Article
Biochemistry & Molecular Biology
Timon Eckes, Sammy Patyna, Alexander Koch, Anke Oftring, Stefan Gauer, Nicholas Obermueller, Stephanie Schwalm, Liliana Schaefer, Jerold Chun, Hermann-Josef Groene, Josef Pfeilschifter
Summary: This study found that S1P(5) deficiency can improve tubular damage and tubulointerstitial fibrosis in a mouse model of adenine-induced nephropathy, and reduce inflammation. Therefore, targeting S1P(5) may be a promising therapeutic target for kidney diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Xuan Zhu, Xinlin Wang, Tianhao Ying, Xiaoli Li, Yidi Tang, Yanfang Wang, Tao Yu, Mengmeng Sun, Jianing Zhao, Yuan Du, Leiming Zhang
Summary: This study investigated the anti-sepsis effects and mechanisms of kaempferol in a lipopolysaccharide-induced sepsis model. The results demonstrated that kaempferol alleviated inflammatory response and stabilized the endothelial barrier in LPS-induced sepsis by regulating the SphK1/S1P signaling pathway. The study also revealed that kaempferol exhibited cell-specific effects on the regulation of SphK1 expression.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Physiology
Lichun Wang, Eleftheria Letsiou, Huashan Wang, Patrick Belvitch, Lucille N. Meliton, Mary E. Brown, Mounica Bandela, Jiwang Chen, Joe G. N. Garcia, Steven M. Dudek
Summary: This study investigated the efficacy of FTY720 S-phosphonate (Tys) in protecting against lung endothelial barrier disruption induced by methicillin-resistant Staphylococcus aureus (MRSA). The results demonstrated that Tys effectively protected lung endothelial cells from barrier disruption and attenuated MRSA-induced inflammatory signaling in vitro. In vivo experiments further showed that Tys reduced lung permeability and levels of inflammatory cells in response to MRSA, indicating its potential as a therapeutic strategy for ARDS.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2022)
Review
Cell Biology
Maryam Jamil, Lauren Ashley Cowart
Summary: In this review, the vital roles of sphingolipids in cellular membranes and cell signaling are discussed, with a focus on their diverse effects on mitochondrial dynamics, cellular bioenergetics, and important cell processes such as apoptosis and mitophagy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Endocrinology & Metabolism
Ilona Juchnicka, Mariusz Kuzmicki, Jacek Szamatowicz
Summary: Obesity is a growing global concern, significantly contributing to the development of diseases like type 2 diabetes and cardiovascular disorders. Excessive lipid accumulation in tissues leads to inflammation and metabolic dysfunction.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Plant Sciences
Guiming Li, Qiaoling Wang, Qian Meng, Guanhua Wang, Fan Xu, Qian Chen, Fang Liu, Yulin Hu, Ming Luo
Summary: Cotton is an important natural fiber crop worldwide, and the ceramide synthase gene GhCS1 plays a crucial role in cotton fiber cell development. GhCS1 affects fiber cell initiation and elongation by modulating substrate utilization.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Cecilia Skoug, Isak Martinsson, Gunnar K. Gouras, Anja Meissner, Joao M. N. Duarte
Summary: The study found that S1PR2 and S1PR4 receptors are located in the active zone of nerve terminals and inhibit neuronal activity. These receptors have control over spontaneous neuronal activity. Future research needs to further explore whether these receptors regulate stimulation-induced neurotransmitter release.
NEUROCHEMICAL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Amrita Balram, Spriha Thapa, Subroto Chatterjee
Summary: This review discusses three major concepts regarding sphingolipids and diabetes: the potential involvement of GM3 in insulin-insulin receptor interactions, the potential roles of Cer and LacCer in apoptosis and mitochondrial dysfunction, and the larger role of LacCer in antioxidant status and inflammation. In addition, the review discusses the efficacy of glycosphingolipid synthesis inhibitors in ameliorating diabetes in experimental animal models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Alex R. Schuurman, Tom D. Y. Reijnders, Anno Saris, Ivan Ramirez Moral, Michiel Schinkel, Justin de Brabander, Christine van Linge, Louis Vermeulen, Brendon P. Scicluna, W. Joost Wiersinga, Felipe A. Vieira Braga, Tom van der Poll
Summary: This study integrated single-cell data from patients with COVID-19, influenza, and non-infectious controls, revealing unique immune features in CAP patients caused by different pathogens, such as varied levels of NK cells and CD8 T EMRA cells.
Review
Oncology
Alhaji H. Janneh, Besim Ogretmen
Summary: Sphingolipids, as important components of cell membranes, play critical roles in regulating cancer cell signaling to control pro-tumoral or antitumoral functions. This review highlights the mechanistic strategies of targeting sphingolipid metabolism for cancer therapeutics. Sphingolipid metabolic signaling plays crucial roles in regulating tumor progression and conferring resistance to anticancer therapies, especially through S1P, which promotes tumor growth/metastasis. Evaluating the prognostic value of sphingolipid enzymes in the overall survival of patients with different malignancies and their clinical implications for anticancer treatment is also discussed.
Article
Toxicology
Jung Hyun Park, Ji-Young Choi, Hye-Kyung Lee, Chulman Jo, Young Ho Koh
Summary: Exposure to PM can lead to endothelial dysfunction in HBMECs in humans, and Notch1 and NICD are potential regulators in this process. PM10-induced NICD signaling increases IL-1β expression and cellular senescence, resulting in increased endothelial permeability in HBMECs. Knockdown of Notch1 blocks PM10-induced endothelial dysfunction by suppressing inflammation and senescence, suggesting that Notch1 and NICD may be target regulators for preventing cerebrovascular endothelial dysfunction caused by ambient air pollutants such as PM.
ARCHIVES OF TOXICOLOGY
(2021)
Review
Medicine, General & Internal
Gehui Sun, Bin Wang, Hongquan Zhu, Junming Ye, Xiaofeng Liu
Summary: This review examines the physiological role of S1P in sepsis-induced intestinal injury. S1P is abundant in the intestine and exerts anti-inflammatory effects, promotes immune cell trafficking, and protects the intestinal barrier. The role and mechanisms of S1P in sepsis-induced intestinal injury have been relatively unexplored.
FRONTIERS IN MEDICINE
(2023)
Article
Cell Biology
Diana Mota V. Toro, Pedro V. da Silva-Neto, Jonatan C. S. A. de Carvalho, Carlos A. M. Fuzo, Malena M. Perez, Vinicius E. Pimentel, Thais F. C. Fraga-Silva, Camilla N. S. R. Oliveira, Glaucia R. Caruso, Adriana F. L. Vilela, Pedro V. Nobre-Azevedo, Thiago V. Defelippo-Felippe, Jamille G. M. M. Argolo, Augusto M. Degiovani, Fatima M. R. Ostini, Marley R. S. Feitosa, Rogerio S. C. Parra, Fernando C. G. Vilar, Gilberto G. Gaspar, Jose J. R. da Rocha, Omar P. Feres, Gabriel P. Costa, Sandra R. C. Maruyama, Elisa M. S. Russo, Ana Paula M. Fernandes, Isabel K. F. M. Santos, Adriana T. Malheiro, Ruxana T. Sadikot, Vania L. D. Bonato, Cristina R. B. Cardoso, Marcelo Dias-Baruffi, Atila A. Trape, Lucia H. A. Faccioli, Carlos A. Sorgi, ImmunoCovid Consortium Grp
Summary: SARS-CoV-2 infection leads to distinct disease patterns with significant changes in host regulatory responses. Severe cases suffer from lung inflammation and systemic effects, while critically ill patients experience a lipid storm that affects inflammation and tissue damage. Sphingolipids play critical roles in various cellular processes and may serve as potential biomarkers and therapeutic targets for COVID-19.
Review
Immunology
Ying Li, Muhuo Ji, Jianjun Yang
Summary: Sepsis is a life-threatening condition that can lead to long-term cognitive impairment after hospital discharge. Mechanisms such as blood-brain barrier disruption and neuroinflammation have been proposed for this impairment. Further studies are needed to develop preventive and treatment strategies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Ophthalmology
Sarah E. Nicholas, Alexander J. Choi, Thi N. Lam, Sandip K. Basu, Nawajes Mandal, Dimitrios Karamichos
Summary: Corneal haze caused by fibrosis can lead to vision loss. Corneal transplantation is currently used to treat severe fibrosis, but it has limitations. This study investigates the role of sphingolipids and their interactions with TGF-beta signaling in corneal fibrosis.
EXPERIMENTAL EYE RESEARCH
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
J. Hu, S. Dziumbla, J. Lin, S. I. Bibli, K. Devraj, S. Liebner, H. P. Hammes, R. Popp, I. Fleming
CARDIOVASCULAR RESEARCH
(2018)
Article
Multidisciplinary Sciences
Kavi Devraj, Sylvaine Guerit, Jakranka Macas, Yvonne Reiss
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2018)
Article
Endocrinology & Metabolism
Daniel Dubinski, Elke Hattingen, Christian Senft, Volker Seifert, Kevin G. Peters, Yvonne Reiss, Kavi Devraj, Karl H. Plate
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2019)
Article
Oncology
Simon Bernatz, Elena I. Ilina, Kavi Devraj, Patrick N. Harter, Klaus Mueller, Sascha Kleber, Yannick Braun, Cornelia Penski, Christoph Renner, Rashi Halder, Lukas Jennewein, Christine Solbach, Frits Thorsen, Bernhard C. Pestalozzi, Axel Mischo, Michel Mittelbronn
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2019)
Article
Oncology
Mariangela Di Tacchio, Jadranka Macas, Jakob Weissenberger, Kathleen Sommer, Oliver Baehr, Joachim P. Steinbach, Christian Senft, Volker Seifert, Martin Glas, Ulrich Herrlinger, Dietmar Krex, Matthias Meinhardt, Astrid Weyerbrock, Marco Timmer, Roland Goldbrunner, Martina Deckert, Andreas H. Scheel, Reinhard Buettner, Oliver M. Grauer, Jens Schittenhelm, Ghazaleh Tabatabai, Patrick N. Harter, Stefan Guenther, Kavi Devraj, Karl H. Plate, Yvonne Reiss
CANCER IMMUNOLOGY RESEARCH
(2019)
Article
Endocrinology & Metabolism
Lars Winkler, Rosel Blasig, Olga Breitkreuz-Korff, Philipp Berndt, Sophie Dithmer, Hans C. Helms, Dmytro Puchkov, Kavi Devraj, Mehmet Kaya, Zhihai Qin, Stefan Liebner, Hartwig Wolburg, Anuska Andjelkovic, Andre Rex, Ingolf E. Blasig, Reiner F. Haseloff
Summary: The study shows that Cldn3 and occludin play a protective role in the stroke by maintaining the integrity of TJ and BBB, but also contribute to the development of edema and infarction.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Neurosciences
Roxane-Isabelle Kestner, Franziska Mayser, Rajkumar Vutukuri, Lena Hansen, Stefan Guenther, Robert Brunkhorst, Kavi Devraj, Waltraud Pfeilschifter
FRONTIERS IN NEUROSCIENCE
(2020)
Article
Clinical Neurology
Gayatri Devraj, Sylvaine Guerit, Jana Seele, Daniel Spitzer, Jadranka Macas, Maryam Khel, Roxana Heidemann, Anne K. Braczynskiz, Wibke Ballhorn, Stefan Guenther, Omolara O. Ogunshola, Michel Mittelbronn, Uwe Koedel, Camelia M. Monoranu, Karl H. Plate, Sven Hammerschmidt, Roland Nau, Kavi Devraj, Volkhard A. J. Kempf
ACTA NEUROPATHOLOGICA
(2020)
Article
Biochemistry & Molecular Biology
Youssef Fouani, Luisa Kirchhof, Laura Stanicek, Guillermo Luxan, Andreas W. Heumueller, Andrea Knau, Ariane Fischer, Kavi Devraj, David John, Philipp Neumann, Albrecht Bindereif, Reinier A. Boon, Stefan Liebner, Ilka Wittig, Carolin Mogler, Madina Karimova, Stefanie Dimmeler, Nicolas Jae
Summary: This study identifies a previously unknown lncRNA NTRAS that plays a crucial role in maintaining vascular integrity by controlling endothelial cell functions. Silencing of NTRAS leads to endothelial cell dysfunction and increased vascular permeability and lethality.
Review
Clinical Neurology
Yvonne Reiss, Sebastian Bauer, Bastian David, Kavi Devraj, Elif Fidan, Elke Hattingen, Stefan Liebner, Nico Melzer, Sven G. Meuth, Felix Rosenow, Theodor Rueber, Laurent M. Willems, Karl H. Plate
Summary: The blood-brain barrier (BBB) is a crucial physiological barrier that maintains the brain microenvironment necessary for proper neuronal function. Dysfunction of the BBB is a characteristic of neurological diseases including ischemia, brain tumors, neurodegenerative diseases, infections, and autoimmune neuroinflammatory disorders. Additionally, BBB dysfunction is involved in epilepsy, a brain disorder characterized by synchronized neuronal activity and seizures. While antiseizure drugs targeting neuronal hyperexcitability are not always effective, drugs specifically targeting the neurovasculature in epilepsy patients have not been explored. Understanding the mechanism of BBB compromise in epilepsy is important for its therapeutic potential.
Meeting Abstract
Physiology
J. Hu, S. Dziumbla, J. Lin, S. -I. Bibli, S. Zukunft, K. Devraj, A. Sodhi, S. Liebner, H-P. Hammes, R. Popp, I. Fleming
Correction
Ophthalmology
Jeanette Eresch, Martin Stumpf, Alexander Koch, Rajkumar Vutukuri, Nerea Ferreiros, Yannick Schreiber, Katrin Schroder, Kavi Devraj, Rudiger Popp, Andrea Huwiler, Lars-Olof Hattenbach, Josef Pfeilschifter, Waltraud Pfeilschifter
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2018)
Meeting Abstract
Physiology
M. S. Leisegang, C. Fork, I. Josipovic, F. Richler, J. Preussner, M. J. Millers, J. Epah, P. Hofmann, S. Anther, C. Valasarajan, F. Moll, J. Heidler, Y. Ponomareva, L. Maegdefesser, S. Uchida, C. Kunne, K. Sleilos, R. T. Schermuly, N. Weissmann, K. Devraj, I. Wittig, R. A. Boon, S. Dimmeler, S. S. Pullamsetti, M. Looso, F. J. Miller, R. P. Brandes
Article
Ophthalmology
Jeanette Eresch, Martin Stumpf, Alexander Koch, Rajkumar Vutukuri, Nerea Ferreiros, Yannick Schreiber, Katrin Schroeder, Kavi Devraj, Ruediger Popp, Lars-Olof Hattenbach, Josef Pfeilschifter, Waltraud Pfeilschifter
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2018)
Article
Biochemistry & Molecular Biology
Pei-Yang Gao, Ya-Nan Ou, Yi-Ming Huang, Zhi-Bo Wang, Yan Fu, Ya-Hui Ma, Qiong-Yao Li, Li-Yun Ma, Rui-Ping Cui, Yin-Chu Mi, Lan Tan, Jin-Tai Yu
Summary: Liver function may play a role in the progression of Alzheimer's disease. The study found that as AD progressed, certain liver function markers increased while others decreased. The relationship between liver function and CSF AD biomarkers indicates a potential mediation effect on cognition.
JOURNAL OF NEUROCHEMISTRY
(2024)