Structural implications of hERG K+channel block by a high-affinity minimally structured blocker

Molecular determinants of loperamide and N -desmethyl loperamide binding in the hERG cardiac K + channel

(2018) Roy J. Vaz et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Probing the molecular basis of hERG drug block with unnatural amino acids

(2018) Logan C. Macdonald et al.   Scientific Reports

Interactions between amiodarone and the hERG potassium channel pore determined with mutagenesis and in silico docking

(2016) Yihong Zhang et al.   BIOCHEMICAL PHARMACOLOGY

A Novel Voltage Sensor in the Orthosteric Binding Site of the M2 Muscarinic Receptor

(2016) Ofra Barchad-Avitzur et al.   BIOPHYSICAL JOURNAL

Structure of the voltage-gated K+ channel Eag1 reveals an alternative voltage sensing mechanism

(2016) J. R. Whicher et al.   SCIENCE

New potential binding determinant for hERG channel inhibitors

(2016) P. Saxena et al.   Scientific Reports

Molecular basis of hERG potassium channel blockade by the class Ic antiarrhythmic flecainide

(2015) Dario Melgari et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

hERG Potassium Channel Blockade by the HCN Channel Inhibitor Bradycardic Agent Ivabradine

(2015) D. Melgari et al.   Journal of the American Heart Association

Blockade of HERG Human K+ Channels by the Antidepressant Drug Paroxetine

(2014) Seung Ho Lee et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Assessing hERG Pore Models As Templates for Drug Docking Using Published Experimental Constraints: The Inactivated State in the Context of Drug Block

(2014) Christopher E. Dempsey et al.   Journal of Chemical Information and Modeling

Ranolazine inhibition of hERG potassium channels: Drug–pore interactions and reduced potency against inactivation mutants

(2014) Chunyun Du et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Computational Design and Discovery of “Minimally Structured” hERG Blockers

(2012) Andrea Cavalli et al.   JOURNAL OF MEDICINAL CHEMISTRY

hERG K+ Channels: Structure, Function, and Clinical Significance

(2012) Jamie I. Vandenberg et al.   PHYSIOLOGICAL REVIEWS

Action Potential Clamp and Pharmacology of the Variant 1 Short QT Syndrome T618I hERG K+ Channel

(2012) Aziza El Harchi et al.   PLoS One

The hERG K+ channel S4 domain L532P mutation: Characterization at 37°C

(2011) Yi H. Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Pharmacological Inhibition of the hERG Potassium Channel Is Modulated by Extracellular But Not Intracellular Acidosis

(2011) C.Y. DU et al.   JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY

Molecular determinants of hERG potassium channel inhibition by disopyramide

(2011) Aziza El Harchi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Acidosis Impairs the Protective Role of hERG K+ Channels Against Premature Stimulation

(2010) CHUN YUN DU et al.   JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY

Characterization of recombinant hERG K+ channel inhibition by the active metabolite of amiodarone desethyl-amiodarone

(2010) Yi H. Zhang et al.   JOURNAL OF ELECTROCARDIOLOGY

SYMPOSIUM REVIEW: Revealing the structural basis of action of hERG potassium channel activators and blockers

(2010) Matthew Perry et al.   JOURNAL OF PHYSIOLOGY-LONDON

Docking Model of Drug Binding to the Human Ether-à-go-go Potassium Channel Guided by Tandem Dimer Mutant Patch-Clamp Data: A Synergic Approach

(2009) Yumi N. Imai et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Pore Domain Outer Helix Contributes to Both Activation and Inactivation of the hERG K+Channel

(2008) Pengchu Ju et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Determinants of hERG Channel Block by Terfenadine and Cisapride

(2008) Kaichiro Kamiya et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Topological Mapping of the Asymmetric Drug Binding to the Human Ether-a-go-go-Related Gene Product (HERG) Potassium Channel by Use of Tandem Dimers

(2008) T. Myokai et al.   MOLECULAR PHARMACOLOGY

Drug Binding to the Inactivated State Is Necessary but Not Sufficient for High-Affinity Binding to Human Ether-a-go-go-Related Gene Channels

(2008) M. J. Perrin et al.   MOLECULAR PHARMACOLOGY

The hERG potassium channel and hERG screening for drug-induced torsades de pointes

(2008) Jules C. Hancox et al.   PHARMACOLOGY & THERAPEUTICS