The S1P2 receptor regulates blood-brain barrier integrity and leukocyte extravasation with implications for neurodegenerative disease

Microglial activation and tau burden predict cognitive decline in Alzheimer’s disease

(2020) Maura Malpetti et al.   BRAIN

Pro - and anti-inflammatory cytokines in the CSF of Alzheimer´s disease patients and their correlation with cognitive decline

(2019) R. Taipa et al.   NEUROBIOLOGY OF AGING

Vascular Cognitive Impairment and Dementia

(2019) Costantino Iadecola et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

S1P2 contributes to microglial activation and M1 polarization following cerebral ischemia through ERK1/2 and JNK

(2019) Arjun Sapkota et al.   Scientific Reports

Blood-brain barrier breakdown, neuroinflammation, and cognitive decline in older adults

(2018) Gene L. Bowman et al.   Alzheimers & Dementia

Size-selective opening of the blood–brain barrier by targeting endothelial sphingosine 1–phosphate receptor 1

(2017) Keisuke Yanagida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tanshinol suppresses inflammatory factors in a rat model of vascular dementia and protects LPS-treated neurons via the MST1-FOXO3 signaling pathway

(2016) Yishu Yang et al.   BRAIN RESEARCH

LPS-induced Murine Neuroinflammation Model: Main Features and Suitability for Pre-clinical Assessment of Nutraceuticals

(2016) Miryam Nava Catorce et al.   Current Neuropharmacology

Regulation of human cerebro-microvascular endothelial baso-lateral adhesion and barrier function by S1P through dual involvement of S1P1 and S1P2 receptors

(2016) Rachael Wiltshire et al.   Scientific Reports

Sphingosine 1-phosphate receptor 2 (S1P2) attenuates reactive oxygen species formation and inhibits cell death: implications for otoprotective therapy

(2016) Deron R. Herr et al.   Scientific Reports

Increasing the Permeability of the Blood-brain Barrier in Three Different Modelsin vivo

(2015) Wei-Ye Liu et al.   CNS Neuroscience & Therapeutics

Lipopolysaccharide-induced blood-brain barrier disruption: roles of cyclooxygenase, oxidative stress, neuroinflammation, and elements of the neurovascular unit

(2015) William A. Banks et al.   Journal of Neuroinflammation

The Blood–Brain Barrier

(2015) Richard Daneman et al.   Cold Spring Harbor Perspectives in Biology

Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin

(2015) Claudia Nussbaum et al.   Nature Communications

Critical role of sphingosine-1-phosphate receptor-2 in the disruption of cerebrovascular integrity in experimental stroke

(2015) Gab Seok Kim et al.   Nature Communications

Sphingosine 1 Phosphate at the Blood Brain Barrier: Can the Modulation of S1P Receptor 1 Influence the Response of Endothelial Cells and Astrocytes to Inflammatory Stimuli?

(2015) Simona F. Spampinato et al.   PLoS One

6-Shogaol, an active constituent of ginger, attenuates neuroinflammation and cognitive deficits in animal models of dementia

(2014) Minho Moon et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease

(2014) Mark D. Turner et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Lysophospholipid receptor nomenclature review: IUPHAR Review 8

(2014) Yasuyuki Kihara et al.   BRITISH JOURNAL OF PHARMACOLOGY

Differential activation of receptors and signal pathways upon stimulation by different doses of sphingosine-1-phosphate in endothelial cells

(2014) Qiang Li et al.   EXPERIMENTAL PHYSIOLOGY

Enhanced sphingosine-1-phosphate receptor 2 expression underlies female CNS autoimmunity susceptibility

(2014) Lillian Cruz-Orengo et al.   JOURNAL OF CLINICAL INVESTIGATION

A sphingosine 1-phosphate receptor 2 selective allosteric agonist

(2013) Hideo Satsu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Mast cell and macrophage chemokines CXCL1/CXCL2 control the early stage of neutrophil recruitment during tissue inflammation

(2013) K. De Filippo et al.   BLOOD

Critical role of sphingosine-1-phosphate receptor 2 (S1PR2) in acute vascular inflammation

(2013) G. Zhang et al.   BLOOD

Sphingosine 1-Phosphate Receptors Are Essential Mediators of Eyelid Closure during Embryonic Development

(2013) Deron R. Herr et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LPS and TNF-α induce expression of sphingosine-1-phosphate receptor-2 in human microvascular endothelial cells

(2012) Jing Du et al.   PATHOLOGY RESEARCH AND PRACTICE

Glycosylation in immune cell trafficking

(2009) Markus Sperandio et al.   IMMUNOLOGICAL REVIEWS

Molecular Basis of the Core Structure of Tight Junctions

(2009) M. Furuse   Cold Spring Harbor Perspectives in Biology