Chromatin de-condensation by switching substrate elasticity

The Cdx2 homeobox gene suppresses intestinal tumorigenesis through non–cell-autonomous mechanisms

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Impact of the physical microenvironment on tumor progression and metastasis

(2016) Fabian Spill et al.   CURRENT OPINION IN BIOTECHNOLOGY

Cellular adhesome screen identifies critical modulators of focal adhesion dynamics, cellular traction forces and cell migration behaviour

(2016) Michiel Fokkelman et al.   Scientific Reports

Cell guidance into quiescent state through chromatin remodeling induced by elastic modulus of substrate

(2015) Morgane Rabineau et al.   BIOMATERIALS

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

Nanoscale changes in chromatin organization represent the initial steps of tumorigenesis: a transmission electron microscopy study

(2014) Lusik Cherkezyan et al.   BMC CANCER

Chromatin Repressive Complexes in Stem Cells, Development, and Cancer

(2014) Anne Laugesen et al.   Cell Stem Cell

Mechanical memory and dosing influence stem cell fate

(2014) Chun Yang et al.   NATURE MATERIALS

Small molecule compound induces chromatin de-condensation and facilitates induced pluripotent stem cell generation

(2014) Xiaoyuan Wei et al.   Journal of Molecular Cell Biology

iPSCs and small molecules: a reciprocal effort towards better approaches for drug discovery

(2013) Ru Zhang et al.   ACTA PHARMACOLOGICA SINICA

Emerging roles for chromatin as a signal integration and storage platform

(2013) Aimee I. Badeaux et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

HDAC Up-Regulation in Early Colon Field Carcinogenesis Is Involved in Cell Tumorigenicity through Regulation of Chromatin Structure

(2013) Yolanda Stypula-Cyrus et al.   PLoS One

Contribution of Soft Substrates to Malignancy and Tumor Suppression during Colon Cancer Cell Division

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Soft fibrin gels promote selection and growth of tumorigenic cells

(2012) Jing Liu et al.   NATURE MATERIALS

Attenuation of Cell Mechanosensitivity in Colon Cancer Cells during In Vitro Metastasis

(2012) Xin Tang et al.   PLoS One

Cdx2 determines the fate of postnatal intestinal endoderm

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Biophysical regulation of tumor cell invasion: moving beyond matrix stiffness

(2011) Amit Pathak et al.   Integrative Biology

Nanoscale surfaces for the long-term maintenance of mesenchymal stem cell phenotype and multipotency

(2011) Rebecca J. McMurray et al.   NATURE MATERIALS

The cancer stem cell: premises, promises and challenges

(2011) Hans Clevers   NATURE MEDICINE

Epigenetics and colorectal cancer

(2011) Victoria Valinluck Lao et al.   Nature Reviews Gastroenterology & Hepatology

Mechanical Force Affects Expression of an In Vitro Metastasis-Like Phenotype in HCT-8 Cells

(2010) Xin Tang et al.   BIOPHYSICAL JOURNAL

Open chromatin in pluripotency and reprogramming

(2010) Alexandre Gaspar-Maia et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Differential expression analysis for sequence count data

(2010) Simon Anders et al.   GENOME BIOLOGY

TopHat: discovering splice junctions with RNA-Seq

(2009) Cole Trapnell et al.   BIOINFORMATICS

Mechanics, malignancy, and metastasis: The force journey of a tumor cell

(2009) Sanjay Kumar et al.   CANCER AND METASTASIS REVIEWS

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Selective and uncoupled role of substrate elasticity in the regulation of replication and transcription in epithelial cells

(2009) L. Kocgozlu et al.   JOURNAL OF CELL SCIENCE

Hepatocyte Nuclear Factor 4 , a Key Factor for Homeostasis, Cell Architecture, and Barrier Function of the Adult Intestinal Epithelium

(2009) A.-L. Cattin et al.   MOLECULAR AND CELLULAR BIOLOGY

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis

(2008) Ulrike Stein et al.   NATURE MEDICINE

Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus

(2008) Ning Wang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY