Review
Immunology
Xiaoyao Peng, Zhixuan Luo, Shuang He, Luhua Zhang, Ying Li
Summary: The article discusses the mechanisms by which lipopolysaccharide damages the blood-brain barrier and its relationship with sepsis-associated encephalopathy. It highlights the damaging effects of inflammatory factors and neurotoxins on brain tissue, as well as the vicious cycle of further BBB destruction.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Peripheral Vascular Disease
Michele Novochadlo, Mariana Pereira Goldim, Sandra Bonfante, Larissa Joaquim, Khiany Mathias, Kiuanne Metzker, Richard Simon Machado, Everton Lanzzarin, Gabriela Bernades, Erick Bagio, Leandro Garbossa, Aloir Neri de Oliveira Junior, Naiana da Rosa, Jaqueline Generoso, Jucelia Jeremias Fortunato, Tatiana Barichello, Fabricia Petronilho
Summary: The study found that folic acid can reduce the impact of sepsis on rat brain function, improve survival rates, and enhance long-term cognitive abilities. The data shows that folic acid reduces memory impairment within 10 days after sepsis by decreasing blood-brain barrier permeability and oxidative stress parameters in the brain.
MICROVASCULAR RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Yedan Liu, Huawei Zhang, Shaoxun Wang, Ya Guo, Xing Fang, Baoying Zheng, Wenjun Gao, Hongwei Yu, Zongbo Chen, Richard J. Roman, Fan Fan
Summary: This study demonstrates that the loss of contractile capability in pericytes in diabetes is associated with enhanced ROS and reduced ATP production. Enhanced advanced glycation end products (AGEs) in diabetes accompany with reduced pericyte and endothelial tight junction coverage in the cortical capillaries of old diabetic rats. These results suggest our previous findings that the impaired cerebral hemodynamics, BBB leakage, and cognitive impairments in old DM model are associated with hyperglycemia-induced cerebrovascular pericyte dysfunction.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jin Yu, Hong Zhu, Mark S. Kindy, Saeid Taheri
Summary: This study demonstrates that suppression of CYP2E1 can alleviate I/R injury and protect BBB integrity by reducing oxidative stress and inflammation. CYP2E1 KO mice showed lower lesion volume and neurological deficits after I/R, with decreased oxidative stress and inflammatory responses.
Article
Pharmacology & Pharmacy
Haidy Abbas, Heba A. Gad, Mohamed A. Khattab, Mai Mansour
Summary: This study developed resveratrol-loaded bilosomes as a promising drug delivery system for Alzheimer's disease, showing superiority over traditional drug suspensions in enhancing therapeutic effects in an AD animal model.
Article
Nanoscience & Nanotechnology
Yong Yang, Guoying Deng, Peng Wang, Guangzhao Lv, Rui Mao, Yuhao Sun, Baofeng Wang, Xijian Liu, Liuguan Bian, Dong Zhou
Summary: The porous Se@SiO2 nanocomposite exerts neuroprotective effects by suppressing oxidative stress, improving neurological function, reducing cell apoptosis, brain edema, and blood-brain barrier permeability in a collagenase-induced ICH mouse model. It may be a potential candidate for the clinical treatment of ICH and oxidative stress-related brain injuries.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Medicine, Research & Experimental
Xingyong Chen, Yanguang Mao, Yueting Guo, Dongyun Xiao, Zejing Lin, Yiyi Huang, Ying Chun Liu, Xu Zhang, Yinzhou Wang
Summary: This study aims to explore the contribution of the immunoproteasome subunit LMP2 in neurobehavioral functions. The results showed that LMP2 gene deletion caused metabolic abnormalities, cognitive impairment, increased anxiety-like behavior, multiple myelin loss, increased blood-brain barrier leakage, and enhanced amyloid-beta protein deposition in rats. These factors led to chronic oxidative stress and neuroinflammation in the brain, contributing to cognitive impairment.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Batoul Ghaddar, Laura Gence, Bryan Veeren, Matthieu Bringart, Jean-Loup Bascands, Olivier Meilhac, Nicolas Diotel
Summary: The aqueous extract of Psiloxylon mauritianum exhibits lipid-lowering effects and prevents weight gain, hyperglycemia, liver steatosis, and detrimental effects on the central nervous system in zebrafish models. It also increases feces production, possibly through its effects on intestinal lipid absorption or microbiota. These findings highlight the potential of Psiloxylon mauritianum as a therapeutic agent for obesity.
Article
Environmental Sciences
Hongjing Zhao, Yu Wang, Menghao Guo, Yachen Liu, Hongxian Yu, Mingwei Xing
Summary: The study found that exposure to cypermethrin and sulfamethoxazole, as well as their mixture in water environment, significantly affects the brain function, oxidative stress, and apoptosis of grass carp. The results showed that these two chemicals induce similar biological responses and may enhance each other's toxic effects.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Immunology
Xin Wang, Jia-ying Yu, Yan Sun, Heng Wang, Hu Shan, Shubai Wang
Summary: Baicalin, a bioactive extract from Scutellaria Baicalensis Georgi, has anti-inflammatory and anti-oxidative functions, and its preventive protection can improve cell apoptosis and Fluorescein sodium infiltration in the brain tissue. Baicalin can also inhibit pro-inflammatory cytokines production, up-regulate Claudin-5 and ZO-1 protein expression, reduce ROS and MDA production, promote SOD production, and activate Nrf2-mediated antioxidant stress pathway to protect blood-brain barrier damage.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Farzane Sivandzade, Faleh Alqahtani, Hemangini Dhaibar, Diana Cruz-Topete, Luca Cucullo
Summary: Traumatic Brain Injury (TBI) is a leading cause of cerebrovascular and neurological disorders worldwide. Smoking is believed to worsen post-TBI brain injury and hinder recovery by affecting the blood-brain barrier endothelium. Antidiabetic drugs such as metformin and rosiglitazone have been found to protect the blood-brain barrier and reduce brain damage caused by chronic smoking.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Marine & Freshwater Biology
Yu Wang, Hongjing Zhao, Yachen Liu, Menghao Guo, Ye Tian, Puyi Huang, Mingwei Xing
Summary: This study investigated the brain damage caused by arsenite exposure in common carp and the protective effects of zinc ion supplementation. Results showed that zinc ion coadministration effectively alleviated oxidative damage, tight junction injuries, nerve conduction depletion, and apoptotic and autophagic cell death induced by arsenite in the brain.
AQUATIC TOXICOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Wenlong Zhang, Huaqing Chen, Liuyan Ding, Junwei Gong, Mengran Zhang, Wenyuan Guo, Pingyi Xu, Shiying Li, Yunlong Zhang
Summary: In this study, a Trojan horse system was used for targeted delivery of a blood brain barrier-penetrating peptide (RVG29) conjugated to nanoparticles loaded with the natural autophagy inducer 4,4 '-dimethoxychalcone (DMC) for the treatment of Parkinson's disease. The neuroprotective effects of DMC were demonstrated, showing improvement in motor deficits and nigral DA neuron death in PD mice without causing adverse effects. rvanism by using RVG-nDMC provides a potentially effective approach for intervention against Parkinson's disease.
Article
Geriatrics & Gerontology
Willian Margotti, Mariana Pereira de Souza Goldim, Richard Simon Machado, Erick Bagio, Carlos Dacoregio, Gabriela Bernades, Everton Lanzzarin, Solange Stork, Thaina Cidreira, Tais Luise Denicol, Larissa Joaquim, Lucineia Gainski Danielski, Kiuanne Lino Lobo Metzker, Sandra Bonfante, Edficher Margotti, Fabricia Petronilho
Summary: This study aimed to evaluate multi-organ oxidative stress in old rats in an animal model of polymicrobial sepsis. The results showed that aging potentiated the increase in MPO activity in the lung, liver, and spleen, and lipid peroxidation occurred in all structures analyzed in the CLP groups, with a higher prevalence in the CLP 210d group compared to 60d.
EXPERIMENTAL GERONTOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shengpan Chen, Lingzhi Li, Chao Peng, Chunjing Bian, Pinar Eser Ocak, John H. Zhang, Yong Yang, Dong Zhou, Guangzhong Chen, Yumin Luo
Summary: This review examines the breakdown of the blood-brain barrier (BBB) after intracerebral hemorrhage (ICH) and focuses on strategies to protect the BBB integrity and potential therapeutic targets.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Neurosciences
Sandra Bonfante, Larissa Joaquim, Maria Eduarda Fileti, Amanda Della Giustina, Mariana Pereira de Souza Goldim, Lucineia Gainski Danielski, Evandro Cittadin, Raquel Jaconi De Carli, Bianca Xavier de Farias, Nicole Alessandra Engel, Naiana Rosa, Jucelia Jeremias Fortunato, Vijayasree Giridharan, Giselli Scaini, Gislaine Tezza Rezin, Jaqueline Generoso, Rafael Mariano de Bitencourt, Silvia Terra, Tatiana Barichello, Fabricia Petronilho
Summary: STC-1 has been shown to have a protective role by inhibiting the inflammatory response, reducing oxidative stress, and improving mitochondrial function, thereby providing neuroprotection against sepsis-associated encephalopathy.
NEUROTOXICITY RESEARCH
(2021)
Article
Behavioral Sciences
Talita Tuon, Sandra S. Meirelles, Airam B. de Moura, Thayse Rosa, Laura A. Borba, Maria Eduarda M. Botelho, Helena M. Abelaira, Gisiane B. de Mathia, Lucineia G. Danielski, Maria Eduarda Fileti, Fabricia Petronilho, Zuleide Maria Ignacio, Joao Quevedo, Gislaine Z. Reus
Summary: This study investigated the effects of PD and stress on depressive-like behavior and oxidative stress using animal models. The results showed that both stress and 6-OHDA induced depressive-like behavior and oxidative stress in the brain.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Neurosciences
Larissa Silva Joaquim, Lucineia Gainski Danielski, Sandra Bonfante, Erica Biehl, Khiany Mathias, Tais Denicol, Erick Bagio, Everton Venicius Lanzzarin, Richard Simon Machado, Gabriela Costa Bernades, Jaqueline Generoso, Amanda Della Giustina, Tatiana Barichello, Fabricia Petronilho
Summary: The study demonstrates that inhibiting NLRP3 activation with MCC950 can reduce brain oxidative damage after cerebral ischemia/reperfusion in rats.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Helena M. Abelaira, Thayse Rosa, Airam B. de Moura, Natalia M. Andrade, Nicoly S. Martinello, Larissa R. Maciel, Maria Eduarda M. Botelho, Laura A. Borba, Beatriz C. Chede, Camila O. Arent, Larissa Joaquim, Sandra Bonfante, Lucineia G. Danielski, Talita Tuon, Fabricia Petronilho, Joao Quevedo, Gislaine Z. Reus
Summary: This study evaluated the treatment effects of ketamine, electroconvulsive stimulation (ECS), escitalopram, alone or in combination, in adult male and female rats subjected to maternal deprivation (MD) animal model. The findings showed that the treatments were able to reverse depressive and anhedonic behavior in females, while elicited different responses in males. Furthermore, the study highlights the importance of considering gender differences in MDD related to early stress and therapeutic strategies.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Neurosciences
Amanda Della Giustina, Judite Filgueiras Rodrigues, Erick Bagio, Sandra Bonfante, Larissa Joaquim, Graciela Zarbato, Solange Stork, Richard Simon Machado, Mariana Pereira de Souza Goldim, Lucineia Gainski Danielski, Khiany Mathias, Carlos Dacoregio, Taise Cardoso, Giulia S. Predroso, Ligia Milanez Venturini, Rubya Pereira Zaccaron, Paulo Cesar Lock Silveira, Ricardo Aurino Pinho, Fabricia Petronilho
Summary: Sepsis is a life-threatening condition caused by a dysregulated response to infection, which leads to organ dysfunction. Inflammation and oxidative stress play major roles in the damage to the lungs and brain in sepsis. A physical exercise program has protective effects against inflammation and oxidative stress in the lungs and brain of septic rats.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Neurosciences
Lucineia Gainski Danielski, Amanda Della Giustina, Fernanda Frederico Gava, Tatiana Barichello, Fabricia Petronilho
Summary: Sepsis is a life-threatening condition that can lead to cognitive and memory damage, which may be associated with astrocytic activation and the release of inflammatory mediators.
MOLECULAR NEUROBIOLOGY
(2022)
Review
Endocrinology & Metabolism
Larissa Joaquim, Amanda Della Giustina, Richard Simon Machado, Kiuanne Lino Lobo Metzker, Sandra Bonfante, Lucineia Gainski Danielski, Mariana Pereira de Souza Goldim, Fabricia Petronilho
Summary: Recovered COVID-19 patients may experience neurological, psychiatric, and cognitive problems, although the exact prevalence and outcome of cognitive sequelae are unclear. The mechanisms behind COVID-19-induced cognitive dysfunction may involve neuroinflammation mediated by sustained systemic inflammation, disrupted brain barrier, and glial reactiveness.
NEUROIMMUNOMODULATION
(2022)
Article
Neurosciences
Fernanda Tanaka, Gustavo Mazzardo, Daiana C. Salm, Bruna H. de Oliveira, Larissa Joaquim, Richard S. Machado, Thaina Cidreira, Edsel Balduino Bittencourt, Gianluca Bianco, Franciane Bobinski, Anna Paula Piovezan, John Z. Srbely, Jay P. Shah, Ari O. O. More, Leidiane Mazzardo-Martins, Daniel F. Martins
Summary: This study investigated the involvement of peripheral formyl peptide receptor 2 (FPR2/ALX) in the antihyperalgesic effect of electroacupuncture (EA) on persistent inflammatory pain. It was found that EA treatment increased the levels of IL-10 and catalase activity in the inflamed paw, which were partially dependent on the activation of peripheral FPR2/ALX.