KCNE1 induces fenestration in the Kv7.1/KCNE1 channel complex that allows for highly specific pharmacological targeting

The ladder-shaped polyether toxin gambierol anchors the gating machinery of Kv3.1 channels in the resting state

(2013) Ivan Kopljar et al.   JOURNAL OF GENERAL PHYSIOLOGY

Side pockets provide the basis for a new mechanism of Kv channel–specific inhibition

(2013) Stefanie Marzian et al.   Nature Chemical Biology

How Does KCNE1 Regulate the Kv7.1 Potassium Channel? Model-Structure, Mutations, and Dynamics of the Kv7.1-KCNE1 Complex

(2012) Yana Gofman et al.   STRUCTURE

The KCNE Tango – How KCNE1 Interacts with Kv7.1

(2012) Eva Wrobel et al.   Frontiers in Pharmacology

Diazirine based photoaffinity labeling

(2011) Luba Dubinsky et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Structural Basis of Slow Activation Gating in the Cardiac IKs Channel Complex

(2011) Nathalie Strutz-Seebohm et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Aliphatic Diazirines as Photoaffinity Probes for Proteins: Recent Developments

(2011) Joydip Das   CHEMICAL REVIEWS

The crystal structure of a voltage-gated sodium channel

(2011) Jian Payandeh et al.   NATURE

KV7 channelopathies

(2010) Snezana Maljevic et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Long QT Syndrome-associated Mutations in the Voltage Sensor of IKs Channels

(2009) Ulrike Henrion et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Structural basis for KV7.1–KCNEx interactions in the IKs channel complex

(2009) Alicia Lundby et al.   HEART RHYTHM

Voltage-gated potassium channels as therapeutic targets

(2009) Heike Wulff et al.   NATURE REVIEWS DRUG DISCOVERY

Blockade of the IKs potassium channel: An overlooked cardiovascular liability in drug safety screening?

(2009) Rob Towart et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Use of the viral 2A peptide for bicistronic expression in transgenic mice

(2008) Georgios Trichas et al.   BMC BIOLOGY

SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations

(2008) Hiroyuki Unoki et al.   NATURE GENETICS

Modification of K+channel-drug interactions by ancillary subunits

(2007) Glenna C. L. Bett et al.   JOURNAL OF PHYSIOLOGY-LONDON