Inhibition of the hERG potassium channel by phenanthrene: a polycyclic aromatic hydrocarbon pollutant

Phenanthrene impacts zebrafish cardiomyocyte excitability by inhibiting IKr and shortening action potential duration

(2021) Shiva N. Kompella et al.   JOURNAL OF GENERAL PHYSIOLOGY

Cryo-EM structure of K+-bound hERG channel complexed with the blocker astemizole

(2021) Tatsuki Asai et al.   STRUCTURE

Heart Failure and PAHs, OHPAHs, and Trace Elements Levels in Human Serum: Results from a Preliminary Pilot Study in Greek Population and the Possible Impact of Air Pollution

(2021) Eirini Chrysochou et al.   MOLECULES

Inhibition of hERG Potassium Channels by the Polycylic Aromatic Hydrocarbon Phenanthrene

(2020) Ehab Al-Moubarak et al.   BIOPHYSICAL JOURNAL

An Update on the Structure of hERG

(2020) Andrew Butler et al.   Frontiers in Pharmacology

Serine mutation of a conserved threonine in the hERG K+ channel S6-pore region leads to loss-of-function through trafficking impairment

(2020) Ehab Al-Moubarak et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Targeting the Kv11.1 (hERG) channel with allosteric modulators. Synthesis and biological evaluation of three novel series of LUF7346 derivatives

(2020) Jacobus P.D. van Veldhoven et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Facilitation of IKr current by some hERG channel blockers suppresses early afterdepolarizations

(2019) Kazuharu Furutani et al.   JOURNAL OF GENERAL PHYSIOLOGY

Polycyclic aromatic hydrocarbons phenanthrene and retene modify the action potential via multiple ion currents in rainbow trout Oncorhynchus mykiss cardiac myocytes

(2019) Eeva-Riikka Vehniäinen et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

The Pore-Lipid Interface: Role of Amino-Acid Determinants of Lipophilic Access by Ivabradine to the hERG1 Pore Domain

(2019) Laura Perissinotti et al.   MOLECULAR PHARMACOLOGY

Characterizing Crude Oil Toxicity to Early-Life Stage Fish Based On a Complex Mixture: Are We Making Unsupported Assumptions?

(2019) James P. Meador et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Potent hERG channel inhibition by sarizotan, an investigative treatment for Rett Syndrome

(2019) Hongwei Cheng et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Calculation of absolute binding free energies between the hERG channel and structurally diverse drugs

(2019) Tatsuki Negami et al.   Scientific Reports

Understanding the cardiac toxicity of the anthropogenic pollutant phenanthrene on the freshwater indicator species, the brown trout (Salmo trutta): From whole heart to cardiomyocytes

(2019) Martins Oshioriamhe Ainerua et al.   CHEMOSPHERE

Revealing Molecular Determinants of hERG Blocker and Activator Binding

(2019) Callum J. Dickson et al.   Journal of Chemical Information and Modeling

Polyaromatic hydrocarbons in pollution: a heart‐breaking matter

(2019) C. R. Marris et al.   JOURNAL OF PHYSIOLOGY-LONDON

Identification of a proton sensor that regulates conductance and open time of single hERG channels

(2019) Stacey L. Wilson et al.   Scientific Reports

Emerging therapeutic targets in the short QT syndrome

(2018) Jules C Hancox et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Structural implications of hERG K+channel block by a high-affinity minimally structured blocker

(2018) Matthew V. Helliwell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel Cardiotoxic Mechanism for a Pervasive Global Pollutant

(2017) Fabien Brette et al.   Scientific Reports

Interactions between amiodarone and the hERG potassium channel pore determined with mutagenesis and in silico docking

(2016) Yihong Zhang et al.   BIOCHEMICAL PHARMACOLOGY

A Novel Voltage Sensor in the Orthosteric Binding Site of the M2 Muscarinic Receptor

(2016) Ofra Barchad-Avitzur et al.   BIOPHYSICAL JOURNAL

KCNE1 induces fenestration in the Kv7.1/KCNE1 channel complex that allows for highly specific pharmacological targeting

(2016) Eva Wrobel et al.   Nature Communications

New potential binding determinant for hERG channel inhibitors

(2016) P. Saxena et al.   Scientific Reports

K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac

(2015) Y. Y. Dong et al.   SCIENCE

hERG Potassium Channel Blockade by the HCN Channel Inhibitor Bradycardic Agent Ivabradine

(2015) D. Melgari et al.   Journal of the American Heart Association

Assessing hERG Pore Models As Templates for Drug Docking Using Published Experimental Constraints: The Inactivated State in the Context of Drug Block

(2014) Christopher E. Dempsey et al.   Journal of Chemical Information and Modeling

Ranolazine inhibition of hERG potassium channels: Drug–pore interactions and reduced potency against inactivation mutants

(2014) Chunyun Du et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

hERG 1b is critical for human cardiac repolarization

(2014) David K. Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PNAS Plus: From the Cover: Deepwater Horizon crude oil impacts the developing hearts of large predatory pelagic fish

(2014) J. P. Incardona et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crude Oil Impairs Cardiac Excitation-Contraction Coupling in Fish

(2014) F. Brette et al.   SCIENCE

Side pockets provide the basis for a new mechanism of Kv channel–specific inhibition

(2013) Stefanie Marzian et al.   Nature Chemical Biology

Levels of Polycyclic Aromatic Hydrocarbons, Polychlorinated Biphenyls, and Organochlorine Pesticides in Various Tissues of White-Backed Vulture in India

(2013) V. Dhananjayan et al.   Biomed Research International

Pharmacophore modeling for hERG channel facilitation

(2012) Yuko Yamakawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Comparative study of polycyclic aromatic hydrocarbons (PAHs) in plasma of Eastern Atlantic juvenile and adult nesting loggerhead sea turtles (Caretta caretta)

(2012) María Camacho et al.   MARINE POLLUTION BULLETIN

Baltimore PM2.5 Supersite: highly time-resolved organic compounds—sampling duration and phase distribution—implications for health effects studies

(2011) Wolfgang F. Rogge et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

A mechanism underlying compound-induced voltage shift in the current activation of hERG by antiarrhythmic agents

(2011) Kazuharu Furutani et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Enhanced inhibitory effect of acidosis on hERG potassium channels that incorporate the hERG1b isoform

(2011) C.Y. Du et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Molecular determinants of hERG potassium channel inhibition by disopyramide

(2011) Aziza El Harchi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Metabolism of [D10]Phenanthrene to Tetraols in Smokers for Potential Lung Cancer Susceptibility Assessment: Comparison of Oral and Inhalation Routes of Administration

(2011) Y. Zhong et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Mechanistic Insight into Humanether-à-go-go-related Gene (hERG) K+Channel Deactivation Gating from the Solution Structure of the EAG Domain

(2010) Frederick W. Muskett et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acidosis Impairs the Protective Role of hERG K+ Channels Against Premature Stimulation

(2010) CHUN YUN DU et al.   JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY

Characterization of PM2.5-bound polycyclic aromatic hydrocarbons in Atlanta—Seasonal variations at urban, suburban, and rural ambient air monitoring sites

(2009) Zheng Li et al.   ATMOSPHERIC ENVIRONMENT

Block effect of capsaicin on hERG potassium currents is enhanced by S6 mutation at Y652

(2009) Junlian Xing et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Pharmacology of the short QT syndrome N588K-hERG K+channel mutation: differential impact on selected class I and class III antiarrhythmic drugs

(2008) M J McPate et al.   BRITISH JOURNAL OF PHARMACOLOGY

Physiological Properties of hERG 1a/1b Heteromeric Currents and a hERG 1b-Specific Mutation Associated With Long-QT Syndrome

(2008) Harinath Sale et al.   CIRCULATION RESEARCH

Cardiac Arrhythmia Is the Primary Response of Embryonic Pacific Herring (Clupea pallasi) Exposed to Crude Oil during Weathering

(2008) John P. Incardona et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Drug Binding to the Inactivated State Is Necessary but Not Sufficient for High-Affinity Binding to Human Ether-a-go-go-Related Gene Channels

(2008) M. J. Perrin et al.   MOLECULAR PHARMACOLOGY

The hERG potassium channel and hERG screening for drug-induced torsades de pointes

(2008) Jules C. Hancox et al.   PHARMACOLOGY & THERAPEUTICS