Targeting the Kv11.1 (hERG) channel with allosteric modulators. Synthesis and biological evaluation of three novel series of LUF7346 derivatives

An Update on the Structure of hERG

(2020) Andrew Butler et al.   Frontiers in Pharmacology

LUF7244 plus Dofetilide Rescues Aberrant Kv11.1 Trafficking and Produces Functional IKv11.1

(2020) Muge Qile et al.   MOLECULAR PHARMACOLOGY

LUF7244, an allosteric modulator/activator of K v 11.1 channels, counteracts dofetilide‐induced TdP arrhythmia in the chronic atrioventricular block dog model

(2019) Muge Qile et al.   BRITISH JOURNAL OF PHARMACOLOGY

Trigger vs. Substrate: Multi-Dimensional Modulation of QT-Prolongation Associated Arrhythmic Dynamics by a hERG Channel Activator

(2017) Michael A. Colman et al.   Frontiers in Physiology

Dissociative States: hERG Channel (Kv11.1) Modulators That Enhance Dissociation of Drugs From Their Blocking Receptor

(2016) Saman Rezazadeh et al.   Circulation-Arrhythmia and Electrophysiology

Allosteric Modulation of Kv11.1 (hERG) Channels Protects Against Drug-Induced Ventricular Arrhythmias

(2016) Zhiyi Yu et al.   Circulation-Arrhythmia and Electrophysiology

A new hERG allosteric modulator rescues genetic and drug‐induced long‐QT syndrome phenotypes in cardiomyocytes from isogenic pairs of patient induced pluripotent stem cells

(2016) Luca Sala et al.   EMBO Molecular Medicine

Evidence for the hERG Liability of Antihistamines, Antipsychotics, and Anti-Infective Agents: A Systematic Literature Review From the ARITMO Project

(2016) Lorna Hazell et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Early drug development: assessment of proarrhythmic risk and cardiovascular safety

(2016) Robert M. Lester et al.   Expert Review of Clinical Pharmacology

Synthesis and biological evaluation of negative allosteric modulators of the Kv11.1(hERG) channel

(2015) Zhiyi Yu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Pyrrolo[3,2-b]quinoxaline Derivatives as Types I1/2 and II Eph Tyrosine Kinase Inhibitors: Structure-Based Design, Synthesis, and in Vivo Validation

(2014) Andrea Unzue et al.   JOURNAL OF MEDICINAL CHEMISTRY

Recessive cardiac phenotypes in induced pluripotent stem cell models of Jervell and Lange-Nielsen syndrome: Disease mechanisms and pharmacological rescue

(2014) Miao Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification and Characterization of a Compound That Protects Cardiac Tissue from Human Ether-à-go-go-related Gene (hERG)-related Drug-induced Arrhythmias

(2012) Franck Potet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of an hERG Activator, ICA-105574, on Electrophysiological Properties of Canine Hearts

(2012) Mahoko Asayama et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

hERG K+ Channels: Structure, Function, and Clinical Significance

(2012) Jamie I. Vandenberg et al.   PHYSIOLOGICAL REVIEWS

Modulation of hERG potassium channel gating normalizes action potential duration prolonged by dysfunctional KCNQ1 potassium channel

(2012) H. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhanced Repolarization Capacity: New Potential Antiarrhythmic Strategy Based on hERG Channel Activation

(2011) G. Szabo et al.   CURRENT MEDICINAL CHEMISTRY

The Importance of Being Profiled: Improving Drug Candidate Safety and Efficacy Using Ion Channel Profiling

(2011) Gregory J. Kaczorowski et al.   Frontiers in Pharmacology

A protocol describing the use of a recombinant protein-based, animal product-free medium (APEL) for human embryonic stem cell differentiation as spin embryoid bodies

(2008) Elizabeth S Ng et al.   Nature Protocols