Facilitation of IKr current by some hERG channel blockers suppresses early afterdepolarizations

Cardiac CaMKII activation promotes rapid translocation to its extra-dyadic targets

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Hysteretic Dynamics of Multi-Stable Early Afterdepolarisations with Repolarisation Reserve Attenuation: A Potential Dynamical Mechanism for Cardiac Arrhythmias

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Meta-analysis of the efficacies of amiodarone and nifekalant in shock-resistant ventricular fibrillation and pulseless ventricular tachycardia

(2017) Shiho Sato et al.   Scientific Reports

Evolution of strategies to improve preclinical cardiac safety testing

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Narrow therapeutic index drugs: a clinical pharmacological consideration to flecainide

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Representing Variability and Transmural Differences in a Model of Human Heart Failure

(2015) Mohamed M. Elshrif et al.   IEEE Journal of Biomedical and Health Informatics

A Study of Early Afterdepolarizations in a Model for Human Ventricular Tissue

(2014) Nele Vandersickel et al.   PLoS One

Rechanneling the cardiac proarrhythmia safety paradigm: A meeting report from the Cardiac Safety Research Consortium

(2013) Philip T. Sager et al.   AMERICAN HEART JOURNAL

MICE Models: Superior to the HERG Model in Predicting Torsade de Pointes

(2013) James Kramer et al.   Scientific Reports

Revisiting the ionic mechanisms of early afterdepolarizations in cardiomyocytes: predominant by Ca waves or Ca currents?

(2012) Zhenghang Zhao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Pharmacophore modeling for hERG channel facilitation

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A mechanism underlying compound-induced voltage shift in the current activation of hERG by antiarrhythmic agents

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Comparison of the IKr blockers moxifloxacin, dofetilide and E-4031 in five screening models of pro-arrhythmia reveals lack of specificity of isolated cardiomyocytes

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Simulation of multiple ion channel block provides improved early prediction of compounds’ clinical torsadogenic risk

(2011) Gary R. Mirams et al.   CARDIOVASCULAR RESEARCH

Simulation of the Undiseased Human Cardiac Ventricular Action Potential: Model Formulation and Experimental Validation

(2011) Thomas O'Hara et al.   PLoS Computational Biology

Irregularly Appearing Early Afterdepolarizations in Cardiac Myocytes: Random Fluctuations or Dynamical Chaos?

(2010) Daisuke Sato et al.   BIOPHYSICAL JOURNAL

Prevention of Torsade de Pointes in Hospital Settings

(2010) Barbara J. Drew et al.   CIRCULATION

Genesis of Phase 3 Early Afterdepolarizations and Triggered Activity in Acquired Long-QT Syndrome

(2010) Mitsunori Maruyama et al.   Circulation-Arrhythmia and Electrophysiology

The amiodarone derivative KB130015 activates hERG1 potassium channels via a novel mechanism

(2010) Guido Gessner et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Early afterdepolarizations and cardiac arrhythmias

(2010) James N. Weiss et al.   HEART RHYTHM

Rate-dependent action potential alternans in human heart failure implicates abnormal intracellular calcium handling

(2010) Jason D. Bayer et al.   HEART RHYTHM

Electrophysiological Properties of HBI-3000: A New Antiarrhythmic Agent With Multiple-channel Blocking Properties in Human Ventricular Myocytes

(2010) Donglin Guo et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Sensitive and reliable proarrhythmiain vivoanimal models for predicting drug-induced torsades de pointes in patients with remodelled hearts

(2008) A Sugiyama   BRITISH JOURNAL OF PHARMACOLOGY

Cellular basis of drug-induced torsades de pointes

(2008) D M Roden   BRITISH JOURNAL OF PHARMACOLOGY

Oxidative Stress–Induced Afterdepolarizations and Calmodulin Kinase II Signaling

(2008) Lai-Hua Xie et al.   CIRCULATION RESEARCH