionein Expression under Normal and Pathological Conditions: Mechanisms of Gene Regulation Based on In silico Promoter Analysis

(2012) Debby Laukens et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Failure of the Adaptive Unfolded Protein Response in Islets of Obese Mice Is Linked With Abnormalities in  -Cell Gene Expression and Progression to Diabetes

(2012) J. Y. Chan et al.   DIABETES

Mitochondrial oxidative stress contributes differently to rat pancreatic islet cell apoptosis and insulin secretory defects after prolonged culture in a low non-stimulating glucose concentration

(2012) L. P. Roma et al.   DIABETOLOGIA

Disturbed zinc homeostasis in diabetic patients by in vitro and in vivo analysis of insulinomimetic activity of zinc

(2012) Judith Jansen et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

The molecular mechanisms of pancreatic β-cell glucotoxicity: Recent findings and future research directions

(2012) Mohammed Bensellam et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Glucose-Induced O2 Consumption Activates Hypoxia Inducible Factors 1 and 2 in Rat Insulin-Secreting Pancreatic Beta-Cells

(2012) Mohammed Bensellam et al.   PLoS One

Protective Antioxidant and Antiapoptotic Effects of ZnCl2 in Rat Pancreatic Islets Cultured in Low and High Glucose Concentrations

(2012) Jessica Duprez et al.   PLoS One

The combination of metallothionein and superoxide dismutase protects pancreatic β cells from oxidative damage

(2011) Leejin Park et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Tat-enhanced delivery of metallothionein can partially prevent the development of diabetes

(2011) Leejin Park et al.   FREE RADICAL BIOLOGY AND MEDICINE

Glucose Regulates Free Cytosolic Zn2+Concentration, Slc39 (ZiP), and Metallothionein Gene Expression in Primary Pancreatic Islet β-Cells

(2011) Elisa A. Bellomo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

α-Synuclein binds the KATP channel at insulin-secretory granules and inhibits insulin secretion

(2010) Xuehui Geng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Preparation and functional analysis of recombinant protein transduction domain-metallothionein fusion proteins

(2010) Kwang Suk Lim et al.   BIOCHIMIE

Metallothionein as Potential Biomarker of Cadmium Exposure in Persian Sturgeon (Acipenser persicus)

(2010) Fatemeh Shariati et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Early biomarkers of cadmium exposure and nephrotoxicity

(2010) Walter C. Prozialeck et al.   BIOMETALS

Peroxisome-Generated Hydrogen Peroxide as Important Mediator of Lipotoxicity in Insulin-Producing Cells

(2010) M. Elsner et al.   DIABETES

Transgenic expression of haem oxygenase-1 in pancreatic beta cells protects non-obese mice used as a model of diabetes from autoimmune destruction and prolongs graft survival following islet transplantation

(2010) S. H. Huang et al.   DIABETOLOGIA

Gene Expression Profiles of Beta-Cell Enriched Tissue Obtained by Laser Capture Microdissection from Subjects with Type 2 Diabetes

(2010) Lorella Marselli et al.   PLoS One

Cytokines Interleukin-1  and Tumor Necrosis Factor-  Regulate Different Transcriptional and Alternative Splicing Networks in Primary  -Cells

(2009) F. Ortis et al.   DIABETES

Glucose regulation of islet stress responses and β-cell failure in type 2 diabetes

(2009) J. C. Jonas et al.   DIABETES OBESITY & METABOLISM

Cluster analysis of rat pancreatic islet gene mRNA levels after culture in low-, intermediate- and high-glucose concentrations

(2009) M. Bensellam et al.   DIABETOLOGIA

Metallothionein: In Vitro Induction With Zinc and Streptozotocin in Pancreatic Islets of Mice

(2009) Patricia Ohly et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Altered metabolism of copper, zinc, and magnesium is associated with increased levels of glycated hemoglobin in patients with diabetes mellitus

(2009) Alena Viktorínová et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Potential Role of α-Synuclein and Metallothionein in Lead-Induced Inclusion Body Formation

(2009) Peijun Zuo et al.   TOXICOLOGICAL SCIENCES

Polymorphisms in metallothionein-1 and -2 genes associated with the risk of type 2 diabetes mellitus and its complications

(2008) Lina Yang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Zinc protects endothelial cells from hydrogen peroxide via Nrf2-dependent stimulation of glutathione biosynthesis

(2008) Miriam M. Cortese et al.   FREE RADICAL BIOLOGY AND MEDICINE

Redefining the Role of Metallothionein within the Injured Brain

(2008) Roger S. Chung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nrf1 and Nrf2 Play Distinct Roles in Activation of Antioxidant Response Element-dependent Genes

(2008) Makiko Ohtsuji et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

+647 A/C and +1245 MT1A polymorphisms in the susceptibility of diabetes mellitus and cardiovascular complications

(2008) R. Giacconi et al.   MOLECULAR GENETICS AND METABOLISM