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Title
An Update on the Structure of hERG
Authors
Keywords
-
Journal
Frontiers in Pharmacology
Volume 10, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2020-01-24
DOI
10.3389/fphar.2019.01572
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- (2019) Bryan Cernuda et al. PLoS One
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- (2019) Gail A. Robertson et al. BIOPHYSICAL JOURNAL
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- (2019) Hongwei Cheng et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Calculation of absolute binding free energies between the hERG channel and structurally diverse drugs
- (2019) Tatsuki Negami et al. Scientific Reports
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- (2018) Roy J. Vaz et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
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- Structural implications of hERG K+channel block by a high-affinity minimally structured blocker
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- Probing the molecular basis of hERG drug block with unnatural amino acids
- (2018) Logan C. Macdonald et al. Scientific Reports
- Investigating the state dependence of drug binding in hERG channels using a trapped-open channel phenotype
- (2018) Samrat Thouta et al. Scientific Reports
- Multiple clinical profiles of families with the short QT syndrome
- (2017) D Akdis et al. EUROPACE
- A perspective on Na and K channel inactivation
- (2017) Clay M. Armstrong et al. JOURNAL OF GENERAL PHYSIOLOGY
- A new mechanism of voltage-dependent gating exposed by K V 10.1 channels interrupted between voltage sensor and pore
- (2017) Adam P. Tomczak et al. JOURNAL OF GENERAL PHYSIOLOGY
- Development of Safe Drugs: The hERG Challenge
- (2017) Subha Kalyaanamoorthy et al. MEDICINAL RESEARCH REVIEWS
- Gating mechanism of Kv11.1 (hERG) K+ channels without covalent connection between voltage sensor and pore domains
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- Allosteric Modulation of Kv11.1 (hERG) Channels Protects Against Drug-Induced Ventricular Arrhythmias
- (2016) Zhiyi Yu et al. Circulation-Arrhythmia and Electrophysiology
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- (2016) Christian Jorgensen et al. MOLECULAR PHARMACEUTICS
- Structure of the voltage-gated K+ channel Eag1 reveals an alternative voltage sensing mechanism
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- New potential binding determinant for hERG channel inhibitors
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- K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac
- (2015) Y. Y. Dong et al. SCIENCE
- Voltage-dependent gating of KCNH potassium channels lacking a covalent link between voltage-sensing and pore domains
- (2015) Éva Lörinczi et al. Nature Communications
- hERG Potassium Channel Blockade by the HCN Channel Inhibitor Bradycardic Agent Ivabradine
- (2015) D. Melgari et al. Journal of the American Heart Association
- Assessing hERG Pore Models As Templates for Drug Docking Using Published Experimental Constraints: The Inactivated State in the Context of Drug Block
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- Stoichiometry of altered hERG1 channel gating by small molecule activators
- (2014) Wei Wu et al. JOURNAL OF GENERAL PHYSIOLOGY
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- Large-scale mutational analysis of Kv11.1 reveals molecular insights into type 2 long QT syndrome
- (2014) Corey L. Anderson et al. Nature Communications
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- (2013) Michael C Sanguinetti CURRENT OPINION IN PHARMACOLOGY
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- (2013) Matthew D. Perry et al. JOURNAL OF GENERAL PHYSIOLOGY
- Functional interactions of voltage sensor charges with an S2 hydrophobic plug in hERG channels
- (2013) Yen May Cheng et al. JOURNAL OF GENERAL PHYSIOLOGY
- Current pharmacogenomic studies on hERG potassium channels
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- Docking Model of Drug Binding to the Human Ether-à-go-go Potassium Channel Guided by Tandem Dimer Mutant Patch-Clamp Data: A Synergic Approach
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